Research Topics
Species | M S LuciaSummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
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Publications
Inflammation as a target for prostate cancer chemoprevention: pathological and laboratory rationaleM Scott Lucia
Department of Pathology and Preventive Medicine and Biometrics, Unibersity of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Urol 171:S30-4; discussion S35. 2004..We review the literature addressing a potential causal role for chronic or recurrent inflammation or infection in the development of prostate cancer...
Pathologic characteristics of cancers detected in The Prostate Cancer Prevention Trial: implications for prostate cancer detection and chemopreventionM Scott Lucia
University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
Cancer Prev Res (Phila) 1:167-73. 2008....- Growth factors in benign prostatic hyperplasia: basic science implicationsM Scott Lucia
Department of Pathology, University of Colorado DHSC, 12800 East 19th Avenue, PO Box 6511, Aurora, CO 80045, USA
Curr Urol Rep 9:272-8. 2008..As we begin to unravel the precise mechanisms involved, new treatments for BPH aimed at these interacting pathways may emerge... - Finasteride and high-grade prostate cancer in the Prostate Cancer Prevention TrialM Scott Lucia
Department of Pathology, University of Colorado Denver and Health Sciences Center, 4200 E Ninth Ave, Box B 216, Denver, CO 80262, USA
J Natl Cancer Inst 99:1375-83. 2007..We assessed whether the increased high-grade prostate cancer associated with finasteride in the PCPT was due to finasteride's potential effects on tumor morphology or prostate size... - p53 controls prostate-derived factor/macrophage inhibitory cytokine/NSAID-activated gene expression in response to cell density, DNA damage and hypoxia through diverse mechanismsJulie A Kelly
Department of Pathology, University of Colorado Denver, 12801 E 17th Avenue, Aurora, CO 80045, USA
Cancer Lett 277:38-47. 2009..Thus, PDF may represent a novel target of p53 in response to cell stress... - Conference report and review: current status of biomarkers potentially associated with prostate cancer outcomesThomas W Flaig
Department of Medicine, University of Colorado at Denver and Health Sciences University Denver, Aurora, Colorado 80045, USA
J Urol 177:1229-37. 2007..A 2-day Prostate Cancer Biomarker Conference was convened to identify promising areas of research and focus efforts on the most critical needs... - Acute tubular necrosis is characterized by activation of the alternative pathway of complementJoshua M Thurman
Department of Internal Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Kidney Int 67:524-30. 2005..The purpose of this study was to determine whether alternative pathway activation also occurs during the development of ischemic acute tubular necrosis in the human kidney... - Preoperative prediction of unifocal, unilateral, margin-negative, and small volume prostate cancerKenneth A Iczkowski
Department of Pathology, University of Colorado Health Science Center, Denver, Colorado 80045, USA
Urology 71:1166-71. 2008..Subtotal gland ablation by minimally invasive therapies such as cryotherapy demands preoperative prediction of unifocal, unilateral, margin-negative, and small volume (less than 0.5 mL) cancer... - Molecular characterization of human prostate carcinoma cell linesAdrie van Bokhoven
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Prostate 57:205-25. 2003..This study presents a comprehensive survey and characterization of available prostate carcinoma cell lines, most of which have been widely used but are incompletely characterized... - Prostate derived factor in human prostate cancer cells: gene induction by vitamin D via a p53-dependent mechanism and inhibition of prostate cancer cell growthJames R Lambert
Department of Pathology, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
J Cell Physiol 208:566-74. 2006..These data demonstrate that PDF exerts antitumorigenic properties on PCa cells and its regulation by 1,25D may provide insights into the action of 1,25D in PCa... - Connective tissue growth factor expression is increased in biliary epithelial cells in biliary atresiaMichael R Narkewicz
Department of Pediatrics, The Pediatric Liver Center, The Children s Hospital, University of Colorado School of Medicine, Denver, CO 80218, USA
J Pediatr Surg 40:1721-5. 2005..The objective of this study was to evaluate hepatic CTGF messenger RNA (mRNA) expression and its relationship to hepatic histology in children with BA... - Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathwayTao Jiang
