SHELLY CHI LOO LU

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity
    Anna Prudova
    Redox Biology Center and Biochemistry Department, University of Nebraska, Lincoln, NE 68588 0664, USA
    Proc Natl Acad Sci U S A 103:6489-94. 2006
  2. ncbi request reprint Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans?
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 48:1359-61. 2008
  3. pmc Glutathione synthesis
    Shelly C Lu
    Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Biochim Biophys Acta 1830:3143-53. 2013
  4. pmc S-adenosylmethionine in liver health, injury, and cancer
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, Los Angeles, California 90033, USA
    Physiol Rev 92:1515-42. 2012
  5. ncbi request reprint Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
    Shelly C Lu
    USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Alcohol 35:227-34. 2005
  6. pmc Regulation of glutathione synthesis
    Shelly C Lu
    Department of Medicine, Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Mol Aspects Med 30:42-59. 2009
  7. ncbi request reprint Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
    Shelly C Lu
    USC Liver Disease Research Center, USC UCLA Alcoholic Liver and Pancreatic Disease Center, Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine USC, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 21:S61-4. 2006
  8. pmc S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis
    Maria Lauda Tomasi
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California, USA
    Gastroenterology 136:1025-36. 2009
  9. pmc Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
    C Bart Rountree
    Division of Gastroenterology, Children s Hospital, Los Angeles, Los Angeles, CA, USA
    Hepatology 47:1288-97. 2008
  10. ncbi request reprint Role of S-adenosylmethionine in two experimental models of pancreatitis
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
    FASEB J 17:56-8. 2003

Collaborators

Detail Information

Publications62

  1. pmc S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity
    Anna Prudova
    Redox Biology Center and Biochemistry Department, University of Nebraska, Lincoln, NE 68588 0664, USA
    Proc Natl Acad Sci U S A 103:6489-94. 2006
    ..A mechanistic basis for the coordinate changes in redox and methylation metabolism that are a hallmark of several complex diseases is explained by these observations...
  2. ncbi request reprint Antioxidants in the treatment of chronic liver diseases: why is the efficacy evidence so weak in humans?
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 48:1359-61. 2008
  3. pmc Glutathione synthesis
    Shelly C Lu
    Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Biochim Biophys Acta 1830:3143-53. 2013
    ..The second enzyme of GSH synthesis is GSH synthetase (GS)...
  4. pmc S-adenosylmethionine in liver health, injury, and cancer
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine, Los Angeles, California 90033, USA
    Physiol Rev 92:1515-42. 2012
    ..In experimental models, it is effective as a chemopreventive agent in HCC and perhaps other forms of cancer as well...
  5. ncbi request reprint Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
    Shelly C Lu
    USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Alcohol 35:227-34. 2005
    ..It is interesting that SAMe is antiapoptotic in normal hepatocytes, but proapoptotic in liver cancer cells. This should make SAMe an attractive agent for both chemoprevention and treatment of HCC...
  6. pmc Regulation of glutathione synthesis
    Shelly C Lu
    Department of Medicine, Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Mol Aspects Med 30:42-59. 2009
    ..These include diabetes mellitus, pulmonary fibrosis, cholestatic liver injury, endotoxemia and drug-resistant tumor cells. Manipulation of the GSH synthetic capacity is an important target in the treatment of many of these disorders...
  7. ncbi request reprint Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease
    Shelly C Lu
    USC Liver Disease Research Center, USC UCLA Alcoholic Liver and Pancreatic Disease Center, Division of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine USC, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 21:S61-4. 2006
    ..This paper reviews MAT genes and SAMe in relation to alcoholic liver disease and the molecular mechanisms by which SAMe regulates hepatocyte growth and apoptosis...
  8. pmc S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis
    Maria Lauda Tomasi
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California, USA
    Gastroenterology 136:1025-36. 2009
    ..We examined livers of Mat1a KO mice for genomic instability and dysregulation of APEX1...
  9. pmc Expansion of liver cancer stem cells during aging in methionine adenosyltransferase 1A-deficient mice
    C Bart Rountree
    Division of Gastroenterology, Children s Hospital, Los Angeles, Los Angeles, CA, USA
    Hepatology 47:1288-97. 2008
    ..This is the first demonstration of adult liver stem cells possessing tumorigenic potential without the use of a carcinogen or manipulation of tumor-suppressor or oncogene expression...
