Naim M Maalouf

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Low urine pH: a novel feature of the metabolic syndrome
    Naim M Maalouf
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas, USA
    Clin J Am Soc Nephrol 2:883-8. 2007
  2. pmc Metabolic syndrome and the genesis of uric acid stones
    Naim M Maalouf
    Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Ren Nutr 21:128-31. 2011
  3. pmc Metabolic basis for low urine pH in type 2 diabetes
    Naim M Maalouf
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Clin J Am Soc Nephrol 5:1277-81. 2010
  4. pmc Hypocitraturia and hyperoxaluria after Roux-en-Y gastric bypass surgery
    Naim M Maalouf
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Urol 183:1026-30. 2010
  5. pmc Hypercalciuria associated with high dietary protein intake is not due to acid load
    Naim M Maalouf
    Department of Internal Medicine and Charles, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 96:3733-40. 2011
  6. pmc Postmenopausal hormone use and the risk of nephrolithiasis: results from the Women's Health Initiative hormone therapy trials
    Naim M Maalouf
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Arch Intern Med 170:1678-85. 2010
  7. doi request reprint The noncalciotropic actions of vitamin D: recent clinical developments
    Naim M Maalouf
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Curr Opin Nephrol Hypertens 17:408-15. 2008
  8. doi request reprint Nephrolithiasis in topiramate users
    Naim M Maalouf
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Urol Res 39:303-7. 2011
  9. ncbi request reprint Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis
    Mary Ann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 17:1422-8. 2006
  10. pmc Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes
    I Alexandru Bobulescu
    Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885
    Am J Physiol Renal Physiol 305:F1498-503. 2013

