Affiliation: University of California
Lim J, Luderer U. Glutathione deficiency sensitizes cultured embryonic mouse ovaries to benzo[a]pyrene-induced germ cell apoptosis. Toxicol Appl Pharmacol. 2018;352:38-45 pubmed publisher
..These data indicate that Gclm heterozygous or homozygous deletion sensitizes embryonic ovaries to BaP- and tissue culture-induced germ cell apoptosis. ..
Luderer U, Kavanagh T, White C, Faustman E. Gonadotropin regulation of glutathione synthesis in the rat ovary. Reprod Toxicol. 2001;15:495-504 pubmed
..These results support the hypothesis that gonadotropins regulate ovarian GSH synthesis by modulating GCL subunit expression. ..
Lim J, Ortiz L, Nakamura B, Hoang Y, Banuelos J, Flores V, et al
. Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. Reprod Toxicol. 2015;58:24-32 pubmed publisher
..Ovarian follicle numbers did not differ between peripubertal Nrf2-/- and Nrf2+/+ mice, but by middle age, Nrf2-/- mice had significantly fewer primordial follicles than Nrf2+/+ mice, consistent with accelerated ovarian aging. ..
Luderer U, Kesner J, Fuller J, Krieg E, Meadows J, Tramma S, et al
. Effects of gestational and lactational exposure to heptachlor epoxide on age at puberty and reproductive function in men and women. Environ Res. 2013;121:84-94 pubmed publisher
Lim J, Kong W, Lu M, Luderer U. The Mouse Fetal Ovary Has Greater Sensitivity Than the Fetal Testis to Benzo[a]pyrene-Induced Germ Cell Death. Toxicol Sci. 2016;152:372-81 pubmed publisher
..In contrast, the cultured 13.5 dpc fetal testis is relatively resistant to BaP-induced germ cell death. This study provides a novel insight into molecular mechanisms by which BaP has direct gonadotoxicity in the mouse fetal ovary. ..
Mishra B, Ortiz L, Luderer U. Charged iron particles, components of space radiation, destroy ovarian follicles. Hum Reprod. 2016;31:1816-26 pubmed publisher
..Additional support was received from the University of California Irvine Center for Occupational and Environmental Health. The authors have no conflicts of interests. ..
Luderer U, Myers M, Banda M, McKim K, Ortiz L, Parsons B. Ovarian effects of prenatal exposure to benzo[a]pyrene: Roles of embryonic and maternal glutathione status. Reprod Toxicol. 2017;69:187-195 pubmed publisher
..We observed no BaP treatment or Gclm genotype related differences in ovarian Kras codon 12 mutations in F1 offspring. ..
Mishra B, Ripperdan R, Ortiz L, Luderer U. Very low doses of heavy oxygen ion radiation induce premature ovarian failure. Reproduction. 2017;154:123-133 pubmed publisher
..In conclusion, oxygen charged particles are even more potent inducers of ovarian follicle depletion than charged iron particles, raising concern for premature ovarian failure in astronauts exposed to both particles during space travel. ..
Luderer U, Christensen F, Johnson W, She J, Ip H, Zhou J, et al
. Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women. Environ Int. 2017;100:110-120 pubmed publisher
..The results show that environmental exposure to PAHs is associated with changes in endocrine markers of ovarian function in women in a PAH-specific manner. ..