Joseph P Lynch

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Expert Opin Pharmacother 5:1671-86. 2004
  2. doi request reprint Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)
    Joseph P Lynch
    The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, 10833 Le Conte Ave, Room 37 131 CHS, Los Angeles, CA 90095, USA
    Expert Opin Pharmacother 14:199-210. 2013
  3. ncbi request reprint Obliterative (constrictive) bronchiolitis
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Respir Crit Care Med 33:509-32. 2012
  4. doi request reprint Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:189-209. 2009
  5. doi request reprint Burkholderia cepacia complex: impact on the cystic fibrosis lung lesion
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:596-610. 2009
  6. ncbi request reprint Escalation of antimicrobial resistance among Streptococcus pneumoniae: implications for therapy
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Semin Respir Crit Care Med 26:575-616. 2005
  7. ncbi request reprint Idiopathic pulmonary fibrosis
    Joseph P Lynch
    Professor of Clinical Medicine, The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, and Hospitalists, 10833 Le Conte Avenue, Room CHS 37 131, Los Angeles, CA 90095, USA
    Expert Rev Respir Med 1:377-89. 2007
  8. doi request reprint Wegener granulomatosis (granulomatosis with polyangiitis): evolving concepts in treatment
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 32:274-97. 2011
  9. ncbi request reprint Influenza: evolving strategies in treatment and prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 28:144-58. 2007
  10. doi request reprint Streptococcus pneumoniae: does antimicrobial resistance matter?
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:210-38. 2009

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Expert Opin Pharmacother 5:1671-86. 2004
    ..Emerging 'antifibrotic' drugs and strategies for UIP/IPF are discussed. The importance of accurately phenotyping a highly heterogeneous disease process that may require individualised and 'combined' therapies is emphasised...
  2. doi request reprint Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)
    Joseph P Lynch
    The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, 10833 Le Conte Ave, Room 37 131 CHS, Los Angeles, CA 90095, USA
    Expert Opin Pharmacother 14:199-210. 2013
    ..The authors review the mechanisms of antimicrobial resistance among Enterobacteriaceae, epidemiology and global spread of resistance elements and discuss therapeutic options...
  3. ncbi request reprint Obliterative (constrictive) bronchiolitis
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Respir Crit Care Med 33:509-32. 2012
    ..When no cause is identified, the term cryptogenic obliterative bronchiolitis is used. This review discusses the salient clinical, radiographic, and histological features of OB and presents a management approach...
  4. doi request reprint Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:189-209. 2009
    ..In this chapter, we discuss the role of vaccines (both polysaccharide and conjugate) and other preventive strategies to limit this important and potentially lethal disease...
  5. doi request reprint Burkholderia cepacia complex: impact on the cystic fibrosis lung lesion
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:596-610. 2009
    ....
  6. ncbi request reprint Escalation of antimicrobial resistance among Streptococcus pneumoniae: implications for therapy
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Semin Respir Crit Care Med 26:575-616. 2005
    ....
  7. ncbi request reprint Idiopathic pulmonary fibrosis
    Joseph P Lynch
    Professor of Clinical Medicine, The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, and Hospitalists, 10833 Le Conte Avenue, Room CHS 37 131, Los Angeles, CA 90095, USA
    Expert Rev Respir Med 1:377-89. 2007
    ..The prognosis of idiopathic UIP is poor. Mean survival following diagnosis approximates at 3 years. Current medical therapies are of unproven value. Lung transplantation is a viable option for patients failing medical therapy...
  8. doi request reprint Wegener granulomatosis (granulomatosis with polyangiitis): evolving concepts in treatment
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 32:274-97. 2011
    ..Recent studies suggest that rituximab may be useful for induction therapy or CYC-refractory WG. The role of other immunomodulatory agents (including trimethoprim-sulfamethoxazole) is also explored...
  9. ncbi request reprint Influenza: evolving strategies in treatment and prevention
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 28:144-58. 2007
    ..e., the elderly or patients with comorbidities), and expanding the use of vaccines to healthy children and adults reduces the incidence of influenza, pneumonia, and hospitalizations due to respiratory illnesses in the community...
  10. doi request reprint Streptococcus pneumoniae: does antimicrobial resistance matter?
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 30:210-38. 2009
    ....
  11. doi request reprint Influenza: epidemiology, clinical features, therapy, and prevention
    Nina M Clark
    Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Illinois, USA
    Semin Respir Crit Care Med 32:373-92. 2011
    ..e., the elderly or patients with comorbidities), and expanding the use of vaccines to healthy children and adults reduces the incidence of influenza, pneumonia, and hospitalizations due to respiratory illnesses in the community...
  12. doi request reprint Adenovirus
    Joseph P Lynch
    Division of Pulmonary, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 32:494-511. 2011
    ..Vaccines have been shown to be highly efficacious in reducing the risk of respiratory AdV infection but are currently not available...
  13. ncbi request reprint Pulmonary sarcoidosis
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 28:53-74. 2007
    ..Lung transplantation is a viable option for patients with life-threatening disease failing medical therapy...
  14. ncbi request reprint Overview of lung transplantation and criteria for selection of candidates
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 27:441-69. 2006
    ..In this review, we discuss the major diseases treated with LT and the appropriate criteria for LT...
  15. ncbi request reprint Usual interstitial pneumonia
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 27:634-51. 2006
    ..This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future)...
  16. ncbi request reprint Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 171:4844-52. 2003
    ..This supports the notion that CXCL9 interaction with cells expressing CXCR3 has an important role in the recruitment of mononuclear cells, a pivotal event in the pathogenesis of acute lung allograft rejection...
  17. doi request reprint Pulmonary arterial hypertension and lung transplantation
    Rajeev Saggar
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Semin Respir Crit Care Med 31:147-60. 2010
    ..The following discussion mainly focuses on adult IPAH, with some reference to congenital heart disease (CHD) and secondary PAH...
  18. ncbi request reprint CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    J Immunol 175:6931-9. 2005
    ....
  19. ncbi request reprint IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome
    Michael P Keane
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:511-9. 2007
    ..This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis...
  20. ncbi request reprint Bronchiolitis obliterans syndrome: the Achilles' heel of lung transplantation
    S Samuel Weigt
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 34:336-51. 2013
    ..A better understanding of the risk factors and their relationship to the pathological mechanisms of chronic lung allograft rejection should lead to better pharmacological targets to prevent or treat this syndrome. ..
  21. pmc Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation
    Aric L Gregson
    Division of Infectious Diseases, Department of Medicine, School of Public Health, University of California, Los Angeles, CA 90095, USA
    Am J Respir Crit Care Med 187:518-26. 2013
    ..Pseudomonas and the ELR(+) CXC chemokines may interact to negatively influence lung transplant outcomes...
  22. ncbi request reprint A rare occurrence of pulmonary alveolar proteinosis after lung transplantation
    Jeffrey Albores
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Semin Respir Crit Care Med 34:431-8. 2013
    ..PAP is an exceptionally rare cause of dyspnea and radiographic infiltrates after lung transplantation and may be related to toxicity of immune-suppressive medications. ..
  23. pmc Bronchoalveolar immunologic profile of acute human lung transplant allograft rejection
    Aric L Gregson
    Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Transplantation 85:1056-9. 2008
    ..A unique BALF lymphocyte profile was associated with rejection and may provide insight into the pathogenesis of allograft rejection...
  24. pmc Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosis
    David A Zisman
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Chest 133:640-5. 2008
    ..The objective of this study was to validate this method in a separate group of IPF patients...
  25. doi request reprint Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccines
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Curr Opin Pulm Med 16:217-25. 2010
    ..Antimicrobial resistance among pneumococci has escalated dramatically over the past three decades, and is influenced by patterns of antibiotic use, population density, and spread of a few international clones...
  26. doi request reprint Lung transplantation and coronary artery disease
    William Sherman
    Division of Cardiothoracic Surgery, Department of Surgery, Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    Ann Thorac Surg 92:303-8. 2011
    ....
  27. doi request reprint Treprostinil to reverse pulmonary hypertension associated with idiopathic pulmonary fibrosis as a bridge to single-lung transplantation
    Rajeev Saggar
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1690, USA
    J Heart Lung Transplant 28:964-7. 2009
    ..We describe a case where intravenous treprostinil was used to bridge an elderly patient with idiopathic pulmonary fibrosis with severe pulmonary hypertension to successful single-lung transplantation...
  28. pmc Prediction of pulmonary hypertension in idiopathic pulmonary fibrosis
    David A Zisman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Respir Med 101:2153-9. 2007
    ..We tested the hypothesis that the forced vital capacity to diffusing capacity ratio and room air resting pulse oximetry may be combined to predict mean pulmonary artery pressure (MPAP) in idiopathic pulmonary fibrosis...
  29. pmc Non-tuberculous mycobacterium infection after lung transplantation is associated with increased mortality
    Hsuanwen C Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
    J Heart Lung Transplant 30:790-8. 2011
    ..Herein we describe our experience with pulmonary NTM infection after lung transplantation and hypothesized that non-tuberculous mycobacterial infection after lung transplantation would be associated with increased mortality...
  30. doi request reprint Chronic lung allograft rejection: mechanisms and therapy
    John A Belperio
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Proc Am Thorac Soc 6:108-21. 2009
    ....
  31. doi request reprint Chronic allograft rejection: epidemiology, diagnosis, pathogenesis, and treatment
    S Samuel Weigt
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 31:189-207. 2010
    ..A better understanding of the risk factors and their relationship to the pathological mechanisms of chronic lung allograft rejection should lead to better pharmacological targets to prevent or treat this syndrome...
  32. pmc High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosis
    David A Zisman
    Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
    Chest 132:773-9. 2007
    ..We tested the hypothesis that chest CT-determined extent of pulmonary fibrosis and/or main pulmonary artery diameter (MPAD) can be used to identify the presence of PH in patients with advanced IPF...
  33. ncbi request reprint Extended spectrum β-lactamase-producing enterobacteriaceae infection in heart and lung transplant recipients and in mechanical circulatory support recipients
    Kevin T Bui
    1 Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine at UCLA Ronald Reagan UCLA Medical Center, Los Angeles, CA 2 Heart Lung Transplant Ronald Reagan UCLA Medical Center, Los Angeles, CA 3 Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine at UCLA Ronald Reagan UCLA Medical Center, Los Angeles, CA 4 Dvision of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine at UCLA Ronald Reagan UCLA Medical Center, Los Angeles, CA 5 Address correspondence to Bernard M Kubak, Ph D, M D, David Geffen School of Medicine at UCLA, Transplant Infectious Diseases, Heart Lung Transplant, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 7501A, Los Angeles, CA 90095
    Transplantation 97:590-4. 2014
    ....
  34. doi request reprint Usefulness of immune monitoring in lung transplantation using adenosine triphosphate production in activated lymphocytes
    Michael Y Shino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095 1690, USA
    J Heart Lung Transplant 31:996-1002. 2012
    ..We hypothesized that this assay can be used to assess the immune function of lung transplant recipients and identify those at risk of developing acute cellular rejection and respiratory infection...
  35. ncbi request reprint DNA viral infections complicating lung transplantation
    Nina M Clark
    Section of Infectious Diseases, Department of Medicine, Loyola University, Maywood, Illinois, USA
    Semin Respir Crit Care Med 34:380-404. 2013
    ..This article discusses the individual pathogens, their epidemiology and clinical manifestations, as well as treatment and preventive strategies in this era of antiviral treatment regimens. ..
  36. ncbi request reprint Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients
    S Samuel Weigt
    Division of Pulmonary, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 32:471-93. 2011
    ..This article reviews the current information regarding epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of these infections, as well as the aspects of clinical significance of RVIs unique to HSCT or SOT...
  37. ncbi request reprint Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantation
    David J Ross
    Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute for Pulmonary Research, David Geffen School of Medicine U C L A Medical Center, Los Angeles, CA 90095 1690, USA
    Transplantation 78:1222-4. 2004
    ..We therefore speculate that complex interactions between adaptive and innate immunity may contribute to the propagation of airway inflammation in BOS...
  38. pmc Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Clin Invest 115:1150-62. 2005
    ....
