R H Lustig

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Radiation dose-volume effects on growth hormone secretion
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 52:1264-70. 2002
  2. ncbi request reprint The 'skinny' on childhood obesity: how our western environment starves kids' brains
    Robert H Lustig
    Division of Endocrinology, University of California at San Francisco Center for Obesity Assessment, Study and Ttreatment, 94143 0434, USA
    Pediatr Ann 35:898-902, 905-7. 2006
  3. doi request reprint Fructose: metabolic, hedonic, and societal parallels with ethanol
    Robert H Lustig
    Division of Endocrinology, University of California, San Francisco, CA 94143 0434, USA
    J Am Diet Assoc 110:1307-21. 2010
  4. pmc Fructose: it's "alcohol without the buzz"
    Robert H Lustig
    Department of Pediatrics and the Philip R Lee Institute for Health Policy Studies, University of California, San Francisco, CA, USA
    Adv Nutr 4:226-35. 2013
  5. pmc Toward a unifying hypothesis of metabolic syndrome
    Andrew A Bremer
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pediatrics 129:557-70. 2012
  6. pmc Macronutrient intakes and cardio metabolic risk factors in high BMI African American children
    Sushma Sharma
    The Dr Robert C and Veronica Atkins Center for Weight and Health, University of California, Berkeley, CA 94720 3100, USA
    Nutr Metab (Lond) 6:41. 2009
  7. pmc Carbohydrate intake and cardiometabolic risk factors in high BMI African American children
    Sushma Sharma
    The Dr Robert C and Veronica Atkins Center for Weight and Health, University of California, Berkeley, CA 94720 3104, USA
    Nutr Metab (Lond) 7:10. 2010
  8. pmc Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal
    Anthony Accurso
    State University of New York Downstate Medical Center, Brooklyn, New York, USA
    Nutr Metab (Lond) 5:9. 2008
  9. pmc Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children
    Robert H Lustig
    Division of Pediatric Endocrinology, Department of Pediatrics, University of California, San Francisco, USA
    J Pediatr 148:23-9. 2006
  10. pmc A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
    R H Lustig
    Division of Pediatric Endocrinology, University of California San Francisco School of Medicine, San Francisco, CA 94143 0434, USA
    Int J Obes (Lond) 30:331-41. 2006

Detail Information

Publications52

  1. ncbi request reprint Radiation dose-volume effects on growth hormone secretion
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 52:1264-70. 2002
    ..Conformal radiotherapy (CRT) techniques allow for a more accurate determination of hypothalamic dosimetry. We correlated the dosimetry of the hypothalamus and the peak GH value after CRT in children with localized primary brain tumors...
  2. ncbi request reprint The 'skinny' on childhood obesity: how our western environment starves kids' brains
    Robert H Lustig
    Division of Endocrinology, University of California at San Francisco Center for Obesity Assessment, Study and Ttreatment, 94143 0434, USA
    Pediatr Ann 35:898-902, 905-7. 2006
    ..This will require a grassroots, bottom-up effort on the part of parents and community leaders. We as pediatricians must lead the way...
  3. doi request reprint Fructose: metabolic, hedonic, and societal parallels with ethanol
    Robert H Lustig
    Division of Endocrinology, University of California, San Francisco, CA 94143 0434, USA
    J Am Diet Assoc 110:1307-21. 2010
    ..On a societal level, the treatment of fructose as a commodity exhibits market similarities to ethanol. Analogous to ethanol, societal efforts to reduce fructose consumption will likely be necessary to combat the obesity epidemic...
  4. pmc Fructose: it's "alcohol without the buzz"
    Robert H Lustig
    Department of Pediatrics and the Philip R Lee Institute for Health Policy Studies, University of California, San Francisco, CA, USA
    Adv Nutr 4:226-35. 2013
    ..These metabolic and hedonic analogies argue that fructose should be thought of as "alcohol without the buzz."..
  5. pmc Toward a unifying hypothesis of metabolic syndrome
    Andrew A Bremer
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Pediatrics 129:557-70. 2012
    ....
  6. pmc Macronutrient intakes and cardio metabolic risk factors in high BMI African American children
    Sushma Sharma
    The Dr Robert C and Veronica Atkins Center for Weight and Health, University of California, Berkeley, CA 94720 3100, USA
    Nutr Metab (Lond) 6:41. 2009
    ..abstract:..
