David M Lubaroff

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Prostate cancer vaccines in clinical trials
    David M Lubaroff
    Department of Urology, University of Iowa Carver College of Medicine and The Holden Comprehensive Cancer Center, 375 Newton Road, 3210 MERF, Iowa City, IA 52242, USA
    Expert Rev Vaccines 11:857-68. 2012
  2. pmc Phase I clinical trial of an adenovirus/prostate-specific antigen vaccine for prostate cancer: safety and immunologic results
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 15:7375-80. 2009
  3. doi request reprint CpG oligonucleotide as an adjuvant for the treatment of prostate cancer
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, 52242, United States
    Adv Drug Deliv Rev 61:268-74. 2009
  4. ncbi request reprint Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer
    David M Lubaroff
    Department of Urology, 375 Newton Road, 3210 MERF, The University of Iowa, Iowa City, IA, United States
    Vaccine 24:6155-62. 2006
  5. ncbi request reprint Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer
    David M Lubaroff
    Department of Urology and Roland and Ruby Holden Cancer Research Laboratories, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Hum Gene Ther 17:220-9. 2006
  6. pmc Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability
    Andrew Schrepf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 30:S126-34. 2013
  7. pmc Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer
    Aliza Z Weinrib
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 116:4410-9. 2010
  8. pmc Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
    Lauren Clevenger
    Department of Psychology, University of Iowa, Iowa City, IA 52242, United States
    Brain Behav Immun 26:1037-44. 2012
  9. pmc Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 22:890-900. 2008
  10. pmc Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 25:250-5. 2011