Research Grants

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Low urine pH: a novel feature of the metabolic syndrome
    Naim M Maalouf
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Dallas, Texas, USA
    Clin J Am Soc Nephrol 2:883-8. 2007
    ..This study examined the association between the metabolic syndrome and urine pH in individuals without a history of nephrolithiasis...
  2. pmc Metabolic syndrome and the genesis of uric acid stones
    Naim M Maalouf
    Department of Internal Medicine, and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Ren Nutr 21:128-31. 2011
    ....
  3. pmc Metabolic basis for low urine pH in type 2 diabetes
    Naim M Maalouf
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Clin J Am Soc Nephrol 5:1277-81. 2010
    ..This study was conducted to assess the metabolic basis responsible for the excessive urinary acidity of individuals with type 2 diabetes...
  4. pmc Hypocitraturia and hyperoxaluria after Roux-en-Y gastric bypass surgery
    Naim M Maalouf
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Urol 183:1026-30. 2010
    ..To assess the mechanism(s) predisposing to nephrolithiasis after Roux-en-Y gastric bypass we compared urinary tract stone risk profiles in patients who underwent the procedure and normal obese individuals...
  5. pmc Hypercalciuria associated with high dietary protein intake is not due to acid load
    Naim M Maalouf
    Department of Internal Medicine and Charles, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 96:3733-40. 2011
    ..Dietary intake of animal proteins is associated with an increase in urinary calcium and nephrolithiasis risk. We tested the hypothesis that the acid load imposed by dietary proteins causes this hypercalciuria...
  6. pmc Postmenopausal hormone use and the risk of nephrolithiasis: results from the Women's Health Initiative hormone therapy trials
    Naim M Maalouf
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Arch Intern Med 170:1678-85. 2010
    ..Observational studies examining the role of estrogen in the risk of kidney stone formation have shown conflicting results. However, randomized trial evidence on nephrolithiasis risk with estrogen therapy in postmenopausal women is lacking...
  7. doi request reprint The noncalciotropic actions of vitamin D: recent clinical developments
    Naim M Maalouf
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Curr Opin Nephrol Hypertens 17:408-15. 2008
    ..This review summarizes recently described actions of 1,25-dihydroxyvitamin D beyond its function in calcium homeostasis and bone metabolism...
  8. doi request reprint Nephrolithiasis in topiramate users
    Naim M Maalouf
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    Urol Res 39:303-7. 2011
    ..The prevalence of symptomatic nephrolithiasis with long-term topiramate use is higher than reported in short-term studies. Furthermore, clinical prevalence is underestimated due to asymptomatic nephrolithiasis...
  9. ncbi request reprint Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis
    Mary Ann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 17:1422-8. 2006
    ..Higher body mass and increased acid intake can contribute to but cannot entirely account for the lower urine pH in patients with type 2 diabetes...
  10. pmc Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes
    I Alexandru Bobulescu
    Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8885
    Am J Physiol Renal Physiol 305:F1498-503. 2013
    ..A blunted renal ammonium excretory response to dietary acid loads may contribute to the pathogenesis of idiopathic uric acid nephrolithiasis...
  11. pmc Metabolic syndrome and the risk of calcium stones
    Khashayar Sakhaee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Nephrol Dial Transplant 27:3201-9. 2012
    ..This study was conducted to assess whether risk factors associated with calcium nephrolithiasis increase with individual characteristics of the MS...
  12. pmc The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers
    Maryann Cameron
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 81:1123-30. 2012
    ....
  13. ncbi request reprint Circadian variation in urine pH and uric acid nephrolithiasis risk
    Mary Ann Cameron
    Department of Internal Medicine, Children s Medical Center, TX, USA
    Nephrol Dial Transplant 22:2375-8. 2007
  14. ncbi request reprint Biochemical and stone-risk profiles with topiramate treatment
    Brian J Welch
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Kidney Dis 48:555-63. 2006
    ..This study explores the relationship between topiramate treatment and propensity for kidney stone formation...
  15. ncbi request reprint Effects of potassium alkali and calcium supplementation on bone turnover in postmenopausal women
    Khashayar Sakhaee
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 90:3528-33. 2005
    ..In postmenopausal women, combined treatment with potassium citrate and calcium citrate inhibits bone resorption by providing an alkali load and increasing absorbed calcium...
  16. ncbi request reprint Novel insights into the pathogenesis of uric acid nephrolithiasis
    Naim M Maalouf
    Charles and Jane Pak Center of Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Curr Opin Nephrol Hypertens 13:181-9. 2004
    ..The underlying mechanism(s) responsible for these disturbances remain poorly characterized. This review summarizes previous knowledge and highlights some recent developments in the pathophysiology of low urine pH and hyperuricosuria...
  17. pmc Nephrolithiasis-associated bone disease: pathogenesis and treatment options
    Khashayar Sakhaee
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 79:393-403. 2011
    ..This manuscript reviews the epidemiology, pathophysiology, and potential treatments of bone disease in patients with nephrolithiasis...
  18. doi request reprint Mild hyponatremia is associated with an increased risk of death in an ambulatory setting
    Fabrice Gankam-Kengne
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Kidney Int 83:700-6. 2013
    ..75). Thus, mild hyponatremia is associated with an increased risk of death in a young and ethnically diverse community population...
  19. pmc Vitamin D deficiency in obese children and its relationship to glucose homeostasis
    Micah L Olson
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9063, USA
    J Clin Endocrinol Metab 97:279-85. 2012
    ....
  20. pmc Comparison of insulin action on glucose versus potassium uptake in humans
    Trang Q Nguyen
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Clin J Am Soc Nephrol 6:1533-9. 2011
    ..This study examines whether the cellular uptake of these molecules is regulated in concert or independently...
  21. doi request reprint Hepatitis C co-infection and severity of liver disease as risk factors for osteoporotic fractures among HIV-infected patients
    Naim M Maalouf
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Bone Miner Res 28:2577-83. 2013
    ..002-1.014; p = 0.015). In conclusion, among HIV-infected patients, severity of liver disease partly explains the HCV-associated increased risk of osteoporotic fractures. Other determinants of this increased risk remain to be defined...
  22. pmc Hyperinsulinemia and urinary calcium excretion in calcium stone formers with idiopathic hypercalciuria
    Vivienne Yoon
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 98:2589-94. 2013
    ....
  23. pmc Clinical review. Kidney stones 2012: pathogenesis, diagnosis, and management
    Khashayar Sakhaee
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Clin Endocrinol Metab 97:1847-60. 2012
    ..Over the past decade, major advances have been made in the understanding of the pathogenesis, diagnosis, and treatment of kidney stone disease...
  24. ncbi request reprint Bisphosphonate-induced hypocalcemia: report of 3 cases and review of literature
    Naim M Maalouf
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8885, USA
    Endocr Pract 12:48-53. 2006
    ..To report 3 cases of bisphosphonate-induced hypocalcemia and review the relevant literature...
  25. pmc Comparison of semi-empirical and computer derived methods for estimating urinary saturation of brushite
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Urol 181:1423-8. 2009
    ..To attempt resolution the supersaturation index according to the Joint Expert Speciation System and the relative saturation ratio according to Equil 2 were compared with the semi-empirically derived concentration-to-product ratio...
  26. ncbi request reprint Increased propensity for calcium phosphate kidney stones with topiramate use
    Damaris Vega
    University of Texas Southwestern Medical Center, Department of Internal Medicine and Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Expert Opin Drug Saf 6:547-57. 2007
    ....
  27. doi request reprint Metabolic syndrome and uric acid nephrolithiasis
    Khashayar Sakhaee
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Semin Nephrol 28:174-80. 2008
    ..This article reviews the epidemiologic and metabolic studies linking uric acid nephrolithiasis with the metabolic syndrome, and examines the potential mechanisms underlying the unduly acidic urine in these conditions...
  28. doi request reprint Comparison of semi-empirical and computer derived methods for estimating urinary saturation of calcium oxalate
    Charles Y C Pak
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    J Urol 182:2951-6. 2009
    ....
  29. doi request reprint Safety of bisphosphonates
    Catalina Orozco
    Rheumatology Associates, 8144 Walnut Hill Lane, Dallas, TX 75231, USA
    Rheum Dis Clin North Am 38:681-705. 2012
    ..This article summarizes the current knowledge regarding the major side effects associated with the use of bisphosphonates, identifies at-risk populations for these side effects, and provides guidance for their use...
  30. doi request reprint Fasting versus 24-h urine pH in the evaluation of nephrolithiasis
    Giovanna Capolongo
    Department of Internal Medicine, Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Urol Res 39:367-72. 2011
    ..Significant variability between these two parameters is seen in individual patients, emphasizing the cardinal role of 24-h urine collection for evaluating UpH in nephrolithiasis...
  31. pmc Body fat content and distribution and urinary risk factors for nephrolithiasis
    Federica Pigna
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, Department of Internal Medicine, and, Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, Texas
    Clin J Am Soc Nephrol 9:159-65. 2014
    ..Obesity is associated with a higher risk of nephrolithiasis. However, it is not known whether higher body fat mass or abnormal fat distribution influences stone risk independent of dietary factors...
  32. ncbi request reprint Association of urinary pH with body weight in nephrolithiasis
    Naim M Maalouf
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 65:1422-5. 2004
    ..Based on these observations, we hypothesized that urinary pH may be inversely associated to body weight in nephrolithiasis...
  33. ncbi request reprint CLINICAL Review #: the role of receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/osteoprotegerin: clinical implications
    Damaris Vega
    Department of Internal Medicine, Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 92:4514-21. 2007
    ..Receptor activator of nuclear factor-kappaB ligand (RANKL), receptor activator of nuclear factor-kappaB (RANK), and osteoprotegerin (OPG) play a central role in bone remodeling and disorders of mineral metabolism...
  34. pmc Prevalence and spot urine risk factors for renal stones in children taking topiramate
    Nicol Corbin Bush
    University of Texas Southwestern Medical Center, Dallas, TX, USA Children s Medical Center Dallas, Dallas, TX, USA Department of Urology Division of Pediatric Urology, Dallas, TX, USA Electronic address
    J Pediatr Urol 9:884-9. 2013
    ..We screened outpatient TPM-treated children without history of stones to estimate the prevalence of renal stones and to characterize urine stone-risk profiles...
  35. doi request reprint Ectopic atypical parathyroid lipoadenoma: a rare cause of severe primary hyperparathyroidism
    Vivienne Yoon
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390 8885, USA
    J Bone Miner Metab 31:595-600. 2013
    ..In conclusion, this case illustrates a difficult case of an ectopic functioning parathyroid lipoadenoma with chronic sequelae due to severe hyperparathyroidism. ..
  36. ncbi request reprint Treatment of osteoporosis in patients with chronic liver disease and in liver transplant recipients
    Naim M Maalouf
    The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    Curr Treat Options Gastroenterol 9:456-63. 2006
    ..In our opinion, the best treatment approach involves the elucidation of modifiable risk factors and the selection of agents targeted at the underlying derangements...
  37. doi request reprint Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents
    Roger Bedimo
    Department of Medicine, VA North Texas Healthcare System, Dallas, Texas, USA
    AIDS 26:825-31. 2012
    ..Whereas tenofovir (TDF) exposure has been associated with decreased bone density, it remains unclear whether it is associated with increased risk of osteoporotic fractures...
  38. ncbi request reprint A case of chromosome 22q11 deletion syndrome diagnosed in a 32-year-old man with hypoparathyroidism
    Naim M Maalouf
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8885, USA
    J Clin Endocrinol Metab 89:4817-20. 2004
    ..Chromosome 22q11 microdeletions are relatively common, and the diagnosis should be considered even in adults with hypoparathyroidism because of the potential benefit of genetic counseling...
  39. ncbi request reprint Hypercalcemia of malignancy with simultaneous elevation in serum parathyroid hormone--related peptide and 1,25-dihydroxyvitamin D in a patient with metastatic renal cell carcinoma
    Sarika B Shivnani
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8885, USA
    Endocr Pract 15:234-9. 2009
    ..To determine the cause of refractory hypercalcemia in a patient with metastatic renal cell carcinoma...
  40. pmc Variability in urinary oxalate measurements between six international laboratories
    Naim M Maalouf
    Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Nephrol Dial Transplant 26:3954-9. 2011
    ..Hyperoxaluria is a major risk factor for kidney stone formation. Although urinary oxalate measurement is part of all basic stone risk assessment, there is no standardized method for this measurement...
  41. ncbi request reprint Acute interstitial nephritis complicating a new diagnosis of Wegener's granulomatosis
    Licheng Lee
    Department of Medicine, University of Hawai i John A Burns School of Medicine, Honolulu 96813, USA
    Hawaii Med J 67:12-4. 2008
    ..Renal biopsy should be performed in renal insufficiency patients where several concurrent conditions are suspected to obtain the correct diagnosis and institute appropriate treatment...
  42. ncbi request reprint Osteoporosis after solid organ transplantation
    Naim M Maalouf
    Department of Medicine, College of Physicians and Surgeons, Columbia University, PH8 864, 630 West 168th Street, New York, New York 10032, USA
    J Clin Endocrinol Metab 90:2456-65. 2005
    ....

Research Grants2

  1. Mentored Patient-Oriented Research Career Development Award
    Naim Maalouf; Fiscal Year: 2007
    ..abstract_text> ..