Leslie Lyons

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Feline lymphoma in the post-feline leukemia virus era
    Mathilde Louwerens
    Utrecht University, School of Veterinary Medicine, Utrecht, The Netherlands
    J Vet Intern Med 19:329-35. 2005
  2. ncbi Feline polycystic kidney disease is linked to the PKD1 region
    Amy E Young
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1114 Tupper Hall, Davis, California, 95616, USA
    Mamm Genome 16:59-65. 2005
  3. ncbi Chocolate coated cats: TYRP1 mutations for brown color in domestic cats
    Leslie A Lyons
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, 1114 Tupper Hall, Davis, California 95616, USA
    Mamm Genome 16:356-66. 2005
  4. pmc Feline genetics: clinical applications and genetic testing
    Leslie A Lyons
    Department of Population Health and Reproduction, University of California, Davis, CA, USA
    Top Companion Anim Med 25:203-12. 2010
  5. pmc Extent of linkage disequilibrium in the domestic cat, Felis silvestris catus, and its breeds
    Hasan Alhaddad
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e53537. 2013
  6. pmc First WNK4-hypokalemia animal model identified by genome-wide association in Burmese cats
    Barbara Gandolfi
    Department of Population Health and Reproduction, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e53173. 2012
  7. pmc An international parentage and identification panel for the domestic cat (Felis catus)
    M J Lipinski
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 38:371-7. 2007
  8. pmc Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation
    D L Imes
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA
    Anim Genet 37:175-8. 2006
  9. pmc White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1
    M P Cooper
    Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 37:163-5. 2006
  10. pmc Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats
    Robert A Grahn
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    BMC Vet Res 8:207. 2012

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi Feline lymphoma in the post-feline leukemia virus era
    Mathilde Louwerens
    Utrecht University, School of Veterinary Medicine, Utrecht, The Netherlands
    J Vet Intern Med 19:329-35. 2005
    ..A high incidence of mediastinal lymphomas in young Siamese or Oriental breeds also was observed, supporting previous studies. Associations of intestinal lymphoma and inflammatory bowel disease and diet should be further considered...
  2. ncbi Feline polycystic kidney disease is linked to the PKD1 region
    Amy E Young
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1114 Tupper Hall, Davis, California, 95616, USA
    Mamm Genome 16:59-65. 2005
    ..This suggests that the PKD1 gene or another gene within this region may cause feline PKD. Further investigation into the cause of PKD will be valuable for feline health and provide insights into human ADPKD...
  3. ncbi Chocolate coated cats: TYRP1 mutations for brown color in domestic cats
    Leslie A Lyons
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, 1114 Tupper Hall, Davis, California 95616, USA
    Mamm Genome 16:356-66. 2005
    ..Three microsatellite makers had significant linkage to the brown phenotype and two for the TYRP1 mutations in a 60-member pedigree. These mutations could be used to identify carriers of brown phenotypes in the domestic cat...
  4. pmc Feline genetics: clinical applications and genetic testing
    Leslie A Lyons
    Department of Population Health and Reproduction, University of California, Davis, CA, USA
    Top Companion Anim Med 25:203-12. 2010
    ..Highlighted are genetic tests specific to the individual cat, which are a part of the cat's internal genome...
  5. pmc Extent of linkage disequilibrium in the domestic cat, Felis silvestris catus, and its breeds
    Hasan Alhaddad
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e53537. 2013
    ....
  6. pmc First WNK4-hypokalemia animal model identified by genome-wide association in Burmese cats
    Barbara Gandolfi
    Department of Population Health and Reproduction, University of California Davis, Davis, California, United States of America
    PLoS ONE 7:e53173. 2012
    ..Moreover, the identified mutation may help clarify the role of the protein in K⁺ regulation and the cat represents the first animal model for WNK4-associated hypokalemia...
  7. pmc An international parentage and identification panel for the domestic cat (Felis catus)
    M J Lipinski
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 38:371-7. 2007
    ..This international cat parentage and identification panel has a power of exclusion comparable to panels used in other species, ranging from 90.08% to 99.79% across breeds and 99.47% to 99.87% in random-bred cat populations...
  8. pmc Albinism in the domestic cat (Felis catus) is associated with a tyrosinase (TYR) mutation
    D L Imes
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA
    Anim Genet 37:175-8. 2006
    ..Taken together, our results suggest that the TYR gene corresponds to the colour locus in cats and its alleles, from dominant to recessive, are as follows: C (full colour) > c(b) (burmese) > or = c(s) (siamese) > c (albino)...
  9. pmc White spotting in the domestic cat (Felis catus) maps near KIT on feline chromosome B1
    M P Cooper
    Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 37:163-5. 2006
    ..Platelet-derived growth factor alpha (PDGFRA) is also a strong candidate, assuming that the KIT-PDGFRA linkage group, which is conserved in many mammalian species, is also conserved in the cat...
  10. pmc Erythrocyte pyruvate kinase deficiency mutation identified in multiple breeds of domestic cats
    Robert A Grahn
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    BMC Vet Res 8:207. 2012
    ..In domestic cats, PK deficiency has an autosomal recessive mode of inheritance with high variability in onset and severity of clinical symptoms...
  11. pmc Genetic testing in domestic cats
    Leslie A Lyons
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Mol Cell Probes 26:224-30. 2012
    ..This article will review the genetic tests for the domestic cat, and their various applications in different fields of science. Highlighted are genetic tests specific to the individual cat, which are a part of the cat's genome...
  12. pmc The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71
    Barbara Gandolfi
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, 1114 Tupper Hall, Davis, CA 95616, USA
    Mamm Genome 21:509-15. 2010
    ..No other causative mutations for eight different rexoid and hairless cat phenotypes were identified. The allelic series KRT71( + ) > KRT71( hr ) > KRT71( re ) is suggested...
  13. pmc Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood group
    Barbara Bighignoli
    Istituto di Zootecnica, Faculty of Veterinary Medicine, University of Milan, Milan, Italy
    BMC Genet 8:27. 2007
    ..The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types...
  14. ncbi Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus)
    L A Lyons
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
    Anim Genet 36:119-26. 2005
    ..Because the same mutations were identified in different breeds with similar phenotypes, the mutations are likely to be identical by descent rather than multiple mutation events occurring at the same site...
  15. pmc The Tabby cat locus maps to feline chromosome B1
    L A Lyons
    Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Anim Genet 37:383-6. 2006
    ..The linked markers cover a 17-cM region and flank an evolutionary breakpoint, suggesting that the Tabby gene has a homologue on either human chromosome 4 or 8. Alternatively, Tabby could be a unique locus in cats...
  16. ncbi Feline polycystic kidney disease mutation identified in PKD1
    Leslie A Lyons
    Department of Population Health and Reproduction, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, 95616, USA
    J Am Soc Nephrol 15:2548-55. 2004
    ..These data suggest that the stop mutation causes feline PKD, providing a test to identify cats that will develop PKD and demonstrating that the domestic cat is an ideal model for human PKD...
  17. doi Pathogenesis of feline enteric coronavirus infection
    Niels C Pedersen
    Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
    J Feline Med Surg 10:529-41. 2008
    ..Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding...
  18. pmc Are molecular cytogenetics and bioinformatics suggesting diverging models of ancestral mammalian genomes?
    Lutz Froenicke
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
    Genome Res 16:306-10. 2006
  19. ncbi Early-onset, autosomal recessive, progressive retinal atrophy in Persian cats
    Hyungchul Rah
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
    Invest Ophthalmol Vis Sci 46:1742-7. 2005
    ..This study genetically, clinically, and histologically characterized the disease. A breeding colony was established to assist with identification of the causative gene and to provide a resource for vision research...
  20. doi Parthenogenesis in a Brazilian rainbow boa (Epicrates cenchria cenchria)
    Matthew E Kinney
    William R Pritchard Veterinary Medical Teaching Hospital, University of California Davis, Davis, California 95822, USA
    Zoo Biol 32:172-6. 2013
    ..This is the first report of parthenogenesis in a Brazilian rainbow boa and has implications for the conservation of reptiles maintained in captive breeding programs...
  21. ncbi Lack of genetic association among coat colors, progressive retinal atrophy and polycystic kidney disease in Persian cats
    Hyungchul Rah
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, 1114 Tupper Hall, Davis, CA 95616, USA
    J Feline Med Surg 8:357-60. 2006
    ..These data suggest that PRA is not limited to cats with chocolate coat coloration and breeders and veterinarians should be aware that the prevalence of the disease may be higher than currently claimed...
  22. ncbi Myopathy with tubulin-reactive inclusions in two cats
    G Diane Shelton
    Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093 0709, USA
    Acta Neuropathol 114:537-42. 2007
    ..The crystalline structures reacted positively with an antibody against tubulin. This feline myopathy may be the equivalent of the human myopathy with tubulin-positive crystalline inclusions...
  23. pmc The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populations
    Monika J Lipinski
    Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA
    Genomics 91:12-21. 2008
    ..Three recently derived breeds were not distinct from their parental breeds of origin. Pure breeding was associated with a loss of genetic diversity; however, this loss did not correlate with breed popularity or age...
