Ying Lu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Evaluating liver fibrosis progression and the impact of antiretroviral therapy in HIV and hepatitis C coinfection using a noninvasive marker
    Huda Al Mohri
    Department of Microbiology, University of Toronto, Ontario, Canada
    J Acquir Immune Defic Syndr 44:463-9. 2007
  2. ncbi Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?
    B Fan
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Osteoporos Int 21:1227-36. 2010
  3. ncbi Receiver operating characteristic (ROC) analysis for diagnostic examinations with uninterpretable cases
    Ying Lu
    Department of Radiology, Box 1290, University of California, San Francisco, 94143 1290, USA
    Stat Med 21:1849-65. 2002
  4. ncbi Reduction of sampling bias of odds ratios for vertebral fractures using propensity scores
    Y Lu
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    Osteoporos Int 17:507-20. 2006
  5. ncbi A design of phase II cancer trials using total and complete response endpoints
    Ying Lu
    Biostatistics Core, UCSF Comprehensive Cancer Center, USA
    Stat Med 24:3155-70. 2005
  6. ncbi Alternative tree-structured survival analysis based on variance of survival time
    Hua Jin
    Department of Radiology, The University of California at San Francisco, San Francisco, CA 94143 0946, USA
    Med Decis Making 24:670-80. 2004
  7. ncbi Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle
    Y Lu
    Department of Radiology, University of California, San Francisco 94143 0628, USA
    Osteoporos Int 12:438-44. 2001
  8. ncbi On the non-inferiority of a diagnostic test based on paired observations
    Ying Lu
    Department of Radiology, Box 0629, University of California, San Francisco, San Francisco, CA 94143 0629, USA
    Stat Med 22:3029-44. 2003
  9. ncbi Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancer
    Yah-Yuen Tan
    Department of Surgery, UCSF Medical Center at Mount Zion, San Francisco, California, USA
    Breast J 11:338-43. 2005
  10. ncbi Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume
    Joonmi Oh
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 19:546-54. 2004

Research Grants

  1. Statistical methods for utility of multiple tests
    Ying Lu; Fiscal Year: 2003
  2. Statistical Methods for Evaluation and Validation of Diagnostic Tests
    Ying Lu; Fiscal Year: 2007

Detail Information

Publications96

  1. ncbi Evaluating liver fibrosis progression and the impact of antiretroviral therapy in HIV and hepatitis C coinfection using a noninvasive marker
    Huda Al Mohri
    Department of Microbiology, University of Toronto, Ontario, Canada
    J Acquir Immune Defic Syndr 44:463-9. 2007
    ..In conclusion, the APRI may be a useful marker for longitudinal evaluation of the progression of liver disease in HIV-HCV coinfection...
  2. ncbi Does standardized BMD still remove differences between Hologic and GE-Lunar state-of-the-art DXA systems?
    B Fan
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Osteoporos Int 21:1227-36. 2010
    ..Spine L1-L4 and L2-L4 sBMD mean differences between the two systems were 0.042 g/cm(2) (4.1%) and 0.035 g/cm(2) (3.2%), respectively...
  3. ncbi Receiver operating characteristic (ROC) analysis for diagnostic examinations with uninterpretable cases
    Ying Lu
    Department of Radiology, Box 1290, University of California, San Francisco, 94143 1290, USA
    Stat Med 21:1849-65. 2002
    ..Comparisons of conventional with the mixed model ROC analysis are shown in mathematical formulae as well as simulated experiments. An example of diagnosis of spinal fracture in renal transplant patients is presented...
  4. ncbi Reduction of sampling bias of odds ratios for vertebral fractures using propensity scores
    Y Lu
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    Osteoporos Int 17:507-20. 2006
    ..The same diagnostic techniques for the measured discriminatory power, expressed as odds ratios, will differ among studies with different patient and control populations...
  5. ncbi A design of phase II cancer trials using total and complete response endpoints
    Ying Lu
    Biostatistics Core, UCSF Comprehensive Cancer Center, USA
    Stat Med 24:3155-70. 2005
    ..Our design has the advantage of being close to the traditional Simon two-stage design while still having the flexibility to treat responses (PR and CR in this example) differently than SD...
  6. ncbi Alternative tree-structured survival analysis based on variance of survival time
    Hua Jin
    Department of Radiology, The University of California at San Francisco, San Francisco, CA 94143 0946, USA
    Med Decis Making 24:670-80. 2004
    ..A limited simulation study suggests that the proposed algorithm is a competitive alternative to the log-rank or martingale residual-based TSSA approaches...
  7. ncbi Standardization of bone mineral density at femoral neck, trochanter and Ward's triangle
    Y Lu
    Department of Radiology, University of California, San Francisco 94143 0628, USA
    Osteoporos Int 12:438-44. 2001
    ..The subregion calibration formulas are most appropriate for calibrating subregion BMD values and their absolute changes, and should be adopted. Standardization is unnecessary for BMD percentage changes in our clinical trial data...
