Aldons Jake Lusis

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data
    Susanna S Wang
    Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Circ Res 101:e11-30. 2007
  2. pmc Maximal information component analysis: a novel non-linear network analysis method
    Christoph D Rau
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, CA, USA Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, CA, USA
    Front Genet 4:28. 2013
  3. pmc The systems genetics resource: a web application to mine global data for complex disease traits
    Atila Van Nas
    Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Front Genet 4:84. 2013
  4. pmc Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice
    Juyong Brian Kim
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1679, USA
    Circulation 126:1896-906. 2012
  5. pmc ABCC6 localizes to the mitochondria-associated membrane
    Lisa J Martin
    Department of Medicine, Human Genetics, Microbiology, Immunology and Molecular Genetics, 3730 MRL UCLA, Los Angeles, CA 90095 1679, USA
    Circ Res 111:516-20. 2012
  6. pmc Genetics of atherosclerosis
    Aldons J Lusis
    University of California, Los Angeles, Department of Medicine Division of Cardiology, Los Angeles, CA 90095 1679, USA
    Trends Genet 28:267-75. 2012
  7. pmc Dosage compensation is less effective in birds than in mammals
    Yuichiro Itoh
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Biol 6:2. 2007
  8. pmc Genomic analysis of metabolic pathway gene expression in mice
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
    Genome Biol 6:R59. 2005
  9. pmc Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
    Ke Wei Gong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Biol 8:R149. 2007
  10. pmc Gene networks associated with conditional fear in mice identified using a systems genetics approach
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    BMC Syst Biol 5:43. 2011

Research Grants

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data
    Susanna S Wang
    Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Circ Res 101:e11-30. 2007
    ..Thus, global gene expression in peripheral tissues can reflect the systemic perturbations that contribute to atherosclerosis...
  2. pmc Maximal information component analysis: a novel non-linear network analysis method
    Christoph D Rau
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, CA, USA Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, CA, USA
    Front Genet 4:28. 2013
    ....
  3. pmc The systems genetics resource: a web application to mine global data for complex disease traits
    Atila Van Nas
    Department of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Front Genet 4:84. 2013
    ..The web site includes detailed protocols for all of the studies. Data from published studies are freely available; unpublished studies have restricted access during their embargo period...
  4. pmc Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice
    Juyong Brian Kim
    Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1679, USA
    Circulation 126:1896-906. 2012
    ..We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the 2 isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b, in atherosclerosis using knockout mice models...
  5. pmc ABCC6 localizes to the mitochondria-associated membrane
    Lisa J Martin
    Department of Medicine, Human Genetics, Microbiology, Immunology and Molecular Genetics, 3730 MRL UCLA, Los Angeles, CA 90095 1679, USA
    Circ Res 111:516-20. 2012
    ..Mutations of the orphan transporter ABCC6 (ATP-binding cassette, subfamily C, member 6) cause the connective tissue disorder pseudoxanthoma elasticum. ABCC6 was thought to be located on the plasma membrane of liver and kidney cells...
  6. pmc Genetics of atherosclerosis
    Aldons J Lusis
    University of California, Los Angeles, Department of Medicine Division of Cardiology, Los Angeles, CA 90095 1679, USA
    Trends Genet 28:267-75. 2012
    ....
  7. pmc Dosage compensation is less effective in birds than in mammals
    Yuichiro Itoh
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    J Biol 6:2. 2007
    ..Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes...
  8. pmc Genomic analysis of metabolic pathway gene expression in mice
    Anatole Ghazalpour
    Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
    Genome Biol 6:R59. 2005
    ..Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice...
  9. pmc Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells
    Ke Wei Gong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Genome Biol 8:R149. 2007
    ..We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis...
  10. pmc Gene networks associated with conditional fear in mice identified using a systems genetics approach
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    BMC Syst Biol 5:43. 2011
    ..To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution...
  11. pmc Using genetic markers to orient the edges in quantitative trait networks: the NEO software
    Jason E Aten
    Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, USA
    BMC Syst Biol 2:34. 2008
    ....
  12. pmc Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis
    Jennifer M P Woo
    Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    Arthritis Res Ther 12:R93. 2010
    ....