Research Grants

Collaborators

Detail Information

Publications24

  1. doi request reprint Prostate cancer vaccines in clinical trials
    David M Lubaroff
    Department of Urology, University of Iowa Carver College of Medicine and The Holden Comprehensive Cancer Center, 375 Newton Road, 3210 MERF, Iowa City, IA 52242, USA
    Expert Rev Vaccines 11:857-68. 2012
    ..This review also delves into the multiple immune regulatory elements that must be overcome in order to obtain strong antitumor-associated antigen immune responses capable of effectively destroying prostate tumor cells...
  2. pmc Phase I clinical trial of an adenovirus/prostate-specific antigen vaccine for prostate cancer: safety and immunologic results
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 15:7375-80. 2009
    ..We performed a phase I clinical trial of adenovirus/prostate-specific antigen (PSA) vaccine in men with measurable metastatic hormone-refractory disease...
  3. doi request reprint CpG oligonucleotide as an adjuvant for the treatment of prostate cancer
    David M Lubaroff
    Department of Urology, University of Iowa, Iowa City, 52242, United States
    Adv Drug Deliv Rev 61:268-74. 2009
    ..Finally, the reduction of the CD8+ T cells was the result of an observed decrease in the proliferation of the antigen specific cell population...
  4. ncbi request reprint Decreased cytotoxic T cell activity generated by co-administration of PSA vaccine and CpG ODN is associated with increased tumor protection in a mouse model of prostate cancer
    David M Lubaroff
    Department of Urology, 375 Newton Road, 3210 MERF, The University of Iowa, Iowa City, IA, United States
    Vaccine 24:6155-62. 2006
    ....
  5. ncbi request reprint Clinical protocol: phase I study of an adenovirus/prostate-specific antigen vaccine in men with metastatic prostate cancer
    David M Lubaroff
    Department of Urology and Roland and Ruby Holden Cancer Research Laboratories, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Hum Gene Ther 17:220-9. 2006
  6. pmc Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: relationships with depression, fatigue, and disability
    Andrew Schrepf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 30:S126-34. 2013
    ..Improvement in fatigue and vegetative depression is associated with the normalization of IL-6 and cortisol, a pattern which may be relevant for improvements in overall quality of life for ovarian cancer patients...
  7. pmc Diurnal cortisol dysregulation, functional disability, and depression in women with ovarian cancer
    Aliza Z Weinrib
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 116:4410-9. 2010
    ..Here we investigate alterations in diurnal cortisol rhythm in ovarian cancer patients, and potential links with depression, life stress, and functional disability...
  8. pmc Sleep disturbance, cytokines, and fatigue in women with ovarian cancer
    Lauren Clevenger
    Department of Psychology, University of Iowa, Iowa City, IA 52242, United States
    Brain Behav Immun 26:1037-44. 2012
    ..As this study is the first to examine cytokine contributions to sleep and fatigue in ovarian cancer, further research is warranted to clarify the role of biological correlates of sleep and fatigue in this population...
  9. pmc Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 22:890-900. 2008
    ....
  10. pmc Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 25:250-5. 2011
    ..As beta-adrenergic signaling is related to key biological pathways involved in tumor growth, these findings may have implications for patient outcomes in ovarian cancer...
  11. pmc Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Clin Cancer Res 14:6839-46. 2008
    ..This study examined distress, MMPs, and angiogenic cytokines in ovarian cancer patients and in vitro...
  12. ncbi request reprint Paradoxical enhancement of CD8 T cell-dependent anti-tumor protection despite reduced CD8 T cell responses with addition of a TLR9 agonist to a tumor vaccine
    Dev Karan
    VA Medical Center, Iowa City, IA, USA
    Int J Cancer 121:1520-8. 2007
    ..In addition, the results indicate that widely used standard immune parameters may not predict the vaccine efficacy containing a TLR9 agonist as adjuvant...
  13. doi request reprint Proposed mechanisms of action for prostate cancer vaccines
    Sean M Geary
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
    Nat Rev Urol 10:149-60. 2013
    ..Of particular interest are current and future strategies for diminishing the activity of regulatory T lymphocytes...
  14. pmc Social influences on clinical outcomes of patients with ovarian cancer
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
    J Clin Oncol 30:2885-90. 2012
    ..We focused on two types of social support: social attachment, a type of emotional social support reflecting connections with others, and instrumental social support reflecting the availability of tangible assistance...
  15. ncbi request reprint Dual roles of E-cadherin in prostate cancer invasion
    Jirapat Chunthapong
    Department of Anatomy and Cell Biology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242 1109, USA
    J Cell Biochem 91:649-61. 2004
    ..These results suggest that E-cadherin plays an important role in regulating the invasive potential of prostate cancer cells through an unique paracrine mechanism...
  16. pmc Glucose as a prognostic factor in ovarian carcinoma
    Donald M Lamkin
    Department of Psychology, University of Iowa, Iowa City, Iowa 52252, USA
    Cancer 115:1021-7. 2009
    ..This study tested the hypothesis that higher presurgical glucose levels predict shorter disease-specific survival time and time to recurrence in ovarian cancer patients...
  17. pmc Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Brain Behav Immun 24:1231-40. 2010
    ..Effects of HT on toxicities, treatment delay, QOL, and fatigue were not observed. Long-term clinical implications of findings are not known...
  18. ncbi request reprint Psychosocial factors and interleukin-6 among women with advanced ovarian cancer
    Erin S Costanzo
    Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
    Cancer 104:305-13. 2005
    ....
  19. ncbi request reprint Social support, psychological distress, and natural killer cell activity in ovarian cancer
    Susan K Lutgendorf
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 23:7105-13. 2005
    ..We examined relationships among distress, social support, and natural killer (NK) cell activity in ovarian cancer patients in peripheral-blood mononuclear cells (PBMC), ascitic fluid, and tumor-infiltrating lymphocytes (TIL)...
  20. pmc The combination of a low-dose chemotherapeutic agent, 5-fluorouracil, and an adenoviral tumor vaccine has a synergistic benefit on survival in a tumor model system
    Sean M Geary
    Division of Pharmaceutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 8:e67904. 2013
    ..The findings presented here promote the concept of combining adenoviral cancer vaccines with low-dose chemotherapy. ..
  21. pmc Chitosan is a surprising negative modulator of cytotoxic CD8+ T cell responses elicited by adenovirus cancer vaccines
    Caitlin D Lemke
    College of Pharmacy, College of Public Health, University of Iowa, Iowa City, Iowa 52242, United States
    Mol Pharm 8:1652-61. 2011
    ....
  22. pmc Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients
    Susan K Lutgendorf
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    J Clin Oncol 26:4820-7. 2008
    ..The objective of the current study was to examine associations between IL-6, diurnal cortisol rhythms, and facets of depression in epithelial ovarian cancer patients...
  23. pmc Positive psychosocial factors and NKT cells in ovarian cancer patients
    Donald M Lamkin
    Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
    Brain Behav Immun 22:65-73. 2008
    ..Given the anti-tumor activity of CD3+CD56+ cells, these relationships may have relevance for cancer control...
  24. ncbi request reprint Prostatic tumor cell plasticity involves cooperative interactions of distinct phenotypic subpopulations: role in vasculogenic mimicry
    Navesh Sharma
    Department of Anatomy and Cell Biology, The University of Iowa College of Medicine, Iowa City, Iowa 52242 1109, USA
    Prostate 50:189-201. 2002
    ..In the current investigation, we examined whether there is evidence for vasculogenic mimicry in heterogeneous prostatic neoplasms...

Research Grants1

  1. 2nd International Conference on Prostate Cancer Research
    David Lubaroff; Fiscal Year: 2002
    ..Selection of the travel awardees will be made by a subcommittee of the Organizing Committee and will be based upon the quality of the research contained in the submitted abstracts. ..