Research Topics
| Cindy LustigSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The puzzle of schizophrenia: tracking the core role of cognitive deficitsKeith H Nuechterlein
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 300 UCLA Medical Plaza, Los Angeles, CA 90095 6968, USA
Dev Psychopathol 24:529-36. 2012....- The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008.... 
Distinguishing separable domains of cognition in human and animal studies: what separations are optimal for targeting interventions? A summary of recommendations from breakout group 2 at the measurement and treatment research to improve cognition in schizKeith H Nuechterlein
Department of Psychiatry, University of California, Los Angeles, CA 90095, USA
Schizophr Bull 31:870-4. 2005..As part of this process, the group noted several existing animal paradigms that have particular promise as measures in the key cognitive domains in schizophrenia identified by the MATRICS Neurocognition Committee...- Individual placement and support for individuals with recent-onset schizophrenia: integrating supported education and supported employmentKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 6968, USA
Psychiatr Rehabil J 31:340-9. 2008..To describe the adaptation of the Individual Placement and Support model of supported employment to individuals with a recent first episode of schizophrenia or a related psychotic disorder... - Identification of separable cognitive factors in schizophreniaKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
Schizophr Res 72:29-39. 2004..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia... 
CNTRICS final task selection: control of attentionKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behaviour, University of California, LA, CA, USA
Schizophr Bull 35:182-96. 2009....- Neurocognitive predictors of work outcome in recent-onset schizophreniaKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
Schizophr Bull 37:S33-40. 2011..Cognitive remediation and other interventions targeting these early cognitive deficits are of major importance to attempts to prevent chronic disability... - Classifying episodes in schizophrenia and bipolar disorder: criteria for relapse and remission applied to recent-onset samplesKeith H Nuechterlein
UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2251, Los Angeles, CA 90095 6968, United States
Psychiatry Res 144:153-66. 2006.... - The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family StudyKeith H Nuechterlein
UCLA Department of Psychiatry and Biobehavioral Sciences, 300 UCLA Medical Plaza, Room 2240, Los Angeles, CA 90095 6968, USA
Schizophr Res 54:121-30. 2002.... - Translating basic attentional paradigms to schizophrenia research: reconsidering the nature of the deficitsKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90095 6968, USA
Dev Psychopathol 18:831-51. 2006..These refined paradigms should substantially increase our understanding of the specific forms of attentional impairment characterizing schizophrenia and their connections to symptom development and functional outcome... - CNTRICS final biomarker selection: Control of attentionSteven J Luck
Center for Mind and Brain, University of California, 267 Cousteau Place, Davis, CA 95618, USA
Schizophr Bull 38:53-61. 2012.... - Modality differences in timing and temporal memory throughout the lifespanCindy Lustig
Department of Psychology, University of Michigan, Ann Arbor, MI, USA
Brain Cogn 77:298-303. 2011.... - Age differences in deactivation: a link to cognitive control?Jonas Persson
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1109, USA
J Cogn Neurosci 19:1021-32. 2007..Demand-related changes in deactivation magnitude correlated with performance changes, suggesting that individual and group differences in deactivation have functional significance... - Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learningKarin Foerde
Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
Neuropsychology 22:100-9. 2008..In contrast, patients were not impaired at learning on the SRT relative to controls, suggesting that patients with schizophrenia may have dysfunction in a specific corticostriatal subcircuit... - Disruption of large-scale brain systems in advanced agingJessica R Andrews-Hanna
Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
Neuron 56:924-35. 2007..These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition... - Social perception as a mediator of the influence of early visual processing on functional status in schizophreniaMark J Sergi
Department of Psychology, California State University, Northridge, CA 91330 8255, USA
Am J Psychiatry 163:448-54. 2006..The authors used structural equation modeling to test more directly whether one aspect of social cognition (social perception) mediates relations between basic visual perception and functional status in patients with schizophrenia... - A prospective study of childhood neurocognitive functioning in schizophrenic patients and their siblingsTara A Niendam
Department of Psychology, University of California-Los Angeles, Los Angeles, CA 90095, USA
Am J Psychiatry 160:2060-2. 2003..However, the probands exhibited more severe deficits in perceptual-motor speed and speeded processes of working memory than their unaffected siblings... - Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010.... - The Consortium on the Genetics of Schizophrenia: neurocognitive endophenotypesRaquel E Gur
