Research Topics
| KATHERINE F LUZURIAGASummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Genotypic and functional properties of early infant HIV-1 envelopesMichael Kishko
Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA, USA
Retrovirology 8:67. 2011..Following extensive genotypic and phylogenetic analyses, 35 representative clones were selected for functional studies...- Variation in HIV-1 R5 macrophage-tropism correlates with sensitivity to reagents that block envelope: CD4 interactions but not with sensitivity to other entry inhibitorsPaul J Peters
Center for AIDS Research, Program in Molecular Medicine and Department of Molecular Genetics and Microbiology, 373 Plantation Street, University of Massachusetts Medical School, Worcester, MA 01605, USA
Retrovirology 5:5. 2008..These R5 envelopes conferred a wide range of macrophage tropism and included highly macrophage-tropic variants from brain and non-macrophage-tropic variants from lymph node... 
Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical prioritiesKatherine Luzuriaga
University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Suite 318, Worcester, MA 01605, USA
Lancet 368:511-21. 2006..Here, we discuss the scientific and logistical challenges for the development of paediatric HIV vaccines; available vaccines and completed or planned paediatric vaccine trials are also discussed...- Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responsesK Luzuriaga
Department of Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Virol 74:6984-91. 2000..These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication... - A trial of three antiretroviral regimens in HIV-1-infected childrenKatherine Luzuriaga
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Mass 01605, USA
N Engl J Med 350:2471-80. 2004..Depletion of CD4 T-cell counts or progression of human immunodeficiency virus (HIV) disease occurs rapidly in children, but few data address the efficacy of aggressive therapy for HIV-infected children... - Pediatric HIV-1 infection: advances and remaining challengesKatherine Luzuriaga
University of Massachusetts Medical School, Department of Pediatrics, Program in Molecular Medicine, 373 Plantation Street, Biotech II Suite 318, Worcester, MA 01605, USA
AIDS Rev 4:21-6. 2002..Continued efforts to understand MTCT and pediatric HIV-1 pathogenesis and to refine preventive and therapeutic strategies are of high priority... - HIV-1 replication increases HIV-specific CD4+ T cell frequencies but limits proliferative capacity in chronically infected childrenZachary A Scott
Graduate Program in Immunology/Virology and Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 170:5786-92. 2003.... - Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infectionLaura Gibson
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 172:2256-64. 2004..The temporal association between the detection of HCMV-specific CD8(+) T cell responses and the reduction in blood HCMV load supports the importance of CD8(+) T cells in controlling primary HCMV viremia... - Virologic response to potent antiretroviral therapy and modeling of HIV dynamics in early pediatric infectionPaul Palumbo
Department of Pediatrics, University of Medicine and Dentistry New Jersey Medical School, Newark, NJ, USA
J Infect Dis 196:23-9. 2007..Similar studies are needed in pediatric populations, in whom differing dynamics might translate into age-specific treatment approaches... - Non-macrophage-tropic human immunodeficiency virus type 1 R5 envelopes predominate in blood, lymph nodes, and semen: implications for transmission and pathogenesisPaul J Peters
Center for AIDS Research, Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation St, Biotech II Suite 315, Worcester, MA 01605, USA
J Virol 80:6324-32. 2006..The extensive variation in R5 tropism reported here is likely to have an important impact on pathogenesis and on the capacity of HIV-1 to transmit... - Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infantsLaura Gibson
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, and Department of Pediatrics, Baystate Children s Hospital, Springfield, USA
J Infect Dis 195:1789-98. 2007..These data provide additional evidence that young infants can generate diverse CMV-specific CD8+ T cell responses but show that early responses may exhibit relatively focused peptide specificity and lower peptide avidity... 
Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitnessVictor Sanchez-Merino
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Infect Dis 197:300-8. 2008..Better understanding of the balance between CD8(+) T cell selective pressures and viral fitness cost may facilitate the identification of optimal viral sequences for inclusion in HIV-1 vaccines...- Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapyThomas C Greenough
Pediatrics and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Vaccine 26:6883-93. 2008..Plasma HIV-1-specific antibody levels and neutralizing activity were unchanged following vaccination. Poxvirus-based vaccines may merit further study in therapeutic vaccine protocols... - Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usageThomas C Greenough
Pediatrics, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 5:e12926. 2010..To better understand the role of PD-1 in antiviral immunity we examined the expression of PD-1 on Epstein-Barr virus (EBV) epitope-specific CD8+ T cells during acute infectious mononucleosis (AIM) and convalescence... - Gender differences in lymphocyte populations, plasma HIV RNA levels, and disease progression in a cohort of children born to women infected with HIVMarc Foca
Department of Pediatrics, Columbia University, New York, New York, USA
Pediatrics 118:146-55. 2006..We sought to document gender differences in lymphocyte subsets and plasma RNA levels in a pediatric cohort with presumed minimal hormonal differences (on the basis of age)... - HIV-1-specific CD8+ T cell responses and viral evolution in women and infantsVictor Sanchez-Merino
