Jens Lykke-Andersen

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. pmc Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
    Jens Lykke-Andersen
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Mol Cell Biol 22:8114-21. 2002
  2. ncbi request reprint Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping
    Martin Fenger-Grøn
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309, USA
    Mol Cell 20:905-15. 2005
  3. ncbi request reprint Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm
    Guramrit Singh
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Mol Cell 27:780-92. 2007
  4. pmc Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay
    Tobias M Franks
    University of Colorado, Boulder, 80309, USA
    Cell 143:938-50. 2010
  5. pmc A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    Guramrit Singh
    Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS Biol 6:e111. 2008
  6. doi request reprint A tethering approach to study proteins that activate mRNA turnover in human cells
    Sandra L Clement
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA
    Methods Mol Biol 419:121-33. 2008
  7. pmc Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment
    Sandra L Clement
    Molecular, Cellular, and Development Biology, Universit of Colorado, Boulder, Colorado 80309, USA
    Mol Cell Biol 31:256-66. 2011
  8. pmc Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1
    Jens Lykke-Andersen
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 19:351-61. 2005
  9. ncbi request reprint New insights into the formation of active nonsense-mediated decay complexes
    Guramrit Singh
    Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado at Boulder, Boulder, CO 80309 0347, USA
    Trends Biochem Sci 28:464-6. 2003
  10. pmc TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements
    Tobias M Franks
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 21:719-35. 2007

Research Grants

  1. The Function of Processing Bodies in Human mRNA Turnover
    Jens Lykke Andersen; Fiscal Year: 2007

Collaborators

  • Georg Stoecklin
  • Paul J Anderson
  • Randal Kaufman
  • N Kedersha
  • Joachim Weischenfeldt
  • Sandra L Clement
  • Guramrit Singh
  • Tobias M Franks
  • Jens Lykke Andersen
  • Eileen Wagner
  • Indrani Rebbapragada
  • Christy Fillman
  • Christian Kroun Damgaard
  • Martin Fenger-Grøn
  • Jacob Nielsen
  • Claudia Scheckel
  • Mark G Kleedehn
  • Steffen Jakob
  • Bodil Norrild
  • Grete Koch
  • Jan Christiansen
  • Sidsel K Adolph
  • Ewa Rajpert-De Meyts
  • Finn C Nielsen

