WENDY JEAN LYNCH

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Medical School, Box 392 Mayo, Minneapolis 55455, USA
    Psychopharmacology (Berl) 161:304-13. 2002
  2. ncbi request reprint Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Psychopharmacology (Berl) 197:237-46. 2008
  3. doi request reprint Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Psychopharmacology (Berl) 217:3-12. 2011
  4. ncbi request reprint Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats
    Wendy J Lynch
    Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 191:263-71. 2007
  5. pmc Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Brain Res 1213:166-77. 2008
  6. pmc Subjective responses and cardiovascular effects of self-administered cocaine in cocaine-abusing men and women
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health Sciences, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Addict Biol 13:403-10. 2008
  7. pmc Sex and ovarian hormones influence vulnerability and motivation for nicotine during adolescence in rats
    Wendy J Lynch
    Division of Neurobiological Studies, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Pharmacol Biochem Behav 94:43-50. 2009
  8. pmc Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Biol Psychiatry 68:774-7. 2010
  9. pmc Role of progesterone in nicotine addiction: evidence from initiation to relapse
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Research, University of Virginia, Charlottesville, Virginia 22911, USA
    Exp Clin Psychopharmacol 18:451-61. 2010
  10. ncbi request reprint Decreased motivation following cocaine self-administration under extended access conditions: effects of sex and ovarian hormones
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 30:927-35. 2005

