Research Topics
Genomes and Genes | Joseph P LynchSummaryAffiliation: University of California Country: USA Publications
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Publications
Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapyVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
Expert Opin Pharmacother 5:1671-86. 2004..Emerging 'antifibrotic' drugs and strategies for UIP/IPF are discussed. The importance of accurately phenotyping a highly heterogeneous disease process that may require individualised and 'combined' therapies is emphasised...
Evolution of antimicrobial resistance among Enterobacteriaceae (focus on extended spectrum β-lactamases and carbapenemases)Joseph P Lynch
The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, 10833 Le Conte Ave, Room 37 131 CHS, Los Angeles, CA 90095, USA
Expert Opin Pharmacother 14:199-210. 2013..In some cases, infections due to MDR Enterobacteriaceae are untreatable with existing antimicrobial agents. The authors discuss current and future therapeutic options for difficult-to-treat infections due to these organisms...- Obliterative (constrictive) bronchiolitisJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Semin Respir Crit Care Med 33:509-32. 2012..When no cause is identified, the term cryptogenic obliterative bronchiolitis is used. This review discusses the salient clinical, radiographic, and histological features of OB and presents a management approach... - Burkholderia cepacia complex: impact on the cystic fibrosis lung lesionJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 30:596-610. 2009.... - Escalation of antimicrobial resistance among Streptococcus pneumoniae: implications for therapyJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, and Hospitalists, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
Semin Respir Crit Care Med 26:575-616. 2005.... - Streptococcus pneumoniae: epidemiology, risk factors, and strategies for preventionJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 30:189-209. 2009..In this chapter, we discuss the role of vaccines (both polysaccharide and conjugate) and other preventive strategies to limit this important and potentially lethal disease... - Overview of lung transplantation and criteria for selection of candidatesJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 27:441-69. 2006..In this review, we discuss the major diseases treated with LT and the appropriate criteria for LT... - Streptococcus pneumoniae: does antimicrobial resistance matter?Joseph P Lynch
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 30:210-38. 2009.... - Usual interstitial pneumoniaJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 27:634-51. 2006..This review discusses diagnostic criteria for UIP (both histopathological and radiographic), natural history and clinical course, and therapeutic approaches (both current and future)... - Pulmonary sarcoidosisJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 28:53-74. 2007..Lung transplantation is a viable option for patients with life-threatening disease failing medical therapy... - Influenza: evolving strategies in treatment and preventionJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 28:144-58. 2007..e., the elderly or patients with comorbidities), and expanding the use of vaccines to healthy children and adults reduces the incidence of influenza, pneumonia, and hospitalizations due to respiratory illnesses in the community... - Idiopathic pulmonary fibrosisJoseph P Lynch
Professor of Clinical Medicine, The David Geffen School of Medicine at UCLA, Division of Pulmonary, Critical Care Medicine, and Hospitalists, 10833 Le Conte Avenue, Room CHS 37 131, Los Angeles, CA 90095, USA
Expert Rev Respir Med 1:377-89. 2007..The prognosis of idiopathic UIP is poor. Mean survival following diagnosis approximates at 3 years. Current medical therapies are of unproven value. Lung transplantation is a viable option for patients failing medical therapy... - Wegener granulomatosis (granulomatosis with polyangiitis): evolving concepts in treatmentJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
Semin Respir Crit Care Med 32:274-97. 2011..Recent studies suggest that rituximab may be useful for induction therapy or CYC-refractory WG. The role of other immunomodulatory agents (including trimethoprim-sulfamethoxazole) is also explored... - AdenovirusJoseph P Lynch
Division of Pulmonary, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 32:494-511. 2011..Vaccines have been shown to be highly efficacious in reducing the risk of respiratory AdV infection but are currently not available... - Influenza: epidemiology, clinical features, therapy, and preventionNina M Clark
Section of Infectious Diseases, Department of Medicine, University of Illinois at Chicago, Illinois, USA
Semin Respir Crit Care Med 32:373-92. 2011..e., the elderly or patients with comorbidities), and expanding the use of vaccines to healthy children and adults reduces the incidence of influenza, pneumonia, and hospitalizations due to respiratory illnesses in the community... - Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejectionJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California School of Medicine, Los Angeles, CA 90095, USA
J Immunol 171:4844-52. 2003..This supports the notion that CXCL9 interaction with cells expressing CXCR3 has an important role in the recruitment of mononuclear cells, a pivotal event in the pathogenesis of acute lung allograft rejection... - Pulmonary arterial hypertension and lung transplantationRajeev Saggar
Division of Pulmonary, Critical Care Medicine, and Hospitalists, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
Semin Respir Crit Care Med 31:147-60. 2010..The following discussion mainly focuses on adult IPAH, with some reference to congenital heart disease (CHD) and secondary PAH... - CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injuryJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
J Immunol 175:6931-9. 2005.... - IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndromeMichael P Keane
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 178:511-9. 2007..This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis... 
