Research Topics
Genomes and GenesSpecies | Jens Lykke-AndersenSummaryAffiliation: University of Colorado Country: USA Publications
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Detail Information
Publications
New insights into the formation of active nonsense-mediated decay complexesGuramrit Singh
Department of Molecular, Cellular and Developmental Biology, 347 UCB, University of Colorado at Boulder, Boulder, CO 80309-0347, USA
Trends Biochem Sci 28:464-6. 2003..New studies now present evidence that Y14 is directly involved in NMD, and that Y14 is required for hUpf3 activity. These findings suggest unforeseen intricacies in the formation of active NMD complexes...
Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1Jens Lykke-Andersen
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Genes Dev 19:351-61. 2005..This describes a potentially regulated step in activation of mRNA decay...- Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decayJens Lykke-Andersen
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Mol Cell Biol 22:8114-21. 2002..These data suggest that a human decapping complex may be recruited to mRNAs containing premature termination codons by the hUpf proteins... - Communication with the exon-junction complex and activation of nonsense-mediated decay by human Upf proteins occur in the cytoplasmGuramrit Singh
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Mol Cell 27:780-92. 2007..Furthermore, retention of the NMD factor hUpf1 in the nucleus strongly impairs NMD. These observations suggest that the hUpf complex communicates with the EJC and triggers NMD in the cytoplasm... - Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayTobias M Franks
University of Colorado, Boulder, 80309, USA
Cell 143:938-50. 2010..This uncovers a previously unappreciated and potentially regulated step in mRNA decay and raises the question of how other mRNA decay pathways release protein components of substrate mRNPs... - Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitmentSandra L Clement
Molecular, Cellular, and Development Biology, Universit of Colorado, Boulder, Colorado 80309, USA
Mol Cell Biol 31:256-66. 2011..Thus, TTP may remain poised to rapidly reactivate deadenylation of bound transcripts to downregulate gene expression once the p38 MAPK pathway is deactivated... - mRNA surveillance: the perfect persistEileen Wagner
Department of Molecular, Cellular and Developmental Biology, University of Colorado-Boulder, Boulder, CO 80309-0347 USA
J Cell Sci 115:3033-8. 2002..mRNA surveillance thereby prevents the synthesis of truncated and otherwise aberrant proteins, which can have dominant-negative and other deleterious effects... - Multiple processing body factors and the ARE binding protein TTP activate mRNA decappingMartin Fenger-Grøn
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, 80309, USA
Mol Cell 20:905-15. 2005..These observations suggest that multiple proteins involved in human decapping are important subunits of PBs and are activated on ARE-mRNAs by the protein TTP... - Translational coregulation of 5'TOP mRNAs by TIA-1 and TIARChristian Kroun Damgaard
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Genes Dev 25:2057-68. 2011..This presents a fundamental example of how a group of mRNAs can be translationally coregulated in response to changes in the cellular environment... - TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elementsTobias M Franks
Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Genes Dev 21:719-35. 2007..This function of the PB can likely be extended to other mRNA silencing pathways, such as those mediated by microRNAs, premature termination codons, and mRNA deadenylation... 
A tethering approach to study proteins that activate mRNA turnover in human cellsSandra L Clement
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO, USA
Methods Mol Biol 419:121-33. 2008....- RNA decapping inside and outside of processing bodiesChristy Fillman
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Curr Opin Cell Biol 17:326-31. 2005..Recent evidence suggests that the processing bodies may constitute specialized cellular compartments of mRNA turnover, which suggests that mRNA and protein localization may be integral to mRNA decay... - An unconventional human Ccr4-Caf1 deadenylase complex in nuclear cajal bodiesEileen Wagner
MCD Biology, University of Colorado, Boulder, CO 80309, USA
Mol Cell Biol 27:1686-95. 2007.... - A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decayGuramrit Singh
Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, United States of America
PLoS Biol 6:e111. 2008..We speculate that these have evolved to concentrate NMD-inhibiting factors, such as PABP, in spatial proximity of the termination codon... - No mercy for messages that mess with the ribosomeSandra L Clement
Nat Struct Mol Biol 13:299-301. 2006 - Nuclear transit of human zipcode-binding protein IMP1Jacob Nielsen
Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
Biochem J 376:383-91. 2003..Taken together, these results indicate that IMP1 may attach to its target mRNAs in the nucleus and thereby define the cytoplasmic fate of the transcripts... - Making structural sense of nonsense-mediated decayJens Lykke-Andersen
Nat Struct Mol Biol 11:305-6. 2004 - Messenger RNA surveillance: neutralizing natural nonsenseJoachim Weischenfeldt
Section of Gene Therapy Research, Copenhagen University Hospital, Juliane Mariesvej 20 section 9322, DK 2100 Copenhagen, Denmark
Curr Biol 15:R559-62. 2005.... 
Stress granules and processing bodies are dynamically linked sites of mRNP remodelingNancy Kedersha
Division of Rheumatology and Immunology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Cell Biol 169:871-84. 2005..We propose that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation...