Susan V Lynch

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome
    Michael J Cox
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8745. 2010
  2. pmc Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients
    Michael J Cox
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11044. 2010
  3. pmc Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal microbiota
    Susan V Lynch
    Colitis and Crohn s Disease Center, Division of Gastroenterology, Department of Medicine University of California, San Francisco, San Francisco, CA, USA
    Gut Microbes 4:41-7. 2013
  4. pmc Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Microb Pathog 48:197-204. 2010
  5. pmc A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    OMICS 14:9-59. 2010
  6. pmc House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection
    Kei E Fujimura
    Divisions of Gastroenterology and Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 111:805-10. 2014
  7. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
  8. ncbi Increased mortality of ventilated patients with endotracheal Pseudomonas aeruginosa without clinical signs of infection
    Hanjing Zhuo
    Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 36:2495-503. 2008
  9. pmc Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa
    Xiang Xu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Leukoc Biol 91:275-84. 2012
  10. doi Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis
    Nicole A Abreu
    Department of Biology, San Francisco State University, Hensill 534, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Sci Transl Med 4:151ra124. 2012

Detail Information

Publications27

  1. pmc Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome
    Michael J Cox
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8745. 2010
    ....
  2. pmc Airway microbiota and pathogen abundance in age-stratified cystic fibrosis patients
    Michael J Cox
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11044. 2010
    ....
  3. pmc Cystic fibrosis transmembrane conductance regulator knockout mice exhibit aberrant gastrointestinal microbiota
    Susan V Lynch
    Colitis and Crohn s Disease Center, Division of Gastroenterology, Department of Medicine University of California, San Francisco, San Francisco, CA, USA
    Gut Microbes 4:41-7. 2013
    ..Thus, these data provide the first indications that GI bacterial colonization is strongly impacted by the loss of functional CFTR and opens up avenues for alternative therapeutic approaches to improve CF disease management...
  4. pmc Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA
    Microb Pathog 48:197-204. 2010
    ..It also demonstrates the protective effect of anti-PcrV immunotherapy against a multitude of P. aeruginosa strains from diverse global regions with a variety of mutations in PcrV...
  5. pmc A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    OMICS 14:9-59. 2010
    ....
  6. pmc House dust exposure mediates gut microbiome Lactobacillus enrichment and airway immune defense against allergens and virus infection
    Kei E Fujimura
    Divisions of Gastroenterology and Pulmonary and Critical Care Medicine, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 111:805-10. 2014
    ..johnsonii as a pivotal species within the gastrointestinal tract capable of influencing adaptive immunity at remote mucosal surfaces in a manner that is protective against a variety of respiratory insults. ..
  7. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
    ..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present...
  8. ncbi Increased mortality of ventilated patients with endotracheal Pseudomonas aeruginosa without clinical signs of infection
    Hanjing Zhuo
    Cardiovascular Research Institute, University of California San Francisco, CA, USA
    Crit Care Med 36:2495-503. 2008
    ..To investigate the frequency and outcomes of ventilated patients with newly acquired large burdens of Pseudomonas aeruginosa and to test the hypothesis that large quantities of bacteria are associated with adverse patient outcomes...
  9. pmc Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa
    Xiang Xu
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    J Leukoc Biol 91:275-84. 2012
    ..These findings raise the possibility that Pseudomonas-stimulated neutrophils can enhance airway inflammation by producing histamine...
  10. doi Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis
    Nicole A Abreu
    Department of Biology, San Francisco State University, Hensill 534, 1600 Holloway Avenue, San Francisco, CA 94132, USA
    Sci Transl Med 4:151ra124. 2012
    ..These studies demonstrate that sinus mucosal health is highly dependent on the composition of the resident microbiota as well as identify both a new sino-pathogen and a strong bacterial candidate for therapeutic intervention...
  11. pmc Comparison of the respiratory microbiome in healthy nonsmokers and smokers
    Alison Morris
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Respir Crit Care Med 187:1067-75. 2013
    ..Results from 16S rDNA-encoding gene sequence-based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome...
  12. pmc Role of small GTPases and alphavbeta5 integrin in Pseudomonas aeruginosa-induced increase in lung endothelial permeability
    Michael T Ganter
    Department of Anesthesia and Surgery, University of California San Francisco, San Francisco, California 94110, USA
    Am J Respir Cell Mol Biol 40:108-18. 2009
