Research Topics
Genomes and Genes
| Aldons Jake LusisSummaryAffiliation: University of California Country: USA Publications
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Publications
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression dataSusanna S Wang
Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
Circ Res 101:e11-30. 2007..Thus, global gene expression in peripheral tissues can reflect the systemic perturbations that contribute to atherosclerosis...
Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in miceJuyong Brian Kim
Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 1679, USA
Circulation 126:1896-906. 2012..We set out to investigate the potential role of the 9p21.3 locus neighboring genes, including Mtap, the 2 isoforms of Cdkn2a, p16Ink4a and p19Arf, and Cdkn2b, in atherosclerosis using knockout mice models...
ABCC6 localizes to the mitochondria-associated membraneLisa J Martin
Department of Medicine, Human Genetics, Microbiology, Immunology and Molecular Genetics, 3730 MRL UCLA, Los Angeles, CA 90095 1679, USA
Circ Res 111:516-20. 2012..Mutations of the orphan transporter ABCC6 (ATP-binding cassette, subfamily C, member 6) cause the connective tissue disorder pseudoxanthoma elasticum. ABCC6 was thought to be located on the plasma membrane of liver and kidney cells...- Genetics of atherosclerosisAldons J Lusis
University of California, Los Angeles, Department of Medicine Division of Cardiology, Los Angeles, CA 90095 1679, USA
Trends Genet 28:267-75. 2012.... - Dosage compensation is less effective in birds than in mammalsYuichiro Itoh
Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
J Biol 6:2. 2007..Dosage compensation is not understood in birds, in which females (ZW) and males (ZZ) differ in the number of Z chromosomes... 
Genomic analysis of metabolic pathway gene expression in miceAnatole Ghazalpour
Department of Human Genetics, Molecular Biology Institute, University of California, Los Angeles, CA 90095 1679, USA
Genome Biol 6:R59. 2005..Quantitative trait locus analyses were applied to the subcutaneous fat-mass trait and all gene-expression data. These data were then used to identify gene sets that are differentially perturbed in lean and obese mice...- Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cellsKe Wei Gong
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Genome Biol 8:R149. 2007..We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis... - Gene networks associated with conditional fear in mice identified using a systems genetics approachChristopher C Park
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
BMC Syst Biol 5:43. 2011..To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution... - Using genetic markers to orient the edges in quantitative trait networks: the NEO softwareJason E Aten
Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, USA
BMC Syst Biol 2:34. 2008.... - Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosisJennifer M P Woo
Department of Medicine Rheumatology, David Geffen School of Medicine, University of California, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Arthritis Res Ther 12:R93. 2010.... - Genetic basis of atherosclerosis: part II: clinical implicationsAldons J Lusis
Division of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, USA
Circulation 110:2066-71. 2004 - Genetic factors in cardiovascular disease. 10 questionsAldons J Lusis
Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
Trends Cardiovasc Med 13:309-16. 2003..This review, organized into 10 broad questions, summarizes the understanding of the genetics of common, complex forms of CVD. Implications for DNA-based diagnosis, pharmacogenetics, and risk assessment are also discussed... - Metabolic syndrome: from epidemiology to systems biologyAldons J Lusis
Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Rev Genet 9:819-30. 2008..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn... - Genetic basis of atherosclerosis: part I: new genes and pathwaysAldons J Lusis
Department of Medicine/Division of Cardiology, David Geffen School of Medicine at University of California, Los Angeles, USA
Circulation 110:1868-73. 2004 - The problem of passenger genes in transgenic miceAldons J Lusis
Department of Microbiology, Immunology, and Molecular Genetics, UCLA School of Medicine, Los Angeles, CA 90095-1679, USA
Arterioscler Thromb Vasc Biol 27:2100-3. 2007 - Genetics of atherosclerosisAldons J Lusis
Department of 1Human Genetics, University of California, Los Angeles, California 90095, USA
Annu Rev Genomics Hum Genet 5:189-218. 2004..Successful discovery of these genetic factors will require using complementary approaches with animal models, large-scale human genetic studies, and functional experiments. This review emphasizes the common, complex forms of CAD... - AtherosclerosisA J Lusis
Department of Medicine, Biology Institute, University of California, Los Angeles 90095, USA
Nature 407:233-41. 2000..It is now clear that atherosclerosis is not simply an inevitable degenerative consequence of ageing, but rather a chronic inflammatory condition that can be converted into an acute clinical event by plaque rupture and thrombosis... - Transgenic mice express human MPO -463G/A alleles at atherosclerotic lesions, developing hyperlipidemia and obesity in -463G malesLawrence W Castellani
Department of Medicine, University of California Los Angeles, 90095, USA
J Lipid Res 47:1366-77. 2006..The human MPO transgenic model will facilitate studies of MPO involvement in atherosclerosis and lipid homeostasis... - Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traitsMargarete Mehrabian
Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095 1679, USA
Nat Genet 37:1224-33. 2005.... - Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H miceSusanna S Wang
UCLA School of Medicine, Dept of Human Genetics, Box 95167, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
Arterioscler Thromb Vasc Biol 27:2671-6. 2007..To identify the genetic factors involved in lesion initiation, we studied a cross between C3H and the susceptible strain C57BL/6J (B6) on a hyperlipidemic (apolipoprotein E-null) background... - Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strainCarrie L Welch
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
Physiol Genomics 17:48-59. 2004..003 and P = 0.0001 for HDL-C and non-HDL-C levels, respectively). These data are consistent with polygenic inheritance of HDL-C levels in the mouse model and provide candidate loci for HDL-C and non-HDL-C level determination in humans... - Cis-acting expression quantitative trait loci in miceSudheer Doss
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Genome Res 15:681-91. 2005.... - Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosisElizabeth J Tarling
Department of Biological Chemistry, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 1737, USA
Arterioscler Thromb Vasc Biol 30:1174-80. 2010..To generate Abcg1(-/-) Apoe(-/-) mice to understand the mechanism and cell types involved in changes in atherosclerosis after loss of ABCG1... - Positional cloning of the combined hyperlipidemia gene Hyplip1Jackie S Bodnar
Department of Medicine, University of California, Los Angeles, 47 123 CHS, UCLA School of Medicine, Los Angeles, California 90095, USA
Nat Genet 30:110-6. 2002..These results reveal a new pathway of potential clinical significance that contributes to plasma lipid metabolism... - Validation of candidate causal genes for obesity that affect shared metabolic pathways and networksXia Yang
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
Nat Genet 41:415-23. 2009..Integration of gene expression in the design and analysis of traditional F(2) intercross studies allows high-confidence prediction of causal genes and identification of pathways and networks involved... - Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in miceAnatole Ghazalpour
Department of Microbiology Immunology and Molecular Genetics, University of California, Los Angeles, California 90095 1679, USA
Genetics 173:943-51. 2006..This complexity should be considered when interpreting results of knockout studies... - Integrating genetic and network analysis to characterize genes related to mouse weightAnatole Ghazalpour
Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA
PLoS Genet 2:e130. 2006..Our approach results in the identification of genetic targets that influence gene modules (pathways) that are related to the clinical phenotypes of interest... - Expression quantitative trait loci: replication, tissue- and sex-specificity in miceAtila Van Nas
Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Genetics 185:1059-68. 2010..We conclude that most local eQTL are highly replicable between mouse crosses, tissues, and sex as compared to distal eQTL, which exhibited modest replicability... - Synthetic LXR ligand inhibits the development of atherosclerosis in miceSean B Joseph
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1662, USA
Proc Natl Acad Sci U S A 99:7604-9. 2002..These observations provide direct evidence for an atheroprotective effect of LXR agonists and support their further evaluation as potential modulators of human cardiovascular disease... - USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. whites with coronary artery diseaseJenny C Lee
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 27:2222-7. 2007..Here we examined the previously associated rs3737787 SNP in extended Dutch FCHL families (n=532) and in a cohort of US subjects who underwent diagnostic coronary angiography (n=1533)... - Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modelingCharles R Farber
Department of Medicine, University of California Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Physiol Genomics 37:294-302. 2009..To prioritize genes with eQTL we used Network Edge Orienting, a causality modeling tool. These analyses advance our goal of identifying the molecular basis of Carfhg2... - The unfolded protein response is an important regulator of inflammatory genes in endothelial cellsPeter S Gargalovic
UCLA Department of Medicine, Los Angeles, CA 90095-1679, USA
Arterioscler Thromb Vasc Biol 26:2490-6. 2006..CONCLUSIONS: These data suggest that the UPR pathway is a general mediator of vascular inflammation and EC dysfunction in atherosclerosis, and, likely, other inflammatory disorders... - Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificitySusanna Wang
Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
PLoS Genet 2:e15. 2006..These data have implications on the potential effects of sex on the genetic regulation of other complex traits... - Upstream transcription factor 1 influences plasma lipid and metabolic traits in miceSulin Wu
Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095, USA
Hum Mol Genet 19:597-608. 2010..In all three mouse model settings, notable sex specificity was observed, consistent with human studies showing differences in association with USF1 gene polymorphisms between sexes... - Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoEMichelle N Bradley
Howard Hughes Medical Institute and Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California 90095 1662, USA
J Clin Invest 117:2337-46. 2007..These observations indicate that LXRalpha has an essential role in maintaining peripheral cholesterol homeostasis in the context of hypercholesterolemia and provide in vivo support for drug development strategies targeting LXRbeta... - Disruption of the aortic elastic lamina and medial calcification share genetic determinants in miceSusanna S Wang
Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, CA, USA
Circ Cardiovasc Genet 2:573-82. 2009..Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans... - Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolismPeter S Gargalovic
Department of Medicine, Microbiology, University of California, Los Angeles, CA 90095 1679, USA
Circ Cardiovasc Genet 3:60-7. 2010..We previously mapped a quantitative trait locus on chromosome 15 in mice contributing to high-density lipoprotein cholesterol and triglyceride levels and now report the identification of the underlying gene... - Genetic characterization of the Dyscalc locusVeronica V Colinayo
Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 90095, USA
Mamm Genome 13:283-8. 2002..The congenic strains exhibit little or no myocardial or vascular calcification, unlike the background HcB C3H strain, and the calcification segregated as a Mendelian factor, allowing finer mapping of Dyscalc... - Weighted gene coexpression network analysis strategies applied to mouse weightTova F Fuller
Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Mamm Genome 18:463-72. 2007..These examples provide evidence that integration of network properties may well help chart the path across the gene-trait chasm... - Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networksAtila Van Nas
Department of Human Genetics, University of California, Los Angeles, California 90095 1679, USA
Endocrinology 150:1235-49. 2009..This study indicates that gonadal hormones play a strong role in sex differences in gene expression. In addition, it results in the identification of sex-specific gene coexpression networks related to genetic and metabolic traits... - Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stressJesus A Araujo
Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
Circ Res 102:589-96. 2008..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor... - Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic miceAaron Tward
Department of Medicine, University of California, Los Angeles 90095 1679, USA
Circulation 106:484-90. 2002..To evaluate whether PON1 protects against atherosclerosis and lipid oxidation in a dose-dependent manner, we generated and studied human PON1 transgenic mice... - Identifying loci for behavioral traits using genome-tagged miceDahai Liu
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095-1735, USA
J Neurosci Res 74:562-9. 2003..These results suggest that the GTMs should be a valuable resource for mapping and confirmation of loci contributing to complex behavioral traits in the mouse... - Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db miceRichard C Davis
Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Diabetes 59:1616-25. 2010..To identify metabolic derangements contributing to diabetes susceptibility in the leptin receptor-deficient obese C57BLKS/J-db/db (BKS-db) mouse strain... - Trypanosoma congolense: paraoxonase 1 prolongs survival of infected miceKum Kum Bhasin
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Exp Parasitol 114:240-5. 2006..Our data are consistent with an in vivo role of HDL protection against trypanosome infection... - Fine mapping of regulatory loci for mammalian gene expression using radiation hybridsChristopher C Park
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Nat Genet 40:421-9. 2008..Further, this work identifies 2,761 trans ceQTLs harboring no known genes, and provides evidence for a mode of gene expression autoregulation specific to the X chromosome... - An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and associationCharles R Farber
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA
J Bone Miner Res 24:105-16. 2009..Integration of multiple genetic and genomic data sets can substantially improve the efficiency of QTL fine-mapping and candidate gene identification... - Tissue-specific expression and regulation of sexually dimorphic genes in miceXia Yang
