Ming Lu

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump
    M Lu
    Departments of Medicine and Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 276:30407-13. 2001
  2. ncbi request reprint The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function
    Ming Lu
    Department of Medicine University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 277:38409-15. 2002
  3. pmc Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells
    Yuri Y Sautin
    Department of Medicine, Division of Nephrology, Box 100224, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0224, USA
    Mol Cell Biol 25:575-89. 2005
  4. ncbi request reprint Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B
    Shih Hua Chen
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    J Biol Chem 279:7988-98. 2004
  5. ncbi request reprint Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump
    Ming Lu
    Department of Medicine, University of California School of Medicine, San Francisco, California 94143 0532, USA
    J Biol Chem 282:24495-503. 2007
  6. pmc CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Clin Invest 116:797-807. 2006
  7. ncbi request reprint The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase
    Ming Lu
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 279:8732-9. 2004
  8. pmc Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD)
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 120:603-15. 2002
  9. ncbi request reprint Nitroxyl inhibits breast tumor growth and angiogenesis
    Andrew J Norris
    Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Int J Cancer 122:1905-10. 2008
  10. ncbi request reprint EG-1 interacts with c-Src and activates its signaling pathway
    Ming Lu
    Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 29:1013-8. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump
    M Lu
    Departments of Medicine and Anatomy and Cell Biology, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 276:30407-13. 2001
    ..The direct binding interaction between V-ATPase and aldolase may be a new mechanism for the regulation of the V-ATPase and may underlie the proximal tubule acidification defect in hereditary fructose intolerance...
  2. ncbi request reprint The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function
    Ming Lu
    Department of Medicine University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Biol Chem 277:38409-15. 2002
    ..Our data demonstrate the physiological significance of the interaction between the E and H subunits of V-ATPase and extend previous studies on the arrangement of subunits on the peripheral stalk of V-ATPase...
  3. pmc Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells
    Yuri Y Sautin
    Department of Medicine, Division of Nephrology, Box 100224, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0224, USA
    Mol Cell Biol 25:575-89. 2005
    ....
  4. ncbi request reprint Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B
    Shih Hua Chen
    Department of Orthodontics, University of Florida College of Dentistry, Gainesville, Florida 32610, USA
    J Biol Chem 279:7988-98. 2004
    ..This response was fully reversible. The actin binding activities of the B subunits of V-ATPase required 11-amino acid actin-binding motifs that are similar in sequence to the actin-binding site of mammalian profilin I...
  5. ncbi request reprint Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump
    Ming Lu
    Department of Medicine, University of California School of Medicine, San Francisco, California 94143 0532, USA
    J Biol Chem 282:24495-503. 2007
    ..Taken together, these findings strongly suggest an important role for physical association between aldolase and V-ATPase in the regulation of the proton pump...
  6. pmc CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Clin Invest 116:797-807. 2006
    ..We discuss the potential physiological role of this functional switch in renal K handling during water diuresis and the relevance to renal K homeostasis in cystic fibrosis...
  7. ncbi request reprint The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase
    Ming Lu
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 279:8732-9. 2004
    ..Taken together, these findings provide functional evidence that the ATP-generating glycolytic pathway is directly coupled to the ATP-hydrolyzing proton pump through physical interaction between aldolase and V-ATPase...
  8. pmc Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD)
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Gen Physiol 120:603-15. 2002
    ..We conclude that both ATP-dependent formation of PIP2 through membrane-bound phosphoinositide kinases and phosphorylation of SK by PKA play important roles in modulating SK channel activity...
  9. ncbi request reprint Nitroxyl inhibits breast tumor growth and angiogenesis
    Andrew J Norris
    Surgical Oncology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Int J Cancer 122:1905-10. 2008
    ..Therefore, HNO appears to act via mechanism(s) different from those of existing breast cancer drugs, making it a potential candidate to overcome known and emerging drug resistance pathways...
  10. ncbi request reprint EG-1 interacts with c-Src and activates its signaling pathway
    Ming Lu
    Department of Surgery, Division of Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 29:1013-8. 2006
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation...
  11. ncbi request reprint The novel gene EG-1 stimulates cellular proliferation
    Ming Lu
    Department of Surgery, Division of Oncology, School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Cancer Res 65:6159-66. 2005
    ..These observations collectively support the hypothesis that the novel gene EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation...
  12. ncbi request reprint The carboxyl termini of K(ATP) channels bind nucleotides
    Carlos G Vanoye
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical School, Nashville, Tennessee 37232 6304, USA
    J Biol Chem 277:23260-70. 2002
    ..Thus, the COOH termini of K(ATP) tetrameric channels contain the nucleotide-binding pockets of these metabolically regulated channels with four potential nucleotide-binding sites/channel tetramer...
  13. ncbi request reprint Rabdosia rubescens inhibits breast cancer growth and angiogenesis
    Maryam R Sartippour
    Department of Surgery, University of California, Los Angeles, CA, USA
    Int J Oncol 26:121-7. 2005
    ..We conclude that Rabdosia rubescens may potentially be used to treat or prevent breast cancer, and that the extract from this herbal source deserves further studies...
  14. ncbi request reprint Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection
    Jun Zhang
    Department of Physiology, Cardiovascular Research Laboratories, Suite 1619 MRL Bldg, 675 Charles E Young Dr, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Heart Circ Physiol 287:H2364-6. 2004
    ..These findings indicate that a novel type of PKC-tyrosine kinase module (involving Bmx) is formed in the heart and may be involved in pharmacological cardioprotection by NO donors...
  15. ncbi request reprint Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice
    Ming Lu
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520 8026, USA
    J Biol Chem 277:37881-7. 2002
    ..Despite loss of ROMK expression, the normokalemic null mice exhibited significantly increased kaliuresis, indicating alternative mechanisms for K(+) absorption/secretion in the nephron...
  16. ncbi request reprint EphA2 overexpression decreases estrogen dependence and tamoxifen sensitivity
    Ming Lu
    Department of Basic Medical Sciences, Purdue University Cancer Center, West Lafayette, Indiana 47907, USA
    Cancer Res 63:3425-9. 2003
    ..These results have important implications for understanding the molecular basis underlying estrogen dependence and provide further evidence that EphA2 may provide a much-needed therapeutic target for breast cancer...
  17. pmