Research Topics
| JEFFREY LYNESSSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Medical illness burden, trait neuroticism, and depression in older primary care patientsJ M Lyness
Department of Psychiatry, University of Rochester School of Medicine and Dentistry, NY, USA
Am J Psychiatry 155:969-71. 1998..The authors tested the hypotheses that medical illness burden is independently associated with depression and that this association is moderated by neuroticism...- The relationship of medical comorbidity and depression in older, primary care patientsJeffrey M Lyness
Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosomatics 47:435-9. 2006..This generates the hypothesis that, in general primary care populations, the relationship of medical illness to depression may be multimodal and/or may involve shared pathobiological or psychosocial mechanisms... - Outcomes of minor and subsyndromal depression among elderly patients in primary care settingsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
Ann Intern Med 144:496-504. 2006..Although depressive conditions in later life are a major public health problem, the outcomes of minor and subsyndromal depression are largely unknown... 
Naturalistic outcomes of minor and subsyndromal depression in older primary care patientsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Int J Geriatr Psychiatry 23:773-81. 2008..To review the literature regarding the naturalistic outcomes of minor and subsyndromal depression ('Min/SSD') in older primary care patients, synthesizing and critiquing findings and discussing avenues for future research...
Risks for depression onset in primary care elderly patients: potential targets for preventive interventionsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Am J Psychiatry 166:1375-83. 2009..The authors examined a broad range of clinical, functional, and psychosocial predictors of incident depressive episodes in a well-characterized cohort of older primary care patients...- The clinical significance of subsyndromal depression in older primary care patientsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 15:214-23. 2007.... - End-of-life care: issues relevant to the geriatric psychiatristJeffrey M Lyness
Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 12:457-72. 2004.... - Self-rated health, depression, and one-year health outcomes in older primary care patientsJeffrey M Lyness
Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Boulevard, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 12:110-3. 2004..The authors tested the hypothesis that poorer self-rated health is associated with poorer health outcomes... - Cerebrovascular risk factors and 1-year depression outcome in older primary care patientsJ M Lyness
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Psychiatry 157:1499-501. 2000.... - Cerebrovascular risk factors and depression in older primary care patients: testing a vascular brain disease model of depressionJ M Lyness
Department of Psychiatry, University of Rochester Medical Center, NY 14642, USA
Am J Geriatr Psychiatry 7:252-8. 1999..Future work should include longitudinal study with larger sample sizes... - Depressive disorders and symptoms in older primary care patients: one-year outcomesJeffrey M Lyness
Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 10:275-82. 2002..Depressive conditions had considerable rates of persistence, yet the outcome was not uniformly poor. Longer-term naturalistic study is needed, as are treatment studies targeting those at highest risk of recurrence or chronicity... - One-year outcomes of minor and subsyndromal depression in older primary care patientsJeffrey M Lyness
Geriatric Psychiatry Program, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Int Psychogeriatr 21:60-8. 2009.... - Depression, medical illness, and interleukin-1beta in older cardiac patientsJ M Lyness
Department of Psychiatry, University of Rochester Medical Center, New York 14642, USA
Int J Psychiatry Med 31:305-10. 2001..We collected pilot data to test the hypothesis that interleukin-1beta (IL-1beta) is associated with depression in a cardiac patient group... - Outcomes of subsyndromal depression in older primary care patientsAndrew Grabovich
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 18:227-35. 2010..The authors also explored the relative outcomes of three definitions of SSD to determine their relative prognostic value... - Social support, depression, and functional disability in older adult primary-care patientsLinda A Travis
Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 12:265-71. 2004..Future research is needed to further specify the complex relationships among depression, social support, and functional disability... - Does depression precede or follow executive dysfunction? Outcomes in older primary care patientsXingjia Cui
Geriatrics Psychiatry program, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Psychiatry 164:1221-8. 2007..The authors sought to test the potentially reciprocal relationships between depression and executive dysfunction in older patients over time... - Standardizing and personalizing science in medical educationDavid R Lambert
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Acad Med 85:356-62. 2010..Greater personalization demands that physicians possess well-refined skills in information acquisition, interpretation, and application for optimal lifelong learning and effective clinical practice... - Personality and medical illness burden among older adults in primary careBenjamin P Chapman
Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
Psychosom Med 69:277-82. 2007.... - Measurement of the general competencies of the accreditation council for graduate medical education: a systematic reviewStephen J Lurie
Office of Curriculum and Assessment, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Acad Med 84:301-9. 2009..To evaluate published evidence that the Accreditation Council for Graduate Medical Education's six general competencies can each be measured in a valid and reliable way... - Positive affect and suicide ideation in older adult primary care patientsJameson K Hirsch