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Genome Res 16:995-1004. 2006..Moreover, many tissue-specific transcription factor binding sites were found to be enriched in the sexually dimorphic genes... - Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2Carey J Ng
Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
J Biol Chem 281:29491-500. 2006..These results demonstrate that PON2 plays a protective role in atherosclerosis... - Hyplip2, a new gene for combined hyperlipidemia and increased atherosclerosisXuping Wang
Department of Medicine, University of California, Los Angeles 90095 1679, USA
Arterioscler Thromb Vasc Biol 24:1928-34. 2004..The congenic allowed us to confirm the QTL result and to further characterize the properties and location of the underlying gene... - Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout miceBrian W Parks
Department of Microbiology, University of Alabama at Birmingham, 19th St S, Birmingham, AL 35294 2170, USA
Arterioscler Thromb Vasc Biol 26:2703-9. 2006..The G2A receptor mediates chemotaxis of cultured macrophages and T cells to lysophosphatidylcholine, supporting a pro-atherogenic role for this receptor in vivo. We investigated the ability of G2A to modulate atherosclerosis in mice... - Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restrictionKum Kum S Bhasin
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Diabetes 58:559-66. 2009..We have examined maternal mechanisms for adult-onset glucose intolerance, increased adiposity, and atherosclerosis using two mouse models for intrauterine growth restriction (IUGR): maternal protein restriction and hypercholesterolemia... - ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopeniaXuebing Feng
Division of Rheumatology, Department of Medicine, University of California, Los Angeles, CA, USA
J Lipid Res 48:794-805. 2007..Correlations of IgG anti-OxPL with lupus-like disease, atherosclerosis, and bone loss suggested a shared pathway of these disease processes... - The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002)Zory Shaposhnik
Division of Cardiology, David Geffen School of Medicine at University of California at Los Angeles UCLA, Los Angeles, CA 90095, USA
J Lipid Res 50:623-9. 2009..A-002 treatment also resulted in a profound increase in plasma PON activity and significantly larger fibrous caps, suggesting the formation of more stable plaque architecture... - High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatoryNima M Gharavi
Department of Medicine, University of California, Los Angeles, Calif, USA
Arterioscler Thromb Vasc Biol 27:1346-53. 2007..The goal of the current studies was to determine the role of high-density lipoprotein (HDL) in regulating Ox-PAPC signaling in HAECs... - Heme oxygenase-1 expression in macrophages plays a beneficial role in atherosclerosisLuz D Orozco
Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Circ Res 100:1703-11. 2007..We conclude that HO-1 expression in macrophages constitutes an important component of the antiatherogenic effect by increasing antioxidant protection and decreasing the inflammatory component of atherosclerotic lesions... - Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemiaRebecca Mar-Heyming
Department of Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 28:1193-9. 2008..We used the fatty acid desaturation index (the plasma ratio of 18:1/18:0) as a marker of SCD1 activity to investigate the relationship of SCD1 to familial combined hyperlipidemia (FCHL)... - Genetic loci contributing to age-related hippocampal lesions in miceKelly L Krass
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
Neurobiol Dis 13:102-8. 2003..The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus... - Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcificationYucheng Yao
Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1679, USA
Circ Res 107:485-94. 2010..The bone morphogenetic proteins (BMPs), a family of morphogens, have been implicated as mediators of calcification and inflammation in the vascular wall... - Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acidJessica Pilar McLin
Reeve Irvine Research Center, University of California, Irvine, Irvine, CA 92697, USA
Neurobiol Dis 29:391-9. 2008..These results suggest that gene(s) on distal chr18 are important determinants of vulnerability to KA-induced hippocampal neurodegeneration, but not QUIN-induced striatal neurodegeneration... - Loss of G2A promotes macrophage accumulation in atherosclerotic lesions of low density lipoprotein receptor-deficient miceBrian W Parks
Department of Microbiology, University of Alabama, Birmingham, AL 35294 2170, USA
J Lipid Res 46:1405-15. 2005.... - Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarctionHooman Allayee
Department of Preventive Medicine and the Institute for Genetic Medicine, The University of Southern California Keck School of Medicine, Los Angeles, CA 90089 9075, USA
