G S Lynch

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint The effects of endurance exercise on dystrophic mdx mice. II. Contractile properties of skinned muscle fibres
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Proc Biol Sci 253:27-33. 1993
  2. ncbi request reprint Effects of beta 2-agonist administration and exercise on contractile activation of skeletal muscle fibers
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Appl Physiol (1985) 81:1610-8. 1996
  3. ncbi request reprint IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria 3010, Melbourne, Australia
    Neuromuscul Disord 11:260-8. 2001
  4. pmc Contractile properties of skinned muscle fibres from young and adult normal and dystrophic (mdx) mice
    D A Williams
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 460:51-67. 1993
  5. ncbi request reprint Rigor force responses of permeabilized fibres from fast and slow skeletal muscles of aged rats
    D R Plant
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Clin Exp Pharmacol Physiol 28:779-81. 2001
  6. ncbi request reprint In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement
    R Kapsa
    Melbourne Neuromuscular Research Institute and Department of Clinical Neurosciences, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hum Gene Ther 12:629-42. 2001
  7. ncbi request reprint Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
  8. ncbi request reprint Hyperbaric oxygen modulates antioxidant enzyme activity in rat skeletal muscles
    P Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Eur J Appl Physiol 86:24-7. 2001
  9. ncbi request reprint Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury
    J D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Grattan Street, Victoria 3010, Australia
    Gene Ther 13:1657-64. 2006
  10. ncbi request reprint Therapies for improving muscle function in neuromuscular disorders
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Exerc Sport Sci Rev 29:141-8. 2001

Collaborators

Detail Information

Publications14

  1. ncbi request reprint The effects of endurance exercise on dystrophic mdx mice. II. Contractile properties of skinned muscle fibres
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Proc Biol Sci 253:27-33. 1993
    ....
  2. ncbi request reprint Effects of beta 2-agonist administration and exercise on contractile activation of skeletal muscle fibers
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Appl Physiol (1985) 81:1610-8. 1996
    ..Indeed, in the mouse, low-intensity exercise appears to prevent these effects...
  3. ncbi request reprint IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria 3010, Melbourne, Australia
    Neuromuscul Disord 11:260-8. 2001
    ..The findings have important implications for the role of IGF-I in ameliorating muscle wasting associated with the muscular dystrophies...
  4. pmc Contractile properties of skinned muscle fibres from young and adult normal and dystrophic (mdx) mice
    D A Williams
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    J Physiol 460:51-67. 1993
    ..The presence of mixed nucleation and absence of fibres with embryonic contractile characteristics in mdx mice suggest that the dystrophin-negative fibres can repair locally occurring muscle damage...
  5. ncbi request reprint Rigor force responses of permeabilized fibres from fast and slow skeletal muscles of aged rats
    D R Plant
    Department of Physiology, The University of Melbourne, Parkville, Victoria 3010, Australia
    Clin Exp Pharmacol Physiol 28:779-81. 2001
    ..We conclude that the age-related decrease in force output is more likely attributed to a decrease in the force per cross-bridge and/or decreases in the efficiency of excitation-contraction coupling...
  6. ncbi request reprint In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement
    R Kapsa
    Melbourne Neuromuscular Research Institute and Department of Clinical Neurosciences, St Vincent s Hospital, Fitzroy, Victoria, Australia
    Hum Gene Ther 12:629-42. 2001
    ..With further improvements to in vitro and in vivo gene repair efficiencies, SFHR may find some application in DMD and other genetic neuromuscular disorders in humans...
  7. ncbi request reprint Quantitative measurement of resting skeletal muscle [Ca2+]i following acute and long-term downhill running exercise in mice
    G S Lynch
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Cell Calcium 22:373-83. 1997
    ....
  8. ncbi request reprint Hyperbaric oxygen modulates antioxidant enzyme activity in rat skeletal muscles
    P Gregorevic
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Eur J Appl Physiol 86:24-7. 2001
    ..We conclude that both acute and repeated HBO inhalation can alter enzymatic antioxidant activity in skeletal muscles...
  9. ncbi request reprint Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury
    J D Schertzer
    Basic and Clinical Myology Laboratory, Department of Physiology, The University of Melbourne, Grattan Street, Victoria 3010, Australia
    Gene Ther 13:1657-64. 2006
    ..Thus, the relative efficacy of different modes of delivery is an important consideration when assessing the therapeutic potential of various proteins for treating muscle injuries and skeletal muscle diseases...
  10. ncbi request reprint Therapies for improving muscle function in neuromuscular disorders
    G S Lynch
    Department of Physiology, The University of Melbourne, Victoria, Australia
    Exerc Sport Sci Rev 29:141-8. 2001
    ..The information has application for treating the muscular dystrophies, cancer cachexia, weightlessness, immobilization, denervation, and disuse atrophy...
  11. ncbi request reprint The effects of endurance exercise on dystrophic mdx mice. I. Contractile and histochemical properties of intact muscles
    A Hayes
    Department of Physiology, University of Melbourne, Parkville, Victoria, Australia
    Proc Biol Sci 253:19-25. 1993
    ..The endurance exercise was beneficial to the mdx mice, enhancing the regeneration of function of their muscles by increasing the proportion of oxidative fibres and reducing muscle fatiguability...
  12. ncbi request reprint Specific force of the rat extraocular muscles, levator and superior rectus, measured in situ
    B R Frueh
    Department of Physiology, The University of Melbourne, Victoria 3010, Australia
    J Neurophysiol 85:1027-32. 2001
    ..We conclude that extraocular muscles are not intrinsically weaker than skeletal muscles...
  13. pmc Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice
    S M Turpin
    St Vincent s Institute of Medical Research and the Department of Medicine, University of Melbourne, Fitzroy, Australia
    J Physiol 587:1593-605. 2009
    ..A broad transcriptional suppression of pro-apoptotic proteins may explain this resistance to lipid-induced cell death in skeletal muscle...
  14. ncbi request reprint Tackling Australia's future health problems: developing strategies to combat sarcopenia--age-related muscle wasting and weakness
    G S Lynch
    Department of Physiology, The University of Melbourne, Melbourne, Victoria, Australia
    Intern Med J 34:294-6. 2004
    ..Much research is needed to test the safety and efficacy of these exciting experimental strategies before they can be recommended for clinical application...