T F Lue

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Peyronie's disease: a review
    Shahram S Gholami
    Knupps Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 169:1234-41. 2003
  2. ncbi Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part I
    Anthony J Bella
    Department of Urology, University of California San Francisco, San Francisco, CA 94143 0738, USA
    J Sex Med 3:815-20. 2006
  3. ncbi Neurogenic erectile dysfunction
    T F Lue
    Department of Urology, University of California, San Francisco 94143 0738, USA
    Clin Auton Res 11:285-94. 2001
  4. ncbi Summary of the recommendations on sexual dysfunctions in men
    Tom F Lue
    Department of Urology, UCSF, San Francisco, CA, USA
    J Sex Med 1:6-23. 2004
  5. ncbi Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia
    G Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    BJU Int 92:631-5. 2003
  6. ncbi Vascular endothelial growth factor promotes proliferation and migration of cavernous smooth muscle cells
    X Liu
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California, USA
    J Urol 166:354-60. 2001
  7. ncbi The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence
    M E Bakircioglu
    Department of Urology, University of California School of Medicine, San Francisco, California 94143-0738, USA
    J Urol 165:2103-9. 2001
  8. ncbi The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia
    Shahram S Gholami
    Department of Urology, University of California, San Francisco, USA
    J Urol 169:1577-81. 2003
  9. ncbi Decreased trabecular smooth muscle and caveolin-1 expression in the penile tissue of aged rats
    M E Bakircioglu
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California 94115-3465, USA
    J Urol 166:734-8. 2001
  10. ncbi Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury
    Thomas M Fandel
    University of California, San Francisco Urology, San Francisco, CA 94143 0738, USA
    J Sex Med 5:1866-75. 2008

Collaborators

Detail Information

Publications120 found, 100 shown here

  1. ncbi Peyronie's disease: a review
    Shahram S Gholami
    Knupps Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 169:1234-41. 2003
    ..CONCLUSIONS: Currently patients with Peyronie's disease have had improvements in prognosis and experienced an expansion of the available therapeutic options...
  2. ncbi Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part I
    Anthony J Bella
    Department of Urology, University of California San Francisco, San Francisco, CA 94143 0738, USA
    J Sex Med 3:815-20. 2006
    ..Identification of the molecular mechanism of cavernous nerve regeneration is essential for future development of neuroprotective and regenerative strategies...
  3. ncbi Neurogenic erectile dysfunction
    T F Lue
    Department of Urology, University of California, San Francisco 94143 0738, USA
    Clin Auton Res 11:285-94. 2001
    ..This review discusses the physiology, pathophysiology, diagnosis, and treatment of erectile function and dysfunction, as well as strategies for future research...
  4. ncbi Summary of the recommendations on sexual dysfunctions in men
    Tom F Lue
    Department of Urology, UCSF, San Francisco, CA, USA
    J Sex Med 1:6-23. 2004
    ..Disorders of sexual function in men include erectile dysfunction, orgasm/ejaculation disorders, priapism, and Peyronie's disease...
  5. ncbi Neurotrophic effects of vascular endothelial growth factor and neurotrophins on cultured major pelvic ganglia
    G Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    BJU Int 92:631-5. 2003
    ..To investigate the feasibility of using a ganglial culture system to screen various growth factors as potential therapeutic agents for pelvic nerve injuries...
  6. ncbi Vascular endothelial growth factor promotes proliferation and migration of cavernous smooth muscle cells
    X Liu
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California, USA
    J Urol 166:354-60. 2001
    ..Cavernous smooth muscle cells responded to VEGF in terms of cell proliferation and migration. Cavernous smooth muscle cells from rats of different ages expressed different levels of VEGFR-1 but did not express VEGFR-2...
  7. ncbi The effect of adeno-associated virus mediated brain derived neurotrophic factor in an animal model of neurogenic impotence
    M E Bakircioglu
    Department of Urology, University of California School of Medicine, San Francisco, California 94143-0738, USA
    J Urol 165:2103-9. 2001
    ....
  8. ncbi The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia
    Shahram S Gholami
    Department of Urology, University of California, San Francisco, USA
    J Urol 169:1577-81. 2003
    ..VEGF and AAV-BDNF appeared to alleviate partially these changes. CONCLUSIONS: A high fat diet caused erectile dysfunction with accompanying neurological and vascular changes. VEGF and AAV-BDNF seemed to alleviate these problems...
  9. ncbi Decreased trabecular smooth muscle and caveolin-1 expression in the penile tissue of aged rats
    M E Bakircioglu
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California 94115-3465, USA
    J Urol 166:734-8. 2001
    ..CONCLUSIONS: In these aged rats the decreased ratio of trabecular smooth muscle-to-collagen and the reduced expression of caveolin-1 may contribute to erectile dysfunction...
  10. ncbi Intracavernous growth differentiation factor-5 therapy enhances the recovery of erectile function in a rat model of cavernous nerve injury
    Thomas M Fandel
    University of California, San Francisco Urology, San Francisco, CA 94143 0738, USA
    J Sex Med 5:1866-75. 2008
    ..Neurogenic erectile dysfunction remains a serious complication in the postprostatectomy population. Effective protective and regenerative neuromodulatory strategies are needed...
  11. ncbi The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction
    Ming-Chan Lee
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California School of Medicine, San Francisco, California
    J Urol 167:761-7. 2002
    ..Intracavernous injection of VEGF minutes after arterial ligation facilitated the recovery of erectile function...
  12. ncbi Effect of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 complex in cavernous nerve cryoablation
    D Bochinski
    Department of Urology, School of Medicine, University of California, San Francisco, California 94143-0738, USA
    Int J Impot Res 16:418-23. 2004
    ..The reverse effect was noted with the IGFBP-3 complex injection...
  13. ncbi Growth factor therapy and neuronal nitric oxide synthase
    C-S Lin
    Department of Urology, University of California at San Francisco, San Francisco, California 94143-0738, USA
    Int J Impot Res 16:S38-9. 2004
    ..International Journal of Impotence Research (2004) 16, S38-S39. doi:10.1038/sj.ijir.3901214..
  14. ncbi The effect of intracavernous injection of adipose tissue-derived stem cells on hyperlipidemia-associated erectile dysfunction in a rat model
    Yun Ching Huang
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA, USA
    J Sex Med 7:1391-400. 2010
    ..Adipose tissue-derived stem cells (ADSC) have been shown to differentiate into endothelial cells and secrete vasculotrophic and neurotrophic factors...
  15. ncbi Vascular endothelial growth factor restores erectile function through modulation of the insulin-like growth factor system and sex hormone receptors in diabetic rat
    Masato Shirai
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, USA
    Biochem Biophys Res Commun 341:755-62. 2006
    ..These results may be important in understanding the pathogenesis of diabetes-related ED and also in providing better strategies for management of this disease...
  16. ncbi Gene expression profiling of an arteriogenic impotence model
    C S Lin
    Knuppe Molecular Urology Laboratory, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 1695, USA
    Biochem Biophys Res Commun 285:565-9. 2001
    ..Finally, VEGF, whose induction has been identified in many other ischemic tissues, was not induced in corpus cavernous tissue of ligated rats...
  17. ncbi The additive erectile recovery effect of brain-derived neurotrophic factor combined with vascular endothelial growth factor in a rat model of neurogenic impotence
    Kuo-Chiang Chen
    Department of Urology, University of California San Francisco, San Francisco, CA, USA
    BJU Int 95:1077-80. 2005
    ..Intracavernosal injection with either VEGF or AAV-BDNF alone enhances nerve regeneration, with combined therapy (VEGF and AAV-BDNF) promoting neural and erectile recovery additively...
  18. ncbi Effects of birth trauma and estrogen on urethral elastic fibers and elastin expression
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco, San Francisco, California, USA
    Urology 76:1018.e8-13. 2010
    ..To investigate the effects of birth trauma and estrogen on urethral elastic fibers and elastin expression...
  19. ncbi Effects of estrogen, raloxifene and levormeloxifene on alpha1A-adrenergic receptor expression
    Lia Banie
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California San Francisco, San Francisco, California 94143 0738, USA
    J Urol 180:2241-6. 2008
    ..We investigated the effect of estrogen, raloxifene and levormeloxifene on alpha1A-adrenergic receptor expression...
  20. ncbi Treatment of stress urinary incontinence with adipose tissue-derived stem cells
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California, USA
    Cytotherapy 12:88-95. 2010
    ..Effective treatment for stress urinary incontinence (SUI) is lacking. This study investigated whether transplantation of adipose tissue-derived stem cells (ADSC) can treat SUI in a rat model...
  21. ncbi Response of guinea pig smooth and striated urethral sphincter to cromakalim, prazosin, nifedipine, nitroprusside, and electrical stimulation
    B von Heyden
    Department of Urology, University of California School of Medicine, San Francisco, USA
    Neurourol Urodyn 14:153-68. 1995
    ..The potential to weaken sphincteric closure with drugs, exemplified by the results obtained in response to prazosin and cromakalim, would represent a therapeutic advance in the patient with neurogenic bladder dysfunction...
  22. ncbi Identification and regulation of human PDE5A gene promoter
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 1695, USA
    Biochem Biophys Res Commun 280:684-92. 2001
    ..DNase I footprint analysis identified four AP2- and two Sp1-binding sites in the 5' extension and four Sp1-binding sites in the 3' extensions. Cyclic AMP and cGMP had similar stimulatory effects on the PDE5A promoter...
  23. ncbi Neuron-like differentiation of adipose tissue-derived stromal cells and vascular smooth muscle cells
    Hongxiu Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-1695, USA
    Differentiation 74:510-8. 2006
    ..Finally, we showed that vascular smooth muscle cells could also be induced by either NIM or IBMX to differentiate into neuron-like cells that expressed NF70...
  24. ncbi Brain-derived neurotrophic factor (BDNF) acts primarily via the JAK/STAT pathway to promote neurite growth in the major pelvic ganglion of the rat: part 2
    Guiting Lin
    Knuppe Molecular Urology, Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-1695, USA
    J Sex Med 3:821-7; discussion 828-9. 2006
    ..Optimal BDNF dosage for promoting MPG neurite growth was between 25 and 50 ng/mL. BDNF promotes MPG neurite growth primarily by activating the JAK/STAT pathway...
  25. ncbi Fibroblast growth factor 2 promotes endothelial differentiation of adipose tissue-derived stem cells
    Hongxiu Ning
    University of California, School of Medicine, Knuppe Molecular Urology Laboratory Department of Urology, San Francisco, California 94143, USA
    J Sex Med 6:967-79. 2009
    ..Adipose tissue-derived stem cells (ADSC) could potentially restore endothelial function in vasculogenic erectile dysfunction (ED). The mechanism for ADSC endothelial differentiation remained unidentified...
  26. ncbi Tracking intracavernously injected adipose-derived stem cells to bone marrow
    G Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Int J Impot Res 23:268-75. 2011
    ..The significance of these results in relation to SC therapy for ED is discussed...
  27. ncbi Peyronie's disease: an anatomically-based hypothesis and beyond
    T F Lue
    University of California at San Francisco, Department of Urology, San Francisco, California 94143-0738, USA
    Int J Impot Res 14:411-3. 2002
  28. ncbi Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences
    C S Lin
    Department of Urology, University of California, San Francisco 94143, USA
    DNA Cell Biol 19:1-7. 2000
    ....
  29. ncbi Identification of three alternative first exons and an intronic promoter of human PDE5A gene
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, California 94143 1695, USA
    Biochem Biophys Res Commun 268:596-602. 2000
    ..However, the sequence bound by AP-2 (5'-GGGAAACGCTCGCGGGAGAGTTGG) is unusual in that it bears little resemblance to the consensus AP-2-binding sequence...
  30. ncbi Intracavernosal injection of vascular endothelial growth factor induces nitric oxide synthase isoforms
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
    BJU Int 89:955-60. 2002
    ....
  31. ncbi Cyclic AMP and cyclic GMP activate protein kinase G in cavernosal smooth muscle cells: old age is a negative factor
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 1695, USA
    BJU Int 89:576-82. 2002
    ..To investigate protein kinase G-I (PKG-I) expression and activation in cavernosal smooth muscle cells (CSMC) of young and old rats...
  32. ncbi Human PDE5A gene encodes three PDE5 isoforms from two alternate promoters
    C S Lin
    Knuppe Molecular Urology Laboratory, School of Medicine, University of California, San Francisco, CA 94143 1695, USA
    Int J Impot Res 14:15-24. 2002
    ..Both promoters were upregulated by increasing concentrations of either cAMP or cGMP. Several transcription factor AP2 and Sp1-binding sequences identified in the promoters are likely to be the mediators of cAMP/cGMP-responsiveness...
  33. ncbi Expression of three isoforms of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, California 94143 1695, USA
    Biochem Biophys Res Commun 268:628-35. 2000
    ..75, and 6.06 microM, respectively. Their cGMP-catalytic activities were inhibited by zaprinast with IC(50) values of 3.2 microM, 1.3 microM, and 1.6 microM, respectively, and by sildenafil with IC(50) of 28, 14, and 13 nM, respectively...
  34. ncbi Medical student sexuality: how sexual experience and sexuality training impact U.S. and Canadian medical students' comfort in dealing with patients' sexuality in clinical practice
    Alan W Shindel
    Department of Urology, University of California, San Francisco, CA, USA
    Acad Med 85:1321-30. 2010
    ..To determine factors associated with students' comfort in addressing patients' sexuality in the clinical context...
  35. ncbi FK1706 enhances the recovery of erectile function following bilateral cavernous nerve crush injury in the rat
    Anthony J Bella
    Division of Urology, University of California San Francisco, San Francisco, CA, USA
    J Sex Med 4:341-6; discussion 346-7. 2007
    ....
  36. ncbi Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo
    Alan W Shindel
    University of California Knuppe Molecular Urology Laboratory Department of Urology, School of Medicine, San Francisco, CA, USA
    J Sex Med 7:1518-28. 2010
    ..Epimedium species (aka horny goat weed) have been utilized for the treatment of erectile dysfunction in Traditional Chinese Medicine for many years. Icariin (ICA) is the active moiety of Epimedium species...
  37. ncbi Upregulation of penile brain-derived neurotrophic factor (BDNF) and activation of the JAK/STAT signalling pathway in the major pelvic ganglion of the rat after cavernous nerve transection
    Anthony J Bella
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    Eur Urol 52:574-80. 2007
    ....
  38. ncbi Expression, distribution and regulation of phosphodiesterase 5
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, 1657 Scott Street, Room 210, Box 1695, San Francisco, CA 94115, USA
    Curr Pharm Des 12:3439-57. 2006
    ..Virtually all tissues and cell types express PDE5, with heart and cardiomyocytes being contentious. PDE5A1 and PDE5A2 are ubiquitous, but PDE5A3 is specific to smooth muscle...
  39. ncbi Racial disparities in erectile dysfunction among participants in the California Men's Health Study
    James F Smith
    University of California, San Francisco, Department of Urology, San Francisco, CA 94143, USA
    J Sex Med 6:3433-9. 2009
    ..The burden of erectile dysfunction (ED) among different racial and ethnic groups is unclear, in part, because prior studies have not included all four major racial and ethnic groups in the same population-based sample...
  40. ncbi Surgical Atlas. Correction of Peyronie's disease: plaque incision and grafting
    William O Brant
    Department of Urology, University of California, San Francisco, USA
    BJU Int 97:1353-60. 2006
  41. ncbi Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells
    Hongxiu Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94115, USA
    Urology 68:1350-4. 2006
    ..Icariin was able to enhance cGMP levels in SNP-treated cavernous smooth muscle cells...
  42. ncbi Recent advances in andrology-related stem cell research
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California San Francisco, CA 94143, USA
    Asian J Androl 10:171-5. 2008
    ..We are also investigating whether ADSC can differentiate into Leydig, Sertoli and male germ cells. The eventual goal is to use ADSC to treat male infertility and testosterone deficiency...
  43. ncbi A noninvasive, motility independent, sperm sorting method and technology to identify and retrieve individual viable nonmotile sperm for intracytoplasmic sperm injection
    Maurice M Garcia
    Department of Urology, University of California San Francisco, San Francisco, California 94143, USA
    J Urol 184:2466-72. 2010
    ..We assessed the ability of optoelectronic tweezers to distinguish viable from nonviable individual nonmotile human sperm...
  44. ncbi Molecular mechanisms related to parturition-induced stress urinary incontinence
    Guiting Lin
    Department of Urology, School of Medicine, University of California, San Francisco, CA 94143, USA
    Eur Urol 55:1213-22. 2009
    ..The molecular mechanisms underlying stress urinary incontinence (SUI) at the tissue level are poorly understood...
  45. ncbi Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells
    Maurice M Garcia
    Department of Urology, University of California School of Medicine Knuppe Molecular Urology Laboratory, San Francisco, CA 94143 0738, USA
    J Sex Med 7:89-98. 2010
    ..Erectile dysfunction (ED) is a major complication of type 2 diabetes, and many diabetic men with ED are refractory to common ED therapies...
  46. ncbi Effects of transplantation of adipose tissue-derived stem cells on prostate tumor
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Prostate 70:1066-73. 2010
    ..Obesity is a risk factor for prostate cancer development, but the underlying mechanism is unknown. The present study tested the hypothesis that stromal cells of the adipose tissue might be recruited by cancer cells to help tumor growth...
  47. ncbi Defining adipose tissue-derived stem cells in tissue and in culture
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    Histol Histopathol 25:807-15. 2010
    ..In the larger vessels, these ADSC or VSC exist as specialized fibroblasts (having stem cell properties) in the adventitia...
  48. ncbi Penile sonographic and clinical characteristics in men with Peyronie's disease
    James F Smith
    University of California Department of Urology, 1600 Divisadero, Box 1695, San Francisco, CA 94143, USA
    J Sex Med 6:2858-67. 2009
    ..Ultrasonography of the penis is readily available to the urologist and gives good anatomic detail of soft tissue structures. It has not been widely utilized in the assessment of Peyronie's disease (PD)...
  49. ncbi MicroRNA regulation of neuron-like differentiation of adipose tissue-derived stem cells
    Hongxiu Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Differentiation 78:253-9. 2009
    ..Thus, IGF-I signaling and miR-133b co-regulate potential neural differentiation of ADSC through a feedback mechanism, in which IGF-I upregulates miR-133b while miR-133b in turn downregulates IGF-IR...
  50. ncbi Who is the 40-year-old virgin and where did he/she come from? Data from the National Survey of Family Growth
    Michael L Eisenberg
    Department of Urology, University of California, San Francisco, CA 94143 0738, USA
    J Sex Med 6:2154-61. 2009
    ..Individuals who have not engaged in sexual activity may theoretically have diminished overall quality of life, as recent evidence suggests that sexual activity may be related to overall health status in adults...
  51. ncbi Neurotrophic effects of brain-derived neurotrophic factor and vascular endothelial growth factor in major pelvic ganglia of young and aged rats
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA
    BJU Int 105:114-20. 2010
    ..To investigate the neurotrophic effect of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in cultured major pelvic ganglia (MPG) derived from young and aged rats...
  52. ncbi Potential of adipose-derived stem cells for treatment of erectile dysfunction
    Guiting Lin
    School of Medicine, Department of Urology, University of California Knuppe Molecular Urology Laboratory, San Francisco, CA 94143 0738, USA
    J Sex Med 6:320-7. 2009
    ....
  53. ncbi Pentoxifylline attenuates transforming growth factor-β1-stimulated collagen deposition and elastogenesis in human tunica albuginea-derived fibroblasts part 1: impact on extracellular matrix
    Alan W Shindel
    University of California Knuppe Molecular Urology Laboratory, Department of Urology, San Francisco, CA 94143, USA
    J Sex Med 7:2077-85. 2010
    ..Pentoxifylline (PTX) antagonizes the effects of TGF-β1 and has been utilized in our clinic for the management of PD...
  54. ncbi Pentoxifylline attenuates transforming growth factor-beta1-stimulated elastogenesis in human tunica albuginea-derived fibroblasts part 2: Interference in a TGF-beta1/Smad-dependent mechanism and downregulation of AAT1
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 0738, United States
    J Sex Med 7:1787-97. 2010
    ..Pentoxifylline (PTX) antagonizes the effects of TGF-beta1 and has been utilized in our clinic for the management of PD although the mechanisms of action are not entirely clear...
  55. ncbi Androgen blockade for the treatment of high-flow priapism
    Kuwong B Mwamukonda
    Urology Department, University of California San Francisco, California 94143, USA
    J Sex Med 7:2532-7. 2010
    ..In cases that do not resolve spontaneously, standard management is by selective embolization, resulting in resolution rates as high as 78%; however, erectile dysfunction (ED) is a frequent complication, occurring in up to 39% of cases...
  56. ncbi Molecular Yin and Yang of erectile function and dysfunction
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, University of California, San Francisco, CA 94143, USA
    Asian J Androl 10:433-40. 2008
    ..g., Rho kinase and protein kinase G), branching into secondary effectors, and finishing with contractile molecules and phosphodiesterases. Interactions between the Yin and Yang signaling pathways are discussed as well...
  57. ncbi Cyclic nucleotide signaling in cavernous smooth muscle
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California, San Francisco, CA 94143 1695, USA
    J Sex Med 2:478-91. 2005
    ..The involvement of these molecules in the development of erectile dysfunction and the possibility of using them as therapeutic agents or targets are also discussed...
  58. ncbi The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
    Derek Bochinski
    Department of Urology, University of California, San Francisco, CA, USA
    BJU Int 94:904-9. 2004
    ..CONCLUSION: We were able to isolate embryonic stem cells that had differentiated along the neural cell line and, using these NES cells intracavernosally, showed improved erectile function in a rat model of neurogenic impotence...
  59. ncbi Improving erectile function by silencing phosphodiesterase-5
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California-San Francisco 94143-1695, USA
    J Urol 174:1142-8. 2005
    ..PDE5 expression was decreased in the siRNA treated cavernous smooth muscle. CONCLUSIONS: PDE5 expression could be decreased by siRNA, resulting in prolonged cGMP accumulation and improved erection...
  60. ncbi Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism
    Guiting Lin
    Department of Urology, Knuppe Molecular Urology Laboratory, University of California School of Medicine, San Francisco, CA 94143-1695, USA
    J Urol 170:S15-8; discussion S19. 2003
    ..Adequate oxygenation was important for PDE-5 expression. Thus, sicklemic patients may express PDE-5 at abnormally low levels, predisposing them at risk of stuttering priapism...
  61. ncbi Vascular endothelial growth factor induces IP-10 chemokine expression
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, University of California at San Francisco, San Francisco, CA 94143 1695, USA
    Biochem Biophys Res Commun 292:79-82. 2002
    ..Secretion of IP-10 into culture medium peaked at 4 h after treatment of human CSMC with 10 ng/ml of VEGF. Optimal VEGF dosage for IP-10 induction was 50 ng/ml when assayed with cells that were treated for 8 h...
  62. ncbi Upregulation of monocyte chemoattractant protein 1 and effects of transforming growth factor-beta 1 in Peyronie's disease
    Ching Shwun Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 1695, USA
    Biochem Biophys Res Commun 295:1014-9. 2002
    ..Treatment with TGF-beta1-induced higher expression of MCP-1 but not CTGF in all three types of cells, with C cells being the most responsive. Based on these observations, we propose that MCP-1 could be a novel therapeutic target in PD...
  63. ncbi The effect of vascular endothelial growth factor and brain-derived neurotrophic factor on cavernosal nerve regeneration in a nerve-crush rat model
    P-S Hsieh
    Department of Urology, University of California, San Francisco, CA 94143, USA
    BJU Int 92:470-5. 2003
    ..Therefore it might have therapeutic potential for enhancing the recovery of erectile function after radical pelvic surgery...
  64. ncbi Wogonin suppresses cellular proliferation and expression of monocyte chemoattractant protein 1 in Peyronie's plaque-derived cells
    Z Wang
    Department of Urology, School of Medicine, University of California, San Francisco, USA
    BJU Int 92:753-7. 2003
    ..In most cases, the effect of wogonin was greatest against cells derived from the plaque. Wogonin appears to be a worthy candidate for preclinical trials in men with PD...
  65. ncbi Age-related decrease of protein kinase G activation in vascular smooth muscle cells
    C S Lin
    Knuppe Molecular Urology Laboratory, University of California, San Francisco, CA 94143 1695, USA
    Biochem Biophys Res Commun 287:244-8. 2001
    ..We propose that the reduced PKG-I activation may explain why vascular relaxation is decreased in older individuals...
  66. ncbi Peyronie's disease
    S S Gholami
    Department of Urology, University of California San Francisco, San Francisco, California, USA
    Urol Clin North Am 28:377-90. 2001
    ..Education on the pathogenesis and natural history of the disease will allow the patient and his partner to make an informed decision in regards to treatment options and expected outcomes...
  67. ncbi The effect of FK1706 on erectile function following bilateral cavernous nerve crush injury in a rat model
    Narihiko Hayashi
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, 94143, USA
    J Urol 176:824-9. 2006
    ..CONCLUSIONS: Bilateral cavernous nerve crush causes reproducible erectile dysfunction, consistent with prior experiments. High dose subcutaneous FK1706 therapy promotes significant neuroregeneration and erectile function recovery...
  68. ncbi Labeling and tracking of mesenchymal stromal cells with EdU
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Cytotherapy 11:864-73. 2009
    ..In the present study we tested a new thymidine analog, 5-ethynyl-2-deoxyuridine (EdU), for labeling and tracking of mesenchymal stromal cells (MSC), specifically adipose tissue-derived stem cells (ADSC)...
  69. ncbi Treatment of type 1 diabetes with adipose tissue-derived stem cells expressing pancreatic duodenal homeobox 1
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Stem Cells Dev 18:1399-406. 2009
    ..Histological examination showed that the transplanted cells formed tissue-like structures and expressed insulin. Thus, ADSC-expressing Pdx1 appear to be suitable for treatment of DM...
  70. ncbi Approach to management of penile fracture in men with underlying Peyronie's disease
    Thomas X Minor
    Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143, USA
    Urology 68:858-61. 2006
    ..CONCLUSIONS: Patients with PD who have a penile fracture are candidates for combined fracture repair and tunica plication at the same setting...
  71. ncbi Physiology of penile erection and pathophysiology of erectile dysfunction
    Robert C Dean
    Department of Urology, University of California-San Francisco, San Francisco Medical Center, San Francisco, CA 94143-0738, USA
    Urol Clin North Am 32:379-95, v. 2005
    ..The understanding of the nitric oxide pathway has aided not only in the molecular understanding of the tumescence but also greatly in the therapy of erectile dysfunction...
  72. ncbi The potential of hormones and selective oestrogen receptor modulators in preventing voiding dysfunction in rats
    Kavirach Tantiwongse
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco, San Francisco, CA 94143 0738, USA
    BJU Int 102:242-6. 2008
    ..To investigate whether oestrogen, selective oestrogen receptor modulators (SERMs), and growth hormone (GH) can prevent the development of voiding dysfunction in a postpartum postmenopausal rat model of voiding dysfunction...
  73. ncbi A coculture system of cavernous endothelial and smooth muscle cells
    H Ning
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Int J Impot Res 25:63-8. 2013
    ..These data are consistent with previously observed changes in the cavernous tissues of diabetic patients and thus suggest that the coculture system could be utilized for diabetic ED research...
  74. ncbi The treatment of priapism--when and how?
    D J Bochinski
    Department of Urology, University of California, San Francisco, California 94143 0738, USA
    Int J Impot Res 15:S86-90. 2003
    ..As well, the medical and surgical treatment options for these two conditions will be described in detail. A third entity known as stuttering priapism will also be discussed as will its unique treatment alternatives...
  75. ncbi Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction
    M Shirai
    VA Medical Center and UCSF, Urology, San Francisco, California 94121, USA
    Int J Impot Res 15:391-6. 2003
    ..This is the first study to demonstrate that downregulation of sex hormone receptors in aging rat crura is associated with erectile dysfunction...
  76. ncbi Isolation of two isoforms of phosphodiesterase 5 from rat penis
    C S Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco, California 94143 1695, USA
    Int J Impot Res 15:129-36. 2003
    ..International Journal of Impotence Research (2003) 15, 129-136. doi:10.1038/sj.ijir.3900983..
  77. ncbi Androgen, estrogen, and progesterone receptor gene regulation during diabetic erectile dysfunction and insulin treatment
    Masato Shirai
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, School of Medicine, San Francisco, California 94121, USA
    Urology 64:1244-9. 2004
    ..Insulin treatment can restore erectile function through modulation of sex hormone receptor genes...
  78. ncbi Prevention and treatment of erectile dysfunction using lifestyle changes and dietary supplements: what works and what is worthless, part II
    Mark A Moyad
    Department of Urology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0330, USA
    Urol Clin North Am 31:259-73. 2004
    ..The coming years of research should bring enormous excitement and objectivity to this area of medicine...
  79. ncbi Combined penile plication surgery and insertion of penile prosthesis for severe penile curvature and erectile dysfunction
    Nadeem U Rahman
    Department of Urology, University of California-San Francisco, San Francisco, California 94143, USA
    J Urol 171:2346-9. 2004
    ..CONCLUSIONS: In cases of severe penile deformity and curvature with erectile dysfunction the combination of penile plication and inflatable penile prosthesis placement is a method of repair that is well tolerated...
  80. ncbi Longitudinal differences in disease specific quality of life in men with erectile dysfunction: results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction study
    David M Latini
    Department of Urology and Urology Outcomes Research Group, Univeristy of California, San Francisco, USA
    J Urol 169:1437-42. 2003
    ....
  81. ncbi Defining stem and progenitor cells within adipose tissue
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143 0738, USA
    Stem Cells Dev 17:1053-63. 2008
    ..Isolated, ADSC can be induced to differentiate into additional cell types such as osteoblasts and chondrocytes...
  82. ncbi Long-term effect of ovariectomy and simulated birth trauma on the lower urinary tract of female rats
    Julio Resplande
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California-San Francisco, San Francisco, California, USA
    J Urol 168:323-30. 2002
    ..However, this finding was not seen in the muscle layers or in other urogenital tissues. Some ultrastructural changes also occurred that may explain some symptoms that women have after vaginal childbirth and menopause...
  83. ncbi Effect of cell passage and density on protein kinase G expression and activation in vascular smooth muscle cells
    Guiting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, California 94143-1695, USA
    J Cell Biochem 92:104-12. 2004
    ..The results showed that p4 had higher level of PKG-I activation than p11...
  84. ncbi [The in vitro and in vivo experimental models of erectile nerve regeneration]
    Gui Ting Lin
    Department of Urology, University of California, San Francisco, CA 94143, USA
    Zhonghua Nan Ke Xue 13:1059-63. 2007
    ..This has been further established by our in vivo model, which involves the transection or cruch of cavernous nerves and treatment with BDNF...
  85. ncbi Isolated septal fibrosis or hematoma--atypical Peyronie's disease?
    William O Brant
    Department of Urology, University of California San Francisco, San Francisco, California 94143 0738, USA
    J Urol 177:179-82; discussion 183. 2007
    ..We frequently examine patients with suspected Peyronie's disease ultrasonographically and have noted a subset of patients in whom we could identify only a circumscribed septal lesion. We identified characteristics of these patients...
  86. ncbi Identification of potential biomarkers of Peyronie's disease
    Gui-ting Lin
    Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA 94143-1695, USA
    Asian J Androl 7:237-43. 2005
    ..9 kDa that were downregulated in PT cells. CONCLUSION: MCP-1, which is often involved in tissue fibrosis, was expressed at higher levels in PT than that in NT cells. Five potential biomarkers for PD were identified by SELDI-MS analysis...
  87. ncbi An animal model to study lower urinary tract symptoms and erectile dysfunction: the hyperlipidaemic rat
    Nadeem U Rahman
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California San Francisco School of Medicine, San Francisco, CA 94143 0788, USA
    BJU Int 100:658-63. 2007
    ....
  88. ncbi Obstructive lower urinary tract symptoms correlate with erectile dysfunction
    Sean P Elliott
    Department of Urology, University of California, San Francisco, School of Medicine, San Francisco, California 94143-0738, USA
    Urology 63:1148-52. 2004
    ..Although age correlated with ED, it did not add to the power of the multiple linear regression model composed of obstructive IPSS and depression...
  89. ncbi Peyronie's disease: a critical appraisal of current diagnosis and treatment
    J F Smith
    Clinical Fellow Male Infertility and Erectile Dysfunction, University of California, San Francisco, CA 94143, USA
    Int J Impot Res 20:445-59. 2008
    ..The choice of corrective procedure should be tailored to each patient after a detailed evaluation of disease severity and sexual function...
  90. ncbi Health issues of men: prevalence and correlates of erectile dysfunction
    R Shabsigh
    Department of Urology, Columbia University, New York, New York 10032, USA
    J Urol 174:662-7. 2005
    ..The prevalence of erectile dysfunction (ED) and its correlation with patient age, overall health and comorbidities were assessed...
  91. ncbi Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats
    R S Rogers
    Knuppe Molecular Urology Laboratory, Department of Urology, University of California School of Medicine, 94143, USA
    Int J Impot Res 15:26-37. 2003
    ..Intracavernous injection of either VEGF protein or VEGF gene may be a preferred therapy to preserve erectile function in patients in whom testosterone therapy is contraindicated...
  92. ncbi Association of lower urinary tract symptoms and erectile dysfunction: pathophysiological aspects and implications for clinical management
    H Orabi
    Department of Urology, School of Medicine, University of California, San Francisco, CA 94143 0738, USA
    Int J Impot Res 23:99-108. 2011
    ..Much further investigation is required, but it is evident that the association between LUTS and ED is fundamental for future therapies and possible preventative strategies...
  93. ncbi The effect of simulated birth trauma and/or ovariectomy on rodent continence mechanism. Part I: functional and structural change
    K D Sievert
    Department of Urology, University of California, School of Medicine, San Francisco, California 94143-0738, USA
    J Urol 166:311-7. 2001
    ..The alteration in smooth muscle caveolae as well as the membrane protein caveolin may have a role in functional alterations caused by birth trauma and ovariectomy...
  94. ncbi Surgical management: saphenous vein grafts
    J A Chang
    University of California at San Francisco, Department of Urology, 533 Parnassus Avenue, San Francisco, California 94143-0738, USA
    Int J Impot Res 14:375-8. 2002
    ..The technique and results of circular venous grafting for patients with severe penile shortening secondary to Peyronie's disease is also discussed...
  95. ncbi The effect of intracavernosal growth differentiation factor-5 therapy in a rat model of cavernosal nerve injury
    Thomas M Fandel
    Johannes Gutenberg-University School of Medicine, Mainz, Germany
    BJU Int 98:632-6. 2006
    ..The intracavernosal application of GDF-5 enhanced the recovery of erectile function and n-NOS nerve preservation, with a 2-microg dose giving the most promising results...
  96. ncbi Serum response factor, its cofactors, and epithelial-mesenchymal signaling in urinary bladder smooth muscle formation
    Jiang Li
    Department of Urology University of California 400 Parnassus Avenue, ACC 610 California 94143 0738 San Francisco, USA
    Differentiation 74:30-9. 2006
    ..The unique structure of the urinary bladder makes it an ideal model for studies of smooth muscle differentiation and epithelial-mesenchymal signaling...
  97. ncbi Phosphodiesterase type 5 inhibitors for erectile dysfunction
    Culley C Carson
    Department of Surgery, Division of Urology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    BJU Int 96:257-80. 2005
    ..Other PDE5Is offering further potential improvements are under active investigation...
  98. ncbi Up-regulation of estrogen responsive genes in hypospadias: microarray analysis
    Zhong Wang
    Departments of Urology, Ninth People s Hospital, Shanghai Jiaotong University, Shanghai, People s Republic of China
    J Urol 177:1939-46. 2007
    ..We hypothesized that gene expression would differ between hypospadiac vs nonhypospadiac tissue and fraternal twin data would show patterns similar to those of group data on hypospadiac and nonhypospadiac tissue...
  99. ncbi Peyronie's disease (CME)
    Anthony J Bella
    Department of Surgery, Division of Urology, University of Ottawa, Canada
    J Sex Med 4:1527-38. 2007
    ..Despite progress in the understanding of PyD on several fronts, it remains a physically and psychologically devastating condition for the affected patient and partner...
  100. ncbi Brain activation and sexual arousal in healthy, heterosexual males
    Bruce A Arnow
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5722, USA
    Brain 125:1014-23. 2002
    ..Our study demonstrates the feasibility of examining brain activation/sexual response relationships in an fMRI environment and reveals a number of brain structures whose activation is time-locked to sexual arousal...
  101. ncbi Psychological impact of erectile dysfunction: validation of a new health related quality of life measure for patients with erectile dysfunction
    David M Latini
    Department of Urology and Urology Outcomes Research Group, University of California, San Francisco, USA
    J Urol 168:2086-91. 2002
    ....