Marek Ma

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 29:445-51. 2012
  2. ncbi request reprint Fatal myocarditis due to Clostridium novyi type B in a previously healthy woman: case report and literature review
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Scand J Infect Dis 39:77-80. 2007
  3. pmc Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Emerg Med 26:763-8. 2008
  4. pmc Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 215:119-27. 2009
  5. pmc Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 56:34-46. 2013
  6. pmc Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 29:2555-63. 2012
  7. pmc Neuroprotection with delayed calpain inhibition after transient forebrain ischemia
    James R Frederick
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:S481-5. 2008
  8. pmc Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit
    Catherine R von Reyn
    Departments of Bioengineering, Pharmacology, Neurosurgery, Emergency Medicine, and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    J Neurosci 29:10350-6. 2009

Collaborators

Detail Information

Publications8

  1. pmc Short-duration treatment with the calpain inhibitor MDL-28170 does not protect axonal transport in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 29:445-51. 2012
    ..drug treatment groups. These results suggest that early short-duration calpain inhibitor therapy with MDL-28170 is not an effective strategy to prevent disruption of axonal transport following isolated axonal stretch injury in the CNS...
  2. ncbi request reprint Fatal myocarditis due to Clostridium novyi type B in a previously healthy woman: case report and literature review
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Scand J Infect Dis 39:77-80. 2007
    ..Disease in humans typically presents as myonecrosis. C. novyi has not previously been reported as a cause of myocarditis. We report a fatal case with infection of the myocardium by C. novyi type B...
  3. pmc Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Am J Emerg Med 26:763-8. 2008
    ..Our objective was to determine if the biomarker for axonal injury, serum cleaved tau (C-tau), predicts postconcussion syndrome (PCS) in adults after mild traumatic brain injury (mTBI)...
  4. pmc Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 215:119-27. 2009
    ..027). There was no differential protection based on axon size. These results support further clinical investigation of temporally optimized therapeutic hypothermia after traumatic brain injury...
  5. pmc Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurobiol Dis 56:34-46. 2013
    ..These results, in total, provide direct evidence that calpains are responsible for the morphological degeneration of the axon and synapse during Wallerian degeneration...
  6. pmc Calpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 29:2555-63. 2012
    ..8±23.9% in hCAST-expressing RGCs; p=0.038). These results provide direct evidence that axonal calpains play a causal role in transport disruption after in vivo stretch injury...
  7. pmc Neuroprotection with delayed calpain inhibition after transient forebrain ischemia
    James R Frederick
    Department of Emergency Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 36:S481-5. 2008
    ..This study tests the hypothesis that delayed calpain inhibitor therapy can reduce brain calpain activity and neurodegeneration after transient forebrain ischemia...
  8. pmc Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit
    Catherine R von Reyn
    Departments of Bioengineering, Pharmacology, Neurosurgery, Emergency Medicine, and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    J Neurosci 29:10350-6. 2009
    ....

Research Grants2

  1. Calpain Activity in Traumatic Axonal Injury (Career Development Award)
    Marek Ma; Fiscal Year: 2007
    ..Relevance: Every year in the US 2 million people suffer acute brain trauma. To reduce the morbidity and mortality of this disease, it is essential to understand the mechanisms underlying traumatic axonal injury. ..