  10. ncbi request reprint Role of S-adenosylmethionine in two experimental models of pancreatitis
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, Keck School of Medicine USC, Los Angeles, California 90033, USA
    FASEB J 17:56-8. 2003
    ..Third, in contrast to the situation in the liver, where absence of MAT1A and decreased hepatic SAM level can lead to spontaneous tissue injury, in the pancreas the roles of SAM and MAT1A appear more complex and remain to be defined...
  11. pmc Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation
    Komal Ramani
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, HMR Bldg, 413, Department of Medicine, Keck School of Medicine USC, 2011 Zonal Ave, Los Angeles, CA 90033, USA
    Hepatology 51:986-95. 2010
    ..Conclusion: MAT2A and MAT2beta genes are induced during HSC activation and are essential for this process. The SAMe level falls, resulting in global DNA hypomethylation...
  12. ncbi request reprint Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A
    Lixin Chen
    Division of Gastroenterology and Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, USC Liver Disease Research Center, USC School of Medicine, Los Angeles, California 90033, USA
    FASEB J 18:914-6. 2004
    ..Taken together, our findings define a critical role for SAMe in ERK signaling and cyclin D1 regulation during regeneration and suggest chronic hepatic SAMe depletion results in loss of responsiveness to mitogenic signals...
  13. ncbi request reprint Role of abnormal methionine metabolism in alcoholic liver injury
    Shelly C Lu
    USC Liver Disease Research Center, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Alcohol 27:155-62. 2002
    ..These changes can lead to impaired antioxidant defense, altered gene expression, promotion of fibrogenesis, and even hepatocarcinogenesis...
  14. pmc S-Adenosylmethionine in cell growth, apoptosis and liver cancer
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    J Gastroenterol Hepatol 23:S73-7. 2008
    ..This should make SAMe an attractive agent for both chemoprevention and treatment of HCC...
  15. pmc S-adenosylmethionine regulates dual-specificity mitogen-activated protein kinase phosphatase expression in mouse and human hepatocytes
    Maria Lauda Tomasi
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, The Southern California Research Center for Alcoholic and Pancreatic Diseases and Cirrhosis, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 51:2152-61. 2010
    ..SAM treatment in Mat1a KO mice for 7 days raised SAM, DUSP1, mRNA and protein levels and lowered proteosomal and ERK activities...
  16. ncbi request reprint Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells
    Hui Chen
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California, Los Angeles, California 90033, USA
    Gastroenterology 133:207-18. 2007
    ..The role of MAT2A in colon cancer in unknown. The aims of this study were to examine whether MAT2A expression and SAMe and its metabolite methylthioadenosine (MTA) can modulate growth of colon cancer cells...
  17. doi request reprint Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice
    Kwangsuk Ko
    Department of Medicine, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Lab Invest 88:1121-9. 2008
    ..GSH is markedly depleted largely due to lower expression of GCL. Interestingly, SAMe treatment prevented the fall in GCL and helped to preserve the GSH store and prevent liver injury...
  18. ncbi request reprint Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Liver Disease Research Center, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 278:50887-96. 2003
    ..Increased trans-activation of these two sites also contributes to MAT2A up-regulation in HCC...
  19. pmc Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    Mol Cell Biol 25:5933-46. 2005
    ..In conclusion, Nrf1 and Nrf2 regulate rat GCLC promoter by modulating the expression of key AP-1 and NF-kappaB family members...
  20. pmc Forced expression of methionine adenosyltransferase 1A in human hepatoma cells suppresses in vivo tumorigenicity in mice
    Jiaping Li
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine University of Southern California, Los Angeles, CA 90033, USA
    Am J Pathol 176:2456-66. 2010
    ..Our data demonstrate in vivo overexpression of MAT1A in liver cancer cells can suppress tumor growth. They also suggest inducing MAT1A expression might be a strategy to treat hepatocellular carcinoma...
  21. ncbi request reprint Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, California 90033, USA
    J Cell Physiol 210:766-73. 2007
    ..This involves cell density-dependent differences in HGF-induced ERK activation. This may explain why HGF is mitogenic only when there is loss of cell-cell contact in vivo...
  22. pmc Effects of hepatocyte growth factor on glutathione synthesis, growth, and apoptosis is cell density-dependent
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Exp Cell Res 314:398-412. 2008
    ..The increase in cell GSH under low cell density allows HGF to exert its full mitogenic effect but is not necessary for its anti-apoptotic effect...
  23. ncbi request reprint S-adenosylmethionine and its metabolite induce apoptosis in HepG2 cells: Role of protein phosphatase 1 and Bcl-x(S)
    Heping Yang
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, Los Angeles, 90033, USA
    Hepatology 40:221-31. 2004
    ....
  24. pmc Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants
    Meng Xia
    Division of Gastroenterology and Liver Diseases, University of Southern California USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    J Biol Chem 285:20015-21. 2010
    ..In conclusion, MAT2beta variants reside mostly in the nucleus and regulate HuR subcellular content to affect cell proliferation...
  25. pmc Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1
    Heping Yang
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Biochem J 391:399-408. 2005
    ..While NF-kappaB may exert a direct effect on the GCLC promoter, it induces the GCLM and GSS promoters indirectly via c-Jun...
  26. pmc Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta
    Komal Ramani
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 47:521-31. 2008
    ..Pharmacological doses of SAMe or MTA lower expression of both MAT2A and MAT2beta and interfere with leptin signaling...
  27. pmc Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Gastroenterology 134:281-91. 2008
    ..We uncovered multiple splicing variants while characterizing its 5'-flanking region. The aims of our current study are to examine the expression pattern, regulation, and functions of the 2 major variants: V1 and V2...
  28. pmc Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Southern California Research Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Hepatology 51:1291-301. 2010
    ..UDCA and SAMe treatment targets this switch...
  29. ncbi request reprint Abnormal hepatic methionine and glutathione metabolism in patients with alcoholic hepatitis
    Taunia D Lee
    Division of Gastroenterology and Liver Diseases, University of Southern California Liver Disease Research Center, University of Southern California University of California, USA
    Alcohol Clin Exp Res 28:173-81. 2004
    ..These parameters have not been examined simultaneously in patients with less advanced alcoholic liver disease...
  30. pmc S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model
    Shelly C Lu
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Los Angeles, CA 90033, USA
    Hepatology 50:462-71. 2009
    ..SAMe's chemopreventive effect may be related to its proapoptotic action and its ability to inhibit angiogenesis...
  31. pmc Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Hepatology 49:1982-91. 2009
    ..They increased nuclear Nrf2 levels, prevented c-Maf and MafG induction, and prevented the fall in Nrf2 nuclear binding to ARE. Combined treatment had additive effects, reduced liver cell death, and prevented fibrosis...
  32. ncbi request reprint Keratin mutation primes mouse liver to oxidative injury
    Qin Zhou
    Department of Medicine, Palo Alto Veterans Affairs Medical Center and Stanford University Digestive Disease Center, Palo Alto, CA, USA
    Hepatology 41:517-25. 2005
    ..Hence keratin mutations may prime hepatocytes to oxidative injury, which provides a new potential mechanism for how keratin mutations may predispose patients to cirrhosis...
  33. pmc S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation
    Ainhoa Iglesias Ara
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Keck School of Medicine of the University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 47:1655-66. 2008
    ..SAH also inhibited H3K4 binding to TNFalpha and iNOS promoters. Conclusion: The mechanism of SAMe's pharmacologic inhibitory effect on proinflammatory mediators is mainly mediated by MTA and SAH at the level of histone methylation...
  34. pmc Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine
    Xiaopeng Ou
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine USC, Los Angeles, CA 90033, USA
    Biochem J 401:87-96. 2007
    ..While SAM's mechanism is NF-kappaB-dependent, MTA has both NF-kappaB-dependent and -independent mechanisms...
  35. pmc S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells
    Tony W H Li
    Division of Gastroenterology and Liver Diseases, University of Southern California Research Center for Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Mol Pharmacol 76:192-200. 2009
    ..One molecular mechanism identified is the inhibition of cFLIP expression. SAMe and MTA may be attractive agents in the chemoprevention and treatment of colon cancer...