  13. pmc Metabolic syndrome: from epidemiology to systems biology
    Aldons J Lusis
    Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Genet 9:819-30. 2008
    ..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn...
  14. ncbi request reprint The problem of passenger genes in transgenic mice
    Aldons J Lusis
    Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 27:2100-3. 2007
  15. pmc Atherosclerosis
    A J Lusis
    Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
    Nature 407:233-41. 2000
    ..It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis...
  16. ncbi request reprint Genetic basis of atherosclerosis: part I: new genes and pathways
    Aldons J Lusis
    Department of Medicine Division of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, USA
    Circulation 110:1868-73. 2004
  17. ncbi request reprint Genetic basis of atherosclerosis: part II: clinical implications
    Aldons J Lusis
    Division of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, USA
    Circulation 110:2066-71. 2004
  18. ncbi request reprint Genetics of atherosclerosis
    Aldons J Lusis
    Department of 1Human Genetics, University of California, Los Angeles, California 90095, USA
    Annu Rev Genomics Hum Genet 5:189-218. 2004
    ..Successful discovery of these genetic factors will require using complementary approaches with animal models, large-scale human genetic studies, and functional experiments. This review emphasizes the common, complex forms of CAD...
  19. ncbi request reprint Genetic factors in cardiovascular disease. 10 questions
    Aldons J Lusis
    Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Trends Cardiovasc Med 13:309-16. 2003
    ..This review, organized into 10 broad questions, summarizes the understanding of the genetics of common, complex forms of CVD. Implications for DNA-based diagnosis, pharmacogenetics, and risk assessment are also discussed...
  20. ncbi request reprint Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G males
    Lawrence W Castellani
    Department of Medicine, University of California Los Angeles, 90095, USA
    J Lipid Res 47:1366-77. 2006
    ..The human MPO transgenic model will facilitate studies of MPO involvement in atherosclerosis and lipid homeostasis...
  21. ncbi request reprint Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits
    Margarete Mehrabian
    Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
    Nat Genet 37:1224-33. 2005
    ....
  22. ncbi request reprint Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice
    Susanna S Wang
    UCLA School of Medicine, Dept of Human Genetics, Box 95167, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 27:2671-6. 2007
    ..To identify the genetic factors involved in lesion initiation, we studied a cross between C3H and the susceptible strain C57BL/6J (B6) on a hyperlipidemic (apolipoprotein E-null) background...
  23. pmc Positional cloning of the combined hyperlipidemia gene Hyplip1
    Jackie S Bodnar
    Department of Medicine, University of California, Los Angeles, 47 123 CHS, UCLA School of Medicine, Los Angeles, California 90095, USA
    Nat Genet 30:110-6. 2002
    ..These results reveal a new pathway of potential clinical significance that contributes to plasma lipid metabolism...
  24. pmc Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis
    Elizabeth J Tarling
    Department of Biological Chemistry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1737, USA
    Arterioscler Thromb Vasc Biol 30:1174-80. 2010
    ..To generate Abcg1(-/-) Apoe(-/-) mice to understand the mechanism and cell types involved in changes in atherosclerosis after loss of ABCG1...
  25. pmc Cis-acting expression quantitative trait loci in mice
    Sudheer Doss
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Genome Res 15:681-91. 2005
    ....
  26. ncbi request reprint Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain
    Carrie L Welch
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    Physiol Genomics 17:48-59. 2004
    ..003 and P = 0.0001 for HDL-C and non-HDL-C levels, respectively). These data are consistent with polygenic inheritance of HDL-C levels in the mouse model and provide candidate loci for HDL-C and non-HDL-C level determination in humans...
  27. pmc Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
    Xia Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Nat Genet 41:415-23. 2009
    ..Integration of gene expression in the design and analysis of traditional F(2) intercross studies allows high-confidence prediction of causal genes and identification of pathways and networks involved...
  28. ncbi request reprint USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery disease
    Jenny C Lee
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 27:2222-7. 2007
    ..Here we examined the previously associated rs3737787 SNP in extended Dutch FCHL families (n=532) and in a cohort of US subjects who underwent diagnostic coronary angiography (n=1533)...