Department of Pediatrics/Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 175:6976-86. 2005..Altogether, these studies document that HIV-1-specific CD8+ T cell responses contribute to the evolution of the viral quasispecies in HIV-1-infected women and their infants and may have important implications for vaccine design... - Pneumonitis and multi-organ system disease in common marmosets (Callithrix jacchus) infected with the severe acute respiratory syndrome-associated coronavirusThomas C Greenough
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01605, USA
Am J Pathol 167:455-63. 2005..These findings identify the common marmoset as a promising nonhuman primate to study SARS-CoV pathogenesis... - Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in miceThomas C Greenough
Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 02130, USA
J Infect Dis 191:507-14. 2005..Antibodies to both epitopes protected mice against SARS-CoV challenge. Clinical trials are planned to test MAb 201, a fully human MAb specific for the epitope within the receptor-binding region... - Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanismsRobert Winchester
Columbia University, Department of Pediatrics, New York, NY 10032, USA
J Acquir Immune Defic Syndr 36:659-70. 2004.... - Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infectionMelissa L Precopio
Graduate Program in Immunology/Virology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 170:2590-8. 2003..Peripheral blood EBV load directly correlated with the frequency of EBV-specific CD4(+) T cell responses at presentation and over time, suggesting that EBV-specific CD4(+) T cell responses are Ag-driven... - Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosisShalyn C Clute
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
J Clin Invest 115:3602-12. 2005..Our results support the concept that cross-reactive memory CD8+ T cells activated by EBV contribute to the characteristic lymphoproliferation of IM... - Early initiation of lopinavir/ritonavir in infants less than 6 weeks of age: pharmacokinetics and 24-week safety and efficacyEllen Gould Chadwick
Department of Pediatrics, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
Pediatr Infect Dis J 28:215-9. 2009.... - Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCRNishaki Mehta
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
PLoS ONE 4:e5819. 2009..A rapid and cost effective method to diagnose and quantify HIV-1 from DBS is urgently needed to facilitate early diagnosis of HIV-1 infection and monitoring of antiretroviral therapy... - Enhanced culture method for detection of replication-competent virus in peripheral blood mononuclear cells of HIV type 1-infected individualsJohn P Haran
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605
AIDS Res Hum Retroviruses 18:577-83. 2002..This will be a useful technique by which to study viral latency and HIV-1 pathogenesis in adult and pediatric populations... - Evidence for a cytopathogenicity determinant in HIV-1 VprMohan Somasundaran
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 99:9503-8. 2002..This study suggests the presence of a determinant of in vivo cytopathogenicity within HIV-1 Vpr and further indicates that viral replication can be uncoupled from cytopathicity in vitro and in vivo... - Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART eraSharon A Nachman
Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
Arch Pediatr Adolesc Med 163:164-71. 2009.... - Lopinavir exposure with an increased dose during pregnancyMark Mirochnick
Department of Pediatrics, Boston University School of Medicine, and Infectious Disease Division, Children s Hospital Boston, Boston, MA 02118, USA
J Acquir Immune Defic Syndr 49:485-91. 2008..The goal of this study was to determine LPV exposure during the third trimester of pregnancy and 2 weeks postpartum with a higher LPV/RTV dose... - Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccinationNishaki Mehta
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, United States
Vaccine 28:3672-8. 2010..Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals... - Anti-influenza serum and mucosal antibody responses after administration of live attenuated or inactivated influenza vaccines to HIV-infected childrenAdriana Weinberg
Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA
J Acquir Immune Defic Syndr 55:189-96. 2010..Live-attenuated influenza vaccine (LAIV) prevents more cases of influenza in immune-competent children than the trivalent inactivated vaccine (TIV). We compared the antibody responses to LAIV or TIV in HIV-infected children... - Phenotypic and functional heterogeneity of EBV epitope-specific CD8+ T cellsMichelle D Catalina
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 168:4184-91. 2002....
Research Grants
- PEDIATRIC AIDS CLINICAL TRIAL UNITKatherine Luzuriaga; Fiscal Year: 2006..abstract_text> ..
- Western New England Maternal Pediatric Adolescent AIDS Clinical Trials UnitKatherine Luzuriaga; Fiscal Year: 2007..administrative component: ..
- VIRUS-HOST DYNAMICS IN EARLY VERTICAL HIV-1 INFECTIONKatherine Luzuriaga; Fiscal Year: 2007..Data from these studies will improve our understanding of the pathogenesis of early pediatric HIV infection and contribute to the development of strategies to prevent or modify pediatric HIV-1 infection. ..
- HCMV-Specific Cell-Mediated Immunity in Infants/ChildrenKatherine Luzuriaga; Fiscal Year: 2005....
- KILLER CELLS AND VIRAL LOAD IN VERTICAL HIV INFECTIONKatherine Luzuriaga; Fiscal Year: 1999..The proposed studies are important in understanding the pathogenesis of vertical HIV-1 infection and for the development of a vaccine to interrupt vertical infection ..
- KILLER CELLS & VIRAL LOAD IN VERTICAL HIV INFECTIONKatherine Luzuriaga; Fiscal Year: 2003..Data from these studies will be helpful in better understanding the pathogenesis of vertical HIV-1 infection and for the development of a neonatal vaccine to interrupt vertical HIV-1 transmission. ..
- KILLER CELLS & VIRAL LOAD IN VERTICAL HIV INFECTIONKatherine Luzuriaga; Fiscal Year: 2009..Data from these studies will improve our understanding of the pathogenesis of early pediatric HIV infection and contribute to the development of strategies to prevent or modify pediatric HIV-1 infection. ..