Timothy Lyons

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Glycation, carbonyl stress, EAGLEs, and the vascular complications of diabetes
    Timothy J Lyons
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Vasc Med 2:175-89. 2002
  2. pmc Serum inflammatory markers and preeclampsia in type 1 diabetes: a prospective study
    Mei Du
    Harold Hamm Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes Care 36:2054-61. 2013
  3. pmc Plasma lipoproteins and preeclampsia in women with type 1 diabetes: a prospective study
    Arpita Basu
    Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Clin Endocrinol Metab 97:1752-62. 2012
  4. pmc Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers
    Timothy J Lyons
    Harold Hamm Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd, Oklahoma City, OK 73104 5020, USA
    Transl Res 159:303-12. 2012
  5. pmc Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects
    Arpita Basu
    Department of Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Nutr J 8:43. 2009
  6. pmc Increased serum kallistatin levels in type 1 diabetes patients with vascular complications
    Alicia J Jenkins
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Melbourne, Australia
    J Angiogenes Res 2:19. 2010
  7. ncbi request reprint Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort
    Timothy J Lyons
    Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 45:910-8. 2004
  8. ncbi request reprint Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness
    T J Lyons
    Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Diabet Med 23:955-66. 2006
  9. pmc Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells
    Mingyuan Wu
    Harold Hamm Diabetes Center, Oklahoma City, Oklahoma, USA
    Invest Ophthalmol Vis Sci 53:4595-604. 2012
  10. pmc Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase
    Yunzhou Dong
    Harold Hamm Oklahoma Diabetes Center, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Mol Med 13:2899-910. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Glycation, carbonyl stress, EAGLEs, and the vascular complications of diabetes
    Timothy J Lyons
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    Semin Vasc Med 2:175-89. 2002
    ..In this article, the development of the carbonyl stress hypothesis is reviewed, and implications for present and future treatments to prevent complications are discussed...
  2. pmc Serum inflammatory markers and preeclampsia in type 1 diabetes: a prospective study
    Mei Du
    Harold Hamm Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes Care 36:2054-61. 2013
    ..In maternal serum samples, we examined the temporal associations of markers of inflammation with the subsequent development of PE in women with T1DM...
  3. pmc Plasma lipoproteins and preeclampsia in women with type 1 diabetes: a prospective study
    Arpita Basu
    Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Clin Endocrinol Metab 97:1752-62. 2012
    ..In type 1 diabetes mellitus (T1DM), the prevalence of PE is increased 4-fold, but prospective associations with plasma lipoproteins are unknown...
  4. pmc Biomarkers in diabetes: hemoglobin A1c, vascular and tissue markers
    Timothy J Lyons
    Harold Hamm Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, 1000 N Lincoln Blvd, Oklahoma City, OK 73104 5020, USA
    Transl Res 159:303-12. 2012
    ..In the future, we can be optimistic that new blood and tissue-based biomarkers will enable the detection, prevention, and treatment of diabetes and its complications long before overt disease develops...
  5. pmc Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects
    Arpita Basu
    Department of Nutritional Sciences, 301 Human Environmental Sciences, Oklahoma State University, Stillwater, OK 74078, USA
    Nutr J 8:43. 2009
    ..We also tested the tolerability and safety of FSP in subjects with metabolic syndrome. FSP is a concentrated source of polyphenolic flavonoids, fiber and phytosterols...
  6. pmc Increased serum kallistatin levels in type 1 diabetes patients with vascular complications
    Alicia J Jenkins
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Melbourne, Australia
    J Angiogenes Res 2:19. 2010
    ..Kallistatin, a serpin widely produced throughout the body, has vasodilatory, anti-angiogenic, anti-oxidant, and anti-inflammatory effects. Effects of diabetes and its vascular complications on serum kallistatin levels are unknown...
  7. ncbi request reprint Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort
    Timothy J Lyons
    Section of Endocrinology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 45:910-8. 2004
    ..To determine associations between retinopathy status and detailed serum lipoprotein subclass profiles in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC) cohort...
  8. ncbi request reprint Nuclear magnetic resonance-determined lipoprotein subclass profile in the DCCT/EDIC cohort: associations with carotid intima-media thickness
    T J Lyons
    Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Diabet Med 23:955-66. 2006
    ..To relate nuclear magnetic resonance lipoprotein subclass profiles (NMR-LSP) and other lipoprotein-related factors with carotid intima-media thickness (IMT) in Type 1 diabetes...