  36. doi request reprint Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes
    Heping Yang
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Hepatology 49:860-70. 2009
    ..Bile duct-ligated mice treated with a lentivirus harboring c-myc small interfering RNA were protected from hepatic induction of p53 and cyclin D1, a switch from Mnt to Myc nuclear binding to E-box, and hepatocyte apoptosis...
  37. pmc Cloning and characterization of the human glutathione synthetase 5'-flanking region
    Taunia D Lee
    Division of Gastroenterology and Liver Diseases, USC Research Center for Liver Diseases, USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine USC, 2011 Zonal Ave, Los Angeles, CA 90033, USA
    Biochem J 390:521-8. 2005
    ..In summary, two NFE2 sites in the human GSS promoter play important roles in the basal expression of GSS and, similar to the GCL subunits, the human GSS gene expression is also regulated by Nrf2...
  38. ncbi request reprint Role of AP-1 in the coordinate induction of rat glutamate-cysteine ligase and glutathione synthetase by tert-butylhydroquinone
    Heping Yang
    Division of Gastroenterology and Liver Diseases, University of Southern California Liver Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 277:35232-9. 2002
    ..In conclusion, AP-1 is required for basal expression of GCL and GS; while NF1 serves as a repressor of GS, increased AP-1 transactivation is the predominant mechanism for coordinate induction of GCL and GS expression by TBH...
  39. doi request reprint Identification and characterization of an Nrf2-mediated ARE upstream of the rat glutamate cysteine ligase catalytic subunit gene (GCLC)
    Muyao Li
    Department of Medicine, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    J Cell Biochem 107:944-54. 2009
    ....
  40. ncbi request reprint L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine
    Maria L Martinez-Chantar
    Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Universidad de Navarra, Facultad de Medicina, 31008 Pamplona, Spain
    J Biol Chem 278:19885-90. 2003
    ..We conclude that MAT2A gene expression is modulated as an adaptive response of the cell to l-methionine availability through its conversion to AdoMet...
  41. doi request reprint S-adenosylmethionine and proliferation: new pathways, new targets
    Nuria Martínez-López
    Unidad de Metabolómica, CIC bioGUNE Asociacion Centro de Investigación Cooperativa en Biociencias, Parque Tecnologico de Bizkaia, Edificio 801A, 48160 Derio Bizkaia, Spain
    Biochem Soc Trans 36:848-52. 2008
    ..These new findings open a wide range of possibilities to discover novel targets for clinical applications...
  42. doi request reprint Methionine metabolism and liver disease
    Jose M Mato
    CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas ciberhed, Technology Park of Bizkaia, 48160 Derio, Bizkaia, Spain
    Annu Rev Nutr 28:273-93. 2008
    ..Moreover, treatments with various methionine metabolites in experimental animal models of liver disease show hepatoprotective properties...
  43. pmc Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
    M Luz Martínez-Chantar
    CIC bioGUNE, CIBERehd, Technology Park of Bizkaia, Bizkaia, Spain
    Hepatology 47:1191-9. 2008
    ..Conclusion: These data demonstrate that loss of GNMT induces aberrant methylation of DNA and histones, resulting in epigenetic modulation of critical carcinogenic pathways in mice...
  44. ncbi request reprint Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
    Maria L Martinez-Chantar
    Division of Hepatology and Gene Therapy, Department of Medicine, School of Medicine, University of Navarra, Pamplona, Spain
    FASEB J 16:1292-4. 2002
    ..Taken together, our findings define a critical role for S-adenosylmethionine in maintaining normal hepatic function and tumorigenesis of the liver...
  45. pmc Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine
    Enrique Santamaria
    Laboratório de Proteômica, Genómica y Bioinformática, and División de Hepatología y Terapia Génica, Facultad de Medicina, Universidad de Navarra, 31008 Pamplona, Spain
    Proc Natl Acad Sci U S A 100:3065-70. 2003
    ..Importantly, we found the expression of these mitochondrial proteins was abnormal in obob mice and obese patients who are at risk for nonalcoholic steatohepatitis...