  39. doi request reprint Immunosuppressive and cytotoxic therapy: pharmacology, toxicities, and monitoring
    Tisha Wang
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 32:346-70. 2011
    ..Recent studies suggest that rituximab may be useful for induction therapy or for CYC-refractory AAV. This article reviews the key agents used to treat AAV, with a focus on pharmacology, toxicities, and monitoring...
  40. ncbi request reprint Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 169:1037-49. 2002
    ..This supports the notion that ligand/CXCR3 biology plays an important role in the recruitment of mononuclear cells, a pivotal event in the pathogenesis of BOS...
  41. doi request reprint Pulmonary hypertension complicating interstitial lung disease and COPD
    Michael Y Shino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 34:600-19. 2013
    ..A better understanding of the mechanisms underlying PH related to parenchymal lung disease may lead to novel pharmacological targets to prevent or treat this serious complication. ..
  42. doi request reprint Pulmonary hypertension complicating connective tissue disease
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 34:581-99. 2013
    ..We discuss medical therapies for CTD-associated PH and the role of lung transplantation for patients failing medical therapy. ..
  43. ncbi request reprint Antimicrobial resistance among gram-negative organisms in the intensive care unit
    Nina M Clark
    Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Curr Opin Crit Care 9:413-23. 2003
    ....
  44. ncbi request reprint Inflammation and angiogenesis in fibrotic lung disease
    Michael P Keane
    Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1922, USA
    Semin Respir Crit Care Med 27:589-99. 2006
    ..Therefore, the pathogenesis of pulmonary fibrosis is complex and involves the interaction of multiple cell types and compartments within the lung...
  45. pmc Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumonia
    David A Zisman
    Interstitial Lung Disease Center, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
    Chest 135:929-35. 2009
    ..The objective of this study was to examine the relationship between serum albumin concentration and mortality in a large cohort of patients with idiopathic interstitial pneumonia listed for lung transplantation...
  46. ncbi request reprint Pulmonary fibrosis
    David A Zisman
    Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of Califonia, Los Angeles, CA, USA
    Methods Mol Med 117:3-44. 2005
    ....
  47. ncbi request reprint Diagnosis and hemodynamic assessment of pulmonary arterial hypertension
    Rajan Saggar
    Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
    Semin Respir Crit Care Med 30:399-410. 2009
    ..This article provides an overview of the available diagnostic studies for PAH with a particular focus on hemodynamic assessment. Novel approaches to the often delayed diagnosis of PAH are being studied and are also discussed here...
  48. ncbi request reprint Modified reperfusion in clinical lung transplantation: the results of 100 consecutive cases
    Gabriel T Schnickel
    Division of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Calif, USA
    J Thorac Cardiovasc Surg 131:218-23. 2006
    ..We hypothesized that altering the content of the initial reperfusate and maintaining a low reperfusion pressure after surgical implantation would lead to a low incidence of primary graft dysfunction...
  49. pmc Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosis
    Vyacheslav Palchevskiy
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Fibrogenesis Tissue Repair 4:10. 2011
    ..abstract:..
  50. ncbi request reprint Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipients
    John A Belperio
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI 48208, USA
    Transplantation 73:591-9. 2002
    ..Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of the pro-inflammatory cytokine IL-1 and has been associated with a number of fibroproliferative diseases...
  51. ncbi request reprint Neurofibromatosis-associated diffuse lung disease: case report
    Michael Y Shino
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
    Semin Respir Crit Care Med 33:572-5. 2012
    ..Although NF-associated diffuse lung disease (NF-DLD) is disputed as a clinical entity by some, the case presented here adds to the accumulating evidence that NF-DLD is a distinct manifestation of neurofibromatosis...
  52. ncbi request reprint Antimicrobial resistance among gram-positive organisms in the intensive care unit
    Nina M Clark
    Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Curr Opin Crit Care 9:403-12. 2003
    ..The epidemiology of gram-positive pathogens in the intensive care unit are reviewed, recent trends in antimicrobial resistance among these organisms are discussed, and the significance of these data with respect to treatment are considered...
