Yuan Luo

Summary

Affiliation: University of Southern Mississippi
Country: USA

Publications

  1. ncbi request reprint Ginkgo biloba extract: cognitive enhancer or antistress buffer
    Christopher P Ward
    Department of Psychology, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Pharmacol Biochem Behav 72:913-22. 2002
  2. pmc Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
    Yuan Luo
    Departments of Biological Sciences and Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Proc Natl Acad Sci U S A 99:12197-202. 2002
  3. ncbi request reprint Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract
    Yuan Luo
    Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA
    Life Sci 78:2066-72. 2006
  4. ncbi request reprint Long-lived worms and aging
    Yuan Luo
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
    Redox Rep 9:65-9. 2004
  5. pmc Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    Astrid Gutierrez-Zepeda
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Neurosci 6:54. 2005
  6. ncbi request reprint Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761
    Julie Vining Smith
    Laboratory of Cellular and Molecular Neuroscience, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    J Alzheimers Dis 5:287-300. 2003
  7. ncbi request reprint Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model
    Astrid Gutierrez-Zepeda
    Laboratory for Cellular and Molecular Neuroscience Research, Department of Biological Science, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Front Biosci 9:3333-8. 2004
  8. ncbi request reprint Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans
    Zhixin Wu
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406, USA
    Cell Mol Biol (Noisy-le-grand) 48:725-31. 2002
  9. ncbi request reprint Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761
    Amy Strayer
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
    FASEB J 17:2305-7. 2003
  10. ncbi request reprint Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells
    Julie V Smith
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018, USA
    Cell Mol Biol (Noisy-le-grand) 48:699-707. 2002

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Ginkgo biloba extract: cognitive enhancer or antistress buffer
    Christopher P Ward
    Department of Psychology, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Pharmacol Biochem Behav 72:913-22. 2002
    ..EGb 761 had no significant effect on immunoreactivity to CREB from either the hippocampus or the cerebral cortex...
  2. pmc Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761
    Yuan Luo
    Departments of Biological Sciences and Chemistry and Biochemistry, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Proc Natl Acad Sci U S A 99:12197-202. 2002
    ....
  3. ncbi request reprint Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract
    Yuan Luo
    Department of Biological Sciences, The University of Southern Mississippi, 118 College Drive, Hattiesburg, MS 39406, USA
    Life Sci 78:2066-72. 2006
    ....
  4. ncbi request reprint Long-lived worms and aging
    Yuan Luo
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
    Redox Rep 9:65-9. 2004
    ..Results from these studies further support the free radical theory of aging, suggest that the molecular mechanism of aging process may be shared in all organisms, and provide insight for therapeutic intervention in age-related diseases...
  5. pmc Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    Astrid Gutierrez-Zepeda
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg, MS 39406, USA
    BMC Neurosci 6:54. 2005
    ..elegans, that express human beta amyloid (Abeta), were fed with soy derived isoflavones genistein, daidzein and glycitein (100 microg/ml) and then examined for Abeta-induced paralysis and the levels of reactive oxygen species...
  6. ncbi request reprint Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761
    Julie Vining Smith
    Laboratory of Cellular and Molecular Neuroscience, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    J Alzheimers Dis 5:287-300. 2003
    ..elegans, which is accelerated in the AD-associated C. elegans mutant. These results support the hypothesis of the involvement of Abeta and ROS in association with AD...
  7. ncbi request reprint Testing the amyloid toxicity hypothesis of Alzheimer's disease in transgenic Caenorhabditis elegans model
    Astrid Gutierrez-Zepeda
    Laboratory for Cellular and Molecular Neuroscience Research, Department of Biological Science, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Front Biosci 9:3333-8. 2004
    ....
  8. ncbi request reprint Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans
    Zhixin Wu
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406, USA
    Cell Mol Biol (Noisy-le-grand) 48:725-31. 2002
    ..It appears that oxidative stress, a major determinant of life span, as well as other types of stress, can be successfully counteracted by the Ginlkgo biloba extract EGb 761...
  9. ncbi request reprint Expression of the small heat-shock protein Hsp16-2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761
    Amy Strayer
    Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg 39406 5018, USA
    FASEB J 17:2305-7. 2003
    ..These results support the hypothesis that EGb 761 augments the natural antistress system of C. elegans, thus increasing stress resistance and life span...
  10. ncbi request reprint Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells
    Julie V Smith
    Department of Biological Sciences, University of Southern Mississippi, Hattiesburg 39406 5018, USA
    Cell Mol Biol (Noisy-le-grand) 48:699-707. 2002
    ..These results suggest that inhibition of apoptotic machinery may, at least in part, mediate multiple neuroprotective effects of EGb 761, and that EGb 761 and vitamin E act on different molecular paths to provide neuroprotection...
  11. ncbi request reprint Transgenic C. elegans as a model in Alzheimer's research
    Yanjue Wu
    Laboratory of Cellular and Molecular Neuroscience, Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, MS 39406, USA
    Curr Alzheimer Res 2:37-45. 2005
    ..elegans model is a suitable in vivo model to relate Abeta-expression with its toxicity, which may underlie AD pathology. It may also be used as a tool for pharmacological evaluation of novel therapeutic agents...
  12. doi request reprint The tomato brassinosteroid receptor BRI1 increases binding of systemin to tobacco plasma membranes, but is not involved in systemin signaling
    Robert Malinowski
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Plant Mol Biol 70:603-16. 2009
    ..This unusual behavior and the nature of the elusive systemin receptor will be discussed...
  13. ncbi request reprint Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellum
    Kacy J Redd
    Department of Biological Sciences, University of Southern Mississippi, 2609 W 4th Street, Hattiesburg, MS 39406 5018, USA
    J Neurosci Res 70:631-7. 2002
    ..Taken together, these findings indicate colocalization and association of Galpha(o) and Pcp2 in cerebellum and suggest a functional role in regions of synaptic activity...
  14. ncbi request reprint The many faces of amyloid beta in Alzheimer's disease
    Peter K Chiang
    Pharmadyn Inc, 525 Del Rey Ave, Suite B, Sunnyvale, CA 94085 3528, USA
    Curr Mol Med 8:580-4. 2008
    ..elegans worms and Drosophila is indeed detrimental. A less investigated aspect of AD is epigenetics, but in time the investigation of the role of epigenetics in AD may add to our understanding of the development of AD...
  15. ncbi request reprint Ginkgo biloba extract EGb 761 and Wisconsin Ginseng delay sarcopenia in Caenorhabditis elegans
    Zhiming Cao
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Gerontol A Biol Sci Med Sci 62:1337-45. 2007
    ..elegans is a valid model system for testing therapeutic intervention for delaying the progress of sarcopenia...
  16. ncbi request reprint Coumarin derivatives protection against ROS production in cellular models of Abeta toxicities
    Christos A Kontogiorgis
    Aristotle University of Thessaloniki, School of Pharmacy, Department of Pharmaceutical Chemistry, Thessaloniki, Greece
    Free Radic Res 41:1168-80. 2007
    ..Their protective role against cell death further supports this notion. These results suggest that these compounds could be used as a template in the design of new molecules with a possible role in AD...
  17. ncbi request reprint EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    Flaubert Tchantchou
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    FASEB J 21:2400-8. 2007
    ....
  18. ncbi request reprint Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    Yanjue Wu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 26:13102-13. 2006
    ....
  19. ncbi request reprint Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans
    Marishka K Brown
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 N Pine St, PH501, Baltimore, MD 21201, USA
    Pharmacol Biochem Behav 85:620-8. 2006
    ..Other protective mechanisms, in addition to their antioxidant properties, may underlie their differential beneficial effects on aging and physiological behaviors...
  20. ncbi request reprint Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, MD 21201, USA
    Eur J Neurosci 26:2931-9. 2007
    ..Actions of individual EGb 761 components provide further insights into direct mechanisms underlying the effect of EGb 761 on enhancing the cognitive performance of patients with AD...
  21. ncbi request reprint Gotu Kola (Centella Asiatica) extract enhances phosphorylation of cyclic AMP response element binding protein in neuroblastoma cells expressing amyloid beta peptide
    Yanan Xu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
    J Alzheimers Dis 13:341-9. 2008
    ..Taken together, we provide a possible molecular mechanism for memory enhancing property of Gotu Kola extract for the first time...
  22. pmc Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA
    Biochemistry 45:11727-36. 2006
    ..In addition, they represent potential lead compounds for the treatment of rheumatoid arthritis because a growing body of evidence supports a role for PAD4 in the onset and progression of this chronic autoimmune disorder...
  23. pmc A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation
    Yuan Luo
    Department of Chemistry and Biochemistry, University of South Carolina, Columbia, 29208, USA
    J Am Chem Soc 128:1092-3. 2006
    ..The fact that inhibition is of an irreversible nature suggests that, with appropriate functionalization, F-amidine analogues will be robust activity-based protein-profiling and proteomic capture reagents...