Research Topics
Genomes and Genes
| Thomas S LumleySummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Using built environment characteristics to predict walking for exerciseGina S Lovasi
Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
Int J Health Geogr 7:10. 2008..In order to limit confounding by prior health conditions, the sample was restricted to participants in good self-reported health and without a documented history of cardiovascular disease...
A stroke prediction score in the elderly: validation and Web-based applicationThomas Lumley
University of Washington, CHS Coordinating Center, Plaza 600 Building, Suite 700, 600 Stewart St, Seattle, WA 98101, USA
J Clin Epidemiol 55:129-36. 2002..Evaluation of the generalizability and clinical usefulness of this prediction model requires further research...- The importance of the normality assumption in large public health data setsThomas Lumley
Department of Biostatistics, University of Washington, Box 357232, Seattle, Washington 98195, USA
Annu Rev Public Health 23:151-69. 2002..The major limitation on the t-test and linear regression for inference about associations is not a distributional one, but whether detecting and estimating a difference in the mean of the outcome answers the scientific question at hand... - Carryover effects after cessation of drug treatment: trophies or dreams?Thomas Lumley
Cardiovascular Health Research Unit, Seattle, Washington, USA
Am J Hypertens 21:14-6. 2008..We investigated the impact of measurement error in the outcome on results of the trial of preventing hypertension (TROPHY), a trial of candesartan vs. placebo for preventing hypertension in prehypertensive subjects... - Network meta-analysis for indirect treatment comparisonsThomas Lumley
Department of Biostatistics, University of Washington, Box 357232, Seattle, WA 98195 7232, USA
Stat Med 21:2313-24. 2002..A simple estimation procedure using linear mixed models is given and used in a meta-analysis of treatments for acute myocardial infarction... - Endogenous red blood cell membrane fatty acids and sudden cardiac arrestRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Metabolism 59:1029-34. 2010..Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA... - Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic strokeDaniel A Enquobahrie
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
Am J Cardiol 101:1683-8. 2008..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation... - Exhaled nitric oxide in children with asthma and short-term PM2.5 exposure in SeattleTherese F Mar
Department of Environmental Health and Occupational Sciences, University of Washington, Seattle, Washington 98195-7234, USA
Environ Health Perspect 113:1791-4. 2005..6 to 9.9 ppb ) for a 4-hr lag, and 0.5 (95% CI, -1.1 to 2.1 ppb) for an 8-hr lag. These data provide new information concerning the lag structure between PM2.5 exposure and a respiratory health outcome in children with asthma... - Logic regression for analysis of the association between genetic variation in the renin-angiotensin system and myocardial infarction or strokeCharles Kooperberg
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Am J Epidemiol 165:334-43. 2007.... - Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic strokeRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
Atherosclerosis 204:e58-63. 2009..A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC)... - Ambient air pollution and asthma exacerbations in children: an eight-city analysisJonathan S Schildcrout
Department of Biostatistics, School of Medicine, Vanderbilt University, Nashville, TN 27232 2158, USA
Am J Epidemiol 164:505-17. 2006..01, 1.10) and 1.05 (95% CI: 1.01, 1.09), respectively. The authors believe that the observed carbon monoxide and nitrogen dioxide associations can probably be attributed to mobile-source emissions, though more research is required... - Motivating factors for physician ordering of factor V Leiden genetic testsLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, USA
Arch Intern Med 169:68-74. 2009..The factor V Leiden (FVL) genetic test is used by many physicians despite its uncertain clinical utility... - Overlap bias in the case-crossover design, with application to air pollution exposuresHolly Janes
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Stat Med 24:285-300. 2005..We give a derivation of overlap bias, explore its magnitude, and consider how the bias depends on properties of the exposure series. We conclude that the bias is usually small, though highly unpredictable, and easily avoided... - Case-crossover analyses of air pollution exposure data: referent selection strategies and their implications for biasHolly Janes
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
Epidemiology 16:717-26. 2005.... - Risk of new-onset atrial fibrillation in relation to body mass indexSascha Dublin
Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA
Arch Intern Med 166:2322-8. 2006..It is also unknown to what extent cardiovascular risk factors may mediate this association... - Effects of ambient air pollution on symptom severity and medication use in children with asthmaJames C Slaughter
Department of Biostatistics, University of Washington, Seattle, Washington 98195-7232, USA
Ann Allergy Asthma Immunol 91:346-53. 2003..We also found associations with carbon monoxide, but we believe that carbon monoxide is a marker for exposure to combustion byproducts... - Beta2-adrenergic receptor genetic variants and risk of sudden cardiac deathNona Sotoodehnia