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:49-68. 2007.... - Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophreniaKatherine H Karlsgodt
Department of Psychology, UCLA, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 108:143-50. 2009.... - Relatives' affective style and the expression of subclinical psychopathology in patients with schizophreniaStephanie M Woo
Pepperdine University Graduate School of Education and Psychology, Los Angeles, CA 90045, USA
Fam Process 43:233-47. 2004..These findings support a complex, bidirectional model of the role of high EE attitudes in influencing the course of schizophrenia... - Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes... - Evidence for frontally mediated controlled processing differences in older adultsKaterina Velanova
Department of Psychology, Washington University, St Louis, MO 63130, USA
Cereb Cortex 17:1033-46. 2007.... - Targeting latent function: encouraging effective encoding for successful memory training and transferCindy Lustig
Department of Psychology, University of Michigan, Ann Arbor, MI 48109 1043, USA
Psychol Aging 23:754-64. 2008..Training programs that target participants' latent but inefficiently used abilities while allowing flexibility in bringing those abilities to bear may best promote effective training and transfer... - Alterations in functional activation in euthymic bipolar disorder and schizophrenia during a working memory taskLiberty S Hamilton
Laboratory of Neuro Imaging, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 7334, USA
Hum Brain Mapp 30:3958-69. 2009..Both patient groups showed some regional task-related hypoactivation compared to controls across the brain. Within DLPFC specifically, patients with schizophrenia exhibited more severe WM-related dysfunction than bipolar subjects... - Development of a measure of relationship perception in schizophreniaMark J Sergi
Department of Psychology, California State University, Northridge, CA 91330 8255, USA
Psychiatry Res 166:54-62. 2009..The schizophrenia patients' performance on the RAD was moderately related to reading ability and several domains of community functioning... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - Effects of cigarette smoking on prepulse inhibition, its attentional modulation, and vigilance performanceAnthony J Rissling
Department of Psychology, University of Southern California, Los Angeles, California 90089 1061, USA
Psychophysiology 44:627-34. 2007..Abstinence among smokers produced reliably lower vigilance performance compared to ad lib smoking. The results indicate that smoking abstinence affects the early stages of stimulus processing... - Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia InitiativeCameron S Carter
Department of Psychiatry, University of California, Davis, CA 95817, USA
Biol Psychiatry 64:4-10. 2008..The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts... - Electrophysiological analysis of error monitoring in schizophreniaSarah E Morris
Department of Psychology, University of California, Los Angeles, CA, USA
J Abnorm Psychol 115:239-50. 2006..Thus, ERN generation appears to be abnormal in schizophrenia patients even under conditions demonstrated to maximize ERN amplitude; however, functional characteristics of the ERN appear to be intact... - Enhanced control of attention by stimulating mesolimbic-corticopetal cholinergic circuitryMegan St Peters
Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109 8862, USA
J Neurosci 31:9760-71. 2011..Mesolimbic activation of cholinergic projections to the cortex benefits the cognitive control of attentional performance by enhancing the detection of cues and the filtering of distractors... - Impaired implicit learning in schizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
Neuropsychology 22:606-17. 2008..Discussion focuses on possible explanations for schizophrenia patients' poor probabilistic classification task performance... - Exploring the short term visual store in schizophrenia using the attentional blinkJonathan K Wynn
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, United States
J Psychiatr Res 40:599-605. 2006..The findings suggest that the enhanced AB effect in schizophrenia reflects an abnormality in their short term visual memory, as opposed to their enhanced susceptibility to visual masking... - Does anhedonia in schizophrenia reflect faulty memory for subjectively experienced emotions?William P Horan
Aftercare Research Program, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095, USA
J Abnorm Psychol 115:496-508. 2006..In-the-moment pleasure and short-term retention for emotional experiences thus appear to be relatively intact in schizophrenia. Alternative explanations for the hedonic deficit in this disorder are discussed... - Increased extent of object-selective cortex in schizophreniaJonathan K Wynn
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA
Psychiatry Res 164:97-105. 2008..The findings of abnormal spatial organization of LO in schizophrenia patients may converge with behavioral evidence of deficits in schizophrenia patients for object-recognition tasks that are believed to be mediated by LO activity... - The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment... - Stability of visual masking performance in recent-onset schizophrenia: an 18-month longitudinal studyJunghee Lee
