Michael Z Ludwig

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia
    Susan E Lott
    Committee on Genetics and Department of Ecology and Evolution, University of Chicago, 1101 E 57th St, Chicago, Illinois 60637, USA
    Evolution 65:1388-99. 2011
  2. ncbi request reprint Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Development 125:949-58. 1998
  3. ncbi request reprint Evidence for stabilizing selection in a eukaryotic enhancer element
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Nature 403:564-7. 2000
  4. ncbi request reprint Functional evolution of noncoding DNA
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Curr Opin Genet Dev 12:634-9. 2002
  5. pmc Functional evolution of a cis-regulatory module
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois, USA
    PLoS Biol 3:e93. 2005
  6. pmc Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1002364. 2011
  7. pmc Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster
    CECELIA M MILES
    The University of Chicago, Department of Ecology and Evolution, 1101 E 57 St, Chicago, Illinois 60637, USA
    Evolution 65:33-42. 2011
  8. pmc Canalization of segmentation and its evolution in Drosophila
    Susan E Lott
    Committee on Genetics, Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:10926-31. 2007
  9. pmc Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin
    Bin Z He
    Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois 60637
    Genetics 196:557-67. 2014
  10. pmc Sex-specific pattern formation during early Drosophila development
    - Manu
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 194:163-73. 2013

Collaborators

Detail Information

Publications14

  1. pmc Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia
    Susan E Lott
    Committee on Genetics and Department of Ecology and Evolution, University of Chicago, 1101 E 57th St, Chicago, Illinois 60637, USA
    Evolution 65:1388-99. 2011
    ....
  2. ncbi request reprint Functional analysis of eve stripe 2 enhancer evolution in Drosophila: rules governing conservation and change
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA
    Development 125:949-58. 1998
    ..This view allows for a slow but continual turnover of functionally important changes in the stripe 2 enhancer...
  3. ncbi request reprint Evidence for stabilizing selection in a eukaryotic enhancer element
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Nature 403:564-7. 2000
    ..Sequence differences between species have functional consequences, therefore, but they are masked by other co-evolved differences. On the basis of these results, we present a model for the evolution of eukaryotic regulatory sequences...
  4. ncbi request reprint Functional evolution of noncoding DNA
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Curr Opin Genet Dev 12:634-9. 2002
    ..Several experimentally characterized regulatory elements have failed to show sequence similarity even between closely related species...
  5. pmc Functional evolution of a cis-regulatory module
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois, USA
    PLoS Biol 3:e93. 2005
    ..Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules...
  6. pmc Consequences of eukaryotic enhancer architecture for gene expression dynamics, development, and fitness
    Michael Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 7:e1002364. 2011
    ..These results imply that seemingly redundant regulatory sequences beyond the minimal enhancer are necessary for robust gene expression and that "robustness" itself must be an evolved characteristic of the wild-type enhancer...
  7. pmc Artificial selection on egg size perturbs early pattern formation in Drosophila melanogaster
    CECELIA M MILES
    The University of Chicago, Department of Ecology and Evolution, 1101 E 57 St, Chicago, Illinois 60637, USA
    Evolution 65:33-42. 2011
    ..Despite its macroevolutionary conservation, both eve stripe patterning and blastoderm cell number vary genetically both within and between closely related species...
  8. pmc Canalization of segmentation and its evolution in Drosophila
    Susan E Lott
    Committee on Genetics, Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 104:10926-31. 2007
    ..Thus, the developmental mechanism that assures robust scaling within a species does not prevent rapid evolution between species...
  9. pmc Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin
    Bin Z He
    Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois 60637
    Genetics 196:557-67. 2014
    ....
  10. pmc Sex-specific pattern formation during early Drosophila development
    - Manu
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Genetics 194:163-73. 2013
    ....
  11. pmc Rearrangements of 2.5 kilobases of noncoding DNA from the Drosophila even-skipped locus define predictive rules of genomic cis-regulatory logic
    Ah Ram Kim
    Department of Ecology and Evolution, Chicago Center for Systems Biology, University of Chicago, Chicago, Illinois, USA
    PLoS Genet 9:e1003243. 2013
    ....
  12. ncbi request reprint Nanos plays a conserved role in axial patterning outside of the Diptera
    Sabbi Lall
    HHMI Department of Organismal Biology and Anatomy, University of Chicago, 5841 South Maryland Avenue MC1028, Chicago, IL 60637, USA
    Curr Biol 13:224-9. 2003
    ..This is consistent with the notion that an anterior gradient system is not necessary in all insects and that the posterior pole "probably conveys longitudinal polarity on the ensuing germ anlage"...
  13. pmc Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin
    Soo Young Park
    Department of Medicine, University of Chicago, Chicago, Illinois 60637
    Genetics 196:539-55. 2014
    ..The genetic dominance of disease-specific phenotypic variability in our model of misfolded human proinsulin makes this approach amenable to genome-wide association study in a simple F1 screen of natural variation. ..
  14. pmc Naturally occurring deletions of hunchback binding sites in the even-skipped stripe 3+7 enhancer
    Arnar Palsson
    Faculty of Life and Environmental Sciences, University of Iceland, Reykjavik, Iceland Institute of Biology, University of Iceland, Reykjavik, Iceland Biomedical Center, University of Iceland, Reykjavik, Iceland Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e91924. 2014
    ..The data reveal segregating variation in regulatory elements, which may reflect evolutionary turnover of characterized TFBS due to drift or co-evolution. ..