  8. ncbi On the non-inferiority of a diagnostic test based on paired observations
    Ying Lu
    Department of Radiology, Box 0629, University of California, San Francisco, San Francisco, CA 94143 0629, USA
    Stat Med 22:3029-44. 2003
    ..Simulation experiments demonstrate that the new tests and sample size formulae give the appropriate type I and II error rates. Differences between our approach and the approach of Lui and Cumberland are discussed...
  9. ncbi Primary tumor characteristics predict sentinel lymph node macrometastasis in breast cancer
    Yah-Yuen Tan
    Department of Surgery, UCSF Medical Center at Mount Zion, San Francisco, California, USA
    Breast J 11:338-43. 2005
    ..These patients can be identified preoperatively based on imaging and biopsy criteria, allowing the option of selective intraoperative pathologic evaluation of the sentinel node and immediate completion axillary dissection as necessary...
  10. ncbi Survival analysis in patients with glioblastoma multiforme: predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume
    Joonmi Oh
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 19:546-54. 2004
    ....
  11. ncbi Kinetic assessment of breast tumors using high spatial resolution signal enhancement ratio (SER) imaging
    Ka Loh Li
    Department of Radiology, University of California San Francisco, San Francisco, California 94107 0946, USA
    Magn Reson Med 58:572-81. 2007
    ..87+/-0.03). The SER is easy to calculate and may have a unique role in breast tissue characterization...
  12. ncbi High-grade prostatic intraepithelial neoplasia in patients with prostate cancer: MR and MR spectroscopic imaging features--initial experience
    Jeffrey J Hom
    Department of Radiology, University of California, San Francisco, Box 0628, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 242:483-9. 2007
    ..To retrospectively determine the magnetic resonance (MR) and MR spectroscopic imaging features of high-grade prostatic intraepithelial neoplasia (HGPIN) in patients with prostate cancer...
  13. ncbi Identify fracture-critical regions inside the proximal femur using statistical parametric mapping
    Wenjun Li
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Bone 44:596-602. 2009
    ..We identified regions inside the proximal femur that are most strongly associated with hip fracture. Bone densitometry based on such fracture-critical regions showed improved power in discriminating fracture patients from controls...
  14. ncbi Pretreatment endorectal magnetic resonance imaging and magnetic resonance spectroscopic imaging features of prostate cancer as predictors of response to external beam radiotherapy
    Tim Joseph
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Int J Radiat Oncol Biol Phys 73:665-71. 2009
    ....
  15. ncbi Prostate cancer: is inapparent tumor at endorectal MR and MR spectroscopic imaging a favorable prognostic finding in patients who select active surveillance?
    Alvin R Cabrera
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Radiology 247:444-50. 2008
    ..To retrospectively determine whether inapparent tumor at endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging is a favorable prognostic finding in prostate cancer patients who select active surveillance for management...
  16. ncbi Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: diffusion tensor imaging versus cortical gyration
    Amy R Deipolyi
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94143, USA
    Neuroimage 27:579-86. 2005
    ..0001) but not in the tangential diffusivities (P > 0.05)...
  17. ncbi Is it necessary to harvest additional lymph nodes after resection of the most radioactive sentinel lymph node in breast cancer?
    Liang Chih Liu
    Department of Surgery and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA
    J Am Coll Surg 207:853-8. 2008
    ..We hypothesized that the node with the highest radioactivity would have the strongest probability of being a positive SLN, and we sought to determine the lowest radioactive count of a node harboring cancer...
  18. ncbi The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer
    Yang-Guo Fan
    Department of Surgery, University of California San Francisco Medical Center at Mount Zion, San Francisco, 94143-1674, USA
    Ann Surg Oncol 12:705-11. 2005
    ..Higher recurrence rates are also seen in these patients. However, the role of routine ALND in patients with a low SLN tumor burden remains to be further determined by prospective randomized trials...
  19. ncbi Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns
    Savannah C Partridge
    Department of Radiology, University of California-San Francisco, San Francisco, California 94143-2512, USA
    J Magn Reson Imaging 22:467-74. 2005
    ..CONCLUSION: Fiber DTT is feasible in premature newborns, provides more reproducible tract measurements than manual ROI methods, and allows quantitation along the entire tract for more detailed DTI assessment of white matter maturation...
  20. ncbi A three-dimensional MRI analysis of knee kinematics
    Vikas V Patel
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA
    J Orthop Res 22:283-92. 2004
    ..MR imaging allows excellent non-invasive evaluation of knee joint kinematics with weight bearing. This tool may potentially be used for assessing knee kinematics in patients with knee pathology...
