AVERIL I contact MA

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    Barbara A Malynn
    Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:977-80. 2009
  2. pmc ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    Shigeru Oshima
    Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
    Nature 457:906-9. 2009
  3. pmc IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    Erwan Mortier
    Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, Biomedical Sciences Program, Program in Biological Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1213-25. 2008
  4. pmc Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
    Emre E Turer
    Gastrointestinal Division, Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:451-64. 2008
  5. pmc A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis
    Ling Shao
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e62223. 2013
  6. pmc Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    Gianna Elena Hammer
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Immunol 12:1184-93. 2011
  7. pmc A20: linking a complex regulator of ubiquitylation to immunity and human disease
    Averil Ma
    Department of Medicine, University of California, San Francisco, California 94143 0451, USA
    Nat Rev Immunol 12:774-85. 2012
  8. ncbi request reprint Loss of T-bet sends host-microbe mutualism awry
    Averil Ma
    Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0451, USA
    Cell 131:15-7. 2007
  9. ncbi request reprint Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    Averil Ma
    Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, California 94143 0451, USA
    Annu Rev Immunol 24:657-79. 2006
  10. pmc Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis
    Patrick R Burkett
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 200:825-34. 2004

Research Grants

Collaborators

  • JOHN J O'SHEA
  • Mary C Nakamura
  • Baidong Hou
  • Lewis L Lanier
  • M W Musch
  • C A Lowell
  • Boris Reizis
  • David L Boone
  • Barbara A Malynn
  • Rommel Advincula
  • Emre E Turer
  • Julio Barrera
  • Sophia Chai
  • Marcia Chien
  • Erwan Mortier
  • Shigeru Oshima
  • Rima Koka
  • Patrick R Burkett
  • Rita M Tavares
  • James P Lodolce
  • Ling Shao
  • Gianna Elena Hammer
  • Joseph C Sun
  • Bettina Lee
  • Nataliya Shifrin
  • Tammy Woo
  • Osamu Hitotsumatsu
  • Eric G Lee
  • Keishi Kojima
  • Themistocles Dassopoulos
  • Faye Chan
  • Bao Duong
  • Lindsey A Criswell
  • Celia J Fang
  • Eric J Huang
  • Kimberly E Taylor
  • Anthony DeFranco
  • Paul J Utz
  • Lesley Rhee
  • Patrizia Scapini
  • Chih L Liu
  • T S Benedict Yen
  • Benjamin Yen
  • Joseph A Callahan
  • Stephen Chmura
  • Leesun Kim
  • Sara Gozalo
  • Regina Celeste Ahmad
  • Patrick Burkett
  • Colleen Tsui
  • Cecile Pickart
  • Matthew T Wheeler
  • Elizabeth McNally
  • Paula Hurley
  • James Lodolce
  • Hongyu Ren
  • Barbara A Hendrickson
  • Eugene B Chang
  • Michelle Madonia
  • Paula J Gibson
  • Shon Libby
  • Rima M Koka

