Research Topics
Species | Yuan LuoSummaryAffiliation: University of Southern Mississippi Country: USA Publications
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Detail Information
Publications
Ginkgo biloba extract: cognitive enhancer or antistress bufferChristopher P Ward
Department of Psychology, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
Pharmacol Biochem Behav 72:913-22. 2002..EGb 761 had no significant effect on immunoreactivity to CREB from either the hippocampus or the cerebral cortex...
Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761Yuan Luo
Departments of Biological Sciences and Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406, USA
Proc Natl Acad Sci U S A 99:12197-202. 2002....- Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extractYuan Luo
Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA
Life Sci 78:2066-72. 2006.... - Long-lived worms and agingYuan Luo
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
Redox Rep 9:65-9. 2004..Results from these studies further support the free radical theory of aging, suggest that the molecular mechanism of aging process may be shared in all organisms, and provide insight for therapeutic intervention in age-related diseases... 
Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegansAstrid Gutierrez-Zepeda
Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
BMC Neurosci 6:54. 2005..elegans, that express human beta amyloid (Abeta), were fed with soy derived isoflavones genistein, daidzein and glycitein (100 microg/ml) and then examined for Abeta-induced paralysis and the levels of reactive oxygen species...- Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761Julie Vining Smith
Laboratory of Cellular and Molecular Neuroscience, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
J Alzheimers Dis 5:287-300. 2003..elegans, which is accelerated in the AD-associated C. elegans mutant. These results support the hypothesis of the involvement of Abeta and ROS in association with AD... - Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans modelAstrid Gutierrez-Zepeda
Laboratory for Cellular and Molecular Neuroscience Research, Department of Biological Science, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
Front Biosci 9:3333-8. 2004.... - Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegansZhixin Wu
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406, USA
Cell Mol Biol (Noisy-le-grand) 48:725-31. 2002..It appears that oxidative stress, a major determinant of life span, as well as other types of stress, can be successfully counteracted by the Ginlkgo biloba extract EGb 761... - Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761Amy Strayer
Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406-5018, USA
FASEB J 17:2305-7. 2003..These results support the hypothesis that EGb 761 augments the natural antistress system of C. elegans, thus increasing stress resistance and life span... - Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cellsJulie V Smith
Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406-5018, USA
Cell Mol Biol (Noisy-le-grand) 48:699-707. 2002..These results suggest that inhibition of apoptotic machinery may, at least in part, mediate multiple neuroprotective effects of EGb 761, and that EGb 761 and vitamin E act on different molecular paths to provide neuroprotection... - Transgenic C. elegans as a model in Alzheimer's researchYanjue Wu
Laboratory of Cellular and Molecular Neuroscience, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
Curr Alzheimer Res 2:37-45. 2005..elegans model is a suitable in vivo model to relate Abeta-expression with its toxicity, which may underlie AD pathology. It may also be used as a tool for pharmacological evaluation of novel therapeutic agents... 
The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes, but is not involved in systemin signalingRobert Malinowski
Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
Plant Mol Biol 70:603-16. 2009..This unusual behavior and the nature of the elusive systemin receptor will be discussed...- Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellumKacy J Redd
Department of Biological Sciences, University of Southern Mississippi, 2609 W 4th Street, Hattiesburg, MS 39406 5018, USA
J Neurosci Res 70:631-7. 2002..Taken together, these findings indicate colocalization and association of Galpha(o) and Pcp2 in cerebellum and suggest a functional role in regions of synaptic activity... - The many faces of amyloid beta in Alzheimer's diseasePeter K Chiang
Pharmadyn Inc, 525 Del Rey Ave, Suite B, Sunnyvale, CA 94085 3528, USA
Curr Mol Med 8:580-4. 2008..elegans worms and Drosophila is indeed detrimental. A less investigated aspect of AD is epigenetics, but in time the investigation of the role of epigenetics in AD may add to our understanding of the development of AD... - Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegansZhiming Cao
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Gerontol A Biol Sci Med Sci 62:1337-45. 2007..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia... - Coumarin derivatives protection against ROS production in cellular models of Abeta toxicitiesChristos A Kontogiorgis
Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, Thessaloniki, Greece
Free Radic Res 41:1168-80. 2007..Their protective role against cell death further supports this notion. These results suggest that these compounds could be used as a template in the design of new molecules with a possible role in AD... - EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's diseaseFlaubert Tchantchou
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
FASEB J 21:2400-8. 2007.... - Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegansYanjue Wu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 26:13102-13. 2006.... - Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegansMarishka K Brown
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N. Pine St, PH501, Baltimore, MD 21201, USA
Pharmacol Biochem Behav 85:620-8. 2006..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors... - Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cellsYanan Xu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
Eur J Neurosci 26:2931-9. 2007..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD... - Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptideYanan Xu
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
J Alzheimers Dis 13:341-9. 2008..Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time... - Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterizationYuan Luo
Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA
Biochemistry 45:11727-36. 2006..In addition, they represent potential lead compounds for the treatment of rheumatoid arthritis because a growing body of evidence supports a role for PAD4 in the onset and progression of this chronic autoimmune disorder... - A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluationYuan Luo
Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA
J Am Chem Soc 128:1092-3. 2006..The fact that inhibition is of an irreversible nature suggests that, with appropriate functionalization, F-amidine analogues will be robust activity-based protein-profiling and proteomic capture reagents...