  21. ncbi Bone fracture risk estimation based on image similarity
    Wenjun Li
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94143, USA
    Bone 45:560-7. 2009
    ..923, higher than the AUC value of 0.835 when using BMD alone (p-value: 0.0046). Our results showed that combining BMD with image similarity measures resulted in improved hip fracture risk estimation...
  22. ncbi Prostate cancer: endorectal MR imaging and MR spectroscopic imaging--distinction of true-positive results from chance-detected lesions
    Jeffrey J Hom
    Department of Radiology, University of California, Box 0628, M-372, San Francisco, CA 94143-0628, USA
    Radiology 238:192-9. 2006
    ....
  23. ncbi Invasive breast cancer: predicting disease recurrence by using high-spatial-resolution signal enhancement ratio imaging
    Ka Loh Li
    Department of Radiology, University of California, San Francisco, 1 Irving St, San Francisco, CA 94143 1290, USA
    Radiology 248:79-87. 2008
    ..To retrospectively evaluate high-spatial-resolution signal enhancement ratio (SER) imaging for the prediction of disease recurrence in patients with breast cancer who underwent preoperative magnetic resonance (MR) imaging...
  24. ncbi Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients: a meta-analysis and single-institution experience
    Liang Chih Liu
    Department of Surgery, Helen Diller and Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California, USA
    Cancer 117:250-8. 2011
    ..The objective of the current study was to determine the accuracy of intraoperative frozen section (IFS) of SLNs during breast cancer surgery...
  25. ncbi Organ-confined prostate cancer: effect of prior transrectal biopsy on endorectal MRI and MR spectroscopic imaging
    Aliya Qayyum
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
    AJR Am J Roentgenol 183:1079-83. 2004
    ..MRI staging criteria and guidelines for scheduling studies after biopsy may require appropriate modification...
  26. ncbi Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy
    Anne Laprie
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94107-1739, USA
    Int J Radiat Oncol Biol Phys 62:20-31. 2005
    ..Longitudinal multivoxel MRSI measurements have potential value in assessing response to radiation or other therapies, because they offer more coverage than single-voxel techniques and provide reliable spectral data...
  27. ncbi Evaluation of diffuse liver steatosis by ultrasound, computed tomography, and magnetic resonance imaging: which modality is best?
    Aliya Qayyum
    Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Clin Imaging 33:110-5. 2009
    ..To compare ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) determination of diffuse liver steatosis...
  28. ncbi Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: preliminary experience
    Fergus V Coakley
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 233:441-8. 2004
    ..To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy...
  29. ncbi Prognostic implications of positive nonsentinel lymph nodes removed during selective sentinel lymphadenectomy for breast cancer
    Julie E Lang
    Department of Surgery and UCSF Comprehensive Cancer Center, UCSF, San Francisco, CA 94143 1674, USA
    Breast J 15:242-6. 2009
    ..57), or overall survival (p = 0.70). Positive non-SLNs removed during SSL are not a significant risk factor for additional positive nodes on completion axillary nodal dissection (CALND) or for worse survival than positive SLNs...
  30. ncbi Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T
    Yan Li
    University of California, San Francisco University of California, Berkeley UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, California 94143 2532, USA
    J Magn Reson Imaging 28:342-50. 2008
    ..To measure T(1) and T(2) relaxation times of metabolites in glioma patients at 3T and to investigate how these values influence the observed metabolite levels...
  31. ncbi Liver fat: effect of hepatic iron deposition on evaluation with opposed-phase MR imaging
    Antonio C A Westphalen
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 242:450-5. 2007
    ..To retrospectively determine the effect of liver iron deposition on the evaluation of liver fat by using opposed-phase magnetic resonance (MR) imaging...
  32. ncbi Peripheral zone prostate cancer: accuracy of different interpretative approaches with MR and MR spectroscopic imaging
    Antonio C Westphalen
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 246:177-84. 2008
    ....
  33. ncbi Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference
    Ehsan Saadat
    School of Medicine and Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Eur Radiol 18:2292-302. 2008
    ....
  34. ncbi MRI measurements of breast tumor volume predict response to neoadjuvant chemotherapy and recurrence-free survival
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    AJR Am J Roentgenol 184:1774-81. 2005
    ....
  35. ncbi Evaluating the improvement in diagnostic utility from adding new predictors
    Caixia Li
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, 94143 0946, USA
    Biom J 52:417-35. 2010
    ..We use data from the Study of Osteoporotic Fractures as an application example to illustrate our method...
  36. ncbi Prostate cancer: role of pretreatment MR in predicting outcome after external-beam radiation therapy--initial experience
    David A McKenna
    Department of Radiology, University of California, San Francisco, M 372, 505 Parnassus Ave, San Francisco, CA 94143 0628, USA
    Radiology 247:141-6. 2008
    ..To retrospectively determine if pretreatment endorectal magnetic resonance (MR) imaging findings are predictive of outcome in patients who undergo external-beam radiation therapy for prostate cancer...