  9. pmc Oxidative and endoplasmic reticulum stresses mediate apoptosis induced by modified LDL in human retinal Müller cells
    Mingyuan Wu
    Harold Hamm Diabetes Center, Oklahoma City, Oklahoma, USA
    Invest Ophthalmol Vis Sci 53:4595-604. 2012
    ..We previously showed that extravasated, modified LDL is implicated in pericyte loss in diabetic retinopathy (DR). Here, we investigate whether modified LDL induces apoptosis in retinal Müller glial cells...
  10. pmc Activation of protease calpain by oxidized and glycated LDL increases the degradation of endothelial nitric oxide synthase
    Yunzhou Dong
    Harold Hamm Oklahoma Diabetes Center, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Cell Mol Med 13:2899-910. 2009
    ..HOG-LDL may impair endothelial function by inducing calpain-mediated eNOS degradation in a ROS- and Ca(2+)-dependent manner...
  11. pmc Serum carotenoids and fat-soluble vitamins in women with type 1 diabetes and preeclampsia: a longitudinal study
    Madona Azar
    Harold Hamm Oklahoma Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Diabetes Care 34:1258-64. 2011
    ..Prospective measures of fat-soluble vitamins in diabetic pregnancy are therefore of interest...
  12. doi request reprint Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women
    Y Yu
    Harold Hamm Oklahoma Diabetes Center and Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Diabetologia 52:160-8. 2009
    ..In this multicentre prospective study, we determined levels of these and related factors in pregnant women with type 1 diabetes, a condition associated with a fourfold increase in pre-eclampsia...
  13. ncbi request reprint Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes
    Y Yu
    Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, WP1345, Oklahoma City, OK 73104, USA
    Diabetologia 49:2488-98. 2006
    ....
  14. ncbi request reprint Serum lipoproteins in the diabetes control and complications trial/epidemiology of diabetes intervention and complications cohort: associations with gender and glycemia
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina 29403, USA
    Diabetes Care 26:810-8. 2003
    ..To relate the nuclear magnetic resonance (NMR)-determined lipoprotein profile, conventional lipid and apolipoprotein measures, and in vitro oxidizibility of LDL with gender and glycemia in type 1 diabetes...
  15. ncbi request reprint Lipoprotein subclass profiles of hyperlipidemic diabetic mice measured by nuclear magnetic resonance spectroscopy
    Samar M Hammad
    Division of Endocrinology Diabetes and Medical Genetics, Medical University of South Carolina, Charleston 29425, USA
    Metabolism 52:916-21. 2003
    ....
  16. ncbi request reprint Lipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathy
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, South Carolina, USA
    Kidney Int 64:817-28. 2003
    ..The relationship between detailed lipoprotein analyses and diabetic nephropathy is of interest...
  17. ncbi request reprint In vivo glycated low-density lipoprotein is not more susceptible to oxidation than nonglycated low-density lipoprotein in type 1 diabetes
    Alicia J Jenkins
    Division of Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, Charleston 29403, USA
    Metabolism 53:969-76. 2004
    ....
  18. ncbi request reprint 'Lipoproteins, glycoxidation and diabetic angiopathy'
    Alicia J Jenkins
    University of Melbourne, Department of Medicine, St Vincent s Hospital, Fitzroy, Australia
    Diabetes Metab Res Rev 20:349-68. 2004
    ....
  19. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in type 1 diabetes: associations with lipoprotein subclasses
    Richard L Klein
    Department of Medicine, Medical University of South Carolina, Charleston 29425, USA
    Metabolism 53:1296-304. 2004
    ....
  20. ncbi request reprint Apolipoprotein C-III protein concentrations and gene polymorphisms in Type 1 diabetes: associations with microvascular disease complications in the DCCT/EDIC cohort
    Richard L Klein
    Department of Medicine, Division of Endocrinology, Metabolism, and Medical Genetics, Medical University of South Carolina, Charleston, SC 29425, USA
    J Diabetes Complications 19:18-25. 2005
    ..We investigated the associations of apolipoprotein C-III (apoCIII) protein and apoCIII gene variation with microvascular disease complications in Type 1 diabetes...
  21. pmc Risk factors related to inflammation and endothelial dysfunction in the DCCT/EDIC cohort and their relationship with nephropathy and macrovascular complications
    Maria F Lopes-Virella
    Department of Medicine and Laboratory Services, Medical University of South Carolina and Ralph H Johnson VA Medical Center, Charleston, South Carolina, USA
    Diabetes Care 31:2006-12. 2008
    ....
