James Luyendyk

Summary

Affiliation: University of Kansas Medical Center
Country: USA

Publications

  1. pmc Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis
    James P Luyendyk
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Pathol 178:1117-25. 2011
  2. pmc Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 296:G840-9. 2009
  3. pmc Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 250:256-62. 2011
  4. pmc Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Am J Pathol 176:177-86. 2010
  5. pmc Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury
    James P Luyendyk
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 119:233-43. 2011
  6. pmc Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies
    Bradley P Sullivan
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 115:286-94. 2010
  7. doi request reprint Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4
    Patrick M Moriarty
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Cardiol 105:1585-7. 2010
  8. pmc Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression
    Alyson K Baker
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 1018, Kansas City, KS 66160, USA
    Mol Immunol 46:2249-55. 2009
  9. pmc Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    Bo Kong
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 328:116-22. 2009
  10. pmc The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis
    Bradley P Sullivan
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Pathol 177:2837-49. 2010

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Fibrinogen deficiency increases liver injury and early growth response-1 (Egr-1) expression in a model of chronic xenobiotic-induced cholestasis
    James P Luyendyk
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Am J Pathol 178:1117-25. 2011
    ..The results suggest that in this model of chronic cholestasis, fibrin constrains the release of bile constituents from injured intrahepatic bile ducts, thereby limiting the progression of hepatic inflammation and hepatocellular injury...
  2. pmc Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Am J Physiol Gastrointest Liver Physiol 296:G840-9. 2009
    ..The results indicate that ANIT-induced liver injury is accompanied by TF-dependent activation of the coagulation cascade and that TF contributes to the progression of injury during acute cholestatic hepatitis...
  3. pmc Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Toxicol Appl Pharmacol 250:256-62. 2011
    ....
  4. pmc Tissue factor-deficiency and protease activated receptor-1-deficiency reduce inflammation elicited by diet-induced steatohepatitis in mice
    James P Luyendyk
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    Am J Pathol 176:177-86. 2010
    ..The results suggest that TF-dependent thrombin generation and activation of PAR-1 amplify hepatic inflammation and injury during the pathogenesis of steatohepatitis...
  5. pmc Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury
    James P Luyendyk
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 119:233-43. 2011
    ..Moreover, the data suggest a dual role for PAR-4 in ANIT hepatotoxicity, both mediating an early protection against peliosis and contributing to the progression of hepatocellular necrosis...
  6. pmc Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies
    Bradley P Sullivan
    Department of Pharmacology, Toxicology, and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Toxicol Sci 115:286-94. 2010
    ..In contrast, severe thrombocytopenia induces parenchymal-type peliosis in the livers of ANIT-treated mice, a rare hepatic lesion associated with pooling of blood in the liver...
  7. doi request reprint Effect of low-density lipoprotein apheresis on plasma levels of apolipoprotein e4
    Patrick M Moriarty
    Department of Internal Medicine, Division of Clinical Pharmacology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Am J Cardiol 105:1585-7. 2010
    ..816, p = 0.004). In conclusion, LDL apheresis acutely reduced the plasma levels of apoE4. The mechanism of apoE4 reduction by LDL apheresis might be related to the selective reduction of a particular HDL cholesterol...
  8. pmc Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-alpha expression in macrophages by reducing IL-10 expression
    Alyson K Baker
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, MS 1018, Kansas City, KS 66160, USA
    Mol Immunol 46:2249-55. 2009
    ..In contrast, the decrease in LPS-induced TNFalpha and TF expression in PTEN(-/-) PMs also requires an IL-10-independent pathway...
  9. pmc Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    Bo Kong
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 328:116-22. 2009
    ....
  10. pmc The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis
    Bradley P Sullivan
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Am J Pathol 177:2837-49. 2010
    ..These results indicate that a TF-PAR-1 pathway contributes to liver fibrosis induced by chronic cholestasis by increasing expression of the αVβ6 integrin, an important regulator of transforming growth factor-β1 activation...
  11. pmc Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells
    Bradley P Sullivan
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, MS 1018, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 337:471-8. 2011
    ..Overall, the results suggest that p38 contributes to TGF-β1-induced Itgβ6 mRNA expression in MMNK-1 cells by regulating activation of both SMAD and AP-1 transcription factors...

Research Grants3

  1. Mechanisms of xenobiotic-induced biliary inflammation and fibrosis
    James P Luyendyk; Fiscal Year: 2010
    ..The progression of liver disease is linked to environmental chemical exposure. The purpose of this project is to determine the role of the blood clotting system in the progression of liver disease caused by chemical exposure. ..
  2. PI3K in LPS-induced coagulation and inflammation
    James Luyendyk; Fiscal Year: 2006
    ..Ultimately, characterization of the involvement of this pathway in LPS-induced inflammation may allow for development of novel strategies that can be used to treat sepsis. ..