Susan V Lynch

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal microbiota
    Susan V Lynch
    Colitis and Crohn s Disease Center, Division of Gastroenterology, Department of Medicine University of California, San Francisco, San Francisco, CA, USA
    Gut Microbes 4:41-7. 2013
  2. pmc Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Microb Pathog 48:197-204. 2010
  3. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
  4. doi request reprint Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis
    Nicole A Abreu
    Department of Biology, San Francisco State University, Hensill 534, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Sci Transl Med 4:151ra124. 2012
  5. doi request reprint Increased mortality of ventilated patients with endotracheal Pseudomonas aeruginosa without clinical signs of infection
    Hanjing Zhuo
    Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 36:2495-503. 2008
  6. pmc A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    OMICS 14:9-59. 2010
  7. pmc Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome
    Michael J Cox
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8745. 2010
  8. pmc Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa
    Xiang Xu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Leukoc Biol 91:275-84. 2012
  9. pmc The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, Med Sci S357, San Francisco, CA 94143, USA
    Expert Rev Respir Med 5:809-21. 2011
  10. pmc Development of a standardized approach for environmental microbiota investigations related to asthma development in children
    Kei E Fujimura
    Division of Gastroenterology, University of California, San Francisco, CA 94143, United States
    J Microbiol Methods 91:231-9. 2012

Collaborators

Detail Information

Publications21

  1. pmc Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal microbiota
    Susan V Lynch
    Colitis and Crohn s Disease Center, Division of Gastroenterology, Department of Medicine University of California, San Francisco, San Francisco, CA, USA
    Gut Microbes 4:41-7. 2013
    ..Thus, these data provide the first indications that GI bacterial colonization is strongly impacted by the loss of functional CFTR and opens up avenues for alternative therapeutic approaches to improve CF disease management...
  2. pmc Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Microb Pathog 48:197-204. 2010
    ..It also demonstrates the protective effect of anti-PcrV immunotherapy against a multitude of P. aeruginosa strains from diverse global regions with a variety of mutations in PcrV...
  3. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
    ..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present...
  4. doi request reprint Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis
    Nicole A Abreu
    Department of Biology, San Francisco State University, Hensill 534, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Sci Transl Med 4:151ra124. 2012
    ..These studies demonstrate that sinus mucosal health is highly dependent on the composition of the resident microbiota as well as identify both a new sino-pathogen and a strong bacterial candidate for therapeutic intervention...
  5. doi request reprint Increased mortality of ventilated patients with endotracheal Pseudomonas aeruginosa without clinical signs of infection
    Hanjing Zhuo
    Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 36:2495-503. 2008
    ..To investigate the frequency and outcomes of ventilated patients with newly acquired large burdens of Pseudomonas aeruginosa and to test the hypothesis that large quantities of bacteria are associated with adverse patient outcomes...
  6. pmc A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    OMICS 14:9-59. 2010
    ....
  7. pmc Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome
    Michael J Cox
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8745. 2010
    ....
  8. pmc Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa
    Xiang Xu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Leukoc Biol 91:275-84. 2012
    ..These findings raise the possibility that Pseudomonas-stimulated neutrophils can enhance airway inflammation by producing histamine...
  9. pmc The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, Med Sci S357, San Francisco, CA 94143, USA
    Expert Rev Respir Med 5:809-21. 2011
    ....
  10. pmc Development of a standardized approach for environmental microbiota investigations related to asthma development in children
    Kei E Fujimura
    Division of Gastroenterology, University of California, San Francisco, CA 94143, United States
    J Microbiol Methods 91:231-9. 2012
    ....
  11. pmc Role of the gut microbiota in defining human health
    Kei E Fujimura
    Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Expert Rev Anti Infect Ther 8:435-54. 2010
    ....
  12. pmc Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Infect Immun 76:2325-32. 2008
    ..aeruginosa-induced lung injury. However, these therapies also did not increase the lung injury, suggesting that host defense was not compromised by this promising new therapy...
  13. pmc Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability
    Michael T Ganter
    Department of Anesthesia and Surgery, University of California San Francisco, San Francisco, California 94110, USA
    Am J Respir Cell Mol Biol 40:108-18. 2009
    ..aeruginosa-induced lung vascular permeability. In addition, activation of the stress protein response with pharmacologic inhibitors of Hsp90 may protect lungs against P. aeruginosa-induced permeability changes...
  14. doi request reprint Probiotic strategies for treatment of respiratory diseases
    Nabeetha A Nagalingam
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Trends Microbiol 21:485-92. 2013
    ....
  15. doi request reprint House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection
    Kei E Fujimura
    Divisions of Gastroenterology and Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 111:805-10. 2014
    ..johnsonii as a pivotal species within the gastrointestinal tract capable of influencing adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of respiratory insults. ..
  16. pmc Oral and airway microbiota in HIV-infected pneumonia patients
    Shoko Iwai
    University of California San Francisco, San Francisco, California, USA
    J Clin Microbiol 50:2995-3002. 2012
    ....
  17. doi request reprint Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia
    Christian Schwarzer
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Cell Microbiol 14:698-709. 2012
    ..aeruginosa biofilms may contribute to accumulation of apoptotic cells that cannot be cleared from CF lungs. A model to explain the effects of C12 is proposed...
  18. pmc Novel strategies to combat bacterial virulence
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143, USA
    Curr Opin Crit Care 14:593-9. 2008
    ..The purpose of this review is to highlight the recent developments in antibacterial therapy and the novel approaches toward increasing our therapeutic armory against bacterial infection...
  19. pmc The cystic fibrosis airway microbiome
    Susan V Lynch
    Colitis and Crohn s Disease Microbiome Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cold Spring Harb Perspect Med 3:a009738. 2013
    ..This article aims to discuss recent advances in the field of CF airway microbiome research and interpret these findings in the context of CF pulmonary disease...
  20. doi request reprint Nucleic acid extraction efficiency and bacterial recovery from maxillary sinus mucosal samples obtained by brushing or biopsy
    Frederick C Roediger
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143, USA
    Am J Rhinol Allergy 24:263-5. 2010
    ..This study was designed to compare nucleic acid extraction rates and recovery of bacteria for two methods of sampling the maxillary sinus, mucosal biopsy, and brushing...
  21. ncbi request reprint Increased plasminogen activator inhibitor-1 concentrations in bronchoalveolar lavage fluids are associated with increased mortality in a cohort of patients with Pseudomonas aeruginosa
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesthesiology 106:252-61. 2007
    ..The authors hypothesized that PAI-1 concentrations were associated with increased mortality in patients with either Pseudomonas aeruginosa-induced ventilator-associated pneumonia or tracheobronchial colonization...