  37. ncbi A generalized least significant change for individuals measured on different DXA systems
    John A Shepherd
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Clin Densitom 10:249-58. 2007
    ..We conclude that the GLSC, defined using commonly used clinical cross-calibration and precision assessments, is the most accurate method to compare scans between dual-energy X-ray absorptiometry systems...
  38. ncbi Selection of tumorigenic melanoma cells using ALDH
    Jim B Boonyaratanakornkit
    Department of Dermatology, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 130:2799-808. 2010
    ..Thus, ALDH(+) melanoma cells have enhanced tumorigenicity over ALDH(-) cells and superior self-renewal ability...
  39. ncbi Growth rate of hepatocellular carcinoma: evaluation with serial computed tomography or magnetic resonance imaging
    Bachir Taouli
    Department of Radiology, University of California, San Francisco, CA, USA
    J Comput Assist Tomogr 29:425-9. 2005
    ..To evaluate the growth rate of untreated hepatocellular carcinoma (HCC) by calculating tumor volume doubling time (TVDT) on serial computed tomography (CT) or magnetic resonance imaging (MRI) and to predict TVDT based on initial tumor size...
  40. ncbi Identification of MRI and 1H MRSI parameters that may predict survival for patients with malignant gliomas
    Xiaojuan Li
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, 1 Irving St, San Francisco, CA 94143, USA
    NMR Biomed 17:10-20. 2004
    ....
  41. ncbi A multinational study to develop universal standardization of whole-body bone density and composition using GE Healthcare Lunar and Hologic DXA systems
    John A Shepherd
    Department of Radiology and Bioimaging, University of California San Francisco, San Francisco, CA 94143, USA
    J Bone Miner Res 27:2208-16. 2012
    ..The equations we derived reduce differences between BMD and body composition as determined by GE Healthcare Lunar and Hologic systems and will facilitate combining study results in clinical or epidemiological studies...
  42. ncbi An update survey of academic radiologists' clinical productivity
    Ying Lu
    Department of Radiology, University of California, San Francisco, California 94143 0628, USA
    J Am Coll Radiol 5:817-26. 2008
    ..The results can be used to determine faculty staffing requirements and evaluate radiologists' performance...
  43. ncbi Distinction of renal cell carcinomas from high-attenuation renal cysts at portal venous phase contrast-enhanced CT
    Michael Suh
    Department of Radiology, Box 0628, M-372, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
    Radiology 228:330-4. 2003
    ..CONCLUSION: On portal venous phase contrast-enhanced CT scans, attenuation greater than 70 HU or moderate or marked internal heterogeneity favor a diagnosis of renal cell carcinoma over a diagnosis of high-attenuation renal cyst...
  44. ncbi Detection of hepatocellular carcinoma by ferumoxides-enhanced MR imaging in cirrhosis: Incremental value of dynamic gadolinium-enhancement
    Aliya Qayyum
    Department of Radiology, University of California, San Francisco, San Francisco, California 94143, USA
    J Magn Reson Imaging 23:17-22. 2006
    ..To investigate the incremental value of dynamic gadolinium-enhancement performed immediately after ferumoxides-enhanced magnetic resonance (MR) imaging on the detection of hepatocellular carcinoma in patients with cirrhosis...
  45. ncbi T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis
    Timothy C Dunn
    Department of Radiology, University of California at San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107 1739, USA
    Radiology 232:592-8. 2004
    ....
  46. ncbi CT signs of hepatofugal portal venous flow in patients with cirrhosis
    Thomas J Bryce
    Department of Medicine and Department of Radiology, Abdominal Imaging Section, University of California at San Francisco, San Francisco, CA 94143-0628, USA
    AJR Am J Roentgenol 181:1629-33. 2003
    ..This sign may be useful when sonography is limited, or this sign may prompt sonographic assessment in patients not known to have hepatofugal flow...
  47. ncbi Accuracy of plain abdominal radiographs in the detection of retained surgical needles in the peritoneal cavity
    Skorn Ponrartana
    Department of Radiology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Surg 247:8-12. 2008
    ..To determine the accuracy of plain abdominal radiographs in the detection of retained surgical needles of varying size in the peritoneal cavity...
  48. ncbi Comparing BMD results between two similar DXA systems using the generalized least significant change
    John A Shepherd
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 0946, USA
    J Clin Densitom 11:237-42. 2008
    ..A revision of the International Society for Clinical Densitometry's policies for comparing scans from systems of the same technology may be appropriate...
  49. ncbi In vivo application of 3D-line skeleton graph analysis (LSGA) technique with high-resolution magnetic resonance imaging of trabecular bone structure
    Laurent Pothuaud
    Department of Radiology, Magnetic Resonance Science Center, University of California San Francisco, 1 Irving Street, Room AC-109, San Francisco, CA 94143-1290, USA
    Osteoporos Int 15:411-9. 2004
    ..However, this paper demonstrated the feasibility of using 3D-LSGA based evaluation coupled with in vivo high-resolution MR imaging as a complementary approach for the monitoring of trabecular bone changes in individual subjects...
  50. ncbi Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence
    Tracy R McKnight
    Department of Radiology, Biostatistics Core, Comprehensive Cancer Center, University of California, San Francisco 94143, USA
    J Neurosurg 97:794-802. 2002
    ..The information gleaned from the biopsy correlation study was used to test the hypothesis that there is metabolically active tumor in nonenhancing regions of the T2-hyperintense lesion that can be detected using MR spectroscopy...
  51. ncbi Adaptation of the proximal femur to skeletal reloading after long-duration spaceflight
    Thomas F Lang
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Bone Miner Res 21:1224-30. 2006
    ..We observed that the readaptation of the proximal femur to Earth's gravity entailed an increase in bone size and an incomplete recovery of volumetric BMD...
  52. ncbi Cross-calibration and minimum precision standards for dual-energy X-ray absorptiometry: the 2005 ISCD Official Positions
    John A Shepherd
    Department of Radiology, University of California, San Francisco, CA 94143 0946, USA
    J Clin Densitom 9:31-6. 2006
    ..We present here the ISCD Official Positions on these topics that were established as a result of the 2005 PDC, together with the associated rationales and supportive evidence...
  53. ncbi Regional angiographic grading system for collateral flow: correlation with cerebral infarction in patients with middle cerebral artery occlusion
    Jane J Kim
    Department of Radiology, University of California, San Francisco, Calif, USA
    Stroke 35:1340-4. 2004
    ..This study corroborates the correlation between the presence of collateral flow, infarction volume, and clinical outcome, and it reinforces the need to control for collateral flow in clinical trials...
  54. ncbi AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging
    Lisa J Wilmes
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 1290, USA
    Magn Reson Imaging 25:319-27. 2007
    ..Furthermore, the correlative relationship between microvasculature changes and tumor growth inhibition supports DCE-MRI methods as a biomarker of VEGF receptor target inhibition with potential clinical utility...
  55. ncbi Challenges in dynamic contrast-enhanced MRI imaging of cervical lymph nodes to detect metastatic disease
    Susan M Noworolski
    The Magnetic Resonance Science Center, The University of California, San Francisco, California 94143 1290, USA
    J Magn Reson Imaging 17:455-62. 2003
    ..To identify and overcome challenges in using dynamic contrast-enhanced magnetic resonance imaging (MRI) to distinguish tumor from nontumor in the cervical lymph nodes of patients with squamous cell carcinoma of the head and neck...
  56. ncbi Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 22:1302-14. 2004
    ..This work contributes to the understanding of normal white matter development in the preterm neonatal brain, an important step toward the use of DTI for the improved evaluation and treatment of white matter injury of prematurity...
  57. ncbi Dual-energy X-ray absorptiometry with serum ferritin predicts liver iron concentration and changes in concentration better than ferritin alone
    John A Shepherd
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94115, USA
    J Clin Densitom 13:399-406. 2010
    ....
  58. ncbi In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis
    Thomas M Link
    Department of Radiology, Klinikum rechts der Isar, Technische Universitaet, Munich, Germany
    Radiology 231:805-11. 2004
    ..To evaluate, both experimentally and in vivo, if nondedicated standard spiral computed tomography (CT) may be used to obtain reliable bone mineral density (BMD) data...
  59. ncbi MR spectroscopy of normative premature newborns
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA
    J Magn Reson Imaging 33:306-11. 2011
    ..To establish normative metabolite ratios throughout the newborn brain using three-dimensional (3D) MR spectroscopic imaging (MRSI)...
  60. ncbi Voxel-based modeling and quantification of the proximal femur using inter-subject registration of quantitative CT images
    Wenjun Li
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    Bone 41:888-95. 2007
    ..After registration, the average distance between the mapped landmarks and the corresponding landmarks in the target scan was 2.56 mm. The average error due to manual landmark identification was 1.70 mm...
  61. ncbi Topographic enhancement mapping of the cancer-associated breast stroma using breast MRI
    Nima Nabavizadeh
    Department of Radiation Oncology, University of California, San Francisco Comprehensive Cancer Center, 1600 Divisadero Street H1031, San Francisco, CA 94143 1708, USA
    Integr Biol (Camb) 3:490-6. 2011
    ..Identification of a cancer-associated stroma may be further developed to help guide local therapy to reduce recurrence and morbidity in breast cancer patients...