Detail Information

Publications21

  1. pmc Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
    Jens Lykke-Andersen
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Mol Cell Biol 22:8114-21. 2002
    ..These data suggest that a human decapping complex may be recruited to mRNAs containing premature termination codons by the hUpf proteins...
  2. ncbi request reprint Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping
    Martin Fenger-Grøn
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309, USA
    Mol Cell 20:905-15. 2005
    ..These observations suggest that multiple proteins involved in human decapping are important subunits of PBs and are activated on ARE-mRNAs by the protein TTP...
  3. ncbi request reprint Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasm
    Guramrit Singh
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Mol Cell 27:780-92. 2007
    ..Furthermore, retention of the NMD factor hUpf1 in the nucleus strongly impairs NMD. These observations suggest that the hUpf complex communicates with the EJC and triggers NMD in the cytoplasm...
  4. pmc Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay
    Tobias M Franks
    University of Colorado, Boulder, 80309, USA
    Cell 143:938-50. 2010
    ..This uncovers a previously unappreciated and potentially regulated step in mRNA decay and raises the question of how other mRNA decay pathways release protein components of substrate mRNPs...
  5. pmc A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
    Guramrit Singh
    Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS Biol 6:e111. 2008
    ..We speculate that these have evolved to concentrate NMD-inhibiting factors, such as PABP, in spatial proximity of the termination codon...
  6. doi request reprint A tethering approach to study proteins that activate mRNA turnover in human cells
    Sandra L Clement
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA
    Methods Mol Biol 419:121-33. 2008
    ....
  7. pmc Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment
    Sandra L Clement
    Molecular, Cellular, and Development Biology, Universit of Colorado, Boulder, Colorado 80309, USA
    Mol Cell Biol 31:256-66. 2011
    ..Thus, TTP may remain poised to rapidly reactivate deadenylation of bound transcripts to downregulate gene expression once the p38 MAPK pathway is deactivated...
  8. pmc Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1
    Jens Lykke-Andersen
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 19:351-61. 2005
    ..This describes a potentially regulated step in activation of mRNA decay...
  9. ncbi request reprint New insights into the formation of active nonsense-mediated decay complexes
    Guramrit Singh
    Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado at Boulder, Boulder, CO 80309 0347, USA
    Trends Biochem Sci 28:464-6. 2003
    ..New studies now present evidence that Y14 is directly involved in NMD, and that Y14 is required for hUpf3 activity. These findings suggest unforeseen intricacies in the formation of active NMD complexes...
  10. pmc TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements
    Tobias M Franks
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 21:719-35. 2007
    ..This function of the PB can likely be extended to other mRNA silencing pathways, such as those mediated by microRNAs, premature termination codons, and mRNA deadenylation...
  11. pmc The control of mRNA decapping and P-body formation
    Tobias M Franks
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Mol Cell 32:605-15. 2008
    ..Here, we discuss the regulation of decapping machinery recruitment to specific mRNPs and how their assembly into PBs is governed by the relative rates of translational repression, mRNP multimerization, and mRNA decay...
  12. doi request reprint Execution of nonsense-mediated mRNA decay: what defines a substrate?
    Indrani Rebbapragada
    Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
    Curr Opin Cell Biol 21:394-402. 2009
    ..This leads to mRNA decay following translational repression. Recent evidence suggests that in Drosophila and human cells, decay is initiated by the endonuclease Smg6...
  13. ncbi request reprint mRNA surveillance: the perfect persist
    Eileen Wagner
    Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309 0347 USA
    J Cell Sci 115:3033-8. 2002
    ..mRNA surveillance thereby prevents the synthesis of truncated and otherwise aberrant proteins, which can have dominant-negative and other deleterious effects...
  14. pmc An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodies
    Eileen Wagner
    MCD Biology, University of Colorado, Boulder, CO 80309, USA
    Mol Cell Biol 27:1686-95. 2007
    ....
  15. pmc Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR
    Christian Kroun Damgaard
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Genes Dev 25:2057-68. 2011
    ..This presents a fundamental example of how a group of mRNAs can be translationally coregulated in response to changes in the cellular environment...
  16. ncbi request reprint RNA decapping inside and outside of processing bodies
    Christy Fillman
    Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
    Curr Opin Cell Biol 17:326-31. 2005
    ..Recent evidence suggests that the processing bodies may constitute specialized cellular compartments of mRNA turnover, which suggests that mRNA and protein localization may be integral to mRNA decay...
  17. ncbi request reprint No mercy for messages that mess with the ribosome
    Sandra L Clement
    Nat Struct Mol Biol 13:299-301. 2006
  18. ncbi request reprint Messenger RNA surveillance: neutralizing natural nonsense
    Joachim Weischenfeldt
    Section of Gene Therapy Research, Copenhagen University Hospital, Juliane Mariesvej 20 section 9322, DK 2100 Copenhagen, Denmark
    Curr Biol 15:R559-62. 2005
    ....
  19. pmc Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
    Nancy Kedersha
    Division of Rheumatology and Immunology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 169:871-84. 2005
    ..We propose that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation...
  20. ncbi request reprint Making structural sense of nonsense-mediated decay
    Jens Lykke-Andersen
    Nat Struct Mol Biol 11:305-6. 2004
  21. pmc Nuclear transit of human zipcode-binding protein IMP1
    Jacob Nielsen
    Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Biochem J 376:383-91. 2003
    ..Taken together, these results indicate that IMP1 may attach to its target mRNAs in the nucleus and thereby define the cytoplasmic fate of the transcripts...

Research Grants2

  1. The Function of Processing Bodies in Human mRNA Turnover
    Jens Lykke Andersen; Fiscal Year: 2007
    ..Understanding the mechanism behind mRNA turnover will help develop strategies to fight such diseases. ..