  24. doi Nothing 'FISH'y about the rhesus macaque sex ratio
    Pei Hsuan Hung
    Molecular, Cellular, and Integrative Physiology, University of California Davis, Davis, CA 95616, USA
    J Med Primatol 38:42-50. 2009
    ..While the offspring sex ratio is one of the measurements in reproductive studies, this ratio has not been established for rhesus macaques...
  25. pmc What is an "adverse" environment? Interactions of rearing experiences and MAOA genotype in rhesus monkeys
    Genesio M Karere
    Department of Population Health and Reproduction, University of California, Davis, CA, USA
    Biol Psychiatry 65:770-7. 2009
    ....
  26. pmc Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaques
    Erin L Kinnally
    University of California Davis, USA
    Dev Psychopathol 22:35-44. 2010
    ..Finally, we suggest that genetic or environmental factors may mitigate the risk for behavioral dysregulation illustrated in the patterns of behavioral activity and emotional reactivity displayed by infants...
  27. ncbi Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresis
    Cameron L R Jones
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
    J Vet Diagn Invest 16:95-100. 2004
    ....
  28. ncbi Enhancing radiation hybrid mapping through whole genome amplification
    Genesio M Karere
    Department of Population Health and Reproduction, School of Veterinary Medicine, California National Primate Research Center, University of California Davis, Davis, California, USA
    Hereditas 147:103-12. 2010
    ..WGA will allow the analysis of earliest RH clone passages, thus limiting their heterogeneity and RH mapping artifacts...
  29. pmc A high-resolution radiation hybrid map of rhesus macaque chromosome 5 identifies rearrangements in the genome assembly
    Genesio M Karere
    Department of Population Health and Reproduction, School of Veterinary Medicine, California National Primate Research Center, Davis, CA 95616, USA
    Genomics 92:210-8. 2008
    ..This study shows that the 10,000-rad panel is appropriate for the generation of a high-resolution whole-genome RH map suitable for the verification of the rhesus genome assembly...
  30. ncbi Birth of African Wildcat cloned kittens born from domestic cats
    Martha C Gómez
    Audubon Center for Research of Endangered Species, New Orleans, LA 70131, USA
    Cloning Stem Cells 6:247-58. 2004
    ..Subsequent DNA analysis of 12 cat-specific microsatellite loci confirmed that all 17 kittens were clones of the AWC donor male. These AWC kittens represent the first wild carnivores to be produced by nuclear transfer...
  31. doi Cloned embryos from semen. Part 1: in vitro proliferation of epithelial cells on embryonic fibroblasts after isolation from semen by gradient centrifugation
    Liesl Nel-Themaat
    Department of Animal Sciences, LSU Agricultural Center, Baton Rouge, Louisana 70803, USA
    Cloning Stem Cells 10:143-60. 2008
    ..Specifically, cells isolated and cultured from cryopreserved semen of nonliving males could be used for producing embryos by somatic cell nuclear transfer...

Research Grants15

  1. GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASES
    Leslie Lyons; Fiscal Year: 2002
    ..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
  2. Genetic Mapping Resources for Common Mammalian Diseases
    Leslie Lyons; Fiscal Year: 2009
    ....
  3. GENETIC RESOURCES FOR NON-HUMAN PRIMATES
    Leslie Lyons; Fiscal Year: 2007
    ..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
  4. GENETIC RESOURCES FOR NON-HUMAN PRIMATES
    Leslie Lyons; Fiscal Year: 2006
    ..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
  5. GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASES
    Leslie Lyons; Fiscal Year: 2006
    ..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
  6. GENETIC RESOURCES FOR NON-HUMAN PRIMATES
    Leslie Lyons; Fiscal Year: 2005
    ..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
  7. GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASES
    Leslie Lyons; Fiscal Year: 2005
    ..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
  8. GENETIC RESOURCES FOR NON-HUMAN PRIMATES
    Leslie Lyons; Fiscal Year: 2004
    ..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
  9. GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASES
    Leslie Lyons; Fiscal Year: 2004
    ..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
  10. Feline Model of an Inherited Craniofacial Abnormality
    Leslie Lyons; Fiscal Year: 2004
    ..Once identified, mutation analyses of these genes in the cat or other species will lead to understanding the genetics of facial development in humans. ..
  11. GENETIC RESOURCES FOR NON-HUMAN PRIMATES
    Leslie Lyons; Fiscal Year: 2003
    ..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
  12. GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASES
    Leslie Lyons; Fiscal Year: 2003
    ..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
  13. Genetic Mapping Resources for Common Mammalian Diseases
    Leslie A Lyons; Fiscal Year: 2010
    ....