Department of Medicine, The University of Colorado Health Sciences Center, Denver, 80262, USA
J Biol Chem 280:32317-25. 2005..Our results therefore suggest that diet-induced obesity causes increased renal lipid accumulation and glomerulosclerosis in C57BL/6J mice via an SREBP-1c-dependent pathway... - Potential pathologic markers for prostate chemoprevention studiesWael A Sakr
Department of Pathology, School of Medicine, Wayne State University, 540 East Canfield, Detroit, MI 48201, USA
Urol Clin North Am 31:227-35. 2004..More important, it is crucial to demonstrate that modulation of the frequency of the biomarker decreases the rate of cancer development... - Aberrant HOXC expression accompanies the malignant phenotype in human prostateGary J Miller
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Cancer Res 63:5879-88. 2003..We speculate that HOXC overexpression may predispose tumor cells to androgen independence by necessitating adaptation to diminished androgen signaling... - Clinical staging of prostate cancer: a computer-simulated study of transperineal prostate biopsyE David Crawford
Radiation Oncology, Department of Pathology, University of Colorado Health Sciences Center at Fitzsimons, Aurora, CO 80045, USA
BJU Int 96:999-1004. 2005.... - Spectral karyotype (SKY) analysis of human prostate carcinoma cell linesAdrie van Bokhoven
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Prostate 57:226-44. 2003..g., 8p, 10q, 13q, and 16q). CONCLUSIONS: The present study provides a comprehensive karyotypic analysis of a large number of prostate carcinoma cell lines, and offers a valuable resource for future investigations... - Workgroup I: rodent models of prostate cancerM S Lucia
Department of Pathology, University of Colorado, Denver, USA
Prostate 36:49-55. 1998 - The role of inflammation and infection in prostate cancer: Importance in prevention, diagnosis and treatmentH K Koul
Division of Urology, Department of Surgery, University of Colorado at Denver School of Medicine, Aurora, Colorado 80045, USA
Drugs Today (Barc) 46:929-43. 2010..As such, chronic inflammation may represent an important therapeutic target in prostate cancer... - A study of high-dose oral silybin-phytosome followed by prostatectomy in patients with localized prostate cancerThomas W Flaig
Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
Prostate 70:848-55. 2010..The purpose of the current trial was to determine the tissue and blood effects of high-dose silybin-phytosome in prostate cancer patients... - A case of nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosisAndrew S Weiss
Division of Renal Diseases and Hypertension at the University of Colorado Health Sciences Center, Denver, CO 80262, USA
Nat Clin Pract Nephrol 3:111-5. 2007..A 61-year-old female with end-stage renal disease who was undergoing hemodialysis presented with an 8-week history of upper and lower extremity weakness associated with skin tightness and contractures... - VDR and SRD5A2 polymorphisms combine to increase risk for prostate cancer in both non-Hispanic White and Hispanic White menKathleen C Torkko
Department of Pathology, University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado 80045, USA
Clin Cancer Res 14:3223-9. 2008..This study tested the interactions of VDR (CDX2, FokI) and SRD5A2 (V89L, A49T) polymorphisms, and their associations with prostate cancer... - Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal diseaseTao Jiang
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Kidney Int 68:2608-20. 2005..The purpose of this study was to identify a potential role for lipids in mediating age-related renal disease... - A case of polyomavirus-associated nephropathy presenting late after transplantationShweta Bansal
University of Colorado at Denver Health Sciences Center, Department of Renal Disease and Hypertension, 1635 North Ursula Street, Mail Stop F749, PO Box 6510, Denver, CO 80045, USA
Nat Clin Pract Nephrol 4:283-7. 2008..Potential etiologies such as acute T-cell-mediated rejection, acute and chronic antibody-mediated rejection, polyomavirus-associated nephropathy, and calcineurin inhibitor nephrotoxicity were considered... - B7-H4 overexpression in ovarian tumorsBarbara Tringler
Department of Pathology, University of Colorado Health Sciences Center, B-216, 4200 East Ninth Avenue, Denver, CO 80262, USA
Gynecol Oncol 100:44-52. 2006.... 
Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in miceVyacheslav Y Melnikov
Department of Medicine, University of Colorado School of Medicine, 4200 East 9th Avenue, Denver, Colorado 80262, USA
J Clin Invest 110:1083-91. 2002..These results suggest a novel neutrophil-independent mechanism of IL-18-mediated ischemic ARF...- Immunohistochemical localization of the IAP protein survivin in bladder mucosa and transitional cell carcinomaRainer Lehner
Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
Appl Immunohistochem Mol Morphol 10:134-8. 2002..9 months); however, the differences were not statistically significant. Nuclear localization of survivin is a marker of TCC but is rarely present in premalignant or benign bladder mucosal specimens... - Calorie restriction modulates renal expression of sterol regulatory element binding proteins, lipid accumulation, and age-related renal diseaseTao Jiang
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, C281, Denver, CO 80262, USA
J Am Soc Nephrol 16:2385-94. 2005.... - Biomorphometric analysis of human prostatic carcinoma by using three-dimensional computer modelsPriya N Werahera
Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Hum Pathol 35:798-807. 2004..Moreover, our 3-dimensional computer modeling system improves upon other systems: It is more than a simple extension of the planimetric technique, and it is able to demarcate clearly the boundaries of Gleason grades just 1 grade apart... - Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across speciesJenean O'Brien
Department of Medicine, Division of Medical Oncology, University of Colorado Denver, Mail Stop 8117, RC 1 S, 8401K, 12801 E 17 Avenue, UCD, Aurora, CO 80045, USA
Am J Pathol 176:1241-55. 2010..M2 macrophages, IL-4, IL-13, fibrillar collagen accumulation, and proteolysis of collagen are all components of tumor promotional microenvironments, and thus may mediate promotion of breast cancers arising in the postpartum setting... - CBP/p300-mediated acetylation of histone H3 on lysine 56Chandrima Das
Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, PO Box 6511, Aurora Colorado 80045, USA
Nature 459:113-7. 2009.... - The Prostate Cancer Prevention Trial and the future of chemopreventionIan M Thompson
Department of Urology, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
BJU Int 101:933-4. 2008 - The performance of prostate specific antigen for predicting prostate cancer is maintained after a prior negative prostate biopsyIan M Thompson
University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
J Urol 180:544-7. 2008..We compared the performance operating characteristics of prostate specific antigen for prostate cancer between a first and subsequent prostate biopsy in a group of men with complete verification of cancer status... - The influence of finasteride on the development of prostate cancerIan M Thompson
University of Texas Health Science Center, San Antonio, USA
N Engl J Med 349:215-24. 2003.... - Finasteride, prostate cancer, and weight gain: evidence for genetic or environmental factors that affect cancer outcomes during finasteride treatmentYoonju Song
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Prostate 68:281-6. 2008..Finasteride affects both prostate cancer risk and body weight. We examined whether, during 7 years of finasteride treatment, the magnitude of weight change was associated with the diagnosis of no, low-, or high-grade cancer... - Laterally directed biopsies detect more clinically threatening prostate cancer: computer simulated resultsNozomu Kawata
Department Urology, Nihon University School of Medicine, Tokyo, Japan
Prostate 57:118-28. 2003..0082), but not in the autopsy series. CONCLUSIONS: The MFSB technique, which utilizes laterally directed biopsies, appears to be an effective approach to improve the detection of clinically threatening prostatic carcinoma... - Prediction of prostate cancer for patients receiving finasteride: results from the Prostate Cancer Prevention TrialIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Clin Oncol 25:3076-81. 2007..Using data from men in the finasteride group of the Prostate Cancer Prevention Trial (PCPT), we evaluated the impact of prostate-specific antigen (PSA) and other risk factors on the risk of prostate cancer... - Delay in the progression of low-risk prostate cancer: rationale and design of the Reduction by Dutasteride of Clinical Progression Events in Expectant Management (REDEEM) trialNeil Fleshner
University Health Network, Princess Margaret Hospital, Toronto, ON, Canada
Contemp Clin Trials 28:763-9. 2007..Dutasteride, a dual 5alpha-reductase inhibitor (5ARI), may delay prostate cancer progression or extend the time to initiation of more aggressive therapy... - Finasteride decreases the risk of prostatic intraepithelial neoplasiaIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio and Southwest Oncology Group, San Antonio, Texas 78229, USA