  29. pmc Synthetic LXR ligand inhibits the development of atherosclerosis in mice
    Sean B Joseph
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
    Proc Natl Acad Sci U S A 99:7604-9. 2002
    ..These observations provide direct evidence for an atheroprotective effect of LXR agonists and support their further evaluation as potential modulators of human cardiovascular disease...
  30. pmc Integrating genetic and network analysis to characterize genes related to mouse weight
    Anatole Ghazalpour
    Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e130. 2006
    ..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest...
  31. pmc Expression quantitative trait loci: replication, tissue- and sex-specificity in mice
    Atila Van Nas
    Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 185:1059-68. 2010
    ..We conclude that most local eQTL are highly replicable between mouse crosses, tissues, and sex as compared to distal eQTL, which exhibited modest replicability...
  32. pmc Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in mice
    Anatole Ghazalpour
    Department of Microbiology Immunology and Molecular Genetics, University of California, Los Angeles, California 90095 1679, USA
    Genetics 173:943-51. 2006
    ..This complexity should be considered when interpreting results of knockout studies...
  33. pmc Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity
    Susanna Wang
    Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    PLoS Genet 2:e15. 2006
    ..These data have implications on the potential effects of sex on the genetic regulation of other complex traits...
  34. pmc Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE
    Michelle N Bradley
    Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 90095 1662, USA
    J Clin Invest 117:2337-46. 2007
    ..These observations indicate that LXRalpha has an essential role in maintaining peripheral cholesterol homeostasis in the context of hypercholesterolemia and provide in vivo support for drug development strategies targeting LXRbeta...
  35. pmc Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling
    Charles R Farber
    Department of Medicine, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Physiol Genomics 37:294-302. 2009
    ..To prioritize genes with eQTL we used Network Edge Orienting, a causality modeling tool. These analyses advance our goal of identifying the molecular basis of Carfhg2...
  36. ncbi request reprint The unfolded protein response is an important regulator of inflammatory genes in endothelial cells
    Peter S Gargalovic
    UCLA Department of Medicine, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 26:2490-6. 2006
    ..The goal of our studies was to identify pathways mediating the induction of inflammatory genes by oxPAPC...
  37. pmc Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice
    Sulin Wu
    Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:597-608. 2010
    ..In all three mouse model settings, notable sex specificity was observed, consistent with human studies showing differences in association with USF1 gene polymorphisms between sexes...
  38. pmc Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice
    Susanna S Wang
    Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
    Circ Cardiovasc Genet 2:573-82. 2009
    ..Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans...
  39. pmc Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism
    Peter S Gargalovic
    Department of Medicine, Microbiology, University of California, Los Angeles, CA 90095 1679, USA
    Circ Cardiovasc Genet 3:60-7. 2010
    ..We previously mapped a quantitative trait locus on chromosome 15 in mice contributing to high-density lipoprotein cholesterol and triglyceride levels and now report the identification of the underlying gene...
  40. ncbi request reprint Genetic characterization of the Dyscalc locus
    Veronica V Colinayo
    Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 90095, USA
    Mamm Genome 13:283-8. 2002
    ..The congenic strains exhibit little or no myocardial or vascular calcification, unlike the background HcB C3H strain, and the calcification segregated as a Mendelian factor, allowing finer mapping of Dyscalc...
  41. ncbi request reprint Identifying loci for behavioral traits using genome-tagged mice
    Dahai Liu
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095 1735, USA
    J Neurosci Res 74:562-9. 2003
    ..These results suggest that the GTMs should be a valuable resource for mapping and confirmation of loci contributing to complex behavioral traits in the mouse...
  42. ncbi request reprint Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice
    Aaron Tward
    Department of Medicine, University of California, Los Angeles 90095 1679, USA
    Circulation 106:484-90. 2002
    ..To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice...
  43. pmc Weighted gene coexpression network analysis strategies applied to mouse weight
    Tova F Fuller
    Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Mamm Genome 18:463-72. 2007
    ..These examples provide evidence that integration of network properties may well help chart the path across the gene-trait chasm...
  44. pmc Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice
    Richard C Davis
    Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Diabetes 59:1616-25. 2010
    ..To identify metabolic derangements contributing to diabetes susceptibility in the leptin receptor-deficient obese C57BLKS/J-db/db (BKS-db) mouse strain...
  45. pmc Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress
    Jesus A Araujo
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
    Circ Res 102:589-96. 2008
    ..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor...
  46. pmc Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks
    Atila Van Nas
    Department of Human Genetics, University of California, Los Angeles, California 90095 1679, USA
    Endocrinology 150:1235-49. 2009
    ..This study indicates that gonadal hormones play a strong role in sex differences in gene expression. In addition, it results in the identification of sex-specific gene coexpression networks related to genetic and metabolic traits...
  47. ncbi request reprint Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice
    Kum Kum Bhasin
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Exp Parasitol 114:240-5. 2006
    ..Our data are consistent with an in vivo role of HDL protection against trypanosome infection...
  48. pmc Tissue-specific expression and regulation of sexually dimorphic genes in mice
    Xia Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genome Res 16:995-1004. 2006
    ..Moreover, many tissue-specific transcription factor binding sites were found to be enriched in the sexually dimorphic genes...
  49. pmc An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association
    Charles R Farber
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
    J Bone Miner Res 24:105-16. 2009
    ..Integration of multiple genetic and genomic data sets can substantially improve the efficiency of QTL fine-mapping and candidate gene identification...
  50. ncbi request reprint Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice
    Brian W Parks
    Department of Microbiology, University of Alabama at Birmingham, 19th St S, Birmingham, AL 35294 2170, USA
    Arterioscler Thromb Vasc Biol 26:2703-9. 2006
    ..The G2A receptor mediates chemotaxis of cultured macrophages and T cells to lysophosphatidylcholine, supporting a pro-atherogenic role for this receptor in vivo. We investigated the ability of G2A to modulate atherosclerosis in mice...
  51. ncbi request reprint Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2
    Carey J Ng
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 281:29491-500. 2006
    ..These results demonstrate that PON2 plays a protective role in atherosclerosis...
  52. pmc Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction
    Kum Kum S Bhasin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Diabetes 58:559-66. 2009
    ..We have examined maternal mechanisms for adult-onset glucose intolerance, increased adiposity, and atherosclerosis using two mouse models for intrauterine growth restriction (IUGR): maternal protein restriction and hypercholesterolemia...
  53. ncbi request reprint Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosis
    Xuping Wang
    Department of Medicine, University of California, Los Angeles 90095 1679, USA
    Arterioscler Thromb Vasc Biol 24:1928-34. 2004
    ..The congenic allowed us to confirm the QTL result and to further characterize the properties and location of the underlying gene...
  54. pmc Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
    Christopher C Park
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Genet 40:421-9. 2008
    ..Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome...
  55. ncbi request reprint ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia
    Xuebing Feng
    Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA, USA
    J Lipid Res 48:794-805. 2007
    ..Correlations of IgG anti-OxPL with lupus-like disease, atherosclerosis, and bone loss suggested a shared pathway of these disease processes...
  56. ncbi request reprint High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory
    Nima M Gharavi
    Department of Medicine, University of California, Los Angeles, Calif, USA
    Arterioscler Thromb Vasc Biol 27:1346-53. 2007
    ..The goal of the current studies was to determine the role of high-density lipoprotein (HDL) in regulating Ox-PAPC signaling in HAECs...
  57. ncbi request reprint Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosis
    Luz D Orozco
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Circ Res 100:1703-11. 2007
    ..We conclude that HO-1 expression in macrophages constitutes an important component of the antiatherogenic effect by increasing antioxidant protection and decreasing the inflammatory component of atherosclerotic lesions...
  58. pmc Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia
    Rebecca Mar-Heyming
    Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 28:1193-9. 2008
    ..We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL)...
  59. ncbi request reprint Genetic loci contributing to age-related hippocampal lesions in mice
    Kelly L Krass
    Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    Neurobiol Dis 13:102-8. 2003
    ..The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus...
  60. pmc Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification
    Yucheng Yao
    Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 107:485-94. 2010
    ..The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall...
