U Luderer

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women
    Ulrike Luderer
    Center for Occupational and Environmental Health and Division of Occupational and Environmental Medicine, Department of Medicine, University of California Irvine, 100 Theory, Suite 100, Irvine, CA 92617, USA Electronic address
    Environ Res 121:84-94. 2013
  2. ncbi request reprint Gonadotropin regulation of glutathione synthesis in the rat ovary
    U Luderer
    Center for Occupational and Environmental Health, University of California, Irvine, USA
    Reprod Toxicol 15:495-504. 2001
  3. ncbi request reprint Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
    Ulrike Luderer
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, California 92617, USA
    Am J Ind Med 46:614-26. 2004
  4. pmc Temporal association between serum prolactin concentration and exposure to styrene
    U Luderer
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, CA, USA
    Occup Environ Med 61:325-33. 2004
  5. ncbi request reprint Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis
    Ulrike Luderer
    Department of Medicine, Division of Occupational and Environmental Medicine, University of California, Irvine, California 96212, USA
    Mol Reprod Dev 65:254-61. 2003
  6. ncbi request reprint Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific
    Miyun Tsai-Turton
    Department of Community and Environmental Medicine, University of California at Irvine, Irvine, California 92617, USA
    Am J Physiol Endocrinol Metab 289:E391-402. 2005
  7. ncbi request reprint Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine
    Yvonne D Hoang
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California at Irvine, 5201 California Avenue, Suite 100, 92617, USA
    Reprod Toxicol 21:186-96. 2006
  8. ncbi request reprint Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis
    Sarah G Lopez
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California at Irvine, Irvine, CA 92612, USA
    Free Radic Biol Med 36:1366-77. 2004
  9. pmc Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death
    Mabel M Cortes-Wanstreet
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92617, USA
    Mutagenesis 24:211-24. 2009
  10. ncbi request reprint Induction of apoptosis by 9,10-dimethyl-1,2-benzanthracene in cultured preovulatory rat follicles is preceded by a rise in reactive oxygen species and is prevented by glutathione
    Miyun Tsai-Turton
    Department of Community and Environmental Medicine, University of California Irvine, Irvine, California 92617, USA
    Biol Reprod 77:442-51. 2007