  62. ncbi Optimal monitoring time interval between DXA measures in children
    John A Shepherd
    Department of Radiology, Bone and Breast Density Research Group, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 26:2745-52. 2011
    ..MTI was neither useful nor stable in late adolescence and young adulthood. Alternative criteria to determine scan intervals must be used in this age range...
  63. ncbi Diagnostic value of PET/CT for the staging and restaging of pediatric tumors
    Margit Kleis
    Department of Radiology, University of California, 505 Parnassus Avenue, San Francisco, CA 94143 0628, USA
    Eur J Nucl Med Mol Imaging 36:23-36. 2009
    ....
  64. ncbi Prostate cancer localization with endorectal MR imaging and MR spectroscopic imaging: effect of clinical data on reader accuracy
    Rajpal Dhingsa
    Departments of Radiology, Pathology, and Urology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA
    Radiology 230:215-20. 2004
    ..A stricter definition of a true-positive result is associated with reduced sensitivity for prostate cancer nodule detection...
  65. ncbi Diffusion-weighted and fluid-attenuated inversion recovery imaging in Creutzfeldt-Jakob disease: high sensitivity and specificity for diagnosis
    Geoffrey S Young
    Department of Radiology, University of California, San Francisco, 74143, USA
    AJNR Am J Neuroradiol 26:1551-62. 2005
    ..CONCLUSION: Because specific patterns of abnormality on DWI and FLAIR images are highly sensitive and specific for CJD, these sequences should be performed whenever CJD is suspected...
  66. ncbi Labeling human embryonic stem cell-derived cardiomyocytes with indocyanine green for noninvasive tracking with optical imaging: an FDA-compatible alternative to firefly luciferase
    Sophie E Boddington
    Department of Radiology, University of California, San Francisco, CA 94107 0946, USA
    Cell Transplant 19:55-65. 2010
    ..The technique may be useful for assessing different delivery routes in order to improve the engraftment of transplanted hESC-CMs or other stem cell progenitors...
  67. ncbi MRI of the spine: image quality and normal-neoplastic bone marrow contrast at 3 T versus 1.5 T
    Jian Zhao
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, Box 0628, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 192:873-80. 2009
    ..The objectives of our study were to compare image quality of the spine and visualization of spine abnormalities at 3 T and 1.5 T as well as to evaluate differences in quantitative assessment of normal and neoplastic vertebral bone marrow...
  68. ncbi An optical imaging method to monitor stem cell migration in a model of immune-mediated arthritis
    Elizabeth J Sutton
    Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Opt Express 17:24403-13. 2009
    ..The experimental results indicate that DiD integrated into the cell membrane. DiD-labeled MSC localization in the arthritic ankle joints was observed with OI indicating that this method can be applied to monitor MSC in arthritic joints...
  69. ncbi Ratio of positive to total number of sentinel nodes predicts nonsentinel node status in breast cancer patients
    Yah-Yuen Tan
    Department of Surgery, UCSF Medical Center at Mount Zion and UCSF Comprehensive Cancer Center, San Francisco, California 94143-1674, USA
    Breast J 11:248-53. 2005
    ....
  70. ncbi Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight
    Thomas Lang
    Department of Radiology, University of California, San Francisco, California, USA
    J Bone Miner Res 19:1006-12. 2004
    ..There was no compartment-specific loss of bone in the spine. Cortical bone mineral loss in the hip occurred primarily by endocortical thinning...
  71. ncbi Prostate cancer tumor volume: measurement with endorectal MR and MR spectroscopic imaging
    Fergus V Coakley
    Department of Radiology, University of California San Francisco, Box 0628, L-308, 505 Parnassus Ave, San Francisco, CA 94143-0628, USA
    Radiology 223:91-7. 2002
    ....
  72. ncbi Magnetic resonance imaging of patellofemoral kinematics with weight-bearing
    Vikas V Patel
    Department of Orthopaedic Surgery, University of California, 400 Parnassus, ACC-3, San Francisco, CA 94117, USA
    J Bone Joint Surg Am 85:2419-24. 2003
    ..Therefore, we believe that lateral patellar tilt and subluxation observed during arthroscopy of the extended knee may not represent a pathological condition...
  73. ncbi Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients
    Xiaojuan Li
    Department of Radiology, Magnetic Resonance Science Center, University of California-San Francisco, San Francisco, California 94143, USA
    J Magn Reson Imaging 16:229-37. 2002
    ..CONCLUSION: These 3D-MRSI data provide important additional information to conventional MRI for evaluating and characterizing gliomas...
  74. ncbi Sonographic evaluation of liver nodularity: Inspection of deep versus superficial surfaces of the liver
    Roy A Filly
    Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-0628, USA
    J Clin Ultrasound 30:399-407. 2002
    ..As the prevalence of disease increases, the accuracy of assessment of the deep surface in predicting cirrhosis increases...