Detail Information

Publications27

  1. ncbi request reprint Intravenous cocaine and heroin self-administration in rats selectively bred for differential saccharin intake: phenotype and sex differences
    Marilyn E Carroll
    Department of Psychiatry, University of Minnesota, Medical School, Box 392 Mayo, Minneapolis 55455, USA
    Psychopharmacology (Berl) 161:304-13. 2002
    ..The HiS phenotype may be a predictor of abuse of other drugs via other routes of administration...
  2. ncbi request reprint Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Psychopharmacology (Berl) 197:237-46. 2008
    ..Previous work has shown that adult female rats are more sensitive than adult male rats to the reinforcing effects of cocaine, an effect that appears to be due, at least in part, to ovarian hormones...
  3. doi request reprint Severity of drinking as a predictor of efficacy of the combination of ondansetron and topiramate in rat models of ethanol consumption and relapse
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Psychopharmacology (Berl) 217:3-12. 2011
    ..Alcohol dependence is the third leading cause of preventable death in the USA. While single-agent pharmacotherapies have variable efficacy, medication combinations may produce additive effects by modulating multiple neural pathways...
  4. ncbi request reprint Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats
    Wendy J Lynch
    Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 191:263-71. 2007
    ..Chronic cocaine produces changes in the dopamine (DA)/D1/cAMP/protein kinase A (PKA)-regulated signaling pathway that may underlie the development of addiction...
  5. pmc Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA
    Brain Res 1213:166-77. 2008
    ..These data strongly suggest involvement of circadian-associated genes in the brain's response to cocaine and may contribute to an understanding of addictive behavior including disruptions in sleep and circadian rhythmicity...
  6. pmc Subjective responses and cardiovascular effects of self-administered cocaine in cocaine-abusing men and women
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health Sciences, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Addict Biol 13:403-10. 2008
    ..Further research that prospectively controls for hormonal influences upon these measures is needed...
  7. pmc Sex and ovarian hormones influence vulnerability and motivation for nicotine during adolescence in rats
    Wendy J Lynch
    Division of Neurobiological Studies, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia Health System, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Pharmacol Biochem Behav 94:43-50. 2009
    ..These findings demonstrate an enhanced sensitivity in adolescent females as compared to adolescent males to nicotine's reinforcing effects with evidence implicating circulating hormone levels as modulating this sensitivity...
  8. pmc Aerobic exercise attenuates reinstatement of cocaine-seeking behavior and associated neuroadaptations in the prefrontal cortex
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Biol Psychiatry 68:774-7. 2010
    ..The goal of this study was to determine, using an animal model, whether aerobic exercise may block reinstatement of cocaine-seeking and its underlying neurobiology (i.e., neuronal signaling in the prefrontal cortex)...
  9. pmc Role of progesterone in nicotine addiction: evidence from initiation to relapse
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Research, University of Virginia, Charlottesville, Virginia 22911, USA
    Exp Clin Psychopharmacol 18:451-61. 2010
    ..We conclude with future directions including further examination of progesterone as a potential intervention and treatment of nicotine addiction...
  10. ncbi request reprint Decreased motivation following cocaine self-administration under extended access conditions: effects of sex and ovarian hormones
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 30:927-35. 2005
    ..The mechanisms that may underlie these observed sex differences, including the role of estrogen, are discussed...
  11. pmc Incubation of nicotine seeking is associated with enhanced protein kinase A-regulated signaling of dopamine- and cAMP-regulated phosphoprotein of 32 kDa in the insular cortex
    Amir Abdolahi
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 1670 Discovery Drive, Charlottesville, VA 22911, USA
    Eur J Neurosci 31:733-41. 2010
    ....
  12. ncbi request reprint Sex differences in vulnerability to drug self-administration
    Wendy J Lynch
    Department of Psychiatric Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Exp Clin Psychopharmacol 14:34-41. 2006
    ..Preclinical studies, in conjunction with human studies, should further inform a sex-specific model for differences in drug abuse, and such a model may be useful for developing prevention and treatment strategies for drug abuse...
  13. ncbi request reprint Sex differences in the behavioral effects of 24-h/day access to cocaine under a discrete trial procedure
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT 06516, USA
    Neuropsychopharmacology 29:943-51. 2004
    ....
  14. ncbi request reprint Sex and estrogen influence drug abuse
    Marilyn E Carroll
    Department of Psychiatry, Mayo Box 392, University of Minnesota, Minneapolis, MN 55455, USA
    Trends Pharmacol Sci 25:273-9. 2004
    ..In all phases of drug abuse, females seem to be more sensitive to the rewarding effects of drugs than males, and estrogen is a major factor that underlies these sex differences...
  15. pmc Animal models of substance abuse and addiction: implications for science, animal welfare, and society
    Wendy J Lynch
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    Comp Med 60:177-88. 2010
    ....
  16. pmc Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
    Jane R Taylor
    Department of Psychiatry, Division of Molecular Psychiatry and Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 104:4147-52. 2007
    ....
  17. ncbi request reprint Biological basis of sex differences in drug abuse: preclinical and clinical studies
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 164:121-37. 2002
    ..Future research is necessary to provide information on how to design more effective drug abuse treatment programs and resources that are sex specific...
  18. ncbi request reprint Self-reported paranoia during laboratory "binge" cocaine self-administration in humans
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 83:249-56. 2006
    ..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
  19. ncbi request reprint Neonatal isolation stress potentiates cocaine seeking behavior in adult male and female rats
    Wendy J Lynch
    Department of Psychiatry, Yale University, New Haven, CT 06513, USA
    Neuropsychopharmacology 30:322-9. 2005
    ..These findings demonstrate robust and enduring effects of neonatal isolation stress on cocaine seeking behavior in adult male and female rats...
  20. ncbi request reprint A paradigm to investigate the self-regulation of cocaine administration in humans
    Atapol Sughondhabirom
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 180:436-46. 2005
    ..The current study assessed the feasibility, safety, and validity of a model of ad libitum cocaine self-administration, in which participants self-selected the timing of cocaine infusions, using PCA techniques...
  21. ncbi request reprint Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:1310-3. 2007
    ..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
  22. pmc Regulation of cocaine self-administration in humans: lack of evidence for loading and maintenance phases
    Gustavo A Angarita
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 95:51-5. 2010
    ..We sought to examine whether similar phases might characterize self-regulated cocaine use in humans...
  23. ncbi request reprint Treating smoking dependence in depressed alcoholics
    Nassima Ait-Daoud
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, Virginia, USA
    Alcohol Res Health 29:213-20. 2006
    ..Additional treatment strategies targeting dually dependent individuals with comorbid psychiatric disorders, including special populations such as women and adolescents, await further investigation...
  24. ncbi request reprint Psychiatric correlates of gambling in adolescents and young adults grouped by age at gambling onset
    Wendy J Lynch
    Women and Addictive Disorders Core of Women s Health Research and the Division of Substance Abuse of the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 61:1116-22. 2004
    ....
  25. ncbi request reprint Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem NC 27157 1083, USA
    Neurochem Res 27:1181-92. 2002
    ..These changes share commonalities and exhibit differences with previous reports of gene expression changes in the frontal cortex after noncontingent cocaine administration...
  26. ncbi request reprint Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27101, USA
    Drug Alcohol Depend 67:291-9. 2002
    ..This DT procedure provides a method to examine the behavioral and neurochemical effects of high cocaine intake over extended periods without toxicity...
  27. ncbi request reprint Changes in rat frontal cortex gene expression following chronic cocaine
    Willard M Freeman
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Brain Res Mol Brain Res 104:11-20. 2002
    ..This study also validates the use of hybridization arrays for screening of neuronal gene expression changes and the utility of relative protein quantification as a post-hoc confirmation tool...

Research Grants8

  1. Sex, hormones and cocaine self-administration
    Wendy Lynch; Fiscal Year: 2006
    ..Thus, these studies may provide a basis for the development of novel treatment strategies for cocaine abuse/dependence, particularly in women. ..
  2. Dopaminergic and glutamatergic mechanisms of cocaine addiction: sex differences
    WENDY JEAN LYNCH; Fiscal Year: 2010
    ..These studies will provide a much needed foundation for the development of hormonal, pharmacological, and/or molecular based therapeutics for cocaine abuse, especially in women. ..
  3. Rat Models of Alcohol Dependence for Evaluating Combined Medication Effects
    WENDY JEAN LYNCH; Fiscal Year: 2010
    ....
  4. Dopaminergic and glutamatergic mechanisms of cocaine addiction: sex differences
    WENDY JEAN LYNCH; Fiscal Year: 2010
    ....