Kevin G Lynch

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Moderators of response to telephone continuing care for alcoholism
    Kevin G Lynch
    Universityof Pennsylvania, 3440 Market St, Philadelphia, PA 19104, USA
    Am J Health Behav 34:788-800. 2010
  2. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
  3. pmc Does mandating offenders to treatment improve completion rates?
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 44:417-25. 2013
  4. pmc Randomized trial of continuing care enhancements for cocaine-dependent patients following initial engagement
    James R McKay
    Department of Psychology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Consult Clin Psychol 78:111-20. 2010
  5. pmc Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses
    James R McKay
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
    Addiction 106:1760-9. 2011
  6. pmc Enhanced continuing care provided in parallel to intensive outpatient treatment does not improve outcomes for patients with cocaine dependence
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Stud Alcohol Drugs 74:642-51. 2013
  7. pmc A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 43:303-12. 2012
  8. pmc A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA Electronic address
    Drug Alcohol Depend 133:94-9. 2013
  9. doi request reprint The glucocorticoid antagonist RU-486 suppresses HIV infectivity and replication
    Tami D Benton
    Children s Hospital of Philadelphia Research Institute, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neuropsychiatry Clin Neurosci 25:51-7. 2013
  10. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008

Research Grants

Detail Information

Publications82

  1. pmc Moderators of response to telephone continuing care for alcoholism
    Kevin G Lynch
    Universityof Pennsylvania, 3440 Market St, Philadelphia, PA 19104, USA
    Am J Health Behav 34:788-800. 2010
    ..Continuing care was predicted to be more effective for patients with severe substance-use histories, poor initial response to treatment, and other risk factors for relapse...
  2. pmc Initiating acamprosate within-detoxification versus post-detoxification in the treatment of alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900, Chestnut Street, Philadelphia, PA 19104, USA
    Addict Behav 34:581-6. 2009
    ..This trial compared the efficacy of acamprosate, started at the beginning of detoxification, to acamprosate started at the completion of detoxification, in the treatment of alcohol dependence...
  3. pmc Does mandating offenders to treatment improve completion rates?
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 44:417-25. 2013
    ..9, CI=2.0-59.1, p=.006). These findings demonstrate that stipulated treatment for offenders may be an effective way to increase treatment compliance...
  4. pmc Randomized trial of continuing care enhancements for cocaine-dependent patients following initial engagement
    James R McKay
    Department of Psychology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104, USA
    J Consult Clin Psychol 78:111-20. 2010
    ....
  5. pmc Extended telephone-based continuing care for alcohol dependence: 24-month outcomes and subgroup analyses
    James R McKay
    University of Pennsylvania, Department of Psychiatry, Philadelphia, PA 19104, USA
    Addiction 106:1760-9. 2011
    ..To determine whether 18 months of telephone continuing care improves 24-month outcomes for patients with alcohol dependence. Subgroup analyses were performed to identify patients who would benefit most from continuing care...
  6. pmc Enhanced continuing care provided in parallel to intensive outpatient treatment does not improve outcomes for patients with cocaine dependence
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Stud Alcohol Drugs 74:642-51. 2013
    ....
  7. pmc A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 43:303-12. 2012
    ..06). Our negative findings might be explained by gender differences and/or inadequate psychosocial treatment intensity in patients with severe cocaine dependence...
  8. pmc A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence
    Kyle M Kampman
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA Electronic address
    Drug Alcohol Depend 133:94-9. 2013
    ..The current trial was intended to test the ability of topiramate to promote cocaine and alcohol abstinence among patients addicted to both drugs...
  9. doi request reprint The glucocorticoid antagonist RU-486 suppresses HIV infectivity and replication
    Tami D Benton
    Children s Hospital of Philadelphia Research Institute, Division of Allergy and Immunology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Neuropsychiatry Clin Neurosci 25:51-7. 2013
    ..Thus, glucocorticoid antagonism may suppress HIV infectivity and replication ex vivo. Studies to determine the role of glucocorticoid antagonists in the host defense against HIV should be performed...
  10. pmc A placebo-controlled randomized clinical trial of naltrexone in the context of different levels of psychosocial intervention
    David W Oslin
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Alcohol Clin Exp Res 32:1299-308. 2008
    ....
  11. ncbi request reprint Do patient characteristics and initial progress in treatment moderate the effectiveness of telephone-based continuing care for substance use disorders?
    James R McKay
    University of Pennsylvania, Treatment Research Center, Philadelphia, PA 19104, USA
    Addiction 100:216-26. 2005
    ..To determine whether substance use severity, psychiatric severity, social support, self-help attendance or motivation moderated substance use outcomes in a telephone-based continuing care intervention...
  12. pmc A double blind, placebo-controlled trial that combines disulfiram and naltrexone for treating co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Addict Behav 33:651-67. 2008
    ..This is a double blind, placebo-controlled trial that evaluated the efficacy of disulfiram, naltrexone and their combination in patients with co-occurring cocaine and alcohol dependence...
  13. pmc Gender differences with high-dose naltrexone in patients with co-occurring cocaine and alcohol dependence
    Helen M Pettinati
    Department of Psychiatry, Center for the Study of Addictions, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 34:378-90. 2008
    ..Thus, 150 mg/day naltrexone added to a psychosocial treatment resulted in reductions in cocaine and alcohol use and drug severity in men, compared to higher rates of cocaine and alcohol use and drug severity in women...
  14. ncbi request reprint A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 85:129-37. 2006
    ..This trial evaluated the efficacy of amantadine, propranolol and their combination in cocaine dependent patients with severe cocaine withdrawal symptoms...
  15. ncbi request reprint The effectiveness of telephone-based continuing care in the clinical management of alcohol and cocaine use disorders: 12-month outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Consult Clin Psychol 72:967-79. 2004
    ..However, in participants with alcohol dependence only (n = 91), TEL produced better alcohol use outcomes than STND on all measures examined and better outcomes than RP on some of the measures...
  16. pmc A double-blind, placebo-controlled pilot trial of quetiapine for the treatment of Type A and Type B alcoholism
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Clin Psychopharmacol 27:344-51. 2007
    ..Quetiapine is an atypical antipsychotic with a favorable side effect profile, and may be a promising medication for the treatment of alcohol dependence, particularly Type B alcoholism...
  17. pmc The GABA B agonist baclofen reduces cigarette consumption in a preliminary double-blind placebo-controlled smoking reduction study
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia School of Medicine, PA 19104, USA
    Drug Alcohol Depend 103:30-6. 2009
    ..These preliminary results demonstrate provisional evidence of the utility of baclofen to aid in smoking cessation and indicate further investigation...
  18. pmc A randomized trial of extended telephone-based continuing care for alcohol dependence: within-treatment substance use outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania and Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Consult Clin Psychol 78:912-23. 2010
    ....
  19. pmc A double-blind, placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    Addict Behav 36:217-21. 2011
    ..Therefore, we conducted a double-blind placebo-controlled pilot trial of acamprosate for the treatment of cocaine dependence...
  20. doi request reprint Individual characteristics of the literally homeless, marginally housed, and impoverished in a US substance abuse treatment-seeking sample
    Karin M Eyrich-Garg
    School of Social Administration, Dept of Public Health, Temple University College of Health Professions, Philadelphia, PA 19122, USA
    Soc Psychiatry Psychiatr Epidemiol 43:831-42. 2008
    ....
  21. ncbi request reprint Initial reliability and validity studies of the revised Treatment Services Review (TSR-6)
    John S Cacciola
    University of Pennsylvania Center for Studies of Addiction, Philadelphia, PA 19104, USA The Treatment Research Institute, Philadelphia, PA 19106, USA
    Drug Alcohol Depend 92:37-47. 2008
    ..Report the results of initial reliability and validity analyses for a revised Treatment Services Review (TSR-6) instrument which measures a broader range of services than the original TSR...
  22. pmc Study blinding and correlations between perceived group assignment and outcome in a cocaine pharmacotherapy trial
    Catharine E Fairbairn
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Addict 17:387-91. 2008
    ..Furthermore, nurses' perceptions of treatment assignment were significantly related to trial completion, medication compliance, and cocaine use--results that may have training implications for medical personnel...
  23. pmc Who benefits from extended continuing care for cocaine dependence?
    James R McKay
    University of Pennsylvania, 3440 Market Street, Suite 370, Philadelphia, PA 19104, USA Philadelphia VAMC, University and Baltimore Avenues, Philadelphia, PA 19104, USA Electronic address
    Addict Behav 39:660-8. 2014
    ..These results generally do not suggest that patients with greater problem severity or poorer performance early in treatment on the measures considered in this report will benefit to a greater degree from extended continuing care...
  24. pmc Examining naltrexone and alcohol effects in a minority population: results from an initial human laboratory study
    Jennifer G Plebani
    Department of Psychiatry, University of Pennsylvania, Philadelphia, 19104, USA
    Am J Addict 20:330-6. 2011
    ..Future studies should investigate African-American populations with heavy drinking as well as alcohol-dependent subjects in order to strengthen the parallels to clinical findings...
  25. doi request reprint Elevated substance P levels in HIV-infected women in comparison to HIV-negative women
    Steven D Douglas
    Division of Allergy and Immunology, Department of Pediatrics, Joseph Stokes Jr Research Institute at The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    AIDS Res Hum Retroviruses 24:375-8. 2008
    ..We now demonstrate that substance P plasma levels are significantly higher in HIV-infected women in comparison to uninfected control women...
  26. pmc Results of an initial clinical trial of varenicline for the treatment of cocaine dependence
    Jennifer G Plebani
    University of Pennsylvania, Department of Psychiatry, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, United States plebani
    Drug Alcohol Depend 121:163-6. 2012
    ..Cocaine use, abuse and dependence remains a pressing public health problem. Based on its mechanism of action, varenicline, an alpha4beta2 partial agonist seemed to be a likely candidate for treating cocaine dependence...
  27. doi request reprint A randomized, controlled study of treatment for alcohol dependence in patients awaiting liver transplantation
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Liver Transpl 17:539-47. 2011
    ..Further research to validate our findings or to identify better methods to identify and intervene with patients at risk of pretransplant and posttransplant drinking should continue...
  28. pmc Reliability and validity of the alcohol short index of problems and a newly constructed drug short index of problems
    Arthur I Alterman
    Center for Studies of Addiction, University of Pennsylvania, 3440 Market Street, Suite 370, Philadelphia, Pennsylvania 19104, USA
    J Stud Alcohol Drugs 70:304-7. 2009
    ....
  29. pmc Early abstinence in cocaine pharmacotherapy trials predicts successful treatment outcomes
    Jennifer G Plebani
    Department of Psychiatry, University of Pennsylvania, Treatment Research Center, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 37:313-7. 2009
    ..This finding has implications both for treatment research and for clinical practice, suggesting that patients who do not respond early in treatment may need a more intensive intervention...
  30. pmc Menstrual cycle phase at quit date predicts smoking status in an NRT treatment trial: a retrospective analysis
    Teresa R Franklin
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    J Womens Health (Larchmt) 17:287-92. 2008
    ..However, no experimental data have been published to support this claim. Our objective was to determine whether MC phase affected smoking status in premenopausal female smokers participating in a smoking cessation treatment trial...
  31. pmc Prescription OxyContin abuse among patients entering addiction treatment
    Deni Carise
    Treatment Systems Section, Treatment Research Institute, 600 Public Ledger Building, 150 South Independence Mall West, Philadelphia, PA 19106 3475, USA
    Am J Psychiatry 164:1750-6. 2007
    ..The purpose of this study was to characterize the nature and origins of pharmaceutical opioid addiction among patients presenting at substance abuse treatment programs...
  32. doi request reprint Extended-release naltrexone modulates brain response to drug cues in abstinent heroin-dependent patients
    Daniel D Langleben
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA Veterans Administration Health Care System, Philadelphia, PA, USA Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Addict Biol 19:262-71. 2014
    ..Our findings call for further evaluation of the brain fMRI response to drug-related cues and of the 6-beta-naltrexol levels as potential biomarkers of XRNTX therapeutic effects in patients with opioid dependence. ..
  33. pmc Identifying risk factors for marijuana use among veterans affairs patients
    Marina Goldman
    Department of Psychiatry MG, JJS, KL, RS, HX, CPO, DWO, University of Pennsylvania School of Medicine, Philadelphia, PA and Philadelphia Veterans Affairs Medical Center VAMC Philadelphia JJS, Jr, CPO, DWO and VISN 4 Mental Illness Research, Education and Clinical Center MIRECC, Philadelphia, PA
    J Addict Med 4:47-51. 2010
    ..If data commonly collected in the primary care setting (eg, use of alcohol, smoking status, and depression symptoms) could predict cannabis use, then providers can implement targeted marijuana screening in high-risk groups...
  34. pmc A randomized trial of oral naltrexone for treating opioid-dependent offenders
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA coviello
    Am J Addict 19:422-32. 2010
    ..The study provides limited support for the use of oral naltrexone for offenders who are not closely monitored by the criminal justice system...
  35. ncbi request reprint A pilot trial of olanzapine for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, School of Medicine, Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:265-73. 2003
    ....
  36. ncbi request reprint Conceptual, methodological, and analytical issues in the study of relapse
    James R McKay
    University of Pennsylvania, Treatment Research Center, Philadelphia 19104, USA
    Clin Psychol Rev 26:109-27. 2006
    ..Nevertheless, important methodological advances have been and continue to be made in the study of relapse, and our knowledge about the nature and process of relapse has increased considerably over the past 10 years...
  37. ncbi request reprint Addiction Severity Index Recent and Lifetime summary indexes based on nonparametric item response theory methods
    Arthur I Alterman
    Department of Psychiatry, University of Pennsylvania School of Medicine, PA, USA
    Psychol Assess 19:119-32. 2007
    ..NIRT-based methods were able to add to findings produced previously by classical psychometric methods and appear to offer promise for the psychometric analysis of complex, mixed-format instruments such as the ASI-5...
  38. ncbi request reprint Affiliation with deviant peers among children of substance dependent fathers from pre-adolescence into adolescence: associations with problem behaviors
    Howard B Moss
    Treatment Research Center, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 71:117-25. 2003
    ..However, little data are available concerning the developmental trajectories of deviant peer affiliation...
  39. ncbi request reprint The effectiveness of telephone-based continuing care for alcohol and cocaine dependence: 24-month outcomes
    James R McKay
    Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA
    Arch Gen Psychiatry 62:199-207. 2005
    ....
  40. ncbi request reprint A critical review of selective serotonin reuptake inhibitor-associated bleeding: balancing the risk of treating hepatitis C-infected patients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, USA
    J Clin Psychiatry 64:1502-10. 2003
    ..Because there is an increased risk of bleeding in HCV-infected patients who have developed cirrhosis and either portal hypertension or hepatic failure or both, we critically reviewed the literature on SSRI-associated bleeding...
  41. ncbi request reprint Can we design and replicate clinical trials with a multiple drug focus
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia 19104 6178, USA
    Drug Alcohol Depend 70:135-7. 2003
  42. ncbi request reprint Modafinil and cocaine: a double-blind, placebo-controlled drug interaction study
    Charles A Dackis
    Department of Psychiatry, University of Pennsylvania, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 70:29-37. 2003
    ..Furthermore, pretreatment with modafinil did not intensify cocaine euphoria or cocaine-induced craving. In fact, cocaine euphoria was significantly blunted (P=0.02) in one of our subjective measures...
  43. ncbi request reprint Carbohydrate-deficient transferrin levels reflect heavy drinking in alcohol-dependent women seeking treatment
    Margaret R Rukstalis
    Center for the Study of Addictions, Department of Psychiatry, University of Pennsylvania, and Philadelphia Medical Center for Veteran Affairs, Philadelphia Pennsylvania 19104, USA
    Alcohol Clin Exp Res 26:1539-44. 2002
    ..The study also examined the extent that E2 levels mediated the relationship between CDT levels and heavy drinking in the alcohol-dependent women...
  44. ncbi request reprint A double-blind, placebo-controlled trial of modafinil for cocaine dependence
    Charles A Dackis
    University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuropsychopharmacology 30:205-11. 2005
    ..This study provides preliminary evidence, which should be confirmed by a larger study, that modafinil improves clinical outcome when combined with psychosocial treatment for cocaine dependence...
  45. ncbi request reprint Adding a nicotine blocking agent to cigarette tapering
    Peter Gariti
    Treatment Research Center, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Subst Abuse Treat 27:17-25. 2004
    ..Biochemically confirmed abstinence rates at followups did not differ between treatment groups (AD&C = 10%, 13%, 10% vs. PD&C = 3%, 10%, 13%). There is not enough evidence to suggest a Stage II trial...
  46. ncbi request reprint Family functioning and peer affiliation in children of fathers with antisocial personality disorder and substance dependence: associations with problem behaviors
    Howard B Moss
    Center for Education and Drug Abuse Research, University of Pittsburgh and St Francis Medical Center, Pittsburgh, PA, USA
    Am J Psychiatry 159:607-14. 2002
    ..The authors examined associations between the child's psychopathology, paternal substance dependence/antisocial personality disorder status, and measures of family and peer environments...
  47. ncbi request reprint Accumbal neural responses during the initiation and maintenance of intravenous cocaine self-administration
    Laura L Peoples
    Department of Psychology, University of Pennsylvania, Philadelphia 19104, USA
    J Neurophysiol 91:314-23. 2004
    ..Finally, the data have potential implications for understanding mechanisms that transduce accumbal-mediated drug effects that contribute to drug addiction...
  48. pmc A randomized clinical trial of alcohol care management delivered in Department of Veterans Affairs primary care clinics versus specialty addiction treatment
    David W Oslin
    Mental Illness Research, Education and Clinical Center at the Philadelphia VA Medical Center, University of Pennsylvania, Philadelphia, PA, 19104, USA
    J Gen Intern Med 29:162-8. 2014
    ..Available evidence suggests that primary care may play a crucial role in the identification of patients with an alcohol use disorder, delivery of interventions, and the success of treatment...
  49. pmc Content matters: neuroimaging investigation of brain and behavioral impact of televised anti-tobacco public service announcements
    An Li Wang
    Annenberg Public Policy Center, Department of Psychiatry, and Annenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 33:7420-7. 2013
    ..Our findings demonstrate the importance of the quality of content for objective ad outcomes and suggest that fMRI investigation may aid the prerelease evaluation of televised public health ads...
  50. pmc Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: a randomized trial
    George E Woody
    Department of Psychiatry, Treatment Research Institute, University of Pennsylvania, 150 S Independence Mall W, Ste 600, Philadelphia, PA 19106, USA
    JAMA 300:2003-11. 2008
    ..The usual treatment for opioid-addicted youth is detoxification and counseling. Extended medication-assisted therapy may be more helpful...
  51. pmc Characteristics and 9-month outcomes of discharged methadone maintenance clients
    Donna M Coviello
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Subst Abuse Treat 40:165-74. 2011
    ..Despite having more severe problems, the Tx group had fewer opioid-positive urines and reported less IV drug use at 9 months postdischarge compared to the NoTx group. The findings highlight the importance of rapid treatment reengagement...