Detail Information

Publications21

  1. pmc A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    Barbara A Malynn
    Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:977-80. 2009
    ..A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas. These data reveal the role of A20 as a tumor suppressor protein...
  2. pmc ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    Shigeru Oshima
    Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
    Nature 457:906-9. 2009
    ..These studies provide insights into how ubiquitination and ubiquitin sensing proteins regulate cellular and organismal survival...
  3. pmc IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    Erwan Mortier
    Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, Biomedical Sciences Program, Program in Biological Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:1213-25. 2008
    ..These studies define an unprecedented cytokine-receptor biosynthetic pathway in which IL-15Ralpha serves as a chaperone for IL-15, after which membrane-bound IL-15Ralpha-IL-15 complexes activate NK cells via direct cell-cell contact...
  4. pmc Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
    Emre E Turer
    Gastrointestinal Division, Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:451-64. 2008
    ..These findings provide novel insights into how physiological TLR signals are regulated...
  5. pmc A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis
    Ling Shao
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e62223. 2013
    ..Taken together, these findings demonstrate new roles for A20 in restricting β-catenin signaling and preventing colon tumorigenesis...
  6. pmc Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    Gianna Elena Hammer
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Immunol 12:1184-93. 2011
    ..Our findings indicate that DCs need A20 to preserve immune quiescence and suggest that A20-dependent DC functions may underlie IBD and IBD-associated arthritides...
  7. pmc A20: linking a complex regulator of ubiquitylation to immunity and human disease
    Averil Ma
    Department of Medicine, University of California, San Francisco, California 94143 0451, USA
    Nat Rev Immunol 12:774-85. 2012
    ..Taken together, these studies are revealing the importance of A20-mediated regulation of ubiquitin-dependent signalling in human disease...
  8. ncbi request reprint Loss of T-bet sends host-microbe mutualism awry
    Averil Ma
    Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0451, USA
    Cell 131:15-7. 2007
    ..In this issue, Garrett et al. (2007) describe a communicable form of colitis that is induced by deficiency of the transcription factor T-bet in cells of the innate immune system...
  9. ncbi request reprint Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    Averil Ma
    Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, California 94143 0451, USA
    Annu Rev Immunol 24:657-79. 2006
    ..Trans-presentation also raises several novel cell biological and cellular implications concerning how cytokines support lymphoid homeostasis...
  10. pmc Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis
    Patrick R Burkett
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 200:825-34. 2004
    ..These studies indicate that IL-15Ralpha defines homeostatic niches for NK and memory CD8+ T cells by controlling both the production and the presentation of IL-15 in trans to NK and CD8+ memory T cells...
  11. ncbi request reprint Cutting edge: murine dendritic cells require IL-15R alpha to prime NK cells
    Rima Koka
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    J Immunol 173:3594-8. 2004
    ..Finally, presentation of IL-15 by purified IL-15Ralpha/Fc in trans synergizes with IL-12 to support NK cell priming. These findings suggest that murine DCs require IL-15Ralpha to present IL-15 in trans to NK cells during NK cell priming...
  12. ncbi request reprint Fas is not essential for lamina propria T lymphocyte homeostasis
    David L Boone
    Department of Medicine, Inflammatory Bowel Disease Research Center, Committee on Immunology, The University of Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 285:G382-8. 2003
    ..Thus our studies reveal that Fas is dispensable for LP T cell homeostasis and suggest that the intestinal inflammation observed in IL2Ralpha-/- mice is independent of defective Fas-induced cell death...
  13. pmc Interleukin (IL)-15R[alpha]-deficient natural killer cells survive in normal but not IL-15R[alpha]-deficient mice
    Rima Koka
    Department of Medicine, University of Chicago, 5841 S Maryland Ave, MC6084, Chicago, IL 60637, USA
    J Exp Med 197:977-84. 2003
    ..These findings demonstrate that NK cell-independent IL-15Ralpha expression is critical for maintaining peripheral NK cells, while IL-15Ralpha expression on NK cells is not required for this function...
  14. ncbi request reprint Macrophage- and dendritic-cell-derived interleukin-15 receptor alpha supports homeostasis of distinct CD8+ T cell subsets
    Erwan Mortier
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0451, USA
    Immunity 31:811-22. 2009
    ..Moreover, they demonstrate the diversity, specification, and geographic restriction of cytokine signals...
  15. ncbi request reprint Regulation of lymphoid homeostasis by interleukin-15
    James P Lodolce
    Department of Medicine, Ben May Institute for Cancer Research, University of Chicago, 5841 S Maryland Ave MC 6084, Chicago, IL 60637, USA
    Cytokine Growth Factor Rev 13:429-39. 2002
    ..IL-15 has been shown to regulate the homeostasis of both innate and adaptive immune cells, and this review will discuss several ways in which this pleiotropic cytokine may support lymphoid homeostasis...
  16. pmc The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity
    Rita M Tavares
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Immunity 33:181-91. 2010
    ..These findings show that A20 can restrict B cell survival, whereas A20 protects other cells from TNF-induced cell death. Our studies demonstrate how reduced A20 expression predisposes to autoimmunity...
  17. pmc Cutting edge: IL-15-independent NK cell response to mouse cytomegalovirus infection
    Joseph C Sun
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0414, USA
    J Immunol 183:2911-4. 2009
    ..Together, these findings demonstrate a previously unrecognized independence of NK cells on IL-15 or other common gamma signaling cytokines during their response against viral infection...
  18. ncbi request reprint Enteric flora and lymphocyte-derived cytokines determine expression of heat shock proteins in mouse colonic epithelial cells
    Keishi Kojima
    Department of Medicine, The MArtin Boyer Laboratory, The University of Chicago, Illinois 60637, USA
    Gastroenterology 124:1395-407. 2003
    ..This study is aimed at determining if enteric bacteria and/or immune signals regulate their physiologic expression...
  19. ncbi request reprint Interleukin-2-deficient mice develop colitis in the absence of CD28 costimulation
    David L Boone
    Department of Medicine, Ben May Institute for Cancer Research, The University of Chicago, Illinois, USA
    Inflamm Bowel Dis 8:35-42. 2002
    ..This suggests that other costimulatory molecules or T-cell receptor ligation alone drive lymphocyte expansion in IL-2-deficient mice...
  20. ncbi request reprint The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  21. ncbi request reprint Recent advances in understanding NF-kappaB regulation
    David L Boone
    Department of Medicine, Ben May Institute for Cancer Research, IBD Research Center and Committee on Immunology, The University of Chicago, Chicago, Illinois 60637, USA
    Inflamm Bowel Dis 8:201-12. 2002