  7. pmc Carbohydrate intake and cardiometabolic risk factors in high BMI African American children
    Sushma Sharma
    The Dr Robert C and Veronica Atkins Center for Weight and Health, University of California, Berkeley, CA 94720 3104, USA
    Nutr Metab (Lond) 7:10. 2010
    ..This analysis suggests that increases in carbohydrate energy, especially in the form of sugar, may be detrimental to cardiometabolic health in high BMI children...
  8. pmc Dietary carbohydrate restriction in type 2 diabetes mellitus and metabolic syndrome: time for a critical appraisal
    Anthony Accurso
    State University of New York Downstate Medical Center, Brooklyn, New York, USA
    Nutr Metab (Lond) 5:9. 2008
    ..These beneficial effects of carbohydrate restriction do not require weight loss. Finally, the point is reiterated that carbohydrate restriction improves all of the features of metabolic syndrome...
  9. pmc Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children
    Robert H Lustig
    Division of Pediatric Endocrinology, Department of Pediatrics, University of California, San Francisco, USA
    J Pediatr 148:23-9. 2006
    ....
  10. pmc A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion
    R H Lustig
    Division of Pediatric Endocrinology, University of California San Francisco School of Medicine, San Francisco, CA 94143 0434, USA
    Int J Obes (Lond) 30:331-41. 2006
    ....
  11. ncbi request reprint Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial
    Robert H Lustig
    Department of Endocrinology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Endocrinol Metab 88:2586-92. 2003
    ..Octreotide suppressed insulin, and stabilized weight and BMI. Improved quality of life correlated with the degree of insulin suppression. Octreotide was safe and well tolerated...
  12. ncbi request reprint Obesity, leptin resistance, and the effects of insulin reduction
    R H Lustig
    Department of Pediatrics, University of California, San Francisco, CA 94143 0434, USA
    Int J Obes Relat Metab Disord 28:1344-8. 2004
    ..They also support the possibilities that hyperinsulinemia may be a proximate cause of leptin resistance, and that reduction of insulinemia may promote weight loss by improving leptin sensitivity...
  13. ncbi request reprint Optimizing growth hormone efficacy: an evidence-based analysis
    Robert H Lustig
    Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, CA 94143 0434, USA
    Horm Res 62:93-7. 2004
    ..e. increments in IGF-I level have not been shown to correlate with increments in height velocity. Thus, these issues with respect to achievement of final height are far from solved...
  14. ncbi request reprint Autonomic dysfunction of the beta-cell and the pathogenesis of obesity
    Robert H Lustig
    Division of Endocrinology, University of California, San Francisco, CA 94143 0136, USA
    Rev Endocr Metab Disord 4:23-32. 2003
  15. ncbi request reprint Childhood obesity: behavioral aberration or biochemical drive? Reinterpreting the First Law of Thermodynamics
    Robert H Lustig
    Division of Endocrinology, University of California San Francisco, San Francisco, CA 94143 0434, USA
    Nat Clin Pract Endocrinol Metab 2:447-58. 2006
    ..This weight gain is driven by the hyperinsulinemic state, through three mechanisms: energy partitioning into adipose tissue; interference with leptin signal transduction; and interference with extinction of the hedonic response to food...
  16. ncbi request reprint Risk factors for the development of obesity in children surviving brain tumors
    Robert H Lustig
    Departments of Endocrinology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Endocrinol Metab 88:611-6. 2003
    ....
  17. ncbi request reprint Hypothalamic obesity: causes, consequences, treatment
    Robert H Lustig
    Division of Endocrinology, University of California San Francisco, CA 94143 0434, USA
    Pediatr Endocrinol Rev 6:220-7. 2008
    ..Recently, bariatric surgery (Roux-en-Y gastric bypass, laparoscopic gastric banding, vagotomy) have also been attempted with variable results. Early and intensive management is required to stave off the obesity and its consequences...
  18. ncbi request reprint The neuroendocrinology of obesity
    R H Lustig
    Division of Endocrinology, Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA
    Endocrinol Metab Clin North Am 30:765-85. 2001
    ..As the nosology of obesity improves, diagnostic efficiency and therapeutic success should increase, leading to a decrease in associated morbidity, mortality, and socioeconomic ramifications...
  19. pmc Race affects insulin and GLP-1 secretion and response to a long-acting somatostatin analogue in obese adults
    P A Velasquez-Mieyer
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Int J Obes Relat Metab Disord 28:330-3. 2004
    ....
  20. pmc Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects
    P A Velasquez-Mieyer
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA
    Int J Obes Relat Metab Disord 27:1359-64. 2003
    ..The increased GLP-1 concentration could explain the greater insulin concentration and the increased prevalence of hyperinsulinemia-associated disorders including obesity and type 2 diabetes in AAs...
  21. pmc Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults
    P A Velasquez-Mieyer
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, USA
    Int J Obes Relat Metab Disord 27:219-26. 2003
    ..We investigated whether suppression of insulin secretion, without dietary or exercise intervention, could promote weight loss and alter food intake and preference in obese adults...
  22. ncbi request reprint Diagnosis of hidden central hypothyroidism in survivors of childhood cancer
    S R Rose
    University of Tennessee, St Jude Children s Research Hospital, and Methodist LeBonheur Children s Medical Center, Memphis 38103, USA
    J Clin Endocrinol Metab 84:4472-9. 1999
    ..Both TSH surge and response to TRH must be evaluated to identify all of these patients...
  23. ncbi request reprint The neuroendocrinology of childhood obesity
    R H Lustig
    Division of Endocrinology and Metabolism, Departments of Pediatrics and Anatomy and Neurobiology, University of Tennessee Health Science Center and St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Pediatr Clin North Am 48:909-30. 2001
    ..As the nosology of obesity improves, pediatricians will be able to increase the diagnostic efficiency and therapeutic success of this unfortunate, debilitating, and expensive epidemic...
  24. doi request reprint Racial disparity in glucagon-like peptide 1 and inflammation markers among severely obese adolescents
    Pedro A Velasquez-Mieyer
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Diabetes Care 31:770-5. 2008
    ....
  25. pmc Sugar-sweetened beverages, serum uric acid, and blood pressure in adolescents
    Stephanie Nguyen
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    J Pediatr 154:807-13. 2009
    ..To evaluate whether sugar-sweetened beverage consumption, a significant source of dietary fructose, is associated with higher serum uric acid levels and blood pressure in adolescents...
  26. ncbi request reprint Television viewing and hypertension in obese children
    Perrie E Pardee
    Department of Pediatrics, School of Medicine, University of California, Rady Children s Hospital and Health Center, San Diego 92103 845, USA
    Am J Prev Med 33:439-43. 2007
    ..However, the association between TV viewing and hypertension in children is unknown. This study aimed to identify whether TV watching is associated with hypertension in obese children...
  27. ncbi request reprint Childhood obesity: adrift in the "limbic triangle"
    Michele L Mietus-Snyder
    Department of Pediatrics, University of California, San Francisco, California 94143, USA
    Annu Rev Med 59:147-62. 2008
    ..quot; Integrated multidisciplinary family- and community-based education, effective stress reduction, and a societal commitment to alter the food and built environments are all necessary components to battle the global obesity epidemic...
  28. ncbi request reprint Pituitary development and physiology
    CLEMENT C CHEUNG
    Department of Pediatrics, University of California, San Francisco, CA 94142, USA
    Pituitary 10:335-50. 2007
    ..This review concludes with a discussion of several of these genes and the genetic disorders with which they are associated...
  29. pmc Efficacy of a child-centred and family-based program in promoting healthy weight and healthy behaviors in Chinese American children: a randomized controlled study
    Jyu Lin Chen
    Department of Family Health Care Nursing, University of California, San Francisco, CA, USA
    J Public Health (Oxf) 32:219-29. 2010
    ..To examine the efficacy of an interactive, child-centred and family-based program in promoting healthy weight and healthy lifestyles in Chinese American children...
  30. pmc A clinic-based lifestyle intervention for pediatric obesity: efficacy and behavioral and biochemical predictors of response
    Kristine A Madsen
    Department Pediatrics, University of California, San Francisco, CA 94118, USA
    J Pediatr Endocrinol Metab 22:805-14. 2009
    ..To examine efficacy and predictors of response to a lifestyle intervention for obese youth...
  31. ncbi request reprint Pediatric endocrine disorders of energy balance
    Robert H Lustig
    Division of Endocrinology, University of California San Francisco, 94143, USA
    Rev Endocr Metab Disord 6:245-60. 2005
  32. ncbi request reprint Insulin resistance is improved in overweight African American boys but not in girls following a one-year multidisciplinary community intervention program
    Aarthi Raman
    The Dr Robert C and Veronica Atkins Center for Weight and Health, University of California, Berkeley, CA, USA
    J Pediatr Endocrinol Metab 23:109-20. 2010
    ..To assess potential for effectiveness, in a non-randomized pilot study, of a community-based lifestyle intervention program to reduce the risk for type 2 diabetes mellitus in overweight African American (AA) children...
  33. pmc The Active Balance Childhood program for improving coping and quality of life in Chinese American children
    Jyu Lin Chen
    Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
    Nurs Res 59:270-9. 2010
    ..However, few studies have examined whether an intervention that teaches coping strategies in weight management can influence children's coping behavior and psychosocial well-being...
  34. ncbi request reprint Racial and etiopathologic dichotomies in insulin hypersecretion and resistance in obese children
    Chaluntorn Preeyasombat
    Department of Pediatrics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0434, USA
    J Pediatr 146:474-81. 2005
    ..To assess insulin dynamics to oral glucose tolerance testing in obese children, denoting individual contributions of insulin hypersecretion versus resistance to racial and etiopathogenetic specificity...
  35. doi request reprint Adolescent obesity and puberty: the "perfect storm"
    Carolyn Bradner Jasik
    Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0503, USA
    Ann N Y Acad Sci 1135:265-79. 2008
    ..Therefore, intervening prior to pubertal onset becomes even more important given the risk factors present once puberty begins...
  36. doi request reprint Baseline correlates of insulin resistance in inner city high-BMI African-American children
    Aarthi Raman
    Center for Weight and Health, University of California, Berkeley, California, USA
    Obesity (Silver Spring) 16:2039-45. 2008
    ..044) had higher insulin resistance. WC and selected self-esteem parameters predicted insulin resistance in high-BMI AA children. The risk of T2DM may be reduced in these children by targeting these factors...
  37. doi request reprint Socioeconomic status in relation to early menarche among black and white girls
    Dejana Braithwaite
    Department of Epidemiology and Biostatistics, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, 185 Berry Street, Lobby 4 Suite 5700, San Francisco, CA 94107, USA
    Cancer Causes Control 20:713-20. 2009
    ..Early menarche is a risk factor for breast cancer. We investigated the variation in age at menarche by socioeconomic status (SES) and race...
  38. ncbi request reprint Fast food, central nervous system insulin resistance, and obesity
    Elvira Isganaitis
    Department of Pediatrics, University of California, San Francisco, CA 94143 0434, USA
    Arterioscler Thromb Vasc Biol 25:2451-62. 2005
    ..Finally, we analyze the characteristics of fast food, including high-energy density, high fat, high fructose, low fiber, and low dairy intake, which favor the development of CNS insulin resistance and obesity...
  39. ncbi request reprint Diagnosis of ACTH deficiency. Comparison of overnight metyrapone test to either low-dose or high-dose ACTH test
    S R Rose
    Department of Pediatrics, University of Tennessee, Memphis and Methodist LeBonheur Children s Medical Center, Memphis, TN, USA
    Horm Res 52:73-9. 1999
    ..In contrast, the low dose ACTH test accurately diagnoses 90% of patients with ACTH deficiency (100% sensitivity, 68% specificity). The low-dose ACTH test can serve as an accurate and practical screening test for adequacy of ACTH reserve...
  40. pmc Late effects of conformal radiation therapy for pediatric patients with low-grade glioma: prospective evaluation of cognitive, endocrine, and hearing deficits
    Thomas E Merchant
    Department of Radiological Sciences, St Jude Children s Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105 3678, USA
    J Clin Oncol 27:3691-7. 2009
    ..We conducted a prospective trial to evaluate late effects in pediatric patients with low-grade glioma (LGG) treated with conformal radiation therapy (CRT)...