  61. ncbi request reprint Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient mice
    Brian W Parks
    Department of Microbiology, University of Alabama, Birmingham, AL 35294 2170, USA
    J Lipid Res 46:1405-15. 2005
    ....
  62. pmc The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)
    Zory Shaposhnik
    Division of Cardiology, David Geffen School of Medicine at University of California at Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 50:623-9. 2009
    ..A-002 treatment also resulted in a profound increase in plasma PON activity and significantly larger fibrous caps, suggesting the formation of more stable plaque architecture...
  63. pmc Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction
    Hooman Allayee
    Department of Preventive Medicine and the Institute for Genetic Medicine, The University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9075, USA
    Am J Clin Nutr 88:934-40. 2008
    ..We previously reported that variants of a 5-LO promoter repeat polymorphism were associated with carotid atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high dietary n-3 fatty acids...
  64. ncbi request reprint Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid
    Jessica Pilar McLin
    Reeve Irvine Research Center, University of California, Irvine, Irvine, CA 92697, USA
    Neurobiol Dis 29:391-9. 2008
    ..These results suggest that gene(s) on distal chr18 are important determinants of vulnerability to KA-induced hippocampal neurodegeneration, but not QUIN-induced striatal neurodegeneration...
  65. ncbi request reprint ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalities
    Ichiro Nishimura
    The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Box 951668, CHS B3 087, Los Angeles, CA 90095, USA
    Crit Rev Oral Biol Med 14:320-30. 2003
    ..These approaches will produce a wealth of new data on critical genes that influence the size and shape of the human face...
  66. pmc Systems biology asks new questions about sex differences
    Arthur P Arnold
    Department of Physiological Science, University of California, Los Angeles, CA, USA
    Trends Endocrinol Metab 20:471-6. 2009
    ..Measurement of the aggregate behavior of genes uncovers novel sex differences that can be related more effectively to susceptibility to disease...
  67. ncbi request reprint Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia
    Rebecca Mar
    Department of Human Genetics, University of California, Los Angeles, USA
    Circ Res 94:993-9. 2004
    ....
  68. pmc High-resolution mapping of gene expression using association in an outbred mouse stock
    Anatole Ghazalpour
    Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 4:e1000149. 2008
    ..Our results also highlight the importance of correcting for population structure in whole-genome association studies in the outbred stock...
  69. ncbi request reprint Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, University of California, Los Angeles 90095, USA
    Circ Res 90:926-31. 2002
    ..This is one of the first loci identified for apoB levels in humans and is the second major locus implicated in the genetic etiology of FCH...
  70. ncbi request reprint A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids
    Diana M Shih
    Division of Cardiology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 47:384-92. 2006
    ..These data demonstrate that human PON1 expression is repressed by bile acids through the actions of FXR and FGF-19...
  71. ncbi request reprint Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 mice
    Daria Estrada-Smith
    Department of Human Gentics, University of California Los Angeles, USA
    Diabetes 55:2265-71. 2006
    ..Thus, our results define a strategy for studying the poorly understood interactions between diabetes and atherosclerosis and for identifying genes underlying the cardiovascular complications of insulin resistance...
  72. ncbi request reprint FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice
    Yanqiao Zhang
    Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 26:2316-21. 2006
    ..Based on the observation that Fxr-/- mice exhibit a proatherogenic lipoprotein profile, we investigated the role of FXR in the development of atherosclerosis...
  73. ncbi request reprint Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigrees
    Rita M Cantor
    Department of Human Genetics, David Geffen School of Medicine at UCLA, 695 Charles E Young Dr South, Los Angeles, CA 90095 7088, USA
    Arterioscler Thromb Vasc Biol 24:1935-41. 2004
    ..This is a report of a quantitative trait loci (QTL) analysis of FCHL...
  74. ncbi request reprint Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemia
    Hooman Allayee
    Department of Human Genetics, Gonda Genetics Research Center, of California, Los Angeles, Calif 90095, USA
    Circ Res 92:1262-7. 2003
    ..Our results demonstrate that apoA-II is biochemically and genetically associated with FCH and may serve as a useful marker for understanding the mechanism by which FCH develops...
  75. pmc NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection
    Berenice Barajas
    Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
    Arterioscler Thromb Vasc Biol 31:58-66. 2011
    ..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties...
  76. ncbi request reprint Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in mice
    Thomas A Drake
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1732, USA
    Am J Ther 12:503-11. 2005
    ..Recent advances in genetics and gene expression technology have greatly increased the knowledge to be derived from this approach when applied to traditional genetic studies...
  77. pmc Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice
    Brian J Bennett
    Department of Medicine, 675 Charles E Young Dr South, 3730 MRL, School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Arterioscler Thromb Vasc Biol 29:348-55. 2009
    ..We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery, a murine model of advanced atherosclerosis...
  78. ncbi request reprint Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5
    Jeffrey B Smith
    Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
    Immunogenetics 54:599-603. 2002
    ..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus...
  79. ncbi request reprint The allelic structure of common disease
    Desmond J Smith
    Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
    Hum Mol Genet 11:2455-61. 2002
    ..It appears that neither position has been proved or disproved, but the available evidence indicates that common diseases are due at least in part to genes with a small number of disease-associated alleles...
  80. pmc Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Hum Genet 72:903-17. 2003
    ..1 region, we investigated a novel functional and positional candidate gene, helix/forkhead transcription factor (FOXC2), by sequencing and by genotyping of two single-nucleotide polymorphisms in the families...
  81. pmc Systems genetics analysis of gene-by-environment interactions in human cells
    Casey E Romanoski
    Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA
    Am J Hum Genet 86:399-410. 2010
    ....
  82. pmc Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis
    Diana M Shih
    Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
    Adv Exp Med Biol 660:73-87. 2010
    ..Pon3 mRNA was also detected in the atherosclerotic lesion areas at the aortic root of apoE -/- hearts. Our data revealed that mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled...
  83. ncbi request reprint Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    Margarete Mehrabian
    Department of Medicine, UCLA School of Medicine, Los Angeles, Calif 90095 1679, USA
    Circ Res 91:120-6. 2002
    ..These results indicate that 5-LO contributes importantly to the atherogenic process and they provide strong presumptive evidence that reduced 5-LO expression is partly responsible for the resistance to atherosclerosis in CON6 mice...
  84. ncbi request reprint A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background
    Richard C Davis
    Department of Microbiology, Immunology and Molecular Genetics, Department of Medicine, and Department of Human Genetics, University of California, Los Angeles, CA 90095 1679, USA
    Genomics 86:259-70. 2005
    ..These 65 strains cover more than 95% of the autosomal genome and should facilitate the analysis of the many genetic trait differences that have been reported between these parental strains...
  85. ncbi request reprint Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-II
    Lawrence W Castellani
    Department of Medicine, 47 123 CHS, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 45:2377-87. 2004
    ..Rosiglitazone treatment significantly ameliorated IR in the apoA-II transgenic mice, suggesting that the underlying mechanisms of IR in this animal model may share common features with certain types of human IR...
  86. ncbi request reprint Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility
    Richard C Davis
    Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 47 123 CHS, Los Angeles, CA 90095 1679, USA
    Diabetes 54:1191-9. 2005
    ..To further prioritize these candidates, we identified those cis-acting expression quantitative trait loci whose expression significantly correlates with diabetes-related phenotypes...
  87. ncbi request reprint Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitis
    Anna S Gukovskaya
    Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Gastroenterology 122:974-84. 2002
    ..Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation...
  88. pmc Copy number variation influences gene expression and metabolic traits in mice
    Luz D Orozco
    Department of Human Genetics, UCLA, Los Angeles, CA, USA
    Hum Mol Genet 18:4118-29. 2009
    ..Our results suggest that CNVs have a significant impact on gene expression and that CNVs may be playing a role in the mechanisms underlying metabolic traits in mice...
  89. ncbi request reprint A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 background
    Richard C Davis
    Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
    Genomics 90:306-13. 2007
    ....
  90. pmc Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics
    Haijin Meng
    Department of Medicine, Cardiology Division, University of California Los Angeles, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:4530-5. 2007
    ..Our results demonstrate the power of the integrative genomics in discovering causal genes and pathways underlying complex traits...
  91. ncbi request reprint The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL
    Mohamad Navab
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 45:993-1007. 2004
    ..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential...
  92. ncbi request reprint Dissection of multigenic obesity traits in congenic mouse strains
    Daria Estrada-Smith
    Department of Human Genetics, Gonda Goldschmeid Center for Neuroscience and Human Genetics Research, 695 Charles E Young Dr South, Room 6524, Los Angeles, CA 90095 7088, USA
    Mamm Genome 15:14-22. 2004
    ..When fed an atherogenic diet, several traits associated with metabolic syndrome were observed in the distal MOB congenic, while alterations in plasma lipoproteins were observed in the middle MOB congenic strain...
  93. ncbi request reprint Network-centered view of coronary artery disease
    Brian J Bennett
    Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Expert Rev Cardiovasc Ther 5:1095-103. 2007
    ..In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties...
  94. pmc Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance
    Lawrence W Castellani
    Departments of Medicine Cardiology University of California, Los Angeles, Los Angeles, California 90095, USA
    J Biol Chem 283:11633-44. 2008
    ....
  95. ncbi request reprint Metabolic syndrome as a modifier of atherosclerosis in murine models
    Miklos Peterfy
    Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90073, USA
    Curr Drug Targets 8:1215-20. 2007
    ..Furthermore, murine models are invaluable for the evaluation of therapeutic approaches and will no doubt facilitate the genetic dissection of atherosclerosis-susceptibility in the Metabolic Syndrome...
  96. ncbi request reprint Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)
    Paivi Pajukanta
    Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 7088, USA
    Nat Genet 36:371-6. 2004
    ..USF1 encodes a transcription factor known to regulate several genes of glucose and lipid metabolism...
  97. pmc Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids
    Peter S Gargalovic
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:12741-6. 2006
    ....
  98. pmc Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice
    Diana M Shih
    Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
    Circ Res 100:1200-7. 2007
    ..Our study demonstrates that elevated PON3 expression significantly decreases atherosclerotic lesion formation and adiposity in male mice. PON3 may play an important role in protection against obesity and atherosclerosis...
  99. ncbi request reprint FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice
    Lisa Joy Martin
    Interdepartmental Program in Molecular Toxicology, University of California, Los Angeles School of Public Health, Los Angeles, CA 90095, USA
    Toxicol Sci 100:474-85. 2007
    ..The protection afforded by FK506, found by the current study, indicated that CN is likely to be important in the mechanism of cadmium toxicity in the testis and possibly other organs...
  100. ncbi request reprint Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice
    Kerry L Donnelly
    Department of Food Science and Nutrition, University of Minnesota, St Paul, MN, 55108, USA
    J Nutr 134:1475-80. 2004
    ..The absolute total cholesterol synthesis rate was not altered, but esterification of fatty acids to cholesterol provided an additional means to buffer physiologically the negative results of excess fatty acid availability...
  101. ncbi request reprint Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis
    James H Dwyer
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, CA 91803 8000, USA
    N Engl J Med 350:29-37. 2004
    ....

Research Grants10

  1. Dissection of HDL function using mouse models
    Aldons Jake Lusis; Fiscal Year: 2010
    ..This study will define the genetic functions and pathways affecting the HDL functions using experimental mouse models. ..
  2. Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    Aldons Lusis; Fiscal Year: 2005
    ..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
  3. Dissection of HDL function using mouse models
    Aldons Lusis; Fiscal Year: 2009
    ..This study will define the genetic functions and pathways affecting the HDL functions using experimental mouse models. ..
  4. Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    Aldons Lusis; Fiscal Year: 2009
    ..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
  5. Integrative genetic approaches to Atherosclerosis
    Aldons Lusis; Fiscal Year: 2009
    ..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..
  6. Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    Aldons Lusis; Fiscal Year: 2007
    ..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
  7. Genetic Analysis of the Diabetes-Prone C57BLKS Strain
    Aldons Lusis; Fiscal Year: 2006
    ..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
  8. Integrative genetic approaches to Atherosclerosis
    Aldons Jake Lusis; Fiscal Year: 2010
    ..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..