Research Grants41

  1. Ubiquitylation and the Regulation of Immune Homeostasis
    AVERIL I contact MA; Fiscal Year: 2010
    ....
  2. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    AVERIL I MA; Fiscal Year: 2010
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
  3. INRSA Training Grant in Gastroenterology
    Averil Ma; Fiscal Year: 2007
    ..Program graduates will have a well-defined research focus and the tools needed for success with a career in biomedical investigation in the field of gastroenterology. ..
  4. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2007
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  5. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2007
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
  6. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2006
    ....
  7. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2007
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  8. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2006
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
  9. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2006
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  10. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2006
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  11. Ubiquitylation and the Regulation of Immune Homeostasis
    AVERIL I MA; Fiscal Year: 2010
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  12. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2009
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  13. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2009
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  14. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2009
    ..Future attempts to either enhance antiviral vaccine effectiveness or to suppress persistent inflammation in autoimmune conditions may benefit greatly from the mechanistic insights we are gaining into IL-15 biology. ..
  15. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2007
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  16. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2006
    ..abstract_text> ..
  17. Ubiquitylation and the Regulation of Immune Homeostasis
    Averil Ma; Fiscal Year: 2005
    ..Results from these studies promise to yield significant insights into how A20 links the regulation of ubiquitylation with disease. ..
  18. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2005
    ....
  19. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2002
    ....
  20. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2001
    ....
  21. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2001
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  22. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2000
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  23. BOWEL INFLAMMATION IN IL 2 DEFICIENT
    Averil Ma; Fiscal Year: 1999
    ..These studies should not only lead to a better understanding of how IL-2 regulates mucosal immune responses, but may also lead to important insights into the pathogenesis of human IBD. ..
  24. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 1999
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  25. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2002
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  26. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2003
    ..abstract_text> ..
  27. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2005
    ..abstract_text> ..
  28. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2003
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  29. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2005
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  30. IL-15Ra and NK Cell Function
    Averil Ma; Fiscal Year: 2004
    ..These experiments should reveal novel insights into which cells use IL-15Ra to supports NK cells in vivo, and how IL-15Ra performs its unusual molecular function. ..
  31. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2004
    ....
  32. Immune Regulation by A20
    Averil Ma; Fiscal Year: 2004
    ..abstract_text> ..
  33. INTERLEUKIN 15 RECEPTOR AND LYMPHOID HOMEOSTASIS
    Averil Ma; Fiscal Year: 2003
    ..These experiments will reveal how IL-15Ralpha positively supports lymphoid homeostasis and determine how IL-15Ralpha regulates immunological memory. ..
  34. Cytokines and Mucosal Immune Regulation
    Averil Ma; Fiscal Year: 2003
    ....