  41. ncbi request reprint Accuracy of self-assessed Tanner staging against hormonal assessment of sexual maturation in overweight African-American children
    Aarthi Raman
    The Robert C and Veronica Atkins Center for Weight and Health, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 3104, USA
    J Pediatr Endocrinol Metab 22:609-22. 2009
    ..To evaluate the accuracy of self-reported Tanner (SRT) staging against a proxy method of physician's assessment of sexual maturation, using pubertal hormones in overweight African-American (AA) children...
  42. doi request reprint Bariatric surgery in a patient with complete MC4R deficiency
    I R Aslan
    Division of Endocrinology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    Int J Obes (Lond) 35:457-61. 2011
    ..Our experience with this patient suggests that complete MC4R deficiency impairs response to gastric banding and results in poor weight loss after this surgery...
  43. ncbi request reprint Bone mineral decrements in survivors of childhood acute lymphoblastic leukemia: frequency of occurrence and risk factors for their development
    S C Kaste
    Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN 38105, USA
    Leukemia 15:728-34. 2001
    ..BMD z scores of patients who received higher doses of antimetabolites were lower than those of other patients. Childhood ALL survivors are at risk to have low BMD, especially males, Caucasians, and those who received cranial irradiation...
  44. ncbi request reprint Craniopharyngioma: the St. Jude Children's Research Hospital experience 1984-2001
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105 2794, USA
    Int J Radiat Oncol Biol Phys 53:533-42. 2002
    ..To review our institution's experience in the treatment of craniopharyngioma and assess the merits of initial therapy with limited surgery and irradiation...
  45. ncbi request reprint Preirradiation endocrinopathies in pediatric brain tumor patients determined by dynamic tests of endocrine function
    Thomas E Merchant
    Department of Radiation Oncology, St Jude Children s Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
    Int J Radiat Oncol Biol Phys 54:45-50. 2002
    ..To prospectively evaluate pediatric patients with localized primary brain tumors for evidence of endocrinopathy before radiotherapy (RT)...
  46. doi request reprint Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide
    Andrew A Bremer
    Division of Endocrinology, Department of Pediatrics, University of California Davis Medical Center, Sacramento, CA 95817 2208, USA
    Pediatr Diabetes 9:236-9. 2008
    ..We describe a case of an 18-month-old infant with permanent neonatal diabetes due to an activating KCNJ11 mutation successfully transitioned from subcutaneous insulin therapy to oral sulfonylurea therapy in the outpatient setting...
  47. ncbi request reprint Hypothalamic dysfunction after chemotherapy
    Susan R Rose
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    J Pediatr Endocrinol Metab 17:55-66. 2004
    ....
  48. ncbi request reprint Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma
    Thomas E Merchant
    Department of Biostatistics, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105 2794, USA
    J Clin Oncol 22:3156-62. 2004
    ....
  49. ncbi request reprint Childhood obesity
    Phyllis W Speiser
    Division of Pediatric Endocrinology, Schneider Children s Hospital, 269 01 76th Avenue, New Hyde Park, New York 11040, USA
    J Clin Endocrinol Metab 90:1871-87. 2005
    ..In developing a consensus statement, this international group has presented the evidence, developed recommendations, and provided a platform aimed toward future corrective action and ongoing debate in the international community...
  50. ncbi request reprint Which comes first? The obesity or the insulin? The behavior or the biochemistry?
    Robert H Lustig
    J Pediatr 152:601-2. 2008
  51. ncbi request reprint ACTH deficiency in childhood cancer survivors
    Susan R Rose
    Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Blood Cancer 45:808-13. 2005
    ..Adrenocorticotropin deficiency (ACTHD) can be clinically subtle, but life-threatening if not recognized. We assessed the prevalence of ACTHD in survivors of childhood cancer according to tumor diagnosis/therapy...
  52. ncbi request reprint Use of somatostatin receptor ligands in obesity and diabetic complications
    Bernhard O Boehm
    Division of Endocrinology, Ulm University, Robert Koch Strasse 8, Ulm Donau, 89070, Germany
    Best Pract Res Clin Gastroenterol 16:493-509. 2002
    ..The use of somatostatin analogues addressing the various hormonal imbalances of these disorders may provide a novel concept for their pharmacological treatment...