SHIRLEY contact LUCKHART

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae
    Ashley A Brenton
    Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, 95616 Davis, CA, USA
    Parasit Vectors 7:287. 2014
  2. pmc MAPK ERK signaling regulates the TGF-beta1-dependent mosquito response to Plasmodium falciparum
    Win Surachetpong
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, USA
    PLoS Pathog 5:e1000366. 2009
  3. pmc Abundance, behavior and entomological inoculation rates of anthropophilic anophelines from a primary Colombian malaria endemic area
    Nelson Naranjo-Diaz
    Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Medellin, Colombia
    Parasit Vectors 6:61. 2013
  4. pmc Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali
    Rebecca T Trout Fryxell
    Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA
    Malar J 11:133. 2012
  5. pmc Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003180. 2013
  6. pmc Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control
    Jennifer Pon
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, USA
    Malar J 10:318. 2011
  7. pmc Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection
    Ashley A Horton
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    Malar J 9:160. 2010
  8. pmc Population structure analyses and demographic history of the malaria vector Anopheles albimanus from the Caribbean and the Pacific regions of Colombia
    Lina A Gutiérrez
    Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Medellin, Colombia
    Malar J 8:259. 2009
  9. pmc The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases
    Ashley A Horton
    Department of Medical Microbiology and Immunology, School of Medicine, 3146 Tupper Hall, One Shields Avenue, University of California, Davis, CA 95616, USA
    BMC Genomics 12:574. 2011
  10. pmc The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, 3437 Tupper Hall, One Shields Avenue, Davis, CA 95616, USA
    Dev Comp Immunol 31:647-56. 2007

Collaborators

  • MICHAEL RIEHLE
  • Nazzy Pakpour
  • Cecilia Giulivi
  • Yoram Vodovotz
  • Steven A Nadler
  • R Zamora
  • JAN CONN
  • D A Wink
  • Andrew J Gow
  • J R Ryan
  • Ashley A Horton
  • Margarita M Correa
  • Lina A Gutiérrez
  • Tina M L Peterson
  • Ashley A Brenton
  • Nelson Naranjo-Diaz
  • Rebecca T Trout Fryxell
  • Yoosook Lee
  • Gregory C Lanzaro
  • Jennifer Pon
  • Anthony J Cornel
  • Win Surachetpong
  • Mi Ae Kang
  • Astrid V Cienfuegos
  • Anna L Drexler
  • Leyla Akman-Anderson
  • Mario A Zapata
  • Junghwa Lim
  • Matthew J Lieber
  • Aaron C Brault
  • Lattha Souvannaseng
  • Kong Cheung
  • Michael Anishchenko
  • Doris A Rosero
  • Guillermo Rua-Uribe
  • Catelyn C Nieman
  • Abdrahamane Fofana
  • Sekou F Traore
  • Bo Wang
  • Mark S Price
  • James R Faeder
  • Arora Arshi
  • Máté Nagy
  • Lauren Camp
  • Eleonora Napoli
  • Cheick A Coulibaly
  • Vanessa K Rashbrook
  • Kong Wai Cheung
  • Nelson J Naranjo
  • Naresh Singh
  • Carlos E Muskus
  • Luz Marina Jaramillo
  • Carlos Muskus
  • Tiffany M Mott
  • Nelson Naranjo
  • Erin C Tapley
  • Edwin E Lewis
  • Martin Olivier
  • Oscar I Quirós
  • Martha L Quiñones
  • D Channe Gowda
  • Gowdahalli Krishnegowda

Detail Information

Publications25

  1. pmc Engineered single nucleotide polymorphisms in the mosquito MEK docking site alter Plasmodium berghei development in Anopheles gambiae
    Ashley A Brenton
    Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, 95616 Davis, CA, USA
    Parasit Vectors 7:287. 2014
    ....
  2. pmc MAPK ERK signaling regulates the TGF-beta1-dependent mosquito response to Plasmodium falciparum
    Win Surachetpong
    Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA, USA
    PLoS Pathog 5:e1000366. 2009
    ..falciparum development. Taken together, our data demonstrate that malaria parasite development in the mosquito is regulated by a conserved MAPK signaling pathway that mediates the effects of an ingested cytokine...
  3. pmc Abundance, behavior and entomological inoculation rates of anthropophilic anophelines from a primary Colombian malaria endemic area
    Nelson Naranjo-Diaz
    Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Medellin, Colombia
    Parasit Vectors 6:61. 2013
    ..Malaria vector incrimination and the characterization of entomological parameters will allow for a better understanding of malaria transmission dynamics and the design of effective vector control strategies for this region...
  4. pmc Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali
    Rebecca T Trout Fryxell
    Department of Entomology and Plant Pathology, University of Tennessee, Knoxville, TN, 37996, USA
    Malar J 11:133. 2012
    ..The objective of this study was to investigate P. falciparum circumsporozoite protein infection (CSP) positivity among An. gambiae s.s. chromosomal and molecular forms...
  5. pmc Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California, United States of America
    PLoS Pathog 9:e1003180. 2013
    ..Further, quality control of mitochondrial function in the midgut is necessary for the maintenance of midgut health as reflected in energy homeostasis and tissue repair and renewal...
  6. pmc Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control
    Jennifer Pon
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California Davis, USA
    Malar J 10:318. 2011
    ....
  7. pmc Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection
    Ashley A Horton
    Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, USA
    Malar J 9:160. 2010
    ..Laboratory studies have demonstrated that a variety of immune signaling pathways regulate malaria parasite infection in Anopheles gambiae, the primary vector species in Africa...
  8. pmc Population structure analyses and demographic history of the malaria vector Anopheles albimanus from the Caribbean and the Pacific regions of Colombia
    Lina A Gutiérrez
    Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Medellin, Colombia
    Malar J 8:259. 2009
    ....
  9. pmc The mitogen-activated protein kinome from Anopheles gambiae: identification, phylogeny and functional characterization of the ERK, JNK and p38 MAP kinases
    Ashley A Horton
    Department of Medical Microbiology and Immunology, School of Medicine, 3146 Tupper Hall, One Shields Avenue, University of California, Davis, CA 95616, USA
    BMC Genomics 12:574. 2011
    ....
  10. pmc The insulin signaling cascade from nematodes to mammals: insights into innate immunity of Anopheles mosquitoes to malaria parasite infection
    Shirley Luckhart
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, 3437 Tupper Hall, One Shields Avenue, Davis, CA 95616, USA
    Dev Comp Immunol 31:647-56. 2007
    ....
  11. pmc Low levels of mammalian TGF-beta1 are protective against malaria parasite infection, a paradox clarified in the mosquito host
    Shirley Luckhart
    University of California at Davis, Department of Medical Microbiology and Immunology, 3437 Tupper Hall, One Shields Avenue, School of Medicine, Davis, CA 95616, USA
    Exp Parasitol 118:290-6. 2008
    ..These results suggest that TGF-beta1 plays similar roles during parasite infection in mammals and mosquitoes and that this role is linked to the effects of TGF-beta1 on inducible NO synthesis...
  12. pmc Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity
    Shirley Luckhart
    Department of Biochemistry, Virginia Tech, Blacksburg 24061, USA
    Infect Immun 71:3000-9. 2003
    ..stephensi. Together, these observations indicate that, through conserved immunological cross talk, mammalian and mosquito immune systems interface with each other to influence the cycle of Plasmodium development...
  13. pmc Cross-talk between nitric oxide and transforming growth factor-beta1 in malaria
    Yoram Vodovotz
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Mol Med 4:787-97. 2004
    ..Bloodfeeding by Anopheles, therefore, results in a juxtaposition of evolutionarily conserved mosquito and mammalian TGF-beta superfamily homologs that may influence transmission dynamics of Plasmodium in endemic regions...
  14. pmc Induction of nitric oxide synthase in Anopheles stephensi by Plasmodium falciparum: mechanism of signaling and the role of parasite glycosylphosphatidylinositols
    Junghwa Lim
    Department of Medical Microbiology and Immunology, 3146 Tupper Hall, One Shields Avenue, University of California at Davis, School of Medicine, Davis, CA 95616, USA
    Infect Immun 73:2778-89. 2005
    ....
  15. doi request reprint Natural infectivity of Anopheles species from the Pacific and Atlantic Regions of Colombia
    Lina A Gutiérrez
    Grupo de Microbiología Molecular, Escuela de Microbiología, Universidad de Antioquia, Medellin, Colombia
    Acta Trop 107:99-105. 2008
    ..neivai with P. falciparum. Our data support the continued predominance of An. albimanus in the Pacific Coast, and demonstrate that this species is the most abundant in the Atlantic Coast as well...
  16. ncbi request reprint Discrimination of seven Anopheles species from San Pedro de Uraba, Antioquia, Colombia, by polymerase chain reaction-restriction fragment length polymorphism analysis of its sequences
    Mario A Zapata
    Grupo de Microbiología Molecular, Escuela de Microbiología, and Programa para el Estudio y Control de Enfermedades Tropicales, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
    Am J Trop Med Hyg 77:67-72. 2007
    ....
  17. pmc Nitric oxide metabolites induced in Anopheles stephensi control malaria parasite infection
    Tina M L Peterson
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Free Radic Biol Med 42:132-42. 2007
    ..In contrast to facilitating oxygen delivery by hemoglobin in the mammalian vasculature, nitric oxide synthesis in the blood-filled mosquito midgut drives the formation of toxic metabolites that limit parasite development...
  18. pmc Induction of nitric oxide synthase and activation of signaling proteins in Anopheles mosquitoes by the malaria pigment, hemozoin
    Leyla Akman-Anderson
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Infect Immun 75:4012-9. 2007
    ..Together with our previous findings, our data indicate that parasite signaling of innate immunity is conserved in mosquito and mammalian cells...
  19. pmc Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling
    Anna L Drexler
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, CA 95616, USA
    Trends Parasitol 24:333-6. 2008
    ..Even less is known about the genetic, environmental and other factors that impact sporogony in the mosquito host. Here, we summarize current knowledge and review a first attempt to model sporogonic development quantitatively...
  20. pmc Insulin regulates aging and oxidative stress in Anopheles stephensi
    Mi Ae Kang
    Department of Medical Microbiology and Immunology, School of Medicine, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    J Exp Biol 211:741-8. 2008
    ....
  21. ncbi request reprint Evidence for transmission of Plasmodium vivax among a duffy antigen negative population in Western Kenya
    Jeffrey R Ryan
    Walter Reed Army Institute of Research, Washington, DC, USA
    Am J Trop Med Hyg 75:575-81. 2006
    ..A DNA fragment specific for the C terminus of the gene for P. vivax merozoite surface protein 1 (MSP-1) was amplified from the blood of four of these children and subsequently sequenced from two...
  22. pmc A mosquito 2-Cys peroxiredoxin protects against nitrosative and oxidative stresses associated with malaria parasite infection
    Tina M L Peterson
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Free Radic Biol Med 40:1067-82. 2006
    ..Hence, whereas the NO-mediated defense response is toxic to both host and parasite, AsPrx-4783 may shift the balance in favor of the mosquito...
  23. ncbi request reprint Transforming growth factor-betas and related gene products in mosquito vectors of human malaria parasites: signaling architecture for immunological crosstalk
    Matthew J Lieber
    Department of Biochemistry, Virginia Tech, 306 Engel Hall, Mail Stop 0308, West Campus Drive, Blacksburg, VA 24061, USA
    Mol Immunol 41:965-77. 2004
    ..stephensi cell line and in the A. stephensi midgut epithelium, confirming that a conserved signaling architecture is in place to support signaling by divergent exogenous and endogenous TGF-beta superfamily proteins...
  24. ncbi request reprint Anopheles gambiae immune gene variants associated with natural Plasmodium infection
    Shirley Luckhart
    Department of Biochemistry, Virginia Tech, 306 Engel Hall Mail Stop 0308, Virginia Tech, Blacksburg, VA 24061, USA
    Mol Biochem Parasitol 128:83-6. 2003

Research Grants14

  1. Cross-talk among mosquito and mammalian immune factors
    Shirley Luckhart; Fiscal Year: 2004
    ..At a more applied level, the proposed research will likely have implications for the control of malaria. ..
  2. Systems biology approach to MAPK regulation of malaria infection in A. stephensi
    Yoram Vodovotz; Fiscal Year: 2010
    ..These studies will serve to identify the "master switches" that control parasite development in the mosquito. In the long-term, we propose that this information will contribute to novel malaria control methods. ..
  3. An.gambiae immune signaling gene SNPs and natural P. falciparum infection
    SHIRLEY contact LUCKHART; Fiscal Year: 2010
    ..Our studies will identify responses that are important in natural populations of An. gambiae with the long-term goal that this information can contribute to novel malaria control methods. ..
  4. Systems biology approach to MAPK regulation of malaria infection in A. stephensi
    Shirley Luckhart; Fiscal Year: 2009
    ..These studies will serve to identify the "master switches" that control parasite development in the mosquito. In the long-term, we propose that this information will contribute to novel malaria control methods. ..
  5. Plasmodium signaling of innate immunity in Anopheles
    Shirley Luckhart; Fiscal Year: 2007
    ....
  6. Cross-talk among mosquito and mammalian immune factors
    Shirley Luckhart; Fiscal Year: 2007
    ..At a more applied level, the proposed research will likely have implications for the control of malaria. ..
  7. Plasmodium signaling of innate immunity in Anopheles
    Shirley Luckhart; Fiscal Year: 2006
    ....
  8. Cross-talk among mosquito and mammalian immune factors
    Shirley Luckhart; Fiscal Year: 2006
    ..At a more applied level, the proposed research will likely have implications for the control of malaria. ..
  9. Plasmodium signaling of innate immunity in Anopheles
    Shirley Luckhart; Fiscal Year: 2004
    ....
  10. Cross-talk among mosquito and mammalian immune factors
    Shirley Luckhart; Fiscal Year: 2004
    ..At a more applied level, the proposed research will likely have implications for the control of malaria. ..
  11. Plasmodium signaling of innate immunity in Anopheles
    Shirley Luckhart; Fiscal Year: 2005
    ....
  12. Cross-talk among mosquito and mammalian immune factors
    Shirley Luckhart; Fiscal Year: 2005
    ..At a more applied level, the proposed research will likely have implications for the control of malaria. ..
  13. Systems biology approach to MAPK regulation of malaria infection in A. stephensi
    Yoram Vodovotz; Fiscal Year: 2010
    ..These studies will serve to identify the "master switches" that control parasite development in the mosquito. In the long-term, we propose that this information will contribute to novel malaria control methods. ..