Semel Institute for Neuroscience and Human Behavior at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States
Schizophr Res 103:266-74. 2008..Furthermore, the stable performance was observed across all four masking conditions. The findings of this study provide further support for the view that visual masking deficits reflect a possible vulnerability marker for schizophrenia... - Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008.... - Probing attentional dysfunctions in schizophrenia: Startle modification during a continuous performance testErin A Hazlett
Department of Psychiatry, Box 1505, The Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029, USA
Psychophysiology 45:632-42. 2008..Both groups also showed equal inhibition at 120 ms during passively attended prepulses, suggesting that automatic attentional processes were not impaired in these patients... - The validity of Psychosis Proneness Scales as vulnerability indicators in recent-onset schizophrenia patientsWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Schizophr Res 100:224-36. 2008..The longitudinal characteristics of these scales in people who are actually diagnosed with schizophrenia provide key evidence for the validity of three commonly used psychometric indicators of vulnerability to psychosis... - Differential effects of typical and atypical antipsychotics on brain myelination in schizophreniaGeorge Bartzokis
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
Schizophr Res 93:13-22. 2007..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia... - Mean diffusivity: a biomarker for CSF-related disease and genetic liability effects in schizophreniaKatherine L Narr
Laboratory of Neuro Imaging, Geffen School of Medicine, UCLA, Los Angeles, CA, USA
Psychiatry Res 171:20-32. 2009.... - The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardizationRobert S Kern
Department of Psychology, Geffen School of Medicine, University of California, Los Angeles CA 90073, USA
Am J Psychiatry 165:214-20. 2008..S. community sample with the battery administered as a unit... - Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization StudyMichael F Green
Semel Institute for Neuroscience and Human Behavior, UCLA, 300 Medical Plaza, Rm 2263, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:221-8. 2008..e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to evaluate four potential co-primary measures for psychometric properties and validity... - Neurocognitive and social cognitive correlates of formal thought disorder in schizophrenia patientsKenneth L Subotnik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 90095 6968, USA
Schizophr Res 85:84-95. 2006..This pattern of findings is consistent with the view that neurocognitive and, possibly, social cognitive deficits underlie these two aspects of formal thinking disturbance in schizophrenia... - Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling TaskBrett Shurman
University of California Los Angeles, Neuropsychiatric Institute 300 UCLA Medical Plaza, Los Angeles, CA 90095-6968, USA
Schizophr Res 72:215-24. 2005..Results suggest that individuals with schizophrenia display a pattern of compromised decision-making that is somewhat distinct from that found in OFC lesion patients and that may be linked to certain clinical symptoms... - NIMH-MATRICS survey on assessment of neurocognition in schizophreniaRobert S Kern
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, California, USA
Schizophr Res 72:11-9. 2004..This article presents the results of the pre-conference survey that was the first step in the RAND process towards development of the NIMH-MATRICS consensus battery to assess cognition in schizophrenia... - The contributions of disease and genetic factors towards regional cortical thinning in schizophrenia: the UCLA family studyYaling Yang
Laboratory of Neuro Imaging, Geffen School of Medicine at UCLA, Los Angeles, CA 90024, United States
Schizophr Res 123:116-25. 2010..However, it remains unclear whether regional variations in cortical thickness may be attributable to disease-related or genetic-liability factors... - Paracontrast and metacontrast in schizophrenia: clarifying the mechanism for visual masking deficitsYuri Rassovsky
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
Schizophr Res 71:485-92. 2004..These results bolster previous conclusions that schizophrenic patients show deficits on visual masking tasks even when masking on those tasks occurs entirely through the interruption mechanism... - Self-efficacy and neurocognition may be related to coping responses in recent-onset schizophreniaJoseph Ventura
UCLA, Department of Psychiatry and Biobehavioral Sciences, 300 Medical Plaza, Room 2243, Los Angeles, CA 90095 6968, USA
Schizophr Res 69:343-52. 2004..42, p < 0.05). Multiple regression indicated that self-efficacy and sustained attention accounted for 56% of the variance in the use of problem-focused coping, strategies by schizophrenia patients... - The timing of negative symptom exacerbations in relationship to positive symptom exacerbations in the early course of schizophreniaJoseph Ventura
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 300 UCLA Medical Plaza, Room 2243, Los Angeles, CA 90095 6968, USA