  46. ncbi request reprint RXRalpha-regulated liver SAMe and GSH levels influence susceptibility to alcohol-induced hepatotoxicity
    Tiane Dai
    Department of Pathology, Harbor UCLA Research and Education Institute, 1000 West Carson Street, Torrance, CA 90502, USA
    Exp Mol Pathol 75:194-200. 2003
    ..The overall result suggests an important role of RXRalpha in preventing alcohol-induced liver injury...
  47. ncbi request reprint Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver
    Yong Wu
    Department of Pathology, Harbor University of California Los Angeles Research and Education Institute, Torrance, USA
    Mol Pharmacol 65:550-7. 2004
    ..Regulation of hepatic GSH levels by RXRalpha is essential to protect hepatocytes from oxidative stress, whereas up-regulation of phase I drug metabolism genes by RXRalpha may render the liver more sensitive to APAP-induced toxicity...
  48. ncbi request reprint S-Adenosylmethionine: a control switch that regulates liver function
    Jose M Mato
    Division of Hepatology and Gene Therapy, School of Medicine, University of Navarra, 31008 Pamplona, Spain
    FASEB J 16:15-26. 2002
    ..With the availability of AdoMet as a nutritional supplement and evidence of its beneficial role in various liver diseases, this review offers insight into its mechanism of action...
  49. ncbi request reprint Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis
    Jokin Fernández-Irigoyen
    Division of Hepatology and Gene Therapy, CIMA, Universidad de Navarra, 31008 Pamplona, Spain
    Proteomics 5:4964-72. 2005
    ....
  50. ncbi request reprint S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells
    Eduardo Ansorena
    Departamento de Bioquimica, División de Hepatología y Terapia Génica, Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Hepatology 35:274-80. 2002
    ..These effects may participate in the hepatoprotective and chemopreventive properties of this safe and well-tolerated drug...
  51. ncbi request reprint Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases
    Enrique Santamaria
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, 31008 Pamplona, Spain
    J Proteome Res 5:944-53. 2006
    ..Interestingly, seven of these genes were also found to be down-regulated in a pretumoral condition such as cirrhosis, while depletion of only one marker was assessed in less severe liver disorders...
  52. ncbi request reprint Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 86:14-24. 2007
    ..Additionally, decreased concentrations of homocysteine can down-regulate endoplasmic reticulum stress, which leads to the attenuation of apoptosis and fatty acid synthesis...
  53. ncbi request reprint Role of S-adenosyl-L-methionine in liver health and injury
    Jose M Mato
    CIC bioGUNE, Center for Cooperative Research in Biosciences, CIBER HEPAD, Parque Tecnologico de Bizkaia, Derio, Bizkaia
    Hepatology 45:1306-12. 2007
    ..A better understanding of why liver injury occurs when SAMe homeostasis is perturbed and mechanisms of action of pharmacologic doses of SAMe are essential in defining which patients will benefit from its use...
  54. ncbi request reprint Identification of a gene-pathway associated with non-alcoholic steatohepatitis
    Angel Rubio
    TECNUN, Universidad de Navarra, San Sebastian, Gipuzkoa, Spain
    J Hepatol 46:708-18. 2007
    ..We have integrated gene expression profiling of liver biopsies of NASH patients with liver samples of a mouse model of steatohepatitis (MAT1A-KO) to identify a gene-pathway associated with NASH...
  55. ncbi request reprint Homocysteine, the bad thiol
    Jose M Mato
    Hepatology 41:976-9. 2005
  56. pmc Epigallocatechin-3-gallate inhibits growth of activated hepatic stellate cells by enhancing the capacity of glutathione synthesis
    Yumei Fu
    Department of Pathology, School of Medicine, Saint Louis University, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Mol Pharmacol 73:1465-73. 2008
    ..These results support our hypothesis and collectively demonstrate that EGCG increases the level of cellular GSH in HSC by stimulating gene expression of GCLc, leading to the inhibition of cell proliferation of activated HSC in vitro...
  57. pmc Alcohol, cofactors and the genetics of hepatocellular carcinoma
    Mimi C Yu
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Gastroenterol Hepatol 23:S92-7. 2008
    ....
  58. pmc Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma
    Jian Min Yuan
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Hepatology 46:749-58. 2007
    ..003). Individuals possessing the maximum number of mutant alleles (i.e., 4) had an odds ratio of 0.46 (95% confidence interval = 0.23-0.93) for HCC compared with those with no or only 1 mutant allele...
  59. ncbi request reprint 5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes
    Henar Hevia
    División de Hepatología y Terapia Génica, Departamento de Medicina Interna, CIMA, Universidad de Navarra, Pamplona, Spain
    Hepatology 39:1088-98. 2004
    ..In conclusion, these observations demonstrate novel immunomodulatory properties for MTA that may be of value in the management of inflammatory diseases...
  60. ncbi request reprint Methylthioadenosine
    Matias A Avila
    Division of Hepatology and Gene Therapy, F I M A, University of Navarra, Pamplona, Spain
    Int J Biochem Cell Biol 36:2125-30. 2004
    ..Finally, observations carried out in models of liver damage and cancer demonstrate a therapeutic potential for MTA that deserves further consideration...
  61. ncbi request reprint 15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis
    So Young Lim
    College of Pharmacy, Seoul National University, Seoul 151 742, Korea
    J Biol Chem 279:46263-70. 2004
    ..The above findings suggest that 15d-PGJ(2) may act as a survival mediator capable of augmenting cellular thiol antioxidant capacity through up-regulation of the intracellular GSH synthesis in response to the nitrosative insult...
  62. ncbi request reprint S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase
    Maria L Martinez-Chantar
    CIC bioGUNE, Technological Park of Bizkaia, Bizkaia, Spain
    Gastroenterology 131:223-32. 2006
    ....

Research Grants48

  1. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    SHELLY CHI LOO LU; Fiscal Year: 2010
    ..The goal of this project is to understand how SAMe controls these processes and how injury and cancer occur when SAMe metabolism is perturbed. ..
  2. ROLE OF SAMe IN LIVER FUNCTION AND INJURY
    Shelly Lu; Fiscal Year: 2006
    ....
  3. ALTERED METHIONINE METABOLISM IN ALCOHOLIC LIVER INJURY
    Shelly Lu; Fiscal Year: 2005
    ....
  4. REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVER
    Shelly Lu; Fiscal Year: 2005
    ..abstract_text> ..
  5. MAT1A NULL MOUSE: MODEL FOR ALCOHOLIC TISSUE INJURY
    Shelly Lu; Fiscal Year: 2007
    ....
  6. REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS
    Shelly Lu; Fiscal Year: 2007
    ..Our ultimate goal is to utilize this information to improve the treatment and prevent complications that may result from altered hepatic GSH synthesis. ..
  7. Role of MAT and SAMe in Colon Cancer Pathogenesis and Treatment
    SHELLY CHI LOO LU; Fiscal Year: 2010
    ....
  8. REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVER
    SHELLY CHI LOO LU; Fiscal Year: 2010
    ..Our overall goals are to better understand regulation and function of hepatic MAT genes, and to develop novel therapies against abnormal liver growth. ..
  9. Role of MAT and SAMe in Colon Cancer Pathogenesis and Treatment
    Shelly Lu; Fiscal Year: 2009
    ....
  10. REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVER
    Shelly Lu; Fiscal Year: 2009
    ..Our overall goals are to better understand regulation and function of hepatic MAT genes, and to develop novel therapies against abnormal liver growth. ..
  11. REGULATION OF METHIONINE ADENOSYLTRANSFERASE IN LIVER
    Shelly Lu; Fiscal Year: 2007
    ..Our overall goals are to better understand regulation and function of hepatic MAT genes, and to develop novel therapies against abnormal liver growth. ..
  12. REGULATION OF S-ADENOSYLMETHIONINE SYNTHETASE IN LIVER
    Shelly Lu; Fiscal Year: 2000
    ..It is hoped that these studies would enhance our knowledge of a key cellular enzyme and offer possible therapeutic approaches against a cancer that currently lacks effective treatment. ..
  13. REGULATION OF HEPATIC GLUTATHIONE SYNTHESIS
    Shelly Lu; Fiscal Year: 2002
    ..These studies should improve our understanding of GCS, an enzyme critical in cellular defense and growth. ..