Research Topics
Species | S LutgendorfSummaryAffiliation: University of Iowa Country: USA Publications
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Detail Information
Publications
Reciprocal age related change in natural killer cell receptors for MHC class ICharles T Lutz
Department of Pathology, University of Iowa, Iowa City, 52242, USA
Mech Ageing Dev 126:722-31. 2005..The distinct roles of CD94/NKG2A and KIR receptors suggest that shifting MHC class I receptor expression patterns reflect age related changes in NK cell and CD56(+) T cell turnover and function in vivo...- Social influences on clinical outcomes of patients with ovarian cancerSusan K Lutgendorf
Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
J Clin Oncol 30:2885-90. 2012..We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance... - Biobehavioral factors and cancer progression: physiological pathways and mechanismsSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Psychosom Med 73:724-30. 2011..Findings to date are reviewed, and fruitful areas for future research are discussed... 
Psychoneuroimmunology and health psychology: an integrative modelSusan K Lutgendorf
Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, Iowa 52242, USA
Brain Behav Immun 17:225-32. 2003..These interactions are discussed in the context of aging...- Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humansSusan K Lutgendorf
Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
Brain Behav Immun 18:55-64. 2004..Although IL-6 did increase following a neurogenic inflammatory stimulus, it did so subsequent to the maximum flare, suggesting that flare mechanisms are independent of IL-6... - Autonomic response to stress in interstitial cystitisSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
J Urol 172:227-31. 2004..To examine potential autonomic dysregulation in IC we examined the effects of a laboratory mental stress challenge on blood pressure and heart rate (HR) in patients with IC and healthy controls... - Religious participation, interleukin-6, and mortality in older adultsSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Health Psychol 23:465-75. 2004..Findings are consistent with a role for IL-6 in processes mediating the relationship between religious attendance and mortality... - Distress and expression of natural killer receptors on lymphocytesSusan K Lutgendorf
Department of Psychology, University of Iowa, IA, USA
Brain Behav Immun 19:185-94. 2005..Our findings suggest a possible role for NK-associated receptors in distress-related alterations in lymphocyte maturation, trafficking, or activity... - Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patientsSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
J Clin Oncol 26:4820-7. 2008..The objective of the current study was to examine associations between IL-6, diurnal cortisol rhythms, and facets of depression in epithelial ovarian cancer patients... - Social support, psychological distress, and natural killer cell activity in ovarian cancerSusan K Lutgendorf
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
J Clin Oncol 23:7105-13. 2005..We examined relationships among distress, social support, and natural killer (NK) cell activity in ovarian cancer patients in peripheral-blood mononuclear cells (PBMC), ascitic fluid, and tumor-infiltrating lymphocytes (TIL)... - Stress, spirituality, and cytokines in aging and cancerSusan K Lutgendorf
The University of Iowa, Department of Psychology and OB/GYN, E11 Seashore Hall, Iowa City, IA 52242-1407, USA
Gynecol Oncol 99:S139-40. 2005 - Effects of age on responsiveness to adjunct hypnotic analgesia during invasive medical proceduresSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Psychosom Med 69:191-9. 2007..To assess the effects of age on responsiveness to self-hypnotic relaxation as an analgesic adjunct in patients undergoing invasive medical procedures... - Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patientsSusan K Lutgendorf
Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
Brain Behav Immun 22:890-900. 2008.... - Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinomaSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Clin Cancer Res 14:6839-46. 2008..This study examined distress, MMPs, and angiogenic cytokines in ovarian cancer patients and in vitro... - Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approachSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Brain Behav Immun 24:1231-40. 2010..Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known... - Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patientsSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Brain Behav Immun 25:250-5. 2011..As beta-adrenergic signaling is related to key biological pathways involved in tumor growth, these findings may have implications for patient outcomes in ovarian cancer... - Individual differences and immune function: Implications for cancerSusan K Lutgendorf
Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City 52242, USA
