Po H Lu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Myelin breakdown mediates age-related slowing in cognitive processing speed in healthy elderly men
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    Brain Cogn 81:131-8. 2013
  2. ncbi Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Exp Neuropsychol 33:1059-68. 2011
  3. ncbi Donepezil delays progression to AD in MCI subjects with depressive symptoms
    P H Lu
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 72:2115-21. 2009
  4. ncbi Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Alzheimers Dis 23:433-42. 2011
  5. ncbi Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men
    Po H Lu
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arch Neurol 63:177-85. 2006
  6. ncbi Gender and iron genes may modify associations between brain iron and memory in healthy aging
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Neuropsychopharmacology 36:1375-84. 2011
  7. ncbi Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions
    Grace J Lee
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, USA
    Biol Psychiatry 71:814-21. 2012
  8. ncbi Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, USA
    Arch Gen Psychiatry 63:63-72. 2006
  9. ncbi Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia
    George Bartzokis
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:1380-7. 2007
  10. ncbi Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Psychiatry 72:1026-34. 2012

Detail Information

Publications48

  1. ncbi Myelin breakdown mediates age-related slowing in cognitive processing speed in healthy elderly men
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, United States
    Brain Cogn 81:131-8. 2013
    ....
  2. ncbi Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Clin Exp Neuropsychol 33:1059-68. 2011
    ..These results have implications for the neurobiology of the cognitive changes associated with brain aging...
  3. ncbi Donepezil delays progression to AD in MCI subjects with depressive symptoms
    P H Lu
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 72:2115-21. 2009
    ..To determine whether the presence of depression predicts higher rate of progression to Alzheimer disease (AD) in patients with amnestic mild cognitive impairment (aMCI) and whether donepezil treatment beneficially affect this relationship...
  4. ncbi Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    J Alzheimers Dis 23:433-42. 2011
    ..Possession of the ε4 allele is associated with greater temporal and hippocampal volume reduction well before the onset of cognitive deficits...
  5. ncbi Effects of testosterone on cognition and mood in male patients with mild Alzheimer disease and healthy elderly men
    Po H Lu
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arch Neurol 63:177-85. 2006
    ..There is a compelling need for therapies that prevent, defer the onset, slow the progression, or improve the symptoms of Alzheimer disease (AD)...
  6. ncbi Gender and iron genes may modify associations between brain iron and memory in healthy aging
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Neuropsychopharmacology 36:1375-84. 2011
    ..Combining genetic and MRI biomarkers may provide opportunities to design primary prevention clinical trials that target high-risk groups...
  7. ncbi Depressive symptoms in mild cognitive impairment predict greater atrophy in Alzheimer's disease-related regions
    Grace J Lee
    Department of Neurology, David Geffen School of Medicine at University of California Los Angeles, USA
    Biol Psychiatry 71:814-21. 2012
    ..Thus, we examined the neuroanatomical changes associated with depressive symptoms in MCI...
  8. ncbi Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, USA
    Arch Gen Psychiatry 63:63-72. 2006
    ..This may result in a progressive "disconnection" of widely distributed neural networks that may underlie the age risk factor for AD...
  9. ncbi Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia
    George Bartzokis
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 62:1380-7. 2007
    ..Apolipoprotein E (ApoE) 4 allele is the second most important AD risk factor. We tested the hypothesis that ApoE4 accelerates age-related slowing in CPS through the process of myelin breakdown...
  10. ncbi Multimodal magnetic resonance imaging assessment of white matter aging trajectories over the lifespan of healthy individuals
    George Bartzokis
    Department of Psychiatry, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Biol Psychiatry 72:1026-34. 2012
    ..We examined whether known regional differences in axon size and age at myelination influence the timing and rates of development and degeneration/repair trajectories of white matter (WM) microstructure biomarkers...
  11. ncbi Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Schizophr Res 140:122-8. 2012
    ..Insofar as the trajectory of ICM decline in chronic SZ is due to medication non-adherence or pharmacokinetics, it may be modifiable by long acting injection (LAI) formulations...
  12. ncbi Long acting injection versus oral risperidone in first-episode schizophrenia: differential impact on white matter myelination trajectory
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine at UCLA, Los Angeles, California, United States
    Schizophr Res 132:35-41. 2011
    ..Insofar as the trajectory of WM decline associated with chronic disease may be due to medication non-adherence, it may be modifiable by long acting injection (LAI) formulations...
  13. ncbi A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  14. ncbi In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    Schizophr Res 113:322-31. 2009
    ..Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one...
  15. ncbi Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
    Schizophr Res 93:13-22. 2007
    ..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia...
  16. ncbi Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations
    Grace J Lee
    Mary S Easton Center for Alzheimer s Disease Research, 10911 Weyburn Avenue, Suite 200, Los Angeles, CA 90095 7226, USA
    J Neurol Neurosurg Psychiatry 84:154-62. 2013
    ..Using tensor-based morphometry (TBM), we examined brain volume differences between presymptomatic and symptomatic FAD mutation carriers and non-carrier (NC) relatives...