Am J Clin Nutr 88:934-40. 2008..We previously reported that variants of a 5-LO promoter repeat polymorphism were associated with carotid atherosclerosis in humans, an effect that was exacerbated by high dietary AA but mitigated by high dietary n-3 fatty acids... - Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemiaRebecca Mar
Department of Human Genetics, University of California, Los Angeles, USA
Circ Res 94:993-9. 2004.... - Locus for elevated apolipoprotein B levels on chromosome 1p31 in families with familial combined hyperlipidemiaHooman Allayee
Department of Human Genetics, Gonda Genetics Research Center, University of California, Los Angeles 90095, USA
Circ Res 90:926-31. 2002..This is one of the first loci identified for apoB levels in humans and is the second major locus implicated in the genetic etiology of FCH... - A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acidsDiana M Shih
Division of Cardiology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Lipid Res 47:384-92. 2006..These data demonstrate that human PON1 expression is repressed by bile acids through the actions of FXR and FGF-19... - Quantitative trait loci for apolipoprotein B, cholesterol, and triglycerides in familial combined hyperlipidemia pedigreesRita M Cantor
Department of Human Genetics, David Geffen School of Medicine at UCLA, 695 Charles E Young Dr South, Los Angeles, CA 90095 7088, USA
Arterioscler Thromb Vasc Biol 24:1935-41. 2004..This is a report of a quantitative trait loci (QTL) analysis of FCHL... - ENU large-scale mutagenesis and quantitative trait linkage (QTL) analysis in mice: novel technologies for searching polygenetic determinants of craniofacial abnormalitiesIchiro Nishimura
The Jane and Jerry Weintraub Center for Reconstructive Biotechnology, Division of Advanced Prosthodontics, Biomaterials and Hospital Dentistry, UCLA School of Dentistry, Box 951668, CHS B3 087, Los Angeles, CA 90095, USA
Crit Rev Oral Biol Med 14:320-30. 2003..These approaches will produce a wealth of new data on critical genes that influence the size and shape of the human face... - Impact of chromosome 2 obesity loci on cardiovascular complications of insulin resistance in LDL receptor-deficient C57BL/6 miceDaria Estrada-Smith
Department of Human Gentics, University of California Los Angeles, USA
Diabetes 55:2265-71. 2006..Thus, our results define a strategy for studying the poorly understood interactions between diabetes and atherosclerosis and for identifying genes underlying the cardiovascular complications of insulin resistance... - Systems biology asks new questions about sex differencesArthur P Arnold
Department of Physiological Science, University of California, Los Angeles, CA, USA
Trends Endocrinol Metab 20:471-6. 2009..Measurement of the aggregate behavior of genes uncovers novel sex differences that can be related more effectively to susceptibility to disease... - FXR deficiency causes reduced atherosclerosis in Ldlr-/- miceYanqiao Zhang
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 26:2316-21. 2006..Based on the observation that Fxr-/- mice exhibit a proatherogenic lipoprotein profile, we investigated the role of FXR in the development of atherosclerosis... - High-resolution mapping of gene expression using association in an outbred mouse stockAnatole Ghazalpour
Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America
PLoS Genet 4:e1000149. 2008..Our results also highlight the importance of correcting for population structure in whole-genome association studies in the outbred stock... - Metabolic syndrome as a modifier of atherosclerosis in murine modelsMiklos Peterfy
Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90073, USA
Curr Drug Targets 8:1215-20. 2007..Furthermore, murine models are invaluable for the evaluation of therapeutic approaches and will no doubt facilitate the genetic dissection of atherosclerosis-susceptibility in the Metabolic Syndrome... - NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protectionBerenice Barajas
Department of Medicine, University of California, Center for Health Sciences, Los Angeles, CA 90095, USA
Arterioscler Thromb Vasc Biol 31:58-66. 2011..To test the hypothesis that NF-E2-related factor 2 (Nrf2) expression plays an antiatherogenic role by its vascular antioxidant and anti-inflammatory properties... - Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic miceBrian J Bennett
Department of Medicine, 675 Charles E Young Dr South, 3730 MRL, School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
Arterioscler Thromb Vasc Biol 29:348-55. 2009..We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery, a murine model of advanced atherosclerosis... - Copy number variation influences gene expression and metabolic traits in miceLuz D Orozco
Department of Human Genetics, UCLA, Los Angeles, CA, USA
Hum Mol Genet 18:4118-29. 2009..Our results suggest that CNVs have a significant impact on gene expression and that CNVs may be playing a role in the mechanisms underlying metabolic traits in mice... - Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistanceLawrence W Castellani
Departments of Medicine Cardiology University of California, Los Angeles, Los Angeles, California 90095, USA