J Urol 178:107-9; discussion 110. 2007..In the Prostate Cancer Prevention Trial we evaluated the impact of finasteride on the risk of a needle biopsy diagnosis of high grade prostatic intraepithelial neoplasia... - Stage migration and grade inflation in prostate cancer: Will Rogers meets Garrison KeillorIan M Thompson
J Natl Cancer Inst 97:1236-7. 2005 - The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledgeGerald Andriole
Division of Urologic Surgery, School of Medicine, Washington University St Louis, 4960 Children s Place, St Louis, MO 63110, USA
J Urol 174:2098-104. 2005..However, Gleason score 7-10 tumors were significantly more common in the finasteride vs the placebo group. We considered data on the effects of 5ARIs on prostate cancer natural history and detection... - Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliterIan M Thompson
Division of Urology, Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Tex, USA
N Engl J Med 350:2239-46. 2004..1 to 4.0 ng per milliliter. CONCLUSIONS: Biopsy-detected prostate cancer, including high-grade cancers, is not rare among men with PSA levels of 4.0 ng per milliliter or less--levels generally thought to be in the normal range... - 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6Gretchen E Garcia
Departments of Urology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
Clin Cancer Res 12:980-8. 2006..However, neither the chemopreventive role nor the mechanism of 2-methoxyestradiol-induced biological activities is fully understood... - The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasiaJohn D McConnell
University of Texas Southwestern Medical Center, Dallas, TX 75390-9110, USA
N Engl J Med 349:2387-98. 2003..Combination therapy and finasteride alone reduced the long-term risk of acute urinary retention and the need for invasive therapy... - Effect of finasteride on the sensitivity of PSA for detecting prostate cancerIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
J Natl Cancer Inst 98:1128-33. 2006..We examined the impact of finasteride on the sensitivity and area under the receiver operating characteristic curve (AUC) of prostate-specific antigen (PSA) for detecting prostate cancer... - Adjuvant radiotherapy for pathologically advanced prostate cancer: a randomized clinical trialIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, MC 7845, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
JAMA 296:2329-35. 2006..However, the optimal management of these patients after radical prostatectomy is unknown... - Assessing prostate cancer risk: results from the Prostate Cancer Prevention TrialIan M Thompson
Department of Urology, University of Texas Health Science Center, San Antonio, TX 78229, USA
J Natl Cancer Inst 98:529-34. 2006..We used prostate biopsy data from men who participated in the Prostate Cancer Prevention Trial (PCPT) to develop a predictive model of prostate cancer... - Finasteride improves the sensitivity of digital rectal examination for prostate cancer detectionIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
J Urol 177:1749-52. 2007..In the current study we report the impact of finasteride on digital rectal examination sensitivity and specificity... - Operating characteristics of prostate-specific antigen in men with an initial PSA level of 3.0 ng/ml or lowerIan M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, TX 78229, USA
JAMA 294:66-70. 2005..Three fourths of US men older than 50 years have been screened with prostate-specific antigen (PSA) for prostate cancer... - A preliminary study of JM-27: a serum marker that can specifically identify men with symptomatic benign prostatic hyperplasiaGrant W Cannon
James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
J Urol 177:610-4; discussion 614. 2007..The goal of these studies was to determine if a serum based assay to detect JM-27 could distinguish men with different forms of benign prostatic hyperplasia... - First International Conference on Chemoprevention of Prostate Cancer. Overview consensus statementIan M Thompson
University of Texas Health Science Center at San Antonio, Texas 78229, USA
J Urol 171:S3-4. 2004 - Diagnosing prostate cancer: through a glass, darklyIan M Thompson
J Urol 175:1598-9. 2006 - A comprehensive approach toward novel serum biomarkers for benign prostatic hyperplasia: the MPSA ConsortiumChris Mullins
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
J Urol 179:1243-56. 2008.... - Commentary: the ubiquity of prostate cancer: echoes of the past, implications for the present: "what has been will be again, what has been done will be done again; there is nothing new under the sun." ECCLESIASTES 1:9Ian M Thompson
Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Int J Epidemiol 36:287-9. 2007
Research Grants
- MPSA Pathology Coordinating CenterM Lucia; Fiscal Year: 2004..abstract_text> ..
- DIAGNOSTIC CENTERM Lucia; Fiscal Year: 2004..From the published literature, however, it is expected that data on 280 patients will be sufficient to produce meaningful results." They state that a "...subset of approximately 280 cases will have detailed analyses performed." ..