Department of Medicine, University of Washington, Seattle, WA, USA
Circulation 113:1842-8. 2006..Sympathetic activation influences the risk of ventricular arrhythmias and sudden cardiac death (SCD), mediated in part by the beta2-adrenergic receptor (B2AR). We investigated whether variation in the B2AR gene is associated with SCD risk... - New-onset diabetes and risk of all-cause and cardiovascular mortality: the Cardiovascular Health StudyNicholas L Smith
Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
Diabetes Care 29:2012-7. 2006..We hypothesized that risk of all-cause and cardiovascular mortality would be similar among participants with and without new-onset diabetes in the first years of follow-up and rise over time for new-onset diabetes... - Effects of subchronic and chronic exposure to ambient air pollutants on infant bronchiolitisCatherine Karr
Department of Pediatrics, School of Medicine, University of Washington, Seattle 98104, WA, USA
Am J Epidemiol 165:553-60. 2007..5. These unique US data suggest that infant bronchiolitis may be added to the list of adverse effects of PM2.5 exposure... - Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal womenNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, WA, USA
Arterioscler Thromb Vasc Biol 26:2807-12. 2006..Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic genetic variants... - Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patientsKristin D Marciante
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
Am J Epidemiol 166:19-27. 2007..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke... - Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic strokeJoshua C Bis
Department of Medicine, University of Washington, Seattle, WA 981041, USA
Atherosclerosis 198:166-73. 2008.... - Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortiumNicholas L Smith
Cardiovascular Health Study Department of Epidemiology, University of Washington, Seattle, WA 98105, USA
Circ Cardiovasc Genet 3:256-66. 2010.... - Permutation and parametric bootstrap tests for gene-gene and gene-environment interactionsPetra Buzkova
Department of Biostatistics, University of Washington, Seattle, USA
Ann Hum Genet 75:36-45. 2011..We consider interactions of an exposure with single and multiple polymorphisms. Finally, we address when permutation tests of interaction will be approximately valid in large samples for specific test statistics... - Using the whole cohort in the analysis of case-cohort dataNorman E Breslow
Department of Biostatistics, University of Washington, Seattle, Washington 98195 7232, USA
Am J Epidemiol 169:1398-405. 2009..Epidemiologists are encouraged to consider use of these methods to enhance the accuracy of results reported from case-cohort analyses... - Discovering novel risk factors for venous thrombosis: a candidate-gene approachNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, USA
Thromb Res 123:S25-9. 2009..As an example, we present a candidate-gene approach to identify novel associations between variation in 24 clotting genes and the risk of incident venous thrombosis... - Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive populationSusan R Heckbert
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
Am J Hypertens 22:538-44. 2009..Information is scant about the association of beta-blocker use with AF risk in hypertensive patients without heart failure... 
Semiparametric modeling of repeated measurements under outcome-dependent follow-upPetra Buzkova
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Stat Med 28:987-1003. 2009..We illustrate our approach using data from a randomized health services research study with noncompliance to scheduled visits...- Graphical exploration of network meta-analysis data: the use of multidimensional scalingHyoju Chung
Clin Trials 5:301-7. 2008..However, the issue of potential incoherence of the network is not taken into account in statistical models with fixed treatment effects only, which are commonly employed in practice... - Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and strokeLucia A Hindorff
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
Pharmacogenet Genomics 18:677-82. 2008.... - Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) ConsortiumNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Wash 98101, USA
Circulation 121:1382-92. 2010..Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels... - Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic strokeKristin D Marciante
Cardiovascular Health Research Unit, Seattle, Washington 98101, USA
Pharmacogenet Genomics 18:535-43. 2008..We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic stroke... - Surrogate end points and FDA approval: a tale of 2 lipid-altering drugsBruce M Psaty
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
JAMA 299:1474-6. 2008 - Physical activity and incident diabetes in American Indians: the Strong Heart StudyAmanda M Fretts
Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, WA 98101, USA
Am J Epidemiol 170:632-9. 2009..This study identifies physical activity as an important determinant of diabetes among American Indians and suggests the need for physical activity outreach programs that target inactive American Indians... - Simple estimates of haplotype relative risks in case-control dataBenjamin French
Cardiovascular Health Research Unit, University of Washington, Seattle, Washington 98195 7232, USA
Genet Epidemiol 30:485-94. 2006..The potential for phase ambiguity does not necessarily imply uncertainty in imputed diplotypes, especially in large studies of common haplotypes... - Association of genetic variations with nonfatal venous thrombosis in postmenopausal womenNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
JAMA 297:489-98. 2007.... - Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosisNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, USA
JAMA 292:1581-7. 2004..The findings from these trials, which used oral conjugated equine estrogens, may not be generalizable to other estrogen compounds... - Time trends in the use of beta-blockers and other pharmacotherapies in older adults with congestive heart failureNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Wash, USA
Am Heart J 148:710-7. 2004..We describe beta-blocker and other medication temporal treatment trends of CHF in the Cardiovascular Health Study, a community-based cohort study of 5888 adults > or =65 years of age... - Survival associated with two sets of diagnostic criteria for congestive heart failureGina D Schellenbaum
Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
Am J Epidemiol 160:628-35. 2004..Compared with Cardiovascular Health Study central adjudication, Framingham criteria for CHF identified a larger group of participants with incident CHF, but all-cause mortality rates were similar across these diagnostic classifications... - Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patientsJoshua C Bis
Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
Am J Hypertens 16:1011-7. 2003.... - Exposure assessment of particulate matter for susceptible populations in SeattleL J Sally Liu
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98195, USA
Environ Health Perspect 111:909-18. 2003..PM2.5 exposures among the COPD and CHD subjects can be predicted with relatively good power with a microenvironmental model composed of three microenvironments. The prediction power is the lowest for the asthmatic children... - Health outcomes associated with various antihypertensive therapies used as first-line agents: a network meta-analysisBruce M Psaty
Department of Medicine, University of Washington, Seattle, USA
JAMA 289:2534-44. 2003..Establishing relative benefit or harm from specific antihypertensive agents is limited by the complex array of studies that compare treatments. Network meta-analysis combines direct and indirect evidence to better define risk or benefit... - The association between time since last meal and blood pressure in older adults: the cardiovascular health studyNicholas L Smith
Department of Epidemiology, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 51:824-8. 2003..To demonstrate a postprandial hypotensive (PPH) phenomenon in older adults... - Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderlySusan R Heckbert
Department of Epidemiology, University of Washington, Seattle, USA
Circulation 107:2021-4. 2003..We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study... - The association between lipid levels and the risks of incident myocardial infarction, stroke, and total mortality: The Cardiovascular Health StudyBruce M Psaty
Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, Washington 98101, USA
J Am Geriatr Soc 52:1639-47. 2004..To assess the association between lipid levels and cardiovascular events in older adults... - Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarctionAlexander P Reiner
Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
Blood 102:25-30. 2003..03). If confirmed, these findings may permit a better assessment of the cardiovascular risks and benefits associated with postmenopausal estrogen therapy... - Time trends in high blood pressure control and the use of antihypertensive medications in older adults: the Cardiovascular Health StudyBruce M Psaty
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
Arch Intern Med 162:2325-32. 2002..More widespread use of these agents will be an important intervention to prevent the devastating complications of hypertension, including stroke, myocardial infarction, and heart failure... - Civil protection orders and risk of subsequent police-reported violenceVictoria L Holt
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Box 358080 MP474, Seattle, WA 98195 8080, USA
JAMA 288:589-94. 2002..Approximately 1.5 million US women experience intimate partner violence annually. Approximately 20% of these women obtain civil protection orders, but the effectiveness of such orders in preventing future violence is unclear... - Exposure and measurement contributions to estimates of acute air pollution effectsLianne Sheppard
Department of Biostatistics, University of Washington, Seattle, 98195, USA
J Expo Anal Environ Epidemiol 15:366-76. 2005..We conclude that general statements about the implications of measurement error need to be conditioned on the health effect study design and the health effect parameter to be estimated... - beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health StudyLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Am J Hypertens 18:392-7. 2005.... - Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and strokeRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative, Seattle 98101 1448, USA
Arch Intern Med 166:399-404. 2006..The association of these end points with the use of esterified estrogen (EE) is unknown... - Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal womenLucia A Hindorff
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98101, USA
Am J Epidemiol 163:600-7. 2006..These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women... - A case-crossover study of wintertime ambient air pollution and infant bronchiolitisCatherine Karr
Department of Pediatrics, University of Washington, Seattle, Washington 98104, USA
Environ Health Perspect 114:277-81. 2006..We examined the association of infant bronchiolitis with acute exposure to ambient air pollutants... - Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertensionGina D Schellenbaum
Department of Epidemiology, University of Washington, Seattle, Washington, USA
J Am Geriatr Soc 53:1996-2000. 2005..To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults... - Association of beta-blocker use with mortality among patients with congestive heart failure in the Cardiovascular Health Study (CHS)Jeannie D Chan
Department of Pharmacy, University of Washington, Seattle, Washington, USA
Am Heart J 150:464-70. 2005..This study assessed the association between beta-blocker therapy and mortality among community-dwelling older adults with CHF... - Congestive heart failure incidence and prognosis: case identification using central adjudication versus hospital discharge diagnosesGina D Schellenbaum
Department of Epidemiology, University of Washington, Seattle, WA 98101, and Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
Ann Epidemiol 16:115-22. 2006..We compared hospitalized congestive heart failure (CHF) incidence and prognosis estimates using hospital discharge diagnoses or central adjudication... - Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health studyAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
Atherosclerosis 181:175-83. 2005..These findings suggest that modulators of fibrinolytic activity may have a generalized influence on aging, and merit further investigation in studies of genetic determinants of human longevity... - Pulmonary effects of indoor- and outdoor-generated particles in children with asthmaJane Q Koenig
Department of Environmental Health and Occupational Sciences, University of Washington, Seattle, Washington 98195, USA
Environ Health Perspect 113:499-503. 2005..We conclude that the ambient-generated component of PM2.5 exposure is consistently associated with increases in eNO and the indoor-generated component is less strongly associated with eNO... - Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertensionBruce M Psaty
Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
JAMA 287:1680-9. 2002..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown... - Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrestRozenn N Lemaitre
Department of Medicine, University of Washington, Seattle, WA 98101, USA
Metabolism 58:534-40. 2009..The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest... - Panel discussion review: session three--issues involved in interpretation of epidemiologic analyses--statistical modelingThomas F Bateson
National Center for Environmental Assessment, US Environmental Protection Agency, Washington, District of Columbia 20460, USA
J Expo Sci Environ Epidemiol 17:S90-6. 2007.... - The sensitivity and specificity of markers for event timesTianxi Cai
Department of Biostatistics, Harvard University, Boston, MA 02115, USA
Biostatistics 7:182-97. 2006..We illustrate our methods with data from the Cardiovascular Health Study, relating the FR-score measured at enrollment to subsequent risk of cardiovascular events... - Time series analyses of air pollution and health: straining at gnats and swallowing camels?Thomas Lumley
Department of Biostatistics, University of Washington, Seattle 98195, USA
Epidemiology 14:13-4. 2003 - beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and strokeRozenn N Lemaitre
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Hypertens 21:290-6. 2008..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility... - Breast cancer recurrence risk in relation to antidepressant use after diagnosisJessica Chubak
Group Health Center for Health Studies, 1730 Minor Ave, Suite 1600, Seattle, WA 98101 1448, USA
Breast Cancer Res Treat 112:123-32. 2008.... - Per-channel basis normalization methods for flow cytometry dataFlorian Hahne
Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Cytometry A 77:121-31. 2010..Such automated analyses are essential for high-throughput flow cytometry... - Association of alcohol-related laws with deaths due to motor vehicle and motorcycle crashes in the United States, 1980-1997Andres Villaveces
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, USA
Am J Epidemiol 157:131-40. 2003..86, 0.90) and administrative license revocation laws (adjusted RR = 0.95, 95% CI: 0.93, 0.98). Overall motorcycle mortality was lower when administrative license revocation laws were in effect (adjusted RR = 0.95, 95% CI: 0.92, 0.98)...
Research Grants
- CARDIOVASCULAR BIOSTATISTICS TRAININGThomas Lumley; Fiscal Year: 2007..All trainees are additionally required to act as teaching assistants, to provide experience in communicating statistical concepts to non-statisticians. ..
- The Statistical and Computational Analysis of Flow Cytometry DataThomas Lumley; Fiscal Year: 2009..The impact of these tools will be to provide better, more reliable, tools for the analysis of flow cytometry data. The domain of application spans all diseases, but current applications are focused on HIV disease and cancer. ..