  53. doi request reprint Exercise-induced pulmonary hypertension associated with systemic sclerosis: four distinct entities
    Rajeev Saggar
    David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1690, USA
    Arthritis Rheum 62:3741-50. 2010
    ..We undertook this study to describe the hemodynamic response to exercise in a homogeneous population of patients with scleroderma spectrum disorders at risk of developing pulmonary vascular disease...
  54. ncbi request reprint The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine at The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 27:350-64. 2006
    ..Moreover, VALI/VILI can perpetuate the chronic inflammatory response during ALI/ARDS and MODS. This article explores the role of cytokines/chemokines during the pathogenesis of VALI/VILI...
  55. ncbi request reprint Current and emerging strategies for the management of sarcoidosis
    Eric S White
    University of Michigan Medical Center, Division of Pulmonary and Critical Medicine, Department of Internal Medicine, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Expert Opin Pharmacother 8:1293-311. 2007
    ..Agents commonly used to treat patients with sarcoidosis and emerging therapeutic options are discussed...
  56. ncbi request reprint Pulmonary alveolar proteinosis
    Tisha Wang
    Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Semin Respir Crit Care Med 33:498-508. 2012
    ..Autoimmune PAP has also been successfully treated with GM-CSF, both inhaled and systemic, but the optimal dose, duration, and route of administration of GM-CSF have not been elucidated...
  57. ncbi request reprint Levofloxacin for the treatment of community-acquired pneumonia
    Joseph P Lynch
    University of California, Los Angeles, Division of Pulmonary, Critical Care Medicine and Hospitalists, The David Geffen School of Medicine, Los Angeles, CA, USA
    Expert Rev Anti Infect Ther 4:725-42. 2006
    ..However, ciprofloxacin-resistant organisms are becoming more prevalent so prudence must be exercised when prescribing this agent...
  58. ncbi request reprint Cardiac involvement in sarcoidosis: evolving concepts in diagnosis and treatment
    Joseph P Lynch
    Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California
    Semin Respir Crit Care Med 35:372-90. 2014
    ..Cardiac transplantation is a viable option for patients with end-stage cardiac sarcoidosis refractory to medical therapy. ..
  59. ncbi request reprint Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumonia
    Gary W Hunninghake
    Department of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
    Chest 124:1215-23. 2003
    ..To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP)...
  60. ncbi request reprint Pharmacological therapy for Wegener's granulomatosis
    Eric S White
    Division of Pulmonary and Critical Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Drugs 66:1209-28. 2006
    ..However, the current data are conflicting and difficult to interpret. As a result, these newer agents cannot be recommended for routine use until vigorous clinical study confirms their efficacy...
  61. ncbi request reprint Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease
    Kevin R Flaherty
    Department of Radiology, University of Michigan Health System, Ann Arbor, USA
    Am J Respir Crit Care Med 167:1410-5. 2003
    ..005). We conclude that patients with collagen vascular disease-associated usual interstitial pneumonia have fewer fibroblastic foci and improved survival...
  62. ncbi request reprint Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia
    Kevin R Flaherty
    Departments of Radiology and Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 168:543-8. 2003
    ..47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia...
  63. ncbi request reprint Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, Department of Radiology, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 170:904-10. 2004
    ..We conclude that dynamic interactions between clinicians, radiologists, and pathologists improve interobserver agreement and diagnostic confidence...
  64. ncbi request reprint Emerging drugs for idiopathic pulmonary fibrosis
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
    Expert Opin Emerg Drugs 10:707-27. 2005
    ..In this report, the present status of drug development of a number of emerging antifibrotic strategies and agents that may prove more effective in the therapy of this progressive, debilitating and fatal disease are reviewed...
  65. ncbi request reprint Mechanisms of pulmonary fibrosis
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Annu Rev Med 55:395-417. 2004
    ....
  66. ncbi request reprint Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approaches
    Moises Selman
    Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
    Drugs 64:405-30. 2004
    ..Stem cell progenitors of the alveolar epithelial cells and genetic and epigenetic therapies are attractive future approaches for this and other fibrotic lung disorders...
  67. ncbi request reprint Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia
    Vibha N Lama
    Department of Radiology, University of Michigan Health System, University of Michigan School of Public Health, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 168:1084-90. 2003
    ..We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia...