David M Lubaroff

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Prostate cancer vaccines in clinical trials
    David M Lubaroff
    Department of Urology, University of Iowa Carver College of Medicine and The Holden Comprehensive Cancer Center, 375 Newton Road, 3210 MERF, Iowa City, IA 52242, USA
    Expert Rev Vaccines 11:857-68. 2012
  2. ncbi Phase I clinical trial of an adenovirus/prostate-specific antigen vaccine for prostate cancer: safety and immunologic results
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 15:7375-80. 2009
  3. ncbi Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer
    David M Lubaroff
    Department of Urology and Roland and Ruby Holden Cancer Research Laboratories, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Hum Gene Ther 17:220-9. 2006
  4. ncbi Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer
    David M Lubaroff
    Department of Urology, 375 Newton Road, 3210 MERF, The University of Iowa, Iowa City, IA, United States
    Vaccine 24:6155-62. 2006
  5. ncbi CpG oligonucleotide as an adjuvant for the treatment of prostate cancer
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, 52242, United States
    Adv Drug Deliv Rev 61:268-74. 2009
  6. ncbi Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer
    Aliza Z Weinrib
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 116:4410-9. 2010
  7. ncbi Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 25:250-5. 2011
  8. ncbi Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 22:890-900. 2008
  9. ncbi Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 14:6839-46. 2008
  10. ncbi Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine
    Dev Karan
    VA Medical Center, Iowa City, IA, USA
    Int J Cancer 121:1520-8. 2007

Research Grants

  1. 2nd International Conference on Prostate Cancer Research
    David Lubaroff; Fiscal Year: 2002

Collaborators

Detail Information

Publications21

  1. ncbi Prostate cancer vaccines in clinical trials
    David M Lubaroff
    Department of Urology, University of Iowa Carver College of Medicine and The Holden Comprehensive Cancer Center, 375 Newton Road, 3210 MERF, Iowa City, IA 52242, USA
    Expert Rev Vaccines 11:857-68. 2012
    ..This review also delves into the multiple immune regulatory elements that must be overcome in order to obtain strong antitumor-associated antigen immune responses capable of effectively destroying prostate tumor cells...
  2. ncbi Phase I clinical trial of an adenovirus/prostate-specific antigen vaccine for prostate cancer: safety and immunologic results
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 15:7375-80. 2009
    ..We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease...
  3. ncbi Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer
    David M Lubaroff
    Department of Urology and Roland and Ruby Holden Cancer Research Laboratories, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Hum Gene Ther 17:220-9. 2006
  4. ncbi Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer
    David M Lubaroff
    Department of Urology, 375 Newton Road, 3210 MERF, The University of Iowa, Iowa City, IA, United States
    Vaccine 24:6155-62. 2006
    ....
  5. ncbi CpG oligonucleotide as an adjuvant for the treatment of prostate cancer
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, 52242, United States
    Adv Drug Deliv Rev 61:268-74. 2009
    ..Finally, the reduction of the CD8+ T cells was the result of an observed decrease in the proliferation of the antigen specific cell population...
  6. ncbi Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer
    Aliza Z Weinrib
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 116:4410-9. 2010
    ..Here we investigate alterations in diurnal cortisol rhythm in ovarian cancer patients, and potential links with depression, life stress, and functional disability...
  7. ncbi Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 25:250-5. 2011
    ..As beta-adrenergic signaling is related to key biological pathways involved in tumor growth, these findings may have implications for patient outcomes in ovarian cancer...
  8. ncbi Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 22:890-900. 2008
    ....
  9. ncbi Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 14:6839-46. 2008
    ..This study examined distress, MMPs, and angiogenic cytokines in ovarian cancer patients and in vitro...
  10. ncbi Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine
    Dev Karan
    VA Medical Center, Iowa City, IA, USA
    Int J Cancer 121:1520-8. 2007
    ..In addition, the results indicate that widely used standard immune parameters may not predict the vaccine efficacy containing a TLR9 agonist as adjuvant...
  11. ncbi Social influences on clinical outcomes of patients with ovarian cancer
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
    J Clin Oncol 30:2885-90. 2012
    ..We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance...
  12. ncbi Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
    Lauren Clevenger
    Department of Psychology, University of Iowa, Iowa City, IA 52242, United States
    Brain Behav Immun 26:1037-44. 2012
    ..As this study is the first to examine cytokine contributions to sleep and fatigue in ovarian cancer, further research is warranted to clarify the role of biological correlates of sleep and fatigue in this population...
  13. ncbi Glucose as a prognostic factor in ovarian carcinoma
    Donald M Lamkin
    Department of Psychology, University of Iowa, Iowa City, Iowa 52252, USA
    Cancer 115:1021-7. 2009
    ..This study tested the hypothesis that higher presurgical glucose levels predict shorter disease-specific survival time and time to recurrence in ovarian cancer patients...
  14. ncbi Dual roles of E-cadherin in prostate cancer invasion
    Jirapat Chunthapong
    Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    J Cell Biochem 91:649-61. 2004
    ..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism...
  15. ncbi Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 24:1231-40. 2010
    ..Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known...
  16. ncbi Social support, psychological distress, and natural killer cell activity in ovarian cancer
    Susan K Lutgendorf
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 23:7105-13. 2005
    ..We examined relationships among distress, social support, and natural killer (NK) cell activity in ovarian cancer patients in peripheral-blood mononuclear cells (PBMC), ascitic fluid, and tumor-infiltrating lymphocytes (TIL)...
  17. ncbi Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
    Erin S Costanzo
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 104:305-13. 2005
    ..Processes involving IL-6 represent possible pathways by which behavioral factors may contribute to disease outcomes among women with ovarian cancer...
  18. ncbi Chitosan is a surprising negative modulator of cytotoxic CD8+ T cell responses elicited by adenovirus cancer vaccines
    Caitlin D Lemke
    College of Pharmacy, College of Public Health, University of Iowa, Iowa City, Iowa 52242, United States
    Mol Pharm 8:1652-61. 2011
    ....
  19. ncbi Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 26:4820-7. 2008
    ..The objective of the current study was to examine associations between IL-6, diurnal cortisol rhythms, and facets of depression in epithelial ovarian cancer patients...
  20. ncbi Positive psychosocial factors and NKT cells in ovarian cancer patients
    Donald M Lamkin
    Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
    Brain Behav Immun 22:65-73. 2008
    ..Given the anti-tumor activity of CD3+CD56+ cells, these relationships may have relevance for cancer control...
  21. ncbi Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: role in vasculogenic mimicry
    Navesh Sharma
    Department of Anatomy and Cell Biology, The University of Iowa College of Medicine, Iowa City, Iowa 52242-1109, USA
    Prostate 50:189-201. 2002
    ..These results reflect the plasticity of aggressive prostatic tumor cells and may provide new prognostic markers for clinical diagnosis and new therapeutic intervention strategies...

Research Grants1

  1. 2nd International Conference on Prostate Cancer Research
    David Lubaroff; Fiscal Year: 2002
    ..Selection of the travel awardees will be made by a subcommittee of the Organizing Committee and will be based upon the quality of the research contained in the submitted abstracts. ..