    ..aeruginosa-induced lung vascular permeability. In addition, activation of the stress protein response with pharmacologic inhibitors of Hsp90 may protect lungs against P. aeruginosa-induced permeability changes...
  13. pmc Persistent infection with Pseudomonas aeruginosa in ventilator-associated pneumonia
    Ali A El Solh
    Western New York Respiratory Research Center, Department of Medicine, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York 14215, USA
    Am J Respir Crit Care Med 178:513-9. 2008
    ..aeruginosa in patients with VAP may persist in the alveolar space despite adequate antimicrobial therapy. We hypothesized that failure to eradicate P. aeruginosa from the lung is linked to type III secretory system (TTSS) isolates...
  14. pmc Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
    Ivan Vujkovic-Cvijin
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco UCSF, San Francisco, CA 94110, USA
    Sci Transl Med 5:193ra91. 2013
    ..This link suggests that gut-resident microbial populations may influence intestinal homeostasis during HIV disease. ..
  15. pmc Development of a standardized approach for environmental microbiota investigations related to asthma development in children
    Kei E Fujimura
    Division of Gastroenterology, University of California, San Francisco, CA 94143, United States
    J Microbiol Methods 91:231-9. 2012
    ....
  16. pmc The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, Med Sci S357, San Francisco, CA 94143, USA
    Expert Rev Respir Med 5:809-21. 2011
    ....
  17. pmc Novel strategies to combat bacterial virulence
    Susan V Lynch
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California 94143, USA
    Curr Opin Crit Care 14:593-9. 2008
    ..The purpose of this review is to highlight the recent developments in antibacterial therapy and the novel approaches toward increasing our therapeutic armory against bacterial infection...
  18. pmc Role of the gut microbiota in defining human health
    Kei E Fujimura
    Colitis and Crohn s Disease Center, Gastroenterology Division, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Expert Rev Anti Infect Ther 8:435-54. 2010
    ....
  19. pmc Role of integrin alphav beta6 in acute lung injury induced by Pseudomonas aeruginosa
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Infect Immun 76:2325-32. 2008
    ..aeruginosa-induced lung injury. However, these therapies also did not increase the lung injury, suggesting that host defense was not compromised by this promising new therapy...
  20. doi Probiotic strategies for treatment of respiratory diseases
    Nabeetha A Nagalingam
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Trends Microbiol 21:485-92. 2013
    ....
  21. pmc Oral and airway microbiota in HIV-infected pneumonia patients
    Shoko Iwai
    University of California San Francisco, San Francisco, California, USA
    J Clin Microbiol 50:2995-3002. 2012
    ....
  22. ncbi Pseudomonas aeruginosa biofilm-associated homoserine lactone C12 rapidly activates apoptosis in airway epithelia
    Christian Schwarzer
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3200, USA
    Cell Microbiol 14:698-709. 2012
    ..aeruginosa biofilms may contribute to accumulation of apoptotic cells that cannot be cleared from CF lungs. A model to explain the effects of C12 is proposed...
  23. pmc Microbial manipulation of immune function for asthma prevention: inferences from clinical trials
    Jennifer Yoo
    Division of Allergy and Immunology, Department of Medcine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Proc Am Thorac Soc 4:277-82. 2007
    ....
  24. pmc The lung microbiome of Ugandan HIV-infected pneumonia patients is compositionally and functionally distinct from that of San Franciscan patients
    Shoko Iwai
    Division of Gastroenterology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e95726. 2014
    ..Ugandan pneumonia-associated airway microbiome is compositionally and functionally distinct from those detected in comparable patients in developed countries, a feature which may contribute to adverse outcomes in this population. ..
  25. pmc The cystic fibrosis airway microbiome
    Susan V Lynch
    Colitis and Crohn s Disease Microbiome Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cold Spring Harb Perspect Med 3:a009738. 2013
    ..This article aims to discuss recent advances in the field of CF airway microbiome research and interpret these findings in the context of CF pulmonary disease...
  26. doi Nucleic acid extraction efficiency and bacterial recovery from maxillary sinus mucosal samples obtained by brushing or biopsy
    Frederick C Roediger
    Department of Otolaryngology Head and Neck Surgery, University of California, San Francisco, California 94143, USA
    Am J Rhinol Allergy 24:263-5. 2010
    ..This study was designed to compare nucleic acid extraction rates and recovery of bacteria for two methods of sampling the maxillary sinus, mucosal biopsy, and brushing...
  27. ncbi Increased plasminogen activator inhibitor-1 concentrations in bronchoalveolar lavage fluids are associated with increased mortality in a cohort of patients with Pseudomonas aeruginosa
    Yuanlin Song
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
    Anesthesiology 106:252-61. 2007
    ..The authors hypothesized that PAI-1 concentrations were associated with increased mortality in patients with either Pseudomonas aeruginosa-induced ventilator-associated pneumonia or tracheobronchial colonization...