Department of Psychology, Rochester Institute of Technology, Rochester, NY 14623, USA
Psychol Aging 22:380-5. 2007..Clinical and theoretical formulations of late-life suicide should consider the role of positive affect, including the possibility that its protective effects grow more pronounced with age... - Personality traits, education, and health-related quality of life among older adult primary care patientsBenjamin Chapman
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
J Gerontol B Psychol Sci Soc Sci 62:P343-52. 2007..Future research aimed at understanding how personality traits are linked with HRQOL and functioning in later life may enhance the identification of at-risk older adults and inform the development of interventions... - Personality traits predict emergency department utilization over 3 years in older patientsBenjamin P Chapman
Departments of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 17:526-35. 2009..Powerfully tied to health in older adults, the "Big Five" personality traits of neuroticism, extroversion, openness to experience, agreeableness, and conscientiousness may predict ED use... - Gender, race/ethnicity, personality, and interleukin-6 in urban primary care patientsBenjamin P Chapman
Department of Psychiatry, Rochester Center for Mind Body Research, University of Rochester Medical Center, Rochester, NY 14642, USA
Brain Behav Immun 23:636-42. 2009..physical activity itself, and whether IL-6 levels may be reduced by boosting regular activity levels in demographic segments such as women and minorities who appear susceptible to greater inflammation... - Major depression and disability in older primary care patients with heart failureBruce Friedman
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Geriatr Psychiatry Neurol 21:111-22. 2008..602). Our principal conclusion is that the progressively greater likelihood of major depression as the number of IADL dependencies increases has important clinical, personal, social, and public health relevance... - Is insomnia a perpetuating factor for late-life depression in the IMPACT cohort?Wilfred R Pigeon
Department of Psychiatry, University of Rochester Medical Center, Rochester NY, USA
Sleep 31:481-8. 2008..The present longitudinal study examines the relationship of insomnia to the continuation of depression in the context of an intervention study in elderly subjects... - Trait neuroticism, depression, and cognitive function in older primary care patientsLisa L Boyle
Department of Psychiatry, Geriatric Psychiatry Program, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 18:305-12. 2010..The authors tested hypotheses that neuroticism is associated with measures of cognition and that depression moderates these relationships... - Qualitative analysis of medical student impressions of a narrative exercise in the third-year psychiatry clerkshipDavid Garrison
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14641, USA
Acad Med 86:85-9. 2011.... - Development of an audit method to assess the prevalence of the ACGME's general competencies in an undergraduate medical education curriculumChristopher J Mooney
Offices of Medical Education, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Teach Learn Med 22:257-61. 2010..Despite the use of competency-based frameworks to evaluate physicians, the role of competency-based objectives in undergraduate medical education remains uncertain... - Depression predicts cognitive disorders in older primary care patientsLisa L Boyle
Department of Psychiatry, Box PSYCH, University of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642, USA
J Clin Psychiatry 71:74-9. 2010..To investigate whether depression is independently associated with increased risk of incident dementia or cognitive disorder not otherwise specified (NOS) in an older primary care population... - Depression, perceived family criticism, and functional status among older, primary-care patientsDavid B Seaburn
School of Medicine and Dentistry, Dept of Psychiatry, University of Rochester, 300 Crittenden Blvd, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 13:766-72. 2005.... - Does the geriatric depression scale (GDS) distinguish between older adults with high versus low levels of suicidal ideation?Marnin J Heisel
correspondence and reprint requests to Marnin J Heisel, Center for the Study and Prevention of Suicide, Dept of Psychiatry, Univ of Rochester Medical Center, 300 Crittenden Blvd, Rochester, NY 14642 8409, USA
Am J Geriatr Psychiatry 13:876-83. 2005..The present study asked whether 30-item (GDS) and 15-item (GDS-SF) GDS scales differentiate older adults with high versus low levels of suicidal ideation... - Commentary: pitfalls in assessment of competency-based educational objectivesStephen J Lurie
Office of Curriculum and Assessment, and Associate Professor, Department of Family Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Acad Med 86:412-4. 2011.... - Insomnia as a risk factor for onset of depression in the elderlyMichael L Perlis
Department of Psychiatry and UR Neurosciences Program, University of Rochester, NY 14642, USA
Behav Sleep Med 4:104-13. 2006..These data suggest that elderly participants with persistent insomnia are at greater risk for the development of new onset depression... - How are personality traits related to preparation for future care needs in older adults?SILVIA SORENSEN
Department of Psychiatry, Geriatric Psychiatry Program, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
J Gerontol B Psychol Sci Soc Sci 63:P328-36. 2008..Neither concrete planning nor decision making were related to personality variables. Health professionals should consider the impact of individual differences when addressing preparation for future care with older adults... - Outcomes and predictors of late-life depression trajectories in older primary care patientsXingjia Cui