  75. ncbi Universal standardization of forearm bone densitometry
    John A Shepherd
    Department of Radiology, University of California San Francisco, 94143-1349, USA
    J Bone Miner Res 17:734-45. 2002
    ....
  76. ncbi Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae
    Ahi Sema Issever
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143-1290, USA
    Spine 28:123-8. 2003
    ..These observations may be helpful in understanding the pathologic processes and the chronology of degenerative spinal conditions...
  77. ncbi MRI and CT of insufficiency fractures of the pelvis and the proximal femur
    Miguel C Cabarrus
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, San Francisco, CA 94143, USA
    AJR Am J Roentgenol 191:995-1001. 2008
    ....
  78. ncbi Magnetic resonance imaging in patients diagnosed with ductal carcinoma-in-situ: value in the diagnosis of residual disease, occult invasion, and multicentricity
    E Shelley Hwang
    Department of Surgery, University of California San Francisco, San Francisco, California 94115, USA
    Ann Surg Oncol 10:381-8. 2003
    ..We studied the performance of MRI in patients with known DCIS for assessment of residual disease, occult invasion, and multicentricity to determine the clinical role of MRI in this setting...
  79. ncbi Computed tomographic findings in patients undergoing intra-arterial thrombolysis for acute ischemic stroke due to middle cerebral artery occlusion: results from the PROACT II trial
    Heidi C Roberts
    Department of Radiology, University of California, San Francisco, USA
    Stroke 33:1557-65. 2002
    ..The purpose of this study was to evaluate the role of noncontrast CT in the selection of patients to receive thrombolytic therapy for acute ischemic stroke and to predict radiological and clinical outcomes...
  80. ncbi Anti-rejection drug treatment increases basal cell carcinoma burden in Ptch1+/- mice
    Annika Vogt
    Department of Dermatology, University of California, San Francisco, California 94110, USA
    J Invest Dermatol 124:263-7. 2005
    ..5-fold. Thus, these mice provide a good model for study of the effects of long-term administration of ARD on at least one type of non-melanoma skin cancer...
  81. ncbi E2F1 expression in LNCaP prostate cancer cells deregulates androgen dependent growth, suppresses differentiation, and enhances apoptosis
    Stephen J Libertini
    Veterans Affairs Northern California Health Care System, Mather, and Department of Medical Microbiology and Immunology, University of California, Davis, USA
    Prostate 66:70-81. 2006
    ..To investigate the role of E2F/RB in androgen independent proliferation, differentiation, and sensitivity to apoptotic stimuli of LNCaP prostate cancer cells...
  82. ncbi Classification algorithms for hip fracture prediction based on recursive partitioning methods
    Hua Jin
    Department of Radiology University of California, San Francisco 94143-0946, USA
    Med Decis Making 24:386-98. 2004
    ..A dual X-ray absorptiometry hip scan and information from clinical examinations can identify subjects with elevated 5-year hip fracture risk without loss of efficiency to more costly and complicated algorithms...
  83. ncbi Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas
    Isabelle Catalaa
    Service de Neuroradiologie, Hopital Rangueil, Toulouse, France
    NMR Biomed 19:463-75. 2006
    ..The non-enhancing region of grades II and III gliomas had MR parameters consistent with increased cellularity and/or membrane turnover...
  84. ncbi Bone structure of the distal radius and the calcaneus vs BMD of the spine and proximal femur in the prediction of osteoporotic spine fractures
    Thomas M Link
    Department of Clinical Radiology, University of Muenster, Muenster, Germany
    Eur Radiol 12:401-8. 2002
    ..A combination of BMD and structure measures did not yield any additional information on fracture status...
  85. ncbi On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants
    Diana Luca
    Department of Statistics, Carnegie Mellon University Pittsburgh, PA 15213, USA
    Am J Hum Genet 82:453-63. 2008
    ..We perform a GWA by matching Americans with type 1 diabetes (T1D) to controls from Germany. Despite the complex study design, these analyses identify numerous loci known to confer risk for T1D...
  86. ncbi Regression of Novikoff rat hepatocellular carcinoma following locoregional administration of a novel formulation of clofazimine in lipiodol
    Mohammad H Pourgholami
    Department of Surgery, St George Hospital, University of New South Wales, Kogarah, Sydney, NSW 2217, Australia
    Cancer Lett 207:37-47. 2004
    ..Thus, intraarterial administration of the highly lipophilic antiproliferative agent CFZ in lipiodol solution may represent an effective and yet safe strategy for the regional treatment of HCCs...
