Michael Z Ludwig

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. request reprint
    Ludwig M, Patel N, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998;125:949-58 pubmed
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer. ..
  2. request reprint
    Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  3. request reprint
    Ludwig M. Functional evolution of noncoding DNA. Curr Opin Genet Dev. 2002;12:634-9 pubmed
    ..Several experimentally characterized regulatory elements have failed to show sequence similarity even between closely related species. ..
  4. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..

Locale

Detail Information

Publications4

  1. request reprint
    Ludwig M, Patel N, Kreitman M. Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change. Development. 1998;125:949-58 pubmed
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer. ..
  2. request reprint
    Ludwig M, Bergman C, Patel N, Kreitman M. Evidence for stabilizing selection in a eukaryotic enhancer element. Nature. 2000;403:564-7 pubmed
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences. ..
  3. request reprint
    Ludwig M. Functional evolution of noncoding DNA. Curr Opin Genet Dev. 2002;12:634-9 pubmed
    ..Several experimentally characterized regulatory elements have failed to show sequence similarity even between closely related species. ..
  4. Ludwig M, Palsson A, Alekseeva E, Bergman C, Nathan J, Kreitman M. Functional evolution of a cis-regulatory module. PLoS Biol. 2005;3:e93 pubmed
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules. ..