  17. ncbi Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6968, USA
    J Alzheimers Dis 20:333-41. 2010
    ..Clarifying mechanisms of brain iron accumulation may help identify novel interventions for age-related neurodegenerative diseases...
  18. ncbi Lifespan trajectory of myelin integrity and maximum motor speed
    George Bartzokis
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90024, USA
    Neurobiol Aging 31:1554-62. 2010
    ..We tested the hypothesis that the age-related trajectory of FTS is related to brain myelin integrity...
  19. ncbi Time-lapse mapping of cortical changes in schizophrenia with different treatments
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Anges, School of Medicine, Los Angeles, CA 90095 7332, USA
    Cereb Cortex 19:1107-23. 2009
    ..These maps revise current models of schizophrenia progression; due to power limitations, the findings require confirmation in a sample large enough to model group x time interactions...
  20. ncbi Heterogeneous age-related breakdown of white matter structural integrity: implications for cortical "disconnection" in aging and Alzheimer's disease
    George Bartzokis
    Department of Neurology, Univeristy of California School of Medicine, Los Angeles, CA 90095, USA
    Neurobiol Aging 25:843-51. 2004
    ..In AD this process is globally exacerbated, consistent with an extracellular deleterious process such as amyloid beta-peptide toxicity. Non-invasive measures such as R2 may be useful in primary prevention studies of AD...
  21. ncbi Estimating sample sizes for predementia Alzheimer's trials based on the Alzheimer's Disease Neuroimaging Initiative
    Joshua D Grill
    Mary S Easton Center for Alzheimer s Disease Research, Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Neurobiol Aging 34:62-72. 2013
    ..For MCI, the Clinical Dementia Rating scale sum of boxes consistently required the smallest sample sizes. We conclude that predementia clinical trial conduct in Alzheimer's disease is enhanced by the use of biomarker inclusion criteria...
  22. ncbi Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  23. ncbi Reduced quality-of-life ratings in mild cognitive impairment: analyses of subject and informant responses
    Edmond Teng
    Neurobehavior Unit and Geriatric Research Education and Clinical Center, Veterans Affairs Greater Los Angeles Healthcare System, CA, USA
    Am J Geriatr Psychiatry 20:1016-25. 2012
    ..To determine whether quality-of-life (QOL) ratings are reduced in mild cognitive impairment (MCI) and analyze correlations between QOL ratings and cognitive, neuropsychiatric, and functional indices in MCI...
  24. ncbi Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  25. ncbi Identifying cognitively healthy elderly individuals with subsequent memory decline by using automated MR temporoparietal volumes
    Gloria C Chiang
    Department of Radiology, University of California, San Francisco, 505 Parnassus Ave, Room M391, San Francisco, CA, 94143, USA
    Radiology 259:844-51. 2011
    ..To determine whether automated temporoparietal brain volumes can be used to accurately predict future memory decline among a multicenter cohort of cognitively healthy elderly individuals...
  26. ncbi Subtle deficits in instrumental activities of daily living in subtypes of mild cognitive impairment
    Edmond Teng
    Neurobehavior Unit, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Dement Geriatr Cogn Disord 30:189-97. 2010
    ..We explored the relationship between these factors by comparing instrumental activities of daily living (IADLs) among cognitive subtypes of MCI and examining associations between IADL and neuropsychological indices...
  27. ncbi Persistence of neuropsychological testing deficits in mild cognitive impairment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 28:168-78. 2009
    ....
  28. ncbi Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    Dement Geriatr Cogn Disord 24:253-9. 2007
    ..Depression and apathy may identify a subset of MCI subjects at higher risk of progression to Alzheimer's disease (AD). However, it remains uncertain whether a broader spectrum of psychopathology is associated with progression to AD...
  29. ncbi Longitudinal change of biomarkers in cognitive decline
    Raymond Y Lo
    Division of Epidemiology, University of California, Berkeley, 94720 3190, USA
    Arch Neurol 68:1257-66. 2011
    ....
  30. ncbi Myelin breakdown and iron changes in Huntington's disease: pathogenesis and treatment implications
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurochem Res 32:1655-64. 2007
    ..A unique combination of in vivo tissue integrity and iron level assessments was used to examine the hypothesis...
  31. ncbi Quantifying age-related myelin breakdown with MRI: novel therapeutic targets for preventing cognitive decline and Alzheimer's disease
    George Bartzokis
    Department of Neurology, The David Gheffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Alzheimers Dis 6:S53-9. 2004
    ....
  32. ncbi Brain ferritin iron as a risk factor for age at onset in neurodegenerative diseases
    George Bartzokis
    Department of Neurology, UCLA, Los Angeles, California, USA
    Ann N Y Acad Sci 1012:224-36. 2004
    ..In vivo MRI can measure and track brain ferritin iron levels and provides an opportunity to design therapeutic interventions that target high-risk populations early in the course of illness, possibly even before symptoms appear...
  33. ncbi Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 28:414-23. 2007
    ..We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases...
  34. ncbi Deficits in facial emotion processing in mild cognitive impairment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7226, USA
    Dement Geriatr Cogn Disord 23:271-9. 2007
    ..Patients with Alzheimer disease consistently demonstrate impaired performance on tests of facial emotion processing. However, it remains unclear how early in the neurodegenerative process these deficits emerge...
  35. ncbi 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease
    Liana G Apostolova
    Department of Neurology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Alzheimer Dis Assoc Disord 20:224-31. 2006
    ..As a global cognitive measure, MMSE depends on the integrity of widely distributed cortical areas in both brain hemispheres with left-sided predominance...
  36. ncbi Premenopausal hysterectomy is associated with increased brain ferritin iron
    Todd A Tishler
    Department of Psychiatry and Biobehavioral Sciences, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Aging 33:1950-8. 2012
    ..It is possible that brain iron can be influenced by peripheral iron levels and may thus be a modifiable risk factor for age-related degenerative diseases...
  37. ncbi Dysregulated brain development in adult men with schizophrenia: a magnetic resonance imaging study
    George Bartzokis
    Department of Neurology, University of California School of Medicine, Los Angeles 90095-1769, USA
    Biol Psychiatry 53:412-21. 2003
    ..The importance of myelination to the continued maturation and normal functioning of the brain has implications for the diagnosis, treatment, and prognosis of schizophrenia...
  38. ncbi Adjunctive risperidone in the treatment of chronic combat-related posttraumatic stress disorder
    George Bartzokis
    Department of Neurology, University of California School of Medicine, Los Angeles, California, USA
    Biol Psychiatry 57:474-9. 2005
    ..The efficacy and safety of risperidone was evaluated in veteran patients with chronic combat-related posttraumatic stress disorder (PTSD) who were referred to a residential treatment program...
  39. ncbi Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  40. ncbi Patterns of brain atrophy in clinical variants of frontotemporal lobar degeneration
    Po H Lu
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, Calif, USA
    Dement Geriatr Cogn Disord 35:34-50. 2013
    ..More specifically, the bvFTD group showed significant white matter contraction and presence of behavioral symptoms at baseline predicted significant volume loss of the ventromedial prefrontal cortex...
  41. ncbi Normative data for healthy older adults and an abbreviated version of the Stroop test
    Christine Kang
    Veterans Affairs at Loma Linda, Loma Linda, CA, USA
    Clin Neuropsychol 27:276-89. 2013
    ....
  42. ncbi Cortical gray matter volumes are associated with subjective responses to cocaine infusion
    George Bartzokis
    Department of Neurology, University of California Los Angeles School of Medicine, UCLA Alzheimer s Disease Center, 710 Westwood Plaza, Room 2 238, Los Angeles, CA 90095 1769, USA
    Am J Addict 13:64-73. 2004
    ..Given the well-established negative linear relationship between cortical gray matter volume and age, cortical gray matter volume may be a marker for the neurobiological substrate of the age-related reduction in addiction rates...
  43. ncbi Human brain myelination and amyloid beta deposition in Alzheimer's disease
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Alzheimers Dement 3:122-5. 2007
    ....
  44. ncbi Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review
    John M Ringman
    Alzheimer s Disease Research Center, Department of Neurology, University of California, Los Angeles, 10911 Weyburn Ave, Ste 200, Los Angeles, CA 90095 7226, USA
    Arch Neurol 65:412-5. 2008
    ..To describe a case of young-onset Alzheimer disease (AD) due to mosaicism for trisomy 21...
  45. ncbi Brain maturation may be arrested in chronic cocaine addicts
    George Bartzokis
    Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA
    Biol Psychiatry 51:605-11. 2002
    ..The findings suggest that in adults, cocaine dependence may arrest normal white matter maturation in the frontal and temporal lobes of addicts who continue using cocaine...
  46. ncbi Suspect cognitive symptoms in a 9-year-old child: malingering by proxy?
    Po H Lu
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Clin Neuropsychol 16:90-6. 2002
    ..Results demonstrate that children as young as 9 years of age are capable of feigning cognitive impairment, which highlights the need for routine evaluation of effort, irrespective of the age of the patient...
  47. ncbi Effectiveness of the Rey-Osterrieth Complex Figure Test and the Meyers and Meyers recognition trial in the detection of suspect effort
    Po H Lu
    Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
    Clin Neuropsychol 17:426-40. 2003
    ..Thus, the ROCFT+recognition trial show considerable potential for detecting noncredible effort...
  48. ncbi Failure to inhibit the reading response on the Stroop Test: a pathognomonic indicator of suspect effort
    Po H Lu
    Harbor-UCLA Medical Center, Torrance, CA 90509-2910, USA
    J Clin Exp Neuropsychol 26:180-9. 2004
    ....