J Biol Chem 283:11633-44. 2008.... - Systems genetics analysis of gene-by-environment interactions in human cellsCasey E Romanoski
Department of Human Genetics, University of California, Los Angeles, CA, 90095, USA
Am J Hum Genet 86:399-410. 2010.... - Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysisDiana M Shih
Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1679, USA
Adv Exp Med Biol 660:73-87. 2010..Pon3 mRNA was also detected in the atherosclerotic lesion areas at the aortic root of apoE -/- hearts. Our data revealed that mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled... - Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16qPaivi Pajukanta
Department of Human Genetics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, USA
Am J Hum Genet 72:903-17. 2003..1 region, we investigated a novel functional and positional candidate gene, helix/forkhead transcription factor (FOXC2), by sequencing and by genotyping of two single-nucleotide polymorphisms in the families... - Network-centered view of coronary artery diseaseBrian J Bennett
Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
Expert Rev Cardiovasc Ther 5:1095-103. 2007..In this review we discuss how systems-based approaches are being applied to cardiovascular disease, illustrating concepts, such as the integration of orthogonal datasets, coexpression networks and emergent properties... - Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1)Paivi Pajukanta
Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 7088, USA
Nat Genet 36:371-6. 2004..USF1 encodes a transcription factor known to regulate several genes of glucose and lipid metabolism... - Cloning and genomic localization of the murine LPS-induced CXC chemokine (LIX) gene, Scyb5Jeffrey B Smith
Pediatrics Neonatology B2 325, MDCC, David Geffen School of Medicine and Mattel Children s Hospital at UCLA, 10833 Le Conte Avenue, Los Angeles, CA 90095 1752, USA
Immunogenetics 54:599-603. 2002..The sequence and mapping data suggest that the human ENA78-PBP-PF4 and GCP2- psi PBP-PF4V1 loci arose from an evolutionarily recent duplication of an ancestral locus related to the murine Lix-Pbp-Pf4 locus... - Integrating genetic and gene expression data to study the metabolic syndrome and diabetes in miceThomas A Drake
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095 1732, USA
Am J Ther 12:503-11. 2005..Recent advances in genetics and gene expression technology have greatly increased the knowledge to be derived from this approach when applied to traditional genetic studies... - A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J backgroundRichard C Davis
Department of Microbiology, Immunology and Molecular Genetics, Department of Medicine, and Department of Human Genetics, University of California, Los Angeles, CA 90095 1679, USA
Genomics 86:259-70. 2005..These 65 strains cover more than 95% of the autosomal genome and should facilitate the analysis of the many genetic trait differences that have been reported between these parental strains... - Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibilityRichard C Davis
Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, 47 123 CHS, Los Angeles, CA 90095 1679, USA
Diabetes 54:1191-9. 2005..To further prioritize these candidates, we identified those cis-acting expression quantitative trait loci whose expression significantly correlates with diabetes-related phenotypes... - Mechanisms mediating insulin resistance in transgenic mice overexpressing mouse apolipoprotein A-IILawrence W Castellani
Department of Medicine, 47 123 CHS, University of California, Los Angeles, CA 90095, USA
J Lipid Res 45:2377-87. 2004..Rosiglitazone treatment significantly ameliorated IR in the apoA-II transgenic mice, suggesting that the underlying mechanisms of IR in this animal model may share common features with certain types of human IR... - Biochemical and genetic association of plasma apolipoprotein A-II levels with familial combined hyperlipidemiaHooman Allayee
Department of Human Genetics, Gonda Genetics Research Center, of California, Los Angeles, Calif 90095, USA
Circ Res 92:1262-7. 2003..Our results demonstrate that apoA-II is biochemically and genetically associated with FCH and may serve as a useful marker for understanding the mechanism by which FCH develops... - The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDLMohamad Navab
Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Lipid Res 45:993-1007. 2004..Apolipoprotein A-I (apoA-I) and apoA-I mimetic peptides may both promote a reduction in oxidized lipids and enhance reverse cholesterol transport and therefore may have therapeutic potential... - Dissection of multigenic obesity traits in congenic mouse strainsDaria Estrada-Smith
Department of Human Genetics, Gonda Goldschmeid Center for Neuroscience and Human Genetics Research, 695 Charles E Young Dr South, Room 6524, Los Angeles, CA 90095 7088, USA
Mamm Genome 15:14-22. 2004..When fed an atherogenic diet, several traits associated with metabolic syndrome were observed in the distal MOB congenic, while alterations in plasma lipoproteins were observed in the middle MOB congenic strain... - The allelic structure of common diseaseDesmond J Smith
Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095 1735, USA
Hum Mol Genet 11:2455-61. 2002..It appears that neither position has been proved or disproved, but the available evidence indicates that common diseases are due at least in part to genes with a small number of disease-associated alleles... - Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipidsPeter S Gargalovic
Department of Medicine, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 103:12741-6. 2006.... - Neutrophils and NADPH oxidase mediate intrapancreatic trypsin activation in murine experimental acute pancreatitisAnna S Gukovskaya
Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Gastroenterology 122:974-84. 2002..Intrapancreatic activation of digestive enzymes is a key event in the parenchymal cell injury of pancreatitis. We hypothesized that neutrophils recruited to the pancreas during pancreatitis may contribute to such activation... - A genome-wide set of congenic mouse strains derived from CAST/Ei on a C57BL/6 backgroundRichard C Davis
Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095 1679, USA
Genomics 90:306-13. 2007.... - Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in miceMargarete Mehrabian
Department of Medicine, UCLA School of Medicine, Los Angeles, Calif 90095 1679, USA
Circ Res 91:120-6. 2002..These results indicate that 5-LO contributes importantly to the atherogenic process and they provide strong presumptive evidence that reduced 5-LO expression is partly responsible for the resistance to atherosclerosis in CON6 mice... - Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic miceDiana M Shih
Department of Medicine, University of California, Los Angeles, CA 90095 1679, USA
Circ Res 100:1200-7. 2007..Our study demonstrates that elevated PON3 expression significantly decreases atherosclerotic lesion formation and adiposity in male mice. PON3 may play an important role in protection against obesity and atherosclerosis... - Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomicsHaijin Meng
Department of Medicine, Cardiology Division, University of California Los Angeles, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 104:4530-5. 2007..Our results demonstrate the power of the integrative genomics in discovering causal genes and pathways underlying complex traits... - FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in miceLisa Joy Martin
Interdepartmental Program in Molecular Toxicology, University of California, Los Angeles School of Public Health, Los Angeles, CA 90095, USA
Toxicol Sci 100:474-85. 2007..The protection afforded by FK506, found by the current study, indicated that CN is likely to be important in the mechanism of cadmium toxicity in the testis and possibly other organs... - Genetics of gene expression surveyed in maize, mouse and manEric E Schadt
Rosetta Inpharmatics, LLC, 12040 115th Avenue N E, Kirkland, Washington 98034, USA
Nature 422:297-302. 2003..We identify a gene expression pattern strongly associated with obesity in a murine cross, and observe two distinct obesity subtypes. Furthermore, we find that these obesity subtypes are under the control of different loci... - Paradoxical reduction of fatty streak formation in mice lacking endothelial nitric oxide synthaseWeibin Shi
Department of Radiology and Cardiovascular Research Center W S and Surgery, University of Virginia, Charlottesville, VA, USA
Circulation 105:2078-82. 2002..However, eNOS has been shown to generate superoxide, which could oxidize LDL and promote atherosclerosis. We sought to determine the role of eNOS in diet-induced fatty streak formation through the use of eNOS-deficient mice... - Genetic backgrounds but not sizes of atherosclerotic lesions determine medial destruction in the aortic root of apolipoprotein E-deficient miceWeibin Shi
Department of Radiology, University of Virginia, Charlottesville 22908, USA
Arterioscler Thromb Vasc Biol 23:1901-6. 2003..We sought to assess the integrity of atherosclerotic aortic walls in 2 apoE-/- strains, C57BL/6 (B6) and C3H/HeJ (C3H) that differ markedly in atherosclerosis susceptibility... - Atherosclerosis in C3H/HeJ mice reconstituted with apolipoprotein E-null bone marrowWeibin Shi
Department of Radiology and Cardiovascular Research Center, University of Virginia, Charlottesville, USA
Arterioscler Thromb Vasc Biol 22:650-5. 2002..These data indicate that reconstitution of C3H mice with apoE(-/-) bone marrow has no effect on atherosclerosis susceptibility and that apoE promotes accumulation of apoB in the vessel wall...
Research Grants
- Dissection of HDL function using mouse modelsAldons Jake Lusis; Fiscal Year: 2010..This study will define the genetic functions and pathways affecting the HDL functions using experimental mouse models. ..
- Genetic Analysis of the Diabetes-Prone C57BLKS StrainAldons Lusis; Fiscal Year: 2009..The results will provide an enhanced understanding of the mechanisms of obesity-induced diabetes. ..
- Integrative genetic approaches to AtherosclerosisAldons Jake Lusis; Fiscal Year: 2010..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..