Brain Behav Immun 17:S106-8. 2003 - Vascular endothelial growth factor and social support in patients with ovarian carcinomaSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Cancer 95:808-15. 2002..This study examined relationships of social support and depressive symptoms with VEGF levels in preoperative patients with ovarian carcinoma... - Effects of relaxation and stress on the capsaicin-induced local inflammatory responseS Lutgendorf
Department of Psychology, University of Iowa, Iowa City 52242, USA
Psychosom Med 62:524-34. 2000..This study examines the effects of three experimental manipulations: mental stress, relaxation, and control on the local inflammatory response evoked by the intradermal injection of capsaicin, the active ingredient in chili peppers... - Quality of life and mood in women receiving extensive chemotherapy for gynecologic cancerS K Lutgendorf
University of Iowa, Department of Psychology, Iowa City, Iowa 52242, USA
Cancer 89:1402-11. 2000..Quality of life (QOL) and mood were investigated among women who had received intensive chemotherapy for at least 1 year for advanced gynecologic cancers. Relationships of coping styles to QOL and mood in these patients also were examined... - Effects of housing relocation on immunocompetence and psychosocial functioning in older adultsS K Lutgendorf
Department of Psychology, University of Iowa, Iowa City 52242, USA
J Gerontol A Biol Sci Med Sci 56:M97-105. 2001..This research examines effects of voluntary housing relocation on distress and immune function in healthy older adults as a model for studying the effects of moderate life stress... - Illness episodes and cortisol in healthy older adults during a life transitionS K Lutgendorf
Department of Psychology, University of Iowa, Iowa City 52242, USA
Ann Behav Med 23:166-76. 2001..In healthy elders, a temporary life stressor may increase vulnerability to illness but does not.. - Sense of coherence moderates the relationship between life stress and natural killer cell activity in healthy older adultsS K Lutgendorf
Department of Psychology, University of Iowa, Iowa City 52242, USA
Psychol Aging 14:552-63. 1999..These findings are consistent with possible salutogenic contributions of SOC and positive mood to immune function in older adults facing stressful life transitions... - Quality of life and mood in women with gynecologic cancer: a one year prospective studySusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Cancer 94:131-40. 2002..Quality of life (QOL) and mood were prospectively investigated during the first year of treatment among women with gynecologic cancers. Relationships of coping styles to QOL and mood were examined... - Life stress, mood disturbance, and elevated interleukin-6 in healthy older womenS K Lutgendorf
Department of Psychology, University of Iowa, USA
J Gerontol A Biol Sci Med Sci 54:M434-9. 1999..This research cross-sectionally examined levels of IL-6 in three groups of healthy older women with varying levels of life stress and mood disturbance and a healthy group of young women... - Cognitive-behavioral stress management intervention effects on anxiety, 24-hr urinary norepinephrine output, and T-cytotoxic/suppressor cells over time among symptomatic HIV-infected gay menM H Antoni
Department of Psychology, University of Miami, Coral Gables, Florida 33124, USA
J Consult Clin Psychol 68:31-45. 2000..Moreover, greater decreases in NE output and a greater frequency of relaxation home practice during the 10-week CBSM intervention period predicted higher CD3+CD8+ cell counts at follow-up... - Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancerAliza Z Weinrib
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Cancer 116:4410-9. 2010..Here we investigate alterations in diurnal cortisol rhythm in ovarian cancer patients, and potential links with depression, life stress, and functional disability... - Psychosocial factors and interleukin-6 among women with advanced ovarian cancerErin S Costanzo
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Cancer 104:305-13. 2005..Processes involving IL-6 represent possible pathways by which behavioral factors may contribute to disease outcomes among women with ovarian cancer... - Depression, social support, and beta-adrenergic transcription control in human ovarian cancerSusan K Lutgendorf
Department of Psychology, University of Iowa, USA
Brain Behav Immun 23:176-83. 2009..These data show that genome-wide transcriptional profiles are significantly altered in tumors from patients with high behavioral risk profiles, and they identify beta-adrenergic signal transduction as a likely mediator of those effects... - Coping strategies in patients with interstitial cystitis: relationships with quality of life and depressionNan E Rothrock
Departments of Psychology and Urology, University of Iowa, Iowa City, IA, USA
J Urol 169:233-6. 2003..Psychosocial interventions aimed at increasing adaptive coping may positively impact the female experience with interstitial cystitis... - Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell linesSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Clin Cancer Res 9:4514-21. 2003..The goal of this study was to examine possible mechanisms underlying these relationships... - Positive psychosocial factors and NKT cells in ovarian cancer patientsDonald M Lamkin
Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Brain Behav Immun 22:65-73. 2008..Given the anti-tumor activity of CD3+CD56+ cells, these relationships may have relevance for cancer control... - Cancer attributions, distress, and health practices among gynecologic cancer survivorsErin S Costanzo
University of Iowa, Iowa City, Iowa 52242, USA
Psychosom Med 67:972-80. 2005..CONCLUSIONS: Results suggest that stronger attributions are associated with greater distress, but engaging in behavior believed to be important in preventing cancer or recurrence may ameliorate this distress... - Coping and quality of life among women extensively treated for gynecologic cancerErin S Costanzo
University of Iowa, Iowa City, IA 52242, USA
Psychooncology 15:132-42. 2006.... - Quality of life as an outcome measure in gynecologic malignanciesB Anderson
Department of Obstetrics an Gynecology, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Curr Opin Obstet Gynecol 12:21-6. 2000..Another area of investigation seeks to define the types of stress and coping mechanisms being used in order to identify predictors of psychologic distress... - The influence of bio-behavioural factors on tumour biology: pathways and mechanismsMichael H Antoni
Department of Psychology, Sylvestor Cancer Center, University of Miami, P.O. Box 248185, Coral Gables, Florida 33124, USA
Nat Rev Cancer 6:240-8. 2006.... - The neuroendocrine impact of chronic stress on cancerPremal H Thaker
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
Cell Cycle 6:430-3. 2007..In this review, we highlight the importance of the neuroendocrine stress response in tumor biology and discuss mechanisms by which the beta-adrenergic receptors on ovarian cancer cells enhance angiogenesis and tumor growth... - Diurnal cortisol variations and symptoms in patients with interstitial cystitisSusan K Lutgendorf
Department of Psychology, University of Iowa, Iowa City, Iowa, USA
J Urol 167:1338-43. 2002..These findings may have treatment implications for patients with interstitial cystitis who have early morning cortisol deficiencies... - Interleukin-6, histamine, and methylhistamine as diagnostic markers for interstitial cystitisLeah M Lamale
Department of Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA
Urology 68:702-6. 2006..A combination of methylhistamine and IL-6 could be used as a sensitive and specific marker for interstitial cystitis... - The assessment and validity of stress-related growth in a community-based sampleAliza Z Weinrib
Department of Psychology, University of Iowa, Iowa City, IA 52242, US
J Consult Clin Psychol 74:851-8. 2006..Higher PTGI scores were associated with greater positive mood and greater depth of processing in the essays. These findings support the validity of stress-related growth as a construct and its assessment via questionnaire... - Depressive symptoms and quality of life in patients with interstitial cystitisNan E Rothrock
Departments of Psychology and Urology, University of Iowa, Iowa City, USA
J Urol 167:1763-7. 2002..CONCLUSIONS: A diagnosis of interstitial cystitis is related to poorer functioning in various life domains. Decrements increase with disease severity... - Concealment of homosexual identity, social support and CD4 cell count among HIV-seropositive gay menPhilip M Ullrich
Department of Psychology, University of Iowa, E-11 Seashore Hall, Iowa City 52242, USA
J Psychosom Res 54:205-12. 2003..In addition, the benefits of being open about homosexuality may be most evident under conditions of greater social support... - Journaling about stressful events: effects of cognitive processing and emotional expressionPhilip M Ullrich
Department of Psychology, University of Iowa, Iowa City 52242, USA
Ann Behav Med 24:244-50. 2002..Writers focusing on emotions alone reported more severe illness symptoms during the study than those in other conditions. This effect appeared to be mediated by a greater focus on negative emotional expression during writing... - Mood and cytokine response to influenza virus in older adultsErin S Costanzo
University of Iowa, Iowa City, IA 52242, USA
J Gerontol A Biol Sci Med Sci 59:1328-33. 2004..CONCLUSIONS: These findings suggest that among older adults, even mild to moderate mood disturbance is associated with an attenuated cellular immune response to live influenza virus and vaccine... - Cancer fear and mood disturbance after radical prostatectomy: consequences of biochemical evidence of recurrencePhilip M Ullrich
Department of Psychology, University of Iowa, Iowa City, 52242, USA
J Urol 169:1449-52. 2003..Urinary symptoms may be an important contributor to psychological distress in patients with prostate cancer who have biochemical recurrence... - Glucose as a prognostic factor in ovarian carcinomaDonald M Lamkin
Department of Psychology, University of Iowa, Iowa City, Iowa 52252, USA
Cancer 115:1021-7. 2009..This study tested the hypothesis that higher presurgical glucose levels predict shorter disease-specific survival time and time to recurrence in ovarian cancer patients... - Symptoms and cystoscopic findings in patients with untreated interstitial cystitisLeah M Lamale