  52. ncbi request reprint An examination of potential sex and race effects in a study of continuing care for alcohol- and cocaine-dependent patients
    James R McKay
    Treatment Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 27:1321-3. 2003
  53. ncbi request reprint Sexual and physical victimization as predictors of HIV risk among felony drug offenders
    Steven Belenko
    Treatment Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19106 3475, USA
    AIDS Behav 9:311-23. 2005
    ..Assessing for specific prior abuse histories of offenders and providing targeted interventions may be useful for developing more effective primary and secondary HIV prevention services for this high-risk population...
  54. pmc Selective serotonin reuptake inhibitor and substance P antagonist enhancement of natural killer cell innate immunity in human immunodeficiency virus/acquired immunodeficiency syndrome
    Dwight L Evans
    Department of Psychiatry, Joseph J Stokes Research Institute of The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Biol Psychiatry 63:899-905. 2008
    ..This study examines the potential role of three underlying regulatory systems that have been under investigation in central nervous system research as well as immune and viral research: serotonin, neurokinin, and glucocorticoid systems...
  55. pmc Treatment outcomes in type A and B alcohol dependence 6 months after serotonergic pharmacotherapy
    William Dundon
    Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6178, USA
    Alcohol Clin Exp Res 28:1065-73. 2004
    ..The purpose of this study was to assess in this original study group whether treatment gains in the type A alcoholics were maintained or whether treatment outcomes changed for the type B alcoholics after discontinuing pharmacotherapy...
  56. ncbi request reprint Selective strengthening of conditioned behaviors that occur during periods of amphetamine exposure
    Xun Wan
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 32:1346-57. 2007
    ..These findings are relevant to hypotheses regarding the etiology of drug addiction...
  57. pmc Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample
    Kyle Peer
    Center for Studies of Addiction, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, United States
    Drug Alcohol Depend 127:215-9. 2013
    ..The changes in diagnostic criteria have important implications for research and for the clinical care of individuals with Substance Use Disorders (SUDs)...
  58. ncbi request reprint Accumbal neurons that are activated during cocaine self-administration are spared from inhibitory effects of repeated cocaine self-administration
    Laura L Peoples
    Department of Psychology, University of Pennsylvania, Philadelphia, PA 19106, USA
    Neuropsychopharmacology 32:1141-58. 2007
    ..The findings of the present study are consistent with a basic prediction of the differential inhibition hypothesis and may be relevant to understanding cocaine addiction...
  59. ncbi request reprint Initial evidence for the reliability and validity of a "Lite" version of the Addiction Severity Index
    John S Cacciola
    University of Pennsylvania Center for Studies of Addiction, 3440 Market Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 87:297-302. 2007
    ..To evaluate the psychometric properties of a shortened version of the baseline ASI-5, the ASI-L-VA...
  60. pmc Effects of an intensive street-level police intervention on syringe exchange program use in Philadelphia, PA
    Corey S Davis
    BS, University of Pennsylvania, Center for the Study of Addiction, HIV AIDS Prevention Research Division, 3535 Market Street, Suite 4058, Philadelphia, PA 19104 3309, USA
    Am J Public Health 95:233-6. 2005
    ..Declines in use among Black and male participants were much more pronounced than decreases among White and female participants...
  61. pmc A multisite pilot study of extended-release injectable naltrexone treatment for previously opioid-dependent parolees and probationers
    Donna M Coviello
    University of Pennsylvania, Philadelphia, Pennsylvania, USA coviello
    Subst Abus 33:48-59. 2012
    ..The findings indicate that XR-NTX holds promise as a feasible, effective treatment option for opioid-dependent offenders...
  62. ncbi request reprint A pilot trial of topiramate for the treatment of cocaine dependence
    Kyle M Kampman
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104, USA
    Drug Alcohol Depend 75:233-40. 2004
    ..Topiramate, an anticonvulsant, raises cerebral GABA levels, facilitates GABAergic neurotransmission and inhibits glutametergic activity at AMPA/kainite receptors. Thus, it may be useful for treating cocaine dependence...
  63. ncbi request reprint Causal mediation analyses with rank preserving models
    Thomas R Ten Have
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Biometrics 63:926-34. 2007
    ..The trade-off between these assumptions is evaluated in the context of two suicide/depression intervention studies...
  64. ncbi request reprint Selective serotonin re-uptake inhibitors and the risk of bleeding
    Robert M Weinrieb
    University of Pennsylvania, Department of Psychiatry, 3440 Market Street, Suite 370, Philadelphia, PA 19104, USA
    Expert Opin Drug Saf 4:337-44. 2005
    ..Clinicians should caution patients about combining SSRIs with aspirin or NSAIDs. Pharmacotherapy to reduce the risk of GI bleeding should be considered in high risk patients...
  65. ncbi request reprint Naltrexone reduces the relative reinforcing value of nicotine in a cigarette smoking choice paradigm
    Margaret Rukstalis
    Tobacco Use Research Center, University of Pennsylvania, 3535 Market Street, Suite 4100, Philadelphia, PA 19104, USA
    Psychopharmacology (Berl) 180:41-8. 2005
    ..Naltrexone and bupropion have been shown to alter ad lib smoking behavior; however, medication effects on nicotine reward in a cigarette choice paradigm have yet to be investigated...
  66. ncbi request reprint Multidimensional assessment of nicotine dependence in adolescents
    Duncan B Clark
    Department of Psychiatry, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 77:235-42. 2005
    ..The findings suggest that the NDSS has acceptable psychometric properties when applied to adolescents, complementing smoking rate and FTND in a multidimensional smoking assessment...
  67. ncbi request reprint Psychiatric and substance use disorders as risk factors for attempted suicide among adolescents: a case control study
    Thomas M Kelly
    Western Psychiatric Institute and Clinic, Pittsburgh Adolescent Alcohol Research Center, University of Pittsburgh Medical School, PA 15213, USA
    Suicide Life Threat Behav 32:301-12. 2002
    ..Evaluation of these particular comorbid conditions should be part of the adolescent suicide risk assessment...
  68. ncbi request reprint Physical and sexual abuse, depression and alcohol use disorders in adolescents: onsets and outcomes
    Duncan B Clark
    Department of Psychiatry and Pharmaceutical Sciences, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Drug Alcohol Depend 69:51-60. 2003
    ..These results indicate that MDD among adolescents with AUD may be partly attributable to PS Abuse...
  69. ncbi request reprint Rapid relapse generally follows treatment for substance use disorders among adolescents
    Jack R Cornelius
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Addict Behav 28:381-6. 2003
    ..1993). In J. S. Baer, G. A. Marlatt, & R. J. McMahon (Eds.), Addictive behaviors across the life span (pp. 160-183). London: SAGE.] in showing that most adolescents relapse quickly following treatment for substance use disorders...
  70. ncbi request reprint A matched comparison study of medical and psychiatric complications and anesthesia and analgesia requirements in methadone-maintained liver transplant recipients
    Robert M Weinrieb
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA
    Liver Transpl 10:97-106. 2004
    ..Posttransplant, 20% of patients receiving MMT used alcohol or illicit drugs. Data do not support withholding the provision of liver transplantation to patients receiving MMT, but larger, well-controlled studies are warranted...
  71. pmc Mediators of telephone-based continuing care for alcohol and cocaine dependence
    Janell Lynn Mensinger
    Clinical Research Unit, Reading Hospital and Medical Center, Reading, PA 19612 6052, USA
    J Consult Clin Psychol 75:775-84. 2007
    ..These results are consistent with a model in which treatment effects are first accounted for by changes in behavior, followed by changes in self-efficacy and in commitment to abstinence...
  72. ncbi request reprint Attention-deficit/hyperactivity disorder and conduct disorder symptomatology in adolescents with alcohol use disorder
    Brooke S G Molina
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychol Addict Behav 16:161-4. 2002
    ..The findings did not differ between boys and girls, revealing that in a treatment sample of adolescents, ADHD-CD comorbidity may need to be assessed and treated, but it is not broadly indicative of severity...