Schizophr Res 69:333-42. 2004..Results suggest that the timing of some negative symptom exacerbations is linked to that of positive symptom exacerbations during the early course of schizophrenia... - Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteriaMichael F Green
Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Biol Psychiatry 56:301-7. 2004..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia... - Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's diseaseGeorge Bartzokis
Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
Neurobiol Aging 25:843-51. 2004..In AD this process is globally exacerbated, consistent with an extracellular deleterious process such as amyloid beta-peptide toxicity. Non-invasive measures such as R2 may be useful in primary prevention studies of AD... - Functional neuroanatomy of visual masking deficits in schizophreniaMichael F Green
Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA 90095 6968, USA
Arch Gen Psychiatry 66:1295-303. 2009..Patients with schizophrenia reliably show deficits on visual masking, and these procedures have been used to explore vulnerability to schizophrenia, probe underlying neural circuits, and help explain functional outcome... - Validity of the family history method for diagnosing schizophrenia, schizophrenia-related psychoses, and schizophrenia-spectrum personality disorders in first-degree relatives of schizophrenia probandsDavid L Fogelson
UCLA Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
Schizophr Res 68:309-17. 2004..576). Using the family history method, the validity of making schizophrenia-related personality disorder diagnoses was comparable to that of making psychotic disorder diagnoses... - MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHDKenneth L Subotnik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
Behav Genet 35:159-75. 2005.... - Are communication deviance and expressed emotion related to family history of psychiatric disorders in schizophrenia?Kenneth L Subotnik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90095 6968, USA
Schizophr Bull 28:719-29. 2002..The findings are consistent with the possibility that CD may be an indicator of a genetic vulnerability factor for schizophrenia... - The Cognitive Assessment Interview (CAI): development and validation of an empirically derived, brief interview-based measure of cognitionJoseph Ventura
Semel Institute for Neuroscience and Human Behavior, Geffen School of Medicine at UCLA, United States
Schizophr Res 121:24-31. 2010.... - Regional brain activity associated with visual backward maskingMichael F Green
Department of Psychiatry and Behavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, CA 90095 6968, USA
J Cogn Neurosci 17:13-23. 2005..These latter regions (including ventral LO, inferior parietal, anterior cingulate, and thalamus) may form the neural substrate of backward masking... - In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophreniaGeorge Bartzokis
Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
Schizophr Res 113:322-31. 2009..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one... - Event-related gamma activity in schizophrenia patients during a visual backward-masking taskJonathan K Wynn
Department of Psychology, UCLA, Los Angeles, CA, USA
Am J Psychiatry 162:2330-6. 2005..This study examined event-related gamma range activity during a visual backward-masking task in schizophrenia patients and normal comparison subjects... - Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophreniaCindy M Yee
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
J Abnorm Psychol 119:71-82. 2010.... - Forward and backward visual masking in unaffected siblings of schizophrenic patientsMichael F Green
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California, Los Angeles, USA
Biol Psychiatry 59:446-51. 2006..Visual masking tasks assess the earliest stages of visual processing. This study examined visual masking performance for forward and backward masking tasks in siblings of schizophrenic patients and healthy comparison subjects... - Modulation of attention during visual masking in schizophreniaYuri Rassovsky
UCLA Department of Psychiatry and Biobehavioral Sciences, 760 Westwood Plaza C8 747 NPI, Los Angeles, CA 90024 1759, USA
Am J Psychiatry 162:1533-5. 2005..Schizophrenia patients consistently demonstrate performance deficits on visual masking procedures. The present study examined whether attentional manipulation would improve subjects' performance on visual masking... - Stability and clinical correlates of personality characteristics in recent-onset schizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90095 6968, CA, USA
Psychol Med 35:995-1005. 2005..While several personality characteristics are implicated in the etiology and phenotypic expression of schizophrenia, little is known about their trait status or clinical correlates during the early course of this disorder... - Visual processing in schizophrenia: Structural equation modeling of visual masking performanceYuri Rassovsky
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, 760 Westwood Plaza C8 747 NPI, Los Angeles, CA 90024 1759, USA
Schizophr Res 78:251-60. 2005..The results also support theories of the different mechanisms underlying performance on these measures... - Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysisJoseph Ventura
UCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, CA 90095 6968, USA