  22. doi request reprint Cross-sectional associations of C-reactive protein with vascular risk factors and vascular complications in the DCCT/EDIC cohort
    Alicia J Jenkins
    Division of Endocrinology, Diabetes, and Medical Genetics, Medical University of South Carolina, Charleston, SC, USA
    J Diabetes Complications 22:153-63. 2008
    ..To determine the relationships between C-reactive protein (CRP) levels and features of Type 1 diabetes...
  23. ncbi request reprint Glycation does not alter LDL-induced secretion of tissue plasminogen activator and plasminogen activator inhibitor-1 from human aortic endothelial cells
    Richard L Klein
    Division of Endocrinology Diabetes Medical Genetics, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann N Y Acad Sci 1043:379-89. 2005
    ..We conclude that oxidation of LDL, but not glycation, may contribute to the altered fibrinolysis observed in diabetes...
  24. ncbi request reprint A lethal tetrad in diabetes: hyperglycemia, dyslipidemia, oxidative stress, and endothelial dysfunction
    Yongxin Yu
    Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Am J Med Sci 330:227-32. 2005
    ..Finally, the "treatment gap" will be addressed. This gap refers to our failure to achieve currently accepted goals to reduce established risk factors for complications in the clinical management of diabetic patients...
  25. ncbi request reprint Effects of oxidized and glycated LDL on gene expression in human retinal capillary pericytes
    Weiwei Song
    Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Invest Ophthalmol Vis Sci 46:2974-82. 2005
    ..To delineate underlying molecular mechanisms, the present study was designed to explore the global effects of modified LDL on pericyte gene expression...
  26. ncbi request reprint Effects of modified low-density lipoproteins on human retinal pericyte survival
    Weiwei Song
    Medicine Endocrinology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Ann N Y Acad Sci 1043:390-5. 2005
    ..Overall, HOG-LDL produced a significantly higher extent of cytotoxicity and apoptosis in retinal pericytes. These results indicate that exposure of pericytes to HOG-LDL could be implicated in the development of diabetic retinopathy...
  27. doi request reprint Increased methionine sulfoxide content of apoA-I in type 1 diabetes
    Jonathan W C Brock
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC, USA
    J Lipid Res 49:847-55. 2008
    ..Using the methods developed here, future studies can address the relationship between Met(O) in apoA-I and the risk, development, or progression of the vascular complications of diabetes...
  28. doi request reprint Intraretinal leakage and oxidation of LDL in diabetic retinopathy
    Mingyuan Wu
    Harold Hamm Oklahoma Diabetes Center and the Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Invest Ophthalmol Vis Sci 49:2679-85. 2008
    ..The pathogenesis of diabetic retinopathy (DR) is not fully understood. Clinical studies suggest that dyslipidemia is associated with the initiation and progression of DR. However, no direct evidence supports this theory...
  29. ncbi request reprint Effect of intensive glycemic control on levels of markers of inflammation in type 1 diabetes mellitus in the diabetes control and complications trial
    Debra A Schaumberg
    Division of Preventive Medicine, Brigham and Womens Hospital, Boston, Mass, USA
    Circulation 111:2446-53. 2005
    ..The present study examined the effect of intensive therapy on levels of several markers of inflammation that have been linked to risk of CVD...
  30. doi request reprint Coated-platelet levels in patients with Type 1 and with Type 2 diabetes mellitus
    Alicia J Jenkins
    Oklahoma Diabetes Center, Oklahoma City, OK 73104, USA
    Diabetes Res Clin Pract 81:e8-10. 2008
    ..In diabetes high coated-platelet levels were related to smoking and glucose control drugs, but not to glycaemia or other drugs. Prospective studies should evaluate coated-platelets and complications and drug effects...

Research Grants3

  1. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy J Lyons; Fiscal Year: 2010
    ..This work, which involves ongoing collaboration with two large federally funded prospective studies of Type 1 and of Type 2 diabetes, addresses markers and mechanisms for the chronic vascular complications of diabetes. ..
  2. Apolipoproteins and the complications of Type 1 diabetes
    Timothy Lyons; Fiscal Year: 2005
    ..The study brings together a unique population (DCCT/EDIC) with an important descriptor of lipoproteins never used in Type 1 diabetes, with the goal of preventing and treating complications ..
  3. Lipoproteins and PEDF in the Vascular Complications of Diabetes
    Timothy Lyons; Fiscal Year: 2009
    ..This work, which involves ongoing collaboration with two large federally funded prospective studies of Type 1 and of Type 2 diabetes, addresses markers and mechanisms for the chronic vascular complications of diabetes. ..