  73. ncbi request reprint Genetic correlations between smoking initiation and smoking behaviors in a twin sample
    Thomas L Hardie
    University of Delaware, Department of Nursing, Rm 361 McDowell Hall, Newark, DE 19716, USA
    Addict Behav 31:2030-7. 2006
    ..The interventional implications of the findings support the importance of a tailored approach to preventing smoking behavior and reducing harm in smokers...
  74. pmc Developing adaptive treatment strategies in substance abuse research
    Susan A Murphy
    University of Michigan, Institute for Social Research, Ann Arbor, MI 48106 1248, USA
    Drug Alcohol Depend 88:S24-30. 2007
    ..Simple analyses that can be used with the SMART design are described. Furthermore, the SMART design is compared with standard experimental designs...
  75. ncbi request reprint The availability of web sites offering to sell opioid medications without prescriptions
    Robert F Forman
    Medical Affairs Alkermes, Inc, 88 Sidney St, Cambridge, MA 02139, USA
    Am J Psychiatry 163:1233-8. 2006
    ..This study was designed to determine the availability of web sites offering to sell opioid medications without prescriptions...
  76. ncbi request reprint A randomized trial of audio computer and in-person interview to assess HIV risk among drug and alcohol users in Rio De Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Rio de Janeiro, Brazil
    J Subst Abuse Treat 30:237-43. 2006
    ..ACASI seems to be a key resource in improving the reporting of sensitive data in Brazil, as it has been in prior international studies...
  77. ncbi request reprint Alcohol relapse as a function of relapse definition in a clinical sample of adolescents
    Stephen A Maisto
    Department of Psychology, Syracuse University, 430 Huntington Hall, Syracuse, NY 13244, USA
    Addict Behav 28:449-59. 2003
    ..Suggestions for the extensions of this investigation in future research are provided...
  78. ncbi request reprint Acceptability of audio computer-assisted self-interview (ACASI) among substance abusers seeking treatment in Rio de Janeiro, Brazil
    Anna Azevedo Simoes
    Health Department of the State Government of Rio de Janeiro, Brazil
    Drug Alcohol Depend 82:S103-7. 2006
    ..The findings extend our understanding of the role of the ACASI method by suggesting the utility of this approach in assessing HIV risk among low-to middle-income drug users in a cultural setting quite different from previous studies...
  79. ncbi request reprint Treatment services received in the CASAWORKS for Families program
    James R McKay
    Treatment Research Institute, University of Pennsylvania, USA
    Eval Rev 27:629-55. 2003
    ..Longer retention was associated with better alcohol use outcomes but was unrelated to employment or drug use outcomes...
  80. pmc The relationship between alcohol and individual differences variables on attitudes and behavioral skills relevant to sexual health among heterosexual young adult men
    Stephen A Maisto
    Department of Psychology and Center for Health and Behavior, Syracuse University, 430 Huntington Hall, Syracuse, New York 13244, USA
    Arch Sex Behav 33:571-84. 2004
    ....
  81. ncbi request reprint Racial disparities in hospitalized elderly patients with chronic heart failure
    Erlinda C Wheeler
    Department of Nursing, University of Delaware, Newark, USA
    J Transcult Nurs 15:291-7. 2004
    ..65, p =.000; and total charges F(3, 99,543) = 38,962.95, p =.000. LOS accounted for 50% of the variance. Studies that examine cultural variables and their effect on LOS and number of procedures are needed...
  82. ncbi request reprint Childhood abuse as a risk factor for suicidal behavior in borderline personality disorder
    Paul H Soloff
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, USA
    J Pers Disord 16:201-14. 2002
    ..Given a history of childhood sexual abuse, the risk of adult suicidal behavior in BPD was increased by antisocial traits, severity of BPD, hopelessness, or comorbid major depressive episode (MDE)...

Research Grants2

  1. Mediation methods in alcohol continuing care research
    Kevin Lynch; Fiscal Year: 2007
    ..This study investigates the performance of new statistical methods for mediation, where a more explicit causal interpretation off mediation may be possible. We compare these methods with standard approaches. ..