Bronchoalveolar immunologic profile of acute human lung transplant allograft rejectionAric L Gregson
Division of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA 90095, USA
Transplantation 85:1056-9. 2008..A unique BALF lymphocyte profile was associated with rejection and may provide insight into the pathogenesis of allograft rejection...- Validation of a method to screen for pulmonary hypertension in advanced idiopathic pulmonary fibrosisDavid A Zisman
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Chest 133:640-5. 2008..The objective of this study was to validate this method in a separate group of IPF patients... - Lung transplantation and coronary artery diseaseWilliam Sherman
Division of Cardiothoracic Surgery, Department of Surgery, Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
Ann Thorac Surg 92:303-8. 2011.... - Treprostinil to reverse pulmonary hypertension associated with idiopathic pulmonary fibrosis as a bridge to single-lung transplantationRajeev Saggar
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1690, USA
J Heart Lung Transplant 28:964-7. 2009..We describe a case where intravenous treprostinil was used to bridge an elderly patient with idiopathic pulmonary fibrosis with severe pulmonary hypertension to successful single-lung transplantation... - Streptococcus pneumoniae: epidemiology and risk factors, evolution of antimicrobial resistance, and impact of vaccinesJoseph P Lynch
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Curr Opin Pulm Med 16:217-25. 2010..Antimicrobial resistance among pneumococci has escalated dramatically over the past three decades, and is influenced by patterns of antibiotic use, population density, and spread of a few international clones... - Prediction of pulmonary hypertension in idiopathic pulmonary fibrosisDavid A Zisman
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Respir Med 101:2153-9. 2007..We tested the hypothesis that the forced vital capacity to diffusing capacity ratio and room air resting pulse oximetry may be combined to predict mean pulmonary artery pressure (MPAP) in idiopathic pulmonary fibrosis... - Chronic lung allograft rejection: mechanisms and therapyJohn A Belperio
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Proc Am Thorac Soc 6:108-21. 2009.... - High-resolution chest CT findings do not predict the presence of pulmonary hypertension in advanced idiopathic pulmonary fibrosisDavid A Zisman
Department of Medicine, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
Chest 132:773-9. 2007..We tested the hypothesis that chest CT-determined extent of pulmonary fibrosis and/or main pulmonary artery diameter (MPAD) can be used to identify the presence of PH in patients with advanced IPF... - Non-tuberculous mycobacterium infection after lung transplantation is associated with increased mortalityHsuanwen C Huang
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1690, USA
J Heart Lung Transplant 30:790-8. 2011..Herein we describe our experience with pulmonary NTM infection after lung transplantation and hypothesized that non-tuberculous mycobacterial infection after lung transplantation would be associated with increased mortality... - Chronic allograft rejection: epidemiology, diagnosis, pathogenesis, and treatmentS Samuel Weigt
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 31:189-207. 2010..A better understanding of the risk factors and their relationship to the pathological mechanisms of chronic lung allograft rejection should lead to better pharmacological targets to prevent or treat this syndrome... - Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantationAric L Gregson
Division of Infectious Diseases, Department of Medicine, School of Public Health, University of California, Los Angeles, CA 90095, USA
Am J Respir Crit Care Med 187:518-26. 2013..Pseudomonas and the ELR(+) CXC chemokines may interact to negatively influence lung transplant outcomes... - Usefulness of immune monitoring in lung transplantation using adenosine triphosphate production in activated lymphocytesMichael Y Shino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095 1690, USA
J Heart Lung Transplant 31:996-1002. 2012..We hypothesized that this assay can be used to assess the immune function of lung transplant recipients and identify those at risk of developing acute cellular rejection and respiratory infection... - Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipientsS Samuel Weigt
Division of Pulmonary, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 32:471-93. 2011..This article reviews the current information regarding epidemiology, pathogenesis, clinical presentation, diagnosis, and treatment of these infections, as well as the aspects of clinical significance of RVIs unique to HSCT or SOT... - Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndromeJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