  87. ncbi Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments
    Jie Gao
    International Joint Cancer Institute and Department of Pharmaceutical Science of College of Pharmacy, The Second Military Medical University, Shanghai, People s Republic of China
    Mol Cancer Ther 7:3399-407. 2008
    ..In conclusion, the resultant PE-NP-S possessed increased cancer therapeutic efficacy and had reduced nonspecific toxicity and immunogenicity, suggesting that it is a potential candidate in cancer therapy...
  88. ncbi Preparation and characterization of PE38KDEL-loaded anti-HER2 nanoparticles for targeted cancer therapy
    Huaiwen Chen
    Department of Pharmaceutical Science, College of Pharmacy, Second Military Medical University, 325 Guo He Road, Shanghai 200433, People s Republic of China
    J Control Release 128:209-16. 2008
    ..92 mg/kg vs. 0.92 mg/kg), indicating the systemic toxicity of PE38KDEL was dramatically reduced by PLGA encapsulation. Thus, the bioconjugates PE-NPs-HER may represent a potentially useful strategy for cancer therapy...
  89. ncbi Volumetric quantitative CT of the spine and hip derived from contrast-enhanced MDCT: conversion factors
    Jan S Bauer
    Department of Radiology, Technische Univerität München, Klinikum rechts der Isar, Institut für Roentgendiagnostik, Ismaninger Str 22, Munchen, Germany 81675
    AJR Am J Roentgenol 188:1294-301. 2007
    ....
  90. ncbi Whole brain voxel-wise analysis of single-subject serial DTI by permutation testing
    SungWon Chung
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, CA, USA
    Neuroimage 39:1693-705. 2008
    ..We describe PERVADE in detail and present results from Monte Carlo simulation supporting the validity of the technique as well as illustrative examples from a healthy subject and patients in the early stages of multiple sclerosis...
  91. ncbi Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice
    Mohammad Hossein Pourgholami
    Cancer Research Laboratories, Department of Surgery, St. George Hospital, University of New South Wales, Sydney, New South Wales, Australia
    Clin Cancer Res 12:1928-35. 2006
    ..CONCLUSIONS: These findings suggest for the first time that in nude mice bearing OVCAR-3 peritoneal tumors, by inhibiting VEGF production, albendazole abolishes tumor angiogenesis and ascites formation...
  92. ncbi Antitumor activities of TEM8-Fc: an engineered antibody-like molecule targeting tumor endothelial marker 8
    Hai Feng Duan
    Beijing Institute of Radiation Medicine, Haidian District, Beijing, China
    J Natl Cancer Inst 99:1551-5. 2007
    ..TEM8-Fc is a novel therapeutic antibody-like agent in the management of solid tumors that may act by trapping M2-PK...
  93. ncbi Characterization of segments from the central region of BRCA1: an intrinsically disordered scaffold for multiple protein-protein and protein-DNA interactions?
    Wen Ying Mark
    Division of Molecular and Structural Biology, Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Toronto, Ont, Canada M5G 2M9
    J Mol Biol 345:275-87. 2005
    ..This supports a model in which the central region may act as a long flexible scaffold for intermolecular interactions, thereby helping to integrate multiple signals in the DNA damage response pathway...
  94. ncbi [The study of treatment of osteoporotic thoracolumbar multi-vertebral compressive fractures by kyphoplasty with one balloon]
    Hai Tang
    Department of Orthopaedic, Beijing Friendship Hospital Affiliate of Capital University of Medical Science, Beijing 100050, China
    Zhonghua Wai Ke Za Zhi 43:1568-71. 2005
    ..To evaluate the effect of kyphoplasty in treating osteoporotic thoracolumbar multi-vertebral compressive fractures with one balloon...
  95. ncbi [3-D endocardial surface modelling based on the convex hull algorithm]
    Ying Lu
    Biomedical Engineering Dept, Communication and Information Engineering Institute, Shanghai University, Shanghai
    Zhongguo Yi Liao Qi Xie Za Zhi 30:410-2. 2006
    ....
  96. ncbi Lifelong menstrual histories are typically erratic and trending: a taxonomy
    Tristan Gorrindo
    Center for Population and Health, 313 Healy Hall, Box 571197, Georgetown University, Washington, DC 20057 1197, USA
    Menopause 14:74-88. 2007
    ..We seek to quantitatively represent menstrual histories from menarche to menopause and to evaluate the clinical belief that regular and stable cycle lengths are the most normative histories...

Research Grants3

  1. Statistical methods for utility of multiple tests
    Ying Lu; Fiscal Year: 2003
    ..based on data from the Study of Osteoporotic Fractures (SOF) and simulation models using cost-effectiveness and population distribution parameters published in literature. ..
  2. Statistical Methods for Evaluation and Validation of Diagnostic Tests
    Ying Lu; Fiscal Year: 2007
    ..Research results will be disseminated through publication of software, research and tutorial papers in both clinical and statistical journals and by influencing position papers of professional organizations. ..