Schizophr Res 113:189-99. 2009..The high degree of intercorrelation among all of these variables leaves unclear whether neurocognition has a direct effect on functional outcome or whether that relationship to functional outcome is partially mediated by symptoms... - Stressful life events in recent-onset schizophrenia: reduced frequencies and altered subjective appraisalsWilliam P Horan
University of California, Los Angeles, CA 90095 9698, USA
Schizophr Res 75:363-74. 2005..Results are discussed in terms of their implications for understanding susceptibility to stress during the early course of schizophrenia... - Regional brain activity during early visual perception in unaffected siblings of schizophrenia patientsJunghee Lee
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095 6968, USA
Biol Psychiatry 68:78-85. 2010..We examined the neural substrates of visual backward performance in unaffected sibling of schizophrenia patients using functional magnetic resonance imaging (fMRI)... - An illustration of multilevel factor analysisSteven P Reise
Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA
J Pers Assess 84:126-36. 2005..In the discussion, we describe difficulties associated with MFA and consider challenges in factor analyzing life event appraisals in psychiatric samples... - Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles Family StudyRobert F Asarnow
Neuropsychiatric Institute and the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Room 48 240C NPI, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
Arch Gen Psychiatry 59:1053-60. 2002.... - Aging, training, and the brain: a review and future directionsCindy Lustig
Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109 1043, USA
Neuropsychol Rev 19:504-22. 2009..Although many open questions remain, this research has greatly increased our understanding of how to promote successful aging of cognition and the brain... - Preserved neural correlates of priming in old age and dementiaCindy Lustig
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Neuron 42:865-75. 2004.... - Distraction as a determinant of processing speedCindy Lustig
Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor 48109 1043, USA
Psychon Bull Rev 13:619-25. 2006.... - Increased distractor vulnerability but preserved vigilance in patients with schizophrenia: Evidence from a translational Sustained Attention TaskElise Demeter
Department of Psychology, 530 Church Street, University of Michigan, Ann Arbor, MI 48109 1109, USA Department of Psychiatry, 4250 Plymouth Road, University of Michigan, Ann Arbor, MI 48109 5765, USA
Schizophr Res 144:136-41. 2013..Here, we examined whether patients would show specific difficulties in selection-control and in avoiding distraction in the dSAT... - Long-term memory for the terrorist attack of September 11: flashbulb memories, event memories, and the factors that influence their retentionWilliam Hirst
Department of Psychology, New School for Social Research, New York, NY 10011, USA
J Exp Psychol Gen 138:161-76. 2009..The results are discussed in terms of community memory practices... - Brain aging: reorganizing discoveries about the aging mindPatricia A Reuter-Lorenz
Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
Curr Opin Neurobiol 15:245-51. 2005..This interdisciplinary, cognitive neuroscience approach reveals dynamic and optimizing processes in aging that might be harnessed to foster the successful aging of the mind... - Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timingCindy Lustig
Department of Psychology, University of Michigan, United States
Brain Cogn 58:9-16. 2005.... - White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging studyGeorge Bartzokis
Department of Neurology, Alzheimer s Disease Center, University of California, Los Angeles, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
Arch Neurol 60:393-8. 2003..6 years and then declines. Postmortem evidence indicates that the structural integrity of myelin sheaths deteriorates during normal aging, especially in late myelinating regions such as the frontal lobes... - Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging studyGeorge Bartzokis
Department of Neurology, University of California School of Medicine, Los Angeles 90095-1769, USA
Biol Psychiatry 53:412-21. 2003..The importance of myelination to the continued maturation and normal functioning of the brain has implications for the diagnosis, treatment, and prognosis of schizophrenia... - Development of a computerized assessment for visual maskingMichael Foster Green
Department of Psychiatry and Biobehavioral Sciences, UCLA, USA
Int J Methods Psychiatr Res 11:83-9. 2002.... - Intra- and interindividual variations in steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients treated chronically with various doses of risperidoneManickam Aravagiri
Psychopharmacology Unit, University of California at Los Angeles, VA Greater Los Angeles Healthcare System, Bldg 210 15, 11301 Wilshire Blvd, Los Angeles, California, USA
Ther Drug Monit 25:657-64. 2003..The current data support the fact that it is important to measure steady-state levels of total active moiety by analyzing both RSP and 9-OHRSP for plasma drug monitoring... - Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memoryJunghoon Kim
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095 1563, USA
Schizophr Res 68:173-87. 2004..These results suggest that while both maintenance and central executive aspects of working memory are impaired in schizophrenic patients, the central executive may be more severely affected... - The MATRICS initiative: developing a consensus cognitive battery for clinical trialsMichael F Green
Schizophr Res 72:1-3. 2004 - Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: the UCLA family studyRobert F Asarnow
Department of Psychiatry and Biobehavioral Science, UCLA Neuropsychiatric Institute, NPI 48 240C, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
Schizophr Res 54:111-20. 2002..These findings suggest the neurocognitive and neuromotor functioning and schizophrenia spectrum disorders can be relatively independent expressions of familial liability to schizophrenia... - Is unawareness of psychotic disorder a neurocognitive or psychological defensiveness problem?Kenneth L Subotnik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
Schizophr Res 75:147-57. 2005.... - Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophreniaTyrone D Cannon
Department of Psychology, University of California, Los Angeles 90095 1563, USA
Arch Gen Psychiatry 62:1071-80. 2005..It remains unclear whether altered regional brain physiological activity in patients with schizophrenia during working memory tasks relates to maintenance-related processes, manipulation-related (ie, executive) processes, or both... - Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia... - Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophreniaKatherine H Karlsgodt
Department of Psychology, University of California, Los Angeles, California 90095 1563, USA
Biol Psychiatry 63:512-8. 2008.... - Do recent-onset schizophrenia patients experience a "social network crisis"?William P Horan
Department of Psychiatry and Biobehavioral Sciences at the University of California, 300 Medical Plaza, Los Angeles, CA 90095 6968, USA
Psychiatry 69:115-29. 2006..Instead, results suggest that functionally relevant social network disturbances often exist by the time of first hospitalization in schizophrenia... - Neurocognitive performance and functional disability in the psychosis prodromeTara A Niendam
Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
Schizophr Res 84:100-11. 2006..This study evaluates the pattern of neuropsychological deficits and their association with clinical symptomatology and social functioning in individuals identified as ultra-high-risk (UHR) for psychosis... - Dynamic testing in schizophrenia: does training change the construct validity of a test?Karl H Wiedl
Department of Psychology, University of Osnabruck, Germany
Schizophr Bull 30:703-11. 2004..It is concluded that the construct validity of the test changes with dynamic administration and that this difference helps to explain why the dynamic version of the WCST predicts functional outcome better than the static version... - A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophreniaRobert W Buchanan
Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
Schizophr Bull 31:5-19. 2005.... - Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies... - Executive functioning component mechanisms and schizophreniaJohn G Kerns
Department of Psychological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Biol Psychiatry 64:26-33. 2008..Although there is general consensus about what cognitive tasks involve executive functioning, there is disagreement about the specific cognitive mechanisms that comprise executive functioning...
Research Grants
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith H Nuechterlein; Fiscal Year: 2010..Potential predictors of response to these treatments will be evaluated. ..
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith Nuechterlein; Fiscal Year: 2003..Assessments of individuals focus on cognitive performance, Assessments of possible environmental factors examine stressful life events, social support, and use of coping strategies. ..
- INTERVENTION RESEARCH TRAINING FOR THE PSYCHOSESKeith Nuechterlein; Fiscal Year: 2004..D.s and the other half Ph.D.s. Trainees will be assigned to primary and secondary mentors who will supervise their training activities in an individualized research mentorship model. ..
- TRANSMISSION OF VULNERABILITY FACTORS FOR SCHIZOPHRENIAKeith Nuechterlein; Fiscal Year: 2006..These goals will be addressed through data collection with schizophrenic probands and their first-degree relatives as well as with demographically matched community controls and their first-degree relatives. ..
- PSYCHOLOGICAL RESEARCH ON SCHIZOPHRENIC CONDITIONSKeith Nuechterlein; Fiscal Year: 2007..D. in psychology or an M.D. followed by a psychiatric residency. Trainees are assigned to primary and secondary mentors who provide hands-on clinical research experience and facilitate development of research careers. ..
- Center for Neurocognition and Emotion in SchizophreniaKeith Nuechterlein; Fiscal Year: 2007..abstract_text> ..
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith Nuechterlein; Fiscal Year: 2007..Potential predictors of response to these treatments will be evaluated. ..
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith Nuechterlein; Fiscal Year: 1993..Long-term follow-up assessments of Sample 1 patients will be staggered over the five grant years to ensure consistency of follow-up interval across patients...
- DEVELOPMENTAL PROCESSES IN SCHIZOPHRENIC DISORDERSKeith Nuechterlein; Fiscal Year: 1992....