J Immunol 169:1037-49. 2002..This supports the notion that ligand/CXCR3 biology plays an important role in the recruitment of mononuclear cells, a pivotal event in the pathogenesis of BOS... - Immunosuppressive and cytotoxic therapy: pharmacology, toxicities, and monitoringTisha Wang
Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
Semin Respir Crit Care Med 32:346-70. 2011..Recent studies suggest that rituximab may be useful for induction therapy or for CYC-refractory AAV. This article reviews the key agents used to treat AAV, with a focus on pharmacology, toxicities, and monitoring... - Role of CXCR2/CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndromeJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Clin Invest 115:1150-62. 2005.... - Increased bronchoalveolar lavage human beta-defensin type 2 in bronchiolitis obliterans syndrome after lung transplantationDavid J Ross
Division of Pulmonary and Critical Care Medicine and the Will Rogers Institute for Pulmonary Research, David Geffen School of Medicine U C L A Medical Center, Los Angeles, CA 90095 1690, USA
Transplantation 78:1222-4. 2004..We therefore speculate that complex interactions between adaptive and innate immunity may contribute to the propagation of airway inflammation in BOS... - Inflammation and angiogenesis in fibrotic lung diseaseMichael P Keane
Division of Pulmonary and Critical Care Medicine, UCLA David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1922, USA
Semin Respir Crit Care Med 27:589-99. 2006..Therefore, the pathogenesis of pulmonary fibrosis is complex and involves the interaction of multiple cell types and compartments within the lung... - Serum albumin concentration and waiting list mortality in idiopathic interstitial pneumoniaDavid A Zisman
Interstitial Lung Disease Center, David Geffen School of Medicine at UCLA, 37 131 Center for Health Sciences, Los Angeles, CA 90095, USA
Chest 135:929-35. 2009..The objective of this study was to examine the relationship between serum albumin concentration and mortality in a large cohort of patients with idiopathic interstitial pneumonia listed for lung transplantation... - Modified reperfusion in clinical lung transplantation: the results of 100 consecutive casesGabriel T Schnickel
Division of Cardiothoracic Surgery, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Calif, USA
J Thorac Cardiovasc Surg 131:218-23. 2006..We hypothesized that altering the content of the initial reperfusate and maintaining a low reperfusion pressure after surgical implantation would lead to a low incidence of primary graft dysfunction... - Diagnosis and hemodynamic assessment of pulmonary arterial hypertensionRajan Saggar
Division of Pulmonary, Critical Care Medicine, and Hospitalists, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1690, USA
Semin Respir Crit Care Med 30:399-410. 2009..This article provides an overview of the available diagnostic studies for PAH with a particular focus on hemodynamic assessment. Novel approaches to the often delayed diagnosis of PAH are being studied and are also discussed here... - Pulmonary fibrosisDavid A Zisman
Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of Califonia, Los Angeles, CA, USA
Methods Mol Med 117:3-44. 2005.... - Immune response CC chemokines CCL2 and CCL5 are associated with pulmonary sarcoidosisVyacheslav Palchevskiy
Division of Pulmonary and Critical Care Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Fibrogenesis Tissue Repair 4:10. 2011..abstract:.. - Antimicrobial resistance among gram-negative organisms in the intensive care unitNina M Clark
Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Curr Opin Crit Care 9:413-23. 2003..SUMMARY: Antibiotic resistance continues to rise among hospital-acquired gram-negative pathogens. Optimal management of these infections requires knowledge of local epidemiology and practices to control their spread... - Interleukin-1 receptor antagonist as a biomarker for bronchiolitis obliterans syndrome in lung transplant recipientsJohn A Belperio
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit, MI 48208, USA
Transplantation 73:591-9. 2002..Interleukin-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of the pro-inflammatory cytokine IL-1 and has been associated with a number of fibroproliferative diseases... - Neurofibromatosis-associated diffuse lung disease: case reportMichael Y Shino
Division of Pulmonary and Critical Care Medicine, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1690, USA
Semin Respir Crit Care Med 33:572-5. 2012..Although NF-associated diffuse lung disease (NF-DLD) is disputed as a clinical entity by some, the case presented here adds to the accumulating evidence that NF-DLD is a distinct manifestation of neurofibromatosis... - Antimicrobial resistance among gram-positive organisms in the intensive care unitNina M Clark
