Research Topics
Species | Leslie LyonsSummaryAffiliation: University of California Country: USA Publications
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Publications
Feline lymphoma in the post-feline leukemia virus eraMathilde Louwerens
Utrecht University, School of Veterinary Medicine, Utrecht, The Netherlands
J Vet Intern Med 19:329-35. 2005..A high incidence of mediastinal lymphomas in young Siamese or Oriental breeds also was observed, supporting previous studies. Associations of intestinal lymphoma and inflammatory bowel disease and diet should be further considered...- Feline polycystic kidney disease is linked to the PKD1 regionAmy E Young
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, 1114 Tupper Hall, Davis, California, 95616, USA
Mamm Genome 16:59-65. 2005..This suggests that the PKD1 gene or another gene within this region may cause feline PKD. Further investigation into the cause of PKD will be valuable for feline health and provide insights into human ADPKD... - Chocolate coated cats: TYRP1 mutations for brown color in domestic catsLeslie A Lyons
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, 1114 Tupper Hall, Davis, California 95616, USA
Mamm Genome 16:356-66. 2005..Three microsatellite makers had significant linkage to the brown phenotype and two for the TYRP1 mutations in a 60-member pedigree. These mutations could be used to identify carriers of brown phenotypes in the domestic cat... 
Feline genetics: clinical applications and genetic testingLeslie A Lyons
Department of Population Health and Reproduction, University of California, Davis, CA, USA
Top Companion Anim Med 25:203-12. 2010..Highlighted are genetic tests specific to the individual cat, which are a part of the cat's internal genome...- Genetic testing in domestic catsLeslie A Lyons
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Mol Cell Probes 26:224-30. 2012..This article will review the genetic tests for the domestic cat, and their various applications in different fields of science. Highlighted are genetic tests specific to the individual cat, which are a part of the cat's genome... - The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71Barbara Gandolfi
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, 1114 Tupper Hall, Davis, CA 95616, USA
Mamm Genome 21:509-15. 2010..No other causative mutations for eight different rexoid and hairless cat phenotypes were identified. The allelic series KRT71( + ) > KRT71( hr ) > KRT71( re ) is suggested... - Cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) mutations associated with the domestic cat AB blood groupBarbara Bighignoli
Istituto di Zootecnica, Faculty of Veterinary Medicine, University of Milan, Milan, Italy
BMC Genet 8:27. 2007..The enzyme cytidine monophospho-N-acetylneuraminic acid hydroxylase (CMAH) determines the sugar bound to the red cell by converting NeuAc to NeuGc. Thus, mutations in CMAH may cause the A and B blood types... - Feline polycystic kidney disease mutation identified in PKD1Leslie A Lyons
Department of Population Health and Reproduction, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, 95616, USA
J Am Soc Nephrol 15:2548-55. 2004..These data suggest that the stop mutation causes feline PKD, providing a test to identify cats that will develop PKD and demonstrating that the domestic cat is an ideal model for human PKD... - The Tabby cat locus maps to feline chromosome B1L A Lyons
Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA 95616, USA
Anim Genet 37:383-6. 2006..The linked markers cover a 17-cM region and flank an evolutionary breakpoint, suggesting that the Tabby gene has a homologue on either human chromosome 4 or 8. Alternatively, Tabby could be a unique locus in cats... - Tyrosinase mutations associated with Siamese and Burmese patterns in the domestic cat (Felis catus)L A Lyons
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
Anim Genet 36:119-26. 2005..Because the same mutations were identified in different breeds with similar phenotypes, the mutations are likely to be identical by descent rather than multiple mutation events occurring at the same site... - Are molecular cytogenetics and bioinformatics suggesting diverging models of ancestral mammalian genomes?Lutz Froenicke
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California 95616, USA
Genome Res 16:306-10. 2006 
Pathogenesis of feline enteric coronavirus infectionNiels C Pedersen
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95694, USA
J Feline Med Surg 10:529-41. 2008..Pregnancy, parturition and lactation had no influence on fecal shedding by queens. Methylprednisolone acetate treatment did not induce non-shedders to shed and shedders to increase shedding...- Early-onset, autosomal recessive, progressive retinal atrophy in Persian catsHyungchul Rah
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA
Invest Ophthalmol Vis Sci 46:1742-7. 2005..A breeding colony that will assist in the identification of the causative gene has been established and is available for studies in vision research... - Lack of genetic association among coat colors, progressive retinal atrophy and polycystic kidney disease in Persian catsHyungchul Rah
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California - Davis, 1114 Tupper Hall, Davis, CA 95616, USA
J Feline Med Surg 8:357-60. 2006..These data suggest that PRA is not limited to cats with chocolate coat coloration and breeders and veterinarians should be aware that the prevalence of the disease may be higher than currently claimed... - Myopathy with tubulin-reactive inclusions in two catsG Diane Shelton
Department of Pathology 0709, University of California, San Diego, La Jolla, CA 92093 0709, USA
Acta Neuropathol 114:537-42. 2007..The crystalline structures reacted positively with an antibody against tubulin. This feline myopathy may be the equivalent of the human myopathy with tubulin-positive crystalline inclusions... - Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaquesErin L Kinnally
University of California Davis, USA
Dev Psychopathol 22:35-44. 2010..Finally, we suggest that genetic or environmental factors may mitigate the risk for behavioral dysregulation illustrated in the patterns of behavioral activity and emotional reactivity displayed by infants... - What is an "adverse" environment? Interactions of rearing experiences and MAOA genotype in rhesus monkeysGenesio M Karere
Department of Population Health and Reproduction, University of California, Davis, CA, USA
Biol Psychiatry 65:770-7. 2009.... - Nothing 'FISH'y about the rhesus macaque sex ratioPei Hsuan Hung
Molecular, Cellular, and Integrative Physiology, University of California Davis, Davis, CA 95616, USA
J Med Primatol 38:42-50. 2009..While the offspring sex ratio is one of the measurements in reproductive studies, this ratio has not been established for rhesus macaques... - The ascent of cat breeds: genetic evaluations of breeds and worldwide random-bred populationsMonika J Lipinski
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California at Davis, Davis, CA 95616, USA
Genomics 91:12-21. 2008..Three recently derived breeds were not distinct from their parental breeds of origin. Pure breeding was associated with a loss of genetic diversity; however, this loss did not correlate with breed popularity or age... - A high-resolution radiation hybrid map of rhesus macaque chromosome 5 identifies rearrangements in the genome assemblyGenesio M Karere
Department of Population Health and Reproduction, School of Veterinary Medicine, California National Primate Research Center, Davis, CA 95616, USA
Genomics 92:210-8. 2008..This study shows that the 10,000-rad panel is appropriate for the generation of a high-resolution whole-genome RH map suitable for the verification of the rhesus genome assembly... - Enhancing radiation hybrid mapping through whole genome amplificationGenesio M Karere
Department of Population Health and Reproduction, School of Veterinary Medicine, California National Primate Research Center, University of California Davis, Davis, California, USA
Hereditas 147:103-12. 2010..WGA will allow the analysis of earliest RH clone passages, thus limiting their heterogeneity and RH mapping artifacts... - Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresisCameron L R Jones
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA
J Vet Diagn Invest 16:95-100. 2004.... - Cloned embryos from semen. Part 1: in vitro proliferation of epithelial cells on embryonic fibroblasts after isolation from semen by gradient centrifugationLiesl Nel-Themaat
Department of Animal Sciences, LSU Agricultural Center, Baton Rouge, Louisana 70803, USA
Cloning Stem Cells 10:143-60. 2008..Specifically, cells isolated and cultured from cryopreserved semen of nonliving males could be used for producing embryos by somatic cell nuclear transfer... - Birth of African Wildcat cloned kittens born from domestic catsMartha C Gómez
Audubon Center for Research of Endangered Species, New Orleans, LA 70131, USA
Cloning Stem Cells 6:247-58. 2004..Subsequent DNA analysis of 12 cat-specific microsatellite loci confirmed that all 17 kittens were clones of the AWC donor male. These AWC kittens represent the first wild carnivores to be produced by nuclear transfer...
Research Grants
- Genetic Mapping Resources for Common Mammalian DiseasesLeslie Lyons; Fiscal Year: 2009....
- GENETIC RESOURCES FOR NON-HUMAN PRIMATESLeslie Lyons; Fiscal Year: 2007..The rationale for this approach is that many primate researchers are unaware of the current primate resources and are unfamiliar with the use and advantages of genetics because it is outside their areas of expertise. ..
- GENETIC MAPPING RESOURCE FOR COMMON MAMMALIAN DISEASESLeslie Lyons; Fiscal Year: 2006..The proposed research is significant because it will provide a framework map comparable to humans in three species that have complex and simple disease traits that plague humans. ..
- Feline Model of an Inherited Craniofacial AbnormalityLeslie Lyons; Fiscal Year: 2004..Once identified, mutation analyses of these genes in the cat or other species will lead to understanding the genetics of facial development in humans. ..
- Genetic Mapping Resources for Common Mammalian DiseasesLeslie A Lyons; Fiscal Year: 2010....