Farah D Lubin

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Epigenetic mechanisms: critical contributors to long-term memory formation
    Farah D Lubin
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuroscientist 17:616-32. 2011
  2. pmc Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    Farah D Lubin
    Department of Neurobiology, The Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 28:10576-86. 2008
  3. pmc Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, United States
    Neurobiol Learn Mem 96:68-78. 2011
  4. pmc Histone methylation regulates memory formation
    Swati Gupta
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 30:3589-99. 2010
  5. pmc Lasting epigenetic influence of early-life adversity on the BDNF gene
    Tania L Roth
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    Biol Psychiatry 65:760-9. 2009
  6. pmc Epigenetic mechanisms in experience-driven memory formation and behavior
    Rosemary E Puckett
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Epigenomics 3:649-64. 2011
  7. pmc G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation
    Swati Gupta-Agarwal
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 32:5440-53. 2012
  8. pmc The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 55:942-57. 2007
  9. doi request reprint Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
  10. pmc Epigenetic mechanisms in schizophrenia
    Tania L Roth
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, 35294, USA
    Biochim Biophys Acta 1790:869-77. 2009

Research Grants

  1. NF-kB activation in epilepsy
    FARAH LUBIN; Fiscal Year: 2007
  2. NF-kB activation in epilepsy
    FARAH LUBIN; Fiscal Year: 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint Epigenetic mechanisms: critical contributors to long-term memory formation
    Farah D Lubin
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuroscientist 17:616-32. 2011
    ..Furthermore, the study of epigenetic gene regulation, in conjunction with transcription factor activation, can provide complementary lines of evidence to further understanding transcriptional mechanisms subserving memory storage...
  2. pmc Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    Farah D Lubin
    Department of Neurobiology, The Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 28:10576-86. 2008
    ..These results suggest epigenetic modification of the bdnf gene as a mechanism for isoform-specific gene readout during memory consolidation...
  3. pmc Epigenetic gene regulation in the adult mammalian brain: multiple roles in memory formation
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, United States
    Neurobiol Learn Mem 96:68-78. 2011
    ..Such research offers novel concepts for understanding epigenetic transcriptional mechanisms subserving adult cognition and mental health, and furthermore promises novel avenues for therapeutic approach in the clinic...
  4. pmc Histone methylation regulates memory formation
    Swati Gupta
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 30:3589-99. 2010
    ..Zif268 DNA methylation levels returned to baseline at 24 h. Together, these data demonstrate that histone methylation is actively regulated in the hippocampus and facilitates long-term memory formation...
  5. pmc Lasting epigenetic influence of early-life adversity on the BDNF gene
    Tania L Roth
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama Birmingham, Birmingham, Alabama 35294, USA
    Biol Psychiatry 65:760-9. 2009
    ..With a rat model of infant maltreatment by a caregiver, we investigated whether early-life adversity leaves lasting epigenetic marks at the brain-derived neurotrophic factor (BDNF) gene in the central nervous system...
  6. pmc Epigenetic mechanisms in experience-driven memory formation and behavior
    Rosemary E Puckett
    Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Epigenomics 3:649-64. 2011
    ....
  7. pmc G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation
    Swati Gupta-Agarwal
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 32:5440-53. 2012
    ..Furthermore, these findings support the possibility of a role for G9a/GLP in the regulation of cellular and molecular cross talk between these two brain regions during LTM formation...
  8. pmc The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 55:942-57. 2007
    ..These data provide insights into IKK-regulated transcriptional mechanisms in hippocampus that are necessary for memory reconsolidation...
  9. doi request reprint Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
    ..However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID...
  10. pmc Epigenetic mechanisms in schizophrenia
    Tania L Roth
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, 35294, USA
    Biochim Biophys Acta 1790:869-77. 2009
    ..This research is likely to lead to the development of epigenetic therapy, which holds the promise of alleviating cognitive deficits associated with schizophrenia...
  11. pmc Direct bisulfite sequencing for examination of DNA methylation with gene and nucleotide resolution from brain tissues
    R Ryley Parrish
    Department of Neurobiology and Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Curr Protoc Neurosci . 2012
    ..This method yields analysis of DNA methylation patterns that is robust, accurate, and reproducible, thereby allowing insights into the role of alterations in DNA methylation in brain tissue...
  12. pmc HDAC activity is required for BDNF to increase quantal neurotransmitter release and dendritic spine density in CA1 pyramidal neurons
    Gaston Calfa
    Department of Neurobiology, Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Hippocampus 22:1493-500. 2012
    ....
  13. pmc NMDA receptor- and ERK-dependent histone methylation changes in the lateral amygdala bidirectionally regulate fear memory formation
    Swati Gupta-Agarwal
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Learn Mem 21:351-62. 2014
    ..Together, the present study suggests that histone lysine methylation regulation in the LA via NMDAR-ERK-dependent signaling is involved in fear memory formation. ..
  14. ncbi request reprint Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation
    Farah D Lubin
    Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA, and Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 103:1381-95. 2007
    ..In summary, our findings provide additional insights into the role of NF-kappaB transcriptional regulation in hippocampus following status epilepticus and suggest that NF-kappaB pathway activation contributes to seizure susceptibility...
  15. pmc c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation
    Hyung Jin Ahn
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 15:539-49. 2008
    ..Together, our results demonstrate that c-Rel is necessary for long-term synaptic potentiation in vitro and hippocampus-dependent memory formation in vivo...
  16. ncbi request reprint Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
    Jonathan M Levenson
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:15763-73. 2006
    ..Considered together, these results suggest that DNMT activity is dynamically regulated in the adult nervous system and that DNMT may play a role in regulating the induction of synaptic plasticity in the mature CNS...
  17. ncbi request reprint Regulation of surface localization of the small conductance Ca2+-activated potassium channel, Sk2, through direct phosphorylation by cAMP-dependent protein kinase
    Yajun Ren
    Cain Foundation Laboratories, Department of Pediatrics, Department of Neurology, Department of Neuroscience, Baylor College of Medicine, Houston, Texas, 77030, USA
    J Biol Chem 281:11769-79. 2006
    ..Thus, our findings suggest that PKA phosphorylation of these three sites is necessary for PKA-mediated reorganization of SK2 surface expression...
  18. ncbi request reprint alpha3beta1 integrin induced suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-(kappa)B activation
    Gongchu Li
    Department of Biological Sciences, Binghamton University SUNY, Binghamton, NY 13902 6000, USA
    Cell Immunol 231:30-9. 2004
    ..These studies define a novel regulatory mechanism which may be important in the control of IEC cytokine responses during inflammation...

Research Grants3

  1. NF-kB activation in epilepsy
    FARAH LUBIN; Fiscal Year: 2007
    ..These studies may also identify novel targets for therapeutics in epilepsy. ..
  2. NF-kB activation in epilepsy
    FARAH LUBIN; Fiscal Year: 2006
    ..These studies may also identify novel targets for therapeutics in epilepsy. ..