Section of Infectious Diseases, Department of Internal Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Curr Opin Crit Care 9:403-12. 2003..In addition, efforts must be made to minimize the selection and spread of these organisms... - The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injuryJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine at The David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 27:350-64. 2006..Moreover, VALI/VILI can perpetuate the chronic inflammatory response during ALI/ARDS and MODS. This article explores the role of cytokines/chemokines during the pathogenesis of VALI/VILI... - Exercise-induced pulmonary hypertension associated with systemic sclerosis: four distinct entitiesRajeev Saggar
David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1690, USA
Arthritis Rheum 62:3741-50. 2010..We undertook this study to describe the hemodynamic response to exercise in a homogeneous population of patients with scleroderma spectrum disorders at risk of developing pulmonary vascular disease... - Current and emerging strategies for the management of sarcoidosisEric S White
University of Michigan Medical Center, Division of Pulmonary and Critical Medicine, Department of Internal Medicine, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
Expert Opin Pharmacother 8:1293-311. 2007..Agents commonly used to treat patients with sarcoidosis and emerging therapeutic options are discussed... - Pulmonary alveolar proteinosisTisha Wang
Division of Pulmonary, Critical Care Medicine, Clinical Immunology, and Allergy, Department of Internal Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Semin Respir Crit Care Med 33:498-508. 2012..Autoimmune PAP has also been successfully treated with GM-CSF, both inhaled and systemic, but the optimal dose, duration, and route of administration of GM-CSF have not been elucidated... - Levofloxacin for the treatment of community-acquired pneumoniaJoseph P Lynch
University of California, Los Angeles, Division of Pulmonary, Critical Care Medicine and Hospitalists, The David Geffen School of Medicine, Los Angeles, CA, USA
Expert Rev Anti Infect Ther 4:725-42. 2006..However, ciprofloxacin-resistant organisms are becoming more prevalent so prudence must be exercised when prescribing this agent... - Pharmacological therapy for Wegener's granulomatosisEric S White
Division of Pulmonary and Critical Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Drugs 66:1209-28. 2006..However, the current data are conflicting and difficult to interpret. As a result, these newer agents cannot be recommended for routine use until vigorous clinical study confirms their efficacy... - Radiologic findings are strongly associated with a pathologic diagnosis of usual interstitial pneumoniaGary W Hunninghake
Department of Medicine, University of Iowa and Veterans Administration Medical Center, Iowa City, IA 52242, USA
Chest 124:1215-23. 2003..To determine which clinical and radiologic findings are independently associated with a pathologic diagnosis of usual interstitial pneumonia (UIP)... - Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumoniaKevin R Flaherty
Departments of Radiology and Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0360, USA
Am J Respir Crit Care Med 168:543-8. 2003..47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia... - Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?Kevin R Flaherty
Division of Pulmonary and Critical Care Medicine, Department of Radiology, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
Am J Respir Crit Care Med 170:904-10. 2004..We conclude that dynamic interactions between clinicians, radiologists, and pathologists improve interobserver agreement and diagnostic confidence... - Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular diseaseKevin R Flaherty
Department of Radiology, University of Michigan Health System, Ann Arbor, USA
Am J Respir Crit Care Med 167:1410-5. 2003..005). We conclude that patients with collagen vascular disease-associated usual interstitial pneumonia have fewer fibroblastic foci and improved survival... - Emerging drugs for idiopathic pulmonary fibrosisVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III1150 W Medical Center Dr, Ann Arbor, MI 48109, USA
Expert Opin Emerg Drugs 10:707-27. 2005..In this report, the present status of drug development of a number of emerging antifibrotic strategies and agents that may prove more effective in the therapy of this progressive, debilitating and fatal disease are reviewed... - Mechanisms of pulmonary fibrosisVictor J Thannickal
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Annu Rev Med 55:395-417. 2004.... - Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumoniaVibha N Lama
Department of Radiology, University of Michigan Health System, University of Michigan School of Public Health, Ann Arbor, MI 48109-0360, USA
Am J Respir Crit Care Med 168:1084-90. 2003..We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia... - Idiopathic pulmonary fibrosis: pathogenesis and therapeutic approachesMoises Selman
Instituto Nacional de Enfermedades Respiratorias, Mexico DF, Mexico
Drugs 64:405-30. 2004..Stem cell progenitors of the alveolar epithelial cells and genetic and epigenetic therapies are attractive future approaches for this and other fibrotic lung disorders...