Research Grants

Collaborators

Detail Information

Publications16

  1. doi request reprint Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women
    Ulrike Luderer
    Center for Occupational and Environmental Health and Division of Occupational and Environmental Medicine, Department of Medicine, University of California Irvine, 100 Theory, Suite 100, Irvine, CA 92617, USA Electronic address
    Environ Res 121:84-94. 2013
    ....
  2. ncbi request reprint Gonadotropin regulation of glutathione synthesis in the rat ovary
    U Luderer
    Center for Occupational and Environmental Health, University of California, Irvine, USA
    Reprod Toxicol 15:495-504. 2001
    ..These results support the hypothesis that gonadotropins regulate ovarian GSH synthesis by modulating GCL subunit expression...
  3. ncbi request reprint Effects of occupational solvent exposure on reproductive hormone concentrations and fecundability in men
    Ulrike Luderer
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, California 92617, USA
    Am J Ind Med 46:614-26. 2004
    ....
  4. pmc Temporal association between serum prolactin concentration and exposure to styrene
    U Luderer
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California, Irvine, CA, USA
    Occup Environ Med 61:325-33. 2004
    ..Previous studies have suggested that occupational exposure to styrene is associated with increased serum levels of the anterior pituitary hormone prolactin (PRL)...
  5. ncbi request reprint Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis
    Ulrike Luderer
    Department of Medicine, Division of Occupational and Environmental Medicine, University of California, Irvine, California 96212, USA
    Mol Reprod Dev 65:254-61. 2003
    ..These results suggest that follicular apoptosis may be associated with down-regulation of Gclm and Gclc transcription in granulosa cells and oocytes...
  6. ncbi request reprint Gonadotropin regulation of glutamate cysteine ligase catalytic and modifier subunit expression in rat ovary is subunit and follicle stage specific
    Miyun Tsai-Turton
    Department of Community and Environmental Medicine, University of California at Irvine, Irvine, California 92617, USA
    Am J Physiol Endocrinol Metab 289:E391-402. 2005
    ..These results demonstrate that gonadotropins regulate follicular GCL expression in a follicle stage-dependent manner and in a GCL subunit-dependent manner...
  7. ncbi request reprint Minimal ovarian upregulation of glutamate cysteine ligase expression in response to suppression of glutathione by buthionine sulfoximine
    Yvonne D Hoang
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California at Irvine, 5201 California Avenue, Suite 100, 92617, USA
    Reprod Toxicol 21:186-96. 2006
    ..These results demonstrate that ovarian follicles and granulosa cells are minimally able to respond to acute GSH depletion by upregulating expression of GCL...
  8. ncbi request reprint Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis
    Sarah G Lopez
    Division of Occupational and Environmental Medicine, Department of Medicine, University of California at Irvine, Irvine, CA 92612, USA
    Free Radic Biol Med 36:1366-77. 2004
    ..More pronounced GSH suppression achieved after BSO treatment did not cause a statistically significant increase in follicular apoptosis. Thus, GSH depletion does not seem to be the mechanism by which CPA causes follicular apoptosis...
  9. pmc Overexpression of glutamate-cysteine ligase protects human COV434 granulosa tumour cells against oxidative and gamma-radiation-induced cell death
    Mabel M Cortes-Wanstreet
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92617, USA
    Mutagenesis 24:211-24. 2009
    ..These findings show that overexpression of GCL in granulosa cells can augment GSH synthesis and ameliorate various sequelae associated with exposure to oxidative stress and irradiation...
  10. ncbi request reprint Induction of apoptosis by 9,10-dimethyl-1,2-benzanthracene in cultured preovulatory rat follicles is preceded by a rise in reactive oxygen species and is prevented by glutathione
    Miyun Tsai-Turton
    Department of Community and Environmental Medicine, University of California Irvine, Irvine, California 92617, USA
    Biol Reprod 77:442-51. 2007
    ..These findings suggest that GSH is a critical protective mechanism against DMBA-induced apoptosis in antral follicles and that ROS generation may mediate DMBA-induced GC apoptosis...
  11. ncbi request reprint Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles
    Miyun Tsai-Turton
    Center for Occupational and Environmental Health, University of California Irvine, 5201 California Avenue, Suite 100, Irvine, California 92617, USA
    Endocrinology 147:1224-36. 2006
    ..These findings provide evidence that oxidative stress induces apoptosis in preovulatory follicles and that the antiapoptotic effect of FSH is mediated in part by stimulation of follicular GSH synthesis and suppression of ROS production...
  12. pmc Lack of maternal glutamate cysteine ligase modifier subunit (Gclm) decreases oocyte glutathione concentrations and disrupts preimplantation development in mice
    Brooke N Nakamura
    Department of Medicine, University of California Irvine, Irvine, California 92617, USA
    Endocrinology 152:2806-15. 2011
    ..The Nnt mutation did not enhance the effects of Gclm genotype on female fertility. These results demonstrate critical roles for maternal GSH in supporting normal preimplantation development...
  13. ncbi request reprint NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of styrene
    Ulrike Luderer
    University of California Irvine, Irvine, CA, USA
    Birth Defects Res B Dev Reprod Toxicol 77:110-93. 2006
  14. pmc Follicle-stimulating hormone and estradiol interact to stimulate glutathione synthesis in rat ovarian follicles and granulosa cells
    Yvonne D Hoang
    Departments of Medicine and Developmental and Cell Biology, University of California Irvine, Irvine, California, USA
    Biol Reprod 81:636-46. 2009
    ..These data demonstrate that maximal stimulation of GSH synthesis by FSH in granulosa cells and follicles requires estradiol. Without estradiol, FSH causes lesser increases in GCL subunit expression via a PKA-dependent pathway...
  15. ncbi request reprint Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion
    Miyun Tsai-Turton
    Department of Community and Environmental Medicine, University of California, Irvine, California 92617, USA
    Toxicol Sci 98:216-30. 2007
    ..These findings are consistent with roles for oxidative stress and GSH depletion in mediating the induction of apoptosis in COV434 cells by cyclophosphamide...
  16. ncbi request reprint NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of 2-bromopropane
    Kim Boekelheide
    Brown University, Providence, RI, USA
    Reprod Toxicol 18:189-217. 2004

Research Grants2

  1. GSH: Protecting Ovarian Follicles from Oxidant Injury
    Ulrike Luderer; Fiscal Year: 2006
    ..Finally, the research plan and career development activities outlined in this proposal will enable Dr. Luderer to successfully make the transition from mentored researcher to independent scientist-clinician. ..