Research Topics
Genomes and Genes | James LuyendykSummaryAffiliation: University of Kansas Medical Center Country: USA Publications
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Publications
Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasisJames P Luyendyk
Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Am J Pathol 178:1117-25. 2011..The results suggest that in this model of chronic cholestasis, fibrin constrains the release of bile constituents from injured intrahepatic bile ducts, thereby limiting the progression of hepatic inflammation and hepatocellular injury...- Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in miceJames P Luyendyk
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
Am J Physiol Gastrointest Liver Physiol 296:G840-9. 2009..The results indicate that ANIT-induced liver injury is accompanied by TF-dependent activation of the coagulation cascade and that TF contributes to the progression of injury during acute cholestatic hepatitis... - Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated miceJames P Luyendyk
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
Toxicol Appl Pharmacol 250:256-62. 2011.... - Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in miceJames P Luyendyk
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
Am J Pathol 176:177-86. 2010..The results suggest that TF-dependent thrombin generation and activation of PAR-1 amplify hepatic inflammation and injury during the pathogenesis of steatohepatitis... - Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injuryJames P Luyendyk
Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Toxicol Sci 119:233-43. 2011..Moreover, the data suggest a dual role for PAR-4 in ANIT hepatotoxicity, both mediating an early protection against peliosis and contributing to the progression of hepatocellular necrosis... - Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategiesBradley P Sullivan
Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
Toxicol Sci 115:286-94. 2010..In contrast, severe thrombocytopenia induces parenchymal-type peliosis in the livers of ANIT-treated mice, a rare hepatic lesion associated with pooling of blood in the liver... 
Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4Patrick M Moriarty
Department of Internal Medicine, Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA
Am J Cardiol 105:1585-7. 2010..816, p = 0.004). In conclusion, LDL apheresis acutely reduced the plasma levels of apoE4. The mechanism of apoE4 reduction by LDL apheresis might be related to the selective reduction of a particular HDL cholesterol...- Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expressionAlyson K Baker
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 1018, Kansas City, KS 66160, USA
Mol Immunol 46:2249-55. 2009..In contrast, the decrease in LPS-induced TNFalpha and TF expression in PTEN(-/-) PMs also requires an IL-10-independent pathway... - Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat dietBo Kong
Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
J Pharmacol Exp Ther 328:116-22. 2009.... - The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasisBradley P Sullivan
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Am J Pathol 177:2837-49. 2010..These results indicate that a TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the αVβ6 integrin, an important regulator of transforming growth factor-β1 activation... - Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cellsBradley P Sullivan
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
J Pharmacol Exp Ther 337:471-8. 2011..Overall, the results suggest that p38 contributes to TGF-β1-induced Itgβ6 mRNA expression in MMNK-1 cells by regulating activation of both SMAD and AP-1 transcription factors...
Research Grants
- Mechanisms of xenobiotic-induced biliary inflammation and fibrosisJames P Luyendyk; Fiscal Year: 2010..The progression of liver disease is linked to environmental chemical exposure. The purpose of this project is to determine the role of the blood clotting system in the progression of liver disease caused by chemical exposure. ..
- PI3K in LPS-induced coagulation and inflammationJames Luyendyk; Fiscal Year: 2006..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. ..