Thomas Ma

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc IL-1beta causes an increase in intestinal epithelial tight junction permeability
    Rana M Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Immunol 178:4641-9. 2007
  2. doi request reprint Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America Albuquerque Veterans Affairs Medical Center, Albuquerque, New Mexico, United States of America
    PLoS ONE 9:e85345. 2014
  3. ncbi request reprint TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation
    Thomas Y Ma
    Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 286:G367-76. 2004
  4. ncbi request reprint Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression
    Thomas Y Ma
    Internal Medicine Gastroenterology, MSC10 5550, 1 Univ of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 288:G422-30. 2005
  5. ncbi request reprint Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    Dongmei Ye
    Department of Internal Medicine Gastroenterology, MSC10 5550, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 290:G496-504. 2006
  6. pmc Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1054-64. 2011
  7. pmc Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Immunol 180:5653-61. 2008
  8. pmc Mechanism of glucocorticoid regulation of the intestinal tight junction barrier
    Michel A Boivin
    Department of Medicine, Univ of New Mexico, Albuquerque, NM 87131, USA
    Am J Physiol Gastrointest Liver Physiol 292:G590-8. 2007
  9. ncbi request reprint Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability
    Karol Dokladny
    Internal Medicine Gastroenterology and Hepatology, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 290:G204-12. 2006
  10. doi request reprint Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder
    Bridget C Lynch
    Department of Pathology, University of New Mexico School of Medicine, MSC 084640 Albuquerque, NM 87131 0001, USA
    Ann Diagn Pathol 12:161-4. 2008

Collaborators

  • James Melvin Anderson
  • Alan S Fanning
  • HAMID SAID
  • Bridget C Lynch
  • Karol Dokladny
  • Dongmei Ye
  • Rana Al-Sadi
  • Pope L Moseley
  • Michel A Boivin
  • John C Kennedy
  • Walker Wharton
  • Shuhong Guo
  • Michel Boivin
  • Neil T Hoa
  • Andrzej Tarnawski
  • Rebecca Lobb
  • Rana M Al-Sadi
  • Veedamali S Subramanian
  • Jehad Barakat
  • Svetlana M Nabokina
  • Ghasan Tabel
  • Joseph Chen
  • Lisa Ereifej
  • Babak Mohajer
  • Mariam Hashimi
  • Andrew Q Giap
  • Moustafa Youssef
  • Khaldun Khatib
  • Angela Bradley
  • Praveen K Roy
  • Tuhama Rihani
  • Jonathan S Marchant
  • Chris Shepela
  • Iris Ma
  • Jeffrey C Dunkelberg
  • Mathew Domek
  • Vimesh Akotia
  • Harry Park
  • Daniel Tran

Detail Information

Publications25

  1. pmc IL-1beta causes an increase in intestinal epithelial tight junction permeability
    Rana M Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Immunol 178:4641-9. 2007
    ..The IL-1beta-induced increase in Caco-2 TJ permeability was mediated in part by the activation of NF-kappaB pathways but not apoptosis...
  2. doi request reprint Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America Albuquerque Veterans Affairs Medical Center, Albuquerque, New Mexico, United States of America
    PLoS ONE 9:e85345. 2014
    ..In conclusion, our studies show for the first time that the IL-6 modulation of intestinal TJ permeability was regulated by JNK activation of AP-1 and AP-1 activation of claudin-2 gene. ..
  3. ncbi request reprint TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation
    Thomas Y Ma
    Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 286:G367-76. 2004
    ..The increase in permeability was associated with NF-kappa B-dependent downregulation of ZO-1 protein expression and alteration in junctional localization...
  4. ncbi request reprint Mechanism of TNF-{alpha} modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression
    Thomas Y Ma
    Internal Medicine Gastroenterology, MSC10 5550, 1 Univ of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 288:G422-30. 2005
    ....
  5. ncbi request reprint Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
    Dongmei Ye
    Department of Internal Medicine Gastroenterology, MSC10 5550, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 290:G496-504. 2006
    ..NF-kappaB p50/p65 activation of the MLCK promoter then leads to a stepwise increase in MLCK transcription, expression and activity, and MLCK-mediated opening of the intestinal TJ barrier...
  6. pmc Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 300:G1054-64. 2011
    ....
  7. pmc Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Immunol 180:5653-61. 2008
    ..Our findings also indicate that the IL-1beta-induced increase in MLCK protein expression and Caco-2 TJ permeability was mediated by an NF-kappaB-dependent increase in MLCK gene transcription...
  8. pmc Mechanism of glucocorticoid regulation of the intestinal tight junction barrier
    Michel A Boivin
    Department of Medicine, Univ of New Mexico, Albuquerque, NM 87131, USA
    Am J Physiol Gastrointest Liver Physiol 292:G590-8. 2007
    ....
  9. ncbi request reprint Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability
    Karol Dokladny
    Internal Medicine Gastroenterology and Hepatology, University of New Mexico, Albuquerque, New Mexico 87131 0001, USA
    Am J Physiol Gastrointest Liver Physiol 290:G204-12. 2006
    ....
  10. doi request reprint Expression of the p16(INK4a) gene product in premalignant and malignant epithelial lesions of the gallbladder
    Bridget C Lynch
    Department of Pathology, University of New Mexico School of Medicine, MSC 084640 Albuquerque, NM 87131 0001, USA
    Ann Diagn Pathol 12:161-4. 2008
    ..049). Our data demonstrate that nuclear p16 expression is absent in normal gallbladder epithelium and is a frequent event in high-grade dysplasia of the gallbladder and gallbladder adenocarcinoma...
  11. pmc Mechanism of interferon-gamma-induced increase in T84 intestinal epithelial tight junction
    Michel A Boivin
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 5271, USA
    J Interferon Cytokine Res 29:45-54. 2009
    ..These results show for the first time that the IFN-gamma modulation of TJ protein and TJ barrier function is regulated by a cross-talk between PI3-K and NF-kappaB pathways...
  12. doi request reprint Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
    Dongmei Ye
    Department of Internal Medicine, University of New Mexico School of Medicine and Albuquerque Veterans Affairs Medical Center, Albuquerque, NM 87131 0001, USA
    J Cell Mol Med 12:1331-46. 2008
    ..These studies provide novel insight into the cellular and molecular mechanisms that regulate basal and TNF-alpha-induced modulation of MLCK gene activity...
  13. pmc Mechanism of cytokine modulation of epithelial tight junction barrier
    Rana Al-Sadi
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Front Biosci (Landmark Ed) 14:2765-78. 2009
    ..In this review, the effects of various pro-inflammatory and anti-inflammatory cytokines on intestinal TJ barrier and the progress into the mechanisms that mediate the cytokine modulation of intestinal TJ barrier are reviewed...
  14. pmc Cellular and molecular mechanisms of heat stress-induced up-regulation of occludin protein expression: regulatory role of heat shock factor-1
    Karol Dokladny
    Internal Medicine Gastroenterology and Hepatology, MSC10 5550, 1 University of New Mexico, Albuquerque, NM 87131 0001, USA
    Am J Pathol 172:659-70. 2008
    ....
  15. doi request reprint Lack of cross-tolerance following heat and cadmium exposure in functional MDCK monolayers
    Karol Dokladny
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Appl Toxicol 28:885-94. 2008
    ..However neither basal levels of occludin, nor alterations in occludin expression, were correlated with epithelial barrier function in MDCK cells either exposed to elevated temperatures or challenged with cadmium...
  16. ncbi request reprint Helicobacter pylori infection inhibits healing of the wounded duodenal epithelium in vitro
    Ghasan Tabel
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA
    J Lab Clin Med 142:421-30. 2003
    ..Hp inhibition of duodenal wound healing may therefore be an important pathogenic factor contributing to duodenal mucosal injury and delay in ulcer healing in vivo...
  17. pmc Induction of physiological thermotolerance in MDCK monolayers: contribution of heat shock protein 70
    Karol Dokladny
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Cell Stress Chaperones 11:268-75. 2006
    ..This study demonstrates an important, albeit complex, protective role for heat shock proteins in the modulation of MDCK epithelial barrier function following a thermal stress...
  18. pmc LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB
    Karol Dokladny
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Cell Stress Chaperones 15:153-63. 2010
    ..We conclude that the effects of heat stress-induced increase in HSP70 protein expression on LPS-induced cytokine elaboration in whole animals can be reproduced by the actions of a single gene product...
  19. ncbi request reprint Changing patterns of gallbladder carcinoma in New Mexico
    Jehad Barakat
    Department of Medicine, Division of Gastroenterology, The University of New Mexico Health Science Center New Mexico VA Health Care System, Albuquerque, New Mexico 87131, USA
    Cancer 106:434-40. 2006
    ..S. have a high incidence of gallbladder carcinoma (GBC). Furthermore, American Indians in New Mexico (NM) have the highest incidence rate of GBC in the U.S. The epidemiology of GBC in NM has not been studied in the past 3 decades...
  20. ncbi request reprint Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1
    Alan S Fanning
    Department of Cell and Molecular Physiology, The University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA
    FASEB J 16:1835-7. 2002
    ..We conclude that direct interactions between ZO-1 and F-actin play a role in several different steps of junction assembly...
  21. ncbi request reprint Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells
    Veedamali S Subramanian
    Department of Medicine, University of California, Irvine, California, USA
    Am J Physiol Cell Physiol 293:C1717-26. 2007
    ..In contrast, the steady-state localization of occludin at the cell surface was dependent on intact microfilaments but not microtubules...
  22. ncbi request reprint A carrier-mediated mechanism for pyridoxine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathway
    Hamid M Said
    Veterans Affairs Medical Center 151, Long Beach, CA 90822, USA
    Am J Physiol Cell Physiol 285:C1219-25. 2003
    ..This system is pH dependent and amiloride sensitive and appears to be under the regulation of an intracellular PKA-mediated pathway...
  23. ncbi request reprint Mechanism and regulation of folate uptake by human pancreatic epithelial MIA PaCa-2 cells
    Svetlana M Nabokina
    Veterans Affairs Medical Center, Long Beach, CA 90822, USA
    Am J Physiol Cell Physiol 287:C142-8. 2004
    ..The results also show the involvement of hRFC in the uptake process and suggest the possible involvement of intracellular cAMP- and PTK-mediated pathways in the regulation of folate uptake...
  24. ncbi request reprint NSAID inhibition of RGM1 gastric monolayer wound re-epithelialization: comparison of selective Cox-2 versus non-selective Cox inhibitors
    Andrew Q Giap
    Department of Medicine, DVA Medical Center, Long Beach, CA, USA
    Life Sci 70:3029-37. 2002
    ....
  25. ncbi request reprint Low dose ethanol potentiates indomethacin induced inhibition of wound re-epithelialization in duodenal monolayers
    Babak Mohajer
    DVA Medical Center, Gastroenterology Section, 5901 E Seventh Street, Long Beach, CA 90822, USA
    Life Sci 70:3143-53. 2002
    ....

Research Grants9

  1. TNF-alpha Modulation of Intestinal Epith. Permeability
    Thomas Ma; Fiscal Year: 2007
    ....
  2. Interleukin-1 Beta Modulation of Intestinal Tight Junction Barrier
    Thomas Ma; Fiscal Year: 2009
    ..The proposed studies also seek to identify potential therapeutic targets and strategies to induce therapeutic re-tightening or normalization of leaky gut in Crohn's disease. ..
  3. TNF-alpha Regulation of Intestinal Paracellular Transport
    Thomas Ma; Fiscal Year: 2009
    ..These studies also seek to identify potential therapeutic targets and strategies to induce therapeutic re-tightening or normalization of leaky gut in Crohn's disease. ..
  4. Interleukin-1 Beta Modulation of Intestinal Tight Junction Barrier
    Thomas Y Ma; Fiscal Year: 2010
    ..The proposed studies also seek to identify potential therapeutic targets and strategies to induce therapeutic re-tightening or normalization of leaky gut in Crohn's disease. ..
  5. TNF-alpha Regulation of Intestinal Paracellular Transport
    Thomas Y Ma; Fiscal Year: 2010
    ..These studies also seek to identify potential therapeutic targets and strategies to induce therapeutic re-tightening or normalization of leaky gut in Crohn's disease. ..