Department of Urology, University of Iowa, Iowa City, Iowa 52242-1089, USA
Urology 67:242-5. 2006.... - Anorectal dysfunction after surgical treatment for cervical cancerAnil K Sood
Department of Obstetrics and Gynecology, and University of Iowa Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, USA
J Am Coll Surg 195:513-9. 2002..02). CONCLUSIONS: Bowel dysfunction is common after radical hysterectomy. Many women exhibit manometric and subjective changes compatible with fecal incontinence... - Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanismMonique B Nilsson
Department of Cancer Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:29919-26. 2007..These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression... - HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinomaLiz Y Han
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, 1155 Herman Pressler, CPB6 3244, Unit 1362, Houston, TX 77030, USA
Clin Cancer Res 14:3372-9. 2008..The purpose of this study is to determine the clinical significance of APM component down-regulation and tumor-infiltrating T cells in ovarian carcinoma... - Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancerCharles N Landen
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
Cancer Res 67:10389-96. 2007.... - Physiologic reactivity to a laboratory stress task among men with benign prostatic hyperplasiaPhilip M Ullrich
Department of Rehabilitation Medicine, University of Washington School of Medicine, Seattle, Washington, USA
Urology 70:487-91; discussion 491-2. 2007..The objective of this study was to examine the associations between psychological stress reactivity and BPH disease parameters... - Effect of interleukin-8 gene silencing with liposome-encapsulated small interfering RNA on ovarian cancer cell growthWilliam M Merritt
Department of Gynecologic Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
J Natl Cancer Inst 100:359-72. 2008..Interleukin-8 (IL-8) is a proangiogenic cytokine that is overexpressed in many human cancers. We investigated the clinical and biologic significance of IL-8 in ovarian carcinoma using human samples and orthotopic mouse models... - Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinomaPremal H Thaker
Department of Gynecologic Oncology, University of Texas (U.T.) M.D. Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, Texas 77030, USA
Nat Med 12:939-44. 2006..These data also suggest that blocking ADRB-mediated angiogenesis could have therapeutic implications for the management of ovarian cancer... - Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathwayYvonne G Lin
Department of Gynecologic Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Clin Cancer Res 13:3423-30. 2007..This study evaluates the effects of curcumin on ovarian cancer growth using an orthotopic murine model of ovarian cancer... - Focal adhesion kinase targeting using in vivo short interfering RNA delivery in neutral liposomes for ovarian carcinoma therapyJyotsnabaran Halder
Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
Clin Cancer Res 12:4916-24. 2006..CONCLUSIONS: Taken together, these findings suggest that FAK siRNA-DOPC plus docetaxel or platinum might be a novel therapeutic approach against ovarian cancer... - Focal adhesion kinase silencing augments docetaxel-mediated apoptosis in ovarian cancer cellsJyotsnabaran Halder
Department of Gynecologic Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 11:8829-36. 2005..FAK silencing promotes the in vitro efficacy of docetaxel in both taxane-sensitive and taxane-resistant cell lines and may serve as a novel therapeutic approach... - Stress, hostility, and disease parameters of benign prostatic hyperplasiaPhilip M Ullrich
Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA
Psychosom Med 67:476-82. 2005..Associations between psychological stress and prostate function have not been directly examined. The objective of this study was to examine associations among stress, hostility, and BPH disease parameters... - Central and peripheral mechanisms in interstitial symptomsSusan K Lutgendorf
J Urol 173:682. 2005
Research Grants
- Healing Touch and Immunity in Advanced Cervical CancerSusan Lutgendorf; Fiscal Year: 2002....
- Biobehavioral-Cytokine Interactions in Ovarian CancerSusan Lutgendorf; Fiscal Year: 2007..Findings will have implications for innovative behavioral and pharmacological intervention strategies for ovarian cancer patients. ..
- Biobehavioral-Cytokine Interactions:Ovarian Cancer(RMI)Susan Lutgendorf; Fiscal Year: 2004..Thus the measurement model we are proposing is highly innovative and could enhance methodology in biobehavioral studies in cancer control. ..
- Healing Touch, Immunity, and Fatigue in Breast CancerSusan Lutgendorf; Fiscal Year: 2004....
- Biobehavioral Influences and the Ovarian Tumor MicroenvironmentSusan K Lutgendorf; Fiscal Year: 2010..A clearer understanding of biobehavioral risk factors and pathways by which they operate is critical for identifying targets for psychosocial and pharmacological intervention for ovarian cancer patients who may be at risk. ..