Geriatric Psychiatry Program, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 16:406-15. 2008..The naturalistic outcomes of depression in older primary care patients have been poorly characterized. The authors sought to identify depressive trajectories over 2 years and to examine specified outcome predictors... - Personality is associated with perceived health and functional status in older primary care patientsPaul R Duberstein
Department of Psychiatry and The Cancer Center, University of Rochester Medical Center, New York 14642, USA
Psychol Aging 18:25-37. 2003..This study underscores the conceptual and heuristic value of examining moderators of the links between personality variables and health... - Detection of depression in older adults by family and friends: distinguishing mood disorder signals from the noise of personality and everyday lifePaul R Duberstein
Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
Int Psychogeriatr 23:634-43. 2011..We hypothesized that the accuracy (sensitivity and specificity) of informant reports would vary with the patient's personality... - Cerebrovascular risk factors, executive dysfunction, and depression in older primary care patientsMichelle L Schoepflin Sanders
Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
Am J Geriatr Psychiatry 14:145-52. 2006..Longitudinal risk factor studies and complementary techniques such as neuroimaging may help identify pathogenetically distinct subgroups of later-life depression that might respond preferentially to specific interventions... - Bereavement in late life: risk factors for complicated bereavementJennifer L Schum
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA
Geriatrics 60:18-20, 24. 2005 - Cognitive and psychiatric effects of vitamin B12 replacement in dementia with low serum B12 levels: a nursing home studyChristopher H van Dyck
Azheimer s Disease Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Int Psychogeriatr 21:138-47. 2009..The aim of this study is to determine whether B12 replacement would ameliorate cognitive and psychiatric symptoms in elderly subjects with dementia and low serum B12 levels... - Minor depression. Diagnosis and management in primary careLinda A Travis
Program in Geriatrics and Neuropsychiatry, Family Program, Department of Psychiatry, University of Rochester Medical Center
Geriatrics 57:65-6. 2002 - Direct estimation of the area under the receiver operating characteristic curve in the presence of verification biasHua He
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Ave, Box 630, Rochester, NY 14642, USA
Stat Med 28:361-76. 2009..Closed-form expressions for the estimator and its variance are derived. We also show that the new estimator is equivalent to the empirical AUC derived from the bias-corrected ROC curve arising from the IPW approach... - Psychiatric emergency services for the U.S. elderly: 2008 and beyondPatrick G Walsh
Department of Psychiatry, University of Rochester, Rochester, NY 14642, USA
Am J Geriatr Psychiatry 16:706-17. 2008..The degree to which the geriatric mental healthcare "crisis" develops will be inversely related to the current system's response to predictable future needs... - Personality and perceived health in older adults: the five factor model in primary careBenjamin P Chapman
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY 14642, USA
J Gerontol B Psychol Sci Soc Sci 61:P362-5. 2006..quot; We discuss implications for understanding personality influences on morbidity, mortality, and health services utilization... - Depression and comorbidity: objects in the mirror are more complex than they appearJeffrey M Lyness
Am J Geriatr Psychiatry 16:181-5. 2008 - Treatments for later-life depressive conditions: a meta-analytic comparison of pharmacotherapy and psychotherapyMartin Pinquart
Institute of Psychology, University of Jena, Am Steiger 3, Haus 1, 07743 Jena, Germany
Am J Psychiatry 163:1493-501. 2006..Given that most older adults with clinically significant depressive symptoms do not have major depression, data on treatments for minor depression and dysthymia are especially needed... - Personality and the association of pain and depressionSarah K Calabrese
Department of Clinical Psychology, The George Washington University, Washington, DC, USA
Am J Geriatr Psychiatry 14:546-9. 2006..CONCLUSIONS: The association of bodily pain with depression may be greater in those previously at lower risk on account of low neuroticism... - Treatment of depressive conditions in later life: real-world light for dark (or dim) tunnelsJeffrey M Lyness
JAMA 291:1626-8. 2004 - Inflammatory markers, depression, and cardiac diseaseJeffrey M Lyness
Am J Psychiatry 162:195; author reply 195. 2005 - Do cerebrovascular risk factors confer risk for suicide in later life? A case-control studySandra S Chan
Department of Psychiatry, The Chinese University of Hong Kong, Hong Kong, China
Am J Geriatr Psychiatry 15:541-4. 2007..Cerebrovascular pathologies have been implicated as a cause of depressive disorders. This study aims to examine the role of cerebrovascular risk factors in late-life suicide... - Primary care physician office visits for depression by older AmericansJeffrey S Harman
Department of Health Services Research, Management and Policy, College of Public Health and Health Professions, University of Florida, Gainesville, FL 32610 0195, USA
J Gen Intern Med 21:926-30. 2006.... - Provisional diagnostic criteria for depression of Alzheimer diseaseJason T Olin
Adult and Geriatric Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9635, USA
Am J Geriatr Psychiatry 10:125-8. 2002....
Research Grants
- LATE LIFE DEPRESSION OUTCOME & MEDICAL ILLNESS SEVERITYJEFFREY LYNESS; Fiscal Year: 2005..The results will directly inform future research, including identifying subjects for interventions as well as identifying theoretical models of depression pathogenesis that merit more definitive testing. ..
- Late-life Depression Outcomes in the Medically IllJEFFREY LYNESS; Fiscal Year: 2007..The PI also will mentor early career researchers at other institutions through national-level training grants and meetings. ..
- Postdoctoral Training in Geriatric Psychiatry ResearchJEFFREY LYNESS; Fiscal Year: 2007..Such training addresses critical "pipeline" shortages in geriatric mental health research. ..