Research Topics
| AVERIL I contact MASummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A20: linking a complex regulator of ubiquitylation to immunity and human diseaseAveril Ma
Department of Medicine, University of California, San Francisco, California 94143 0451, USA
Nat Rev Immunol 12:774-85. 2012..Taken together, these studies are revealing the importance of A20-mediated regulation of ubiquitin-dependent signalling in human disease...
Loss of T-bet sends host-microbe mutualism awryAveril Ma
Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0451, USA
Cell 131:15-7. 2007..In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system...- Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasisAveril Ma
Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, California 94143 0451, USA
Annu Rev Immunol 24:657-79. 2006..Trans-presentation also raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis... - Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cellsRima Koka
Department of Medicine, University of California, San Francisco, CA 94143, USA
J Immunol 173:3594-8. 2004..Finally, presentation of IL-15 by purified IL-15Ralpha/Fc in trans synergizes with IL-12 to support NK cell priming. These findings suggest that murine DCs require IL-15Ralpha to present IL-15 in trans to NK cells during NK cell priming... - Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasisPatrick R Burkett
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 200:825-34. 2004..These studies indicate that IL-15Ralpha defines homeostatic niches for NK and memory CD8+ T cells by controlling both the production and the presentation of IL-15 in trans to NK and CD8+ memory T cells... - Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient miceRima Koka
Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC6084, Chicago, IL 60637, USA
J Exp Med 197:977-84. 2003..These findings demonstrate that NK cell-independent IL-15Ralpha expression is critical for maintaining peripheral NK cells, while IL-15Ralpha expression on NK cells is not required for this function... - Fas is not essential for lamina propria T lymphocyte homeostasisDavid L Boone
Department of Medicine, Inflammatory Bowel Disease Research Center, Committee on Immunology, The University of Chicago, IL 60637, USA
Am J Physiol Gastrointest Liver Physiol 285:G382-8. 2003..Thus our studies reveal that Fas is dispensable for LP T cell homeostasis and suggest that the intestinal inflammation observed in IL2Ralpha-/- mice is independent of defective Fas-induced cell death... 
Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsetsErwan Mortier
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0451, USA
Immunity 31:811-22. 2009..Moreover, they demonstrate the diversity, specification, and geographic restriction of cytokine signals...- A20 takes on tumors: tumor suppression by an ubiquitin-editing enzymeBarbara A Malynn
Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 206:977-80. 2009..A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein... - IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentationErwan Mortier
Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, Biomedical Sciences Program, Program in Biological Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:1213-25. 2008..These studies define an unprecedented cytokine-receptor biosynthetic pathway in which IL-15Ralpha serves as a chaperone for IL-15, after which membrane-bound IL-15Ralpha-IL-15 complexes activate NK cells via direct cell-cell contact... - The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunityRita M Tavares
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Immunity 33:181-91. 2010..These findings show that A20 can restrict B cell survival, whereas A20 protects other cells from TNF-induced cell death. Our studies demonstrate how reduced A20 expression predisposes to autoimmunity... - Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infectionJoseph C Sun
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
J Immunol 183:2911-4. 2009..Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection... - Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20Emre E Turer
Gastrointestinal Division, Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:451-64. 2008..These findings provide novel insights into how physiological TLR signals are regulated... - Regulation of lymphoid homeostasis by interleukin-15James P Lodolce
Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA
Cytokine Growth Factor Rev 13:429-39. 2002..IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis... - Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cellsKeishi Kojima
Department of Medicine, The MArtin Boyer Laboratory, The University of Chicago, Illinois 60637, USA
Gastroenterology 124:1395-407. 2003..Activated LPLs induce YAMC hsp expression, an effect blocked by IL-2 neutralizing antibody. CONCLUSIONS: Enteric flora and mucosal lymphocytes play a role in maintaining physiologic expression of colonocyte hsp25 and hsp72... - Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulationDavid L Boone
Department of Medicine, Ben May Institute for Cancer Research, The University of Chicago, Illinois, USA
Inflamm Bowel Dis 8:35-42. 2002..This suggests that other costimulatory molecules or T-cell receptor ligation alone drive lymphocyte expansion in IL-2-deficient mice... - ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic developmentShigeru Oshima
Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
Nature 457:906-9. 2009..These studies provide insights into how ubiquitination and ubiquitin sensing proteins regulate cellular and organismal survival... - Recent advances in understanding NF-kappaB regulationDavid L Boone
Department of Medicine, Ben May Institute for Cancer Research, IBD Research Center and Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
Inflamm Bowel Dis 8:201-12. 2002 - The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responsesDavid L Boone
Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
Nat Immunol 5:1052-60. 2004..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
Research Grants
- Ubiquitylation and the Regulation of Immune HomeostasisAVERIL I contact MA; Fiscal Year: 2010....
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAVERIL I MA; Fiscal Year: 2010..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
- INRSA Training Grant in GastroenterologyAveril Ma; Fiscal Year: 2007..Program graduates will have a well-defined research focus and the tools needed for success with a career in biomedical investigation in the field of gastroenterology. ..
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAveril Ma; Fiscal Year: 2007..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
- Cytokines and Mucosal Immune RegulationAveril Ma; Fiscal Year: 2006....
- IL-15Ra and NK Cell FunctionAveril Ma; Fiscal Year: 2007..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
- Ubiquitylation and the Regulation of Immune HomeostasisAVERIL I MA; Fiscal Year: 2010..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
- Ubiquitylation and the Regulation of Immune HomeostasisAveril Ma; Fiscal Year: 2009..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
- Ubiquitylation and the Regulation of Immune HomeostasisAveril Ma; Fiscal Year: 2009..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAveril Ma; Fiscal Year: 2009..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
- Immune Regulation by A20Averil Ma; Fiscal Year: 2006..abstract_text> ..
- BOWEL INFLAMMATION IN IL 2 DEFICIENTAveril Ma; Fiscal Year: 1999..These studies should not only lead to a better understanding of how IL-2 regulates mucosal immune responses, but may also lead to important insights into the pathogenesis of human IBD. ..
- INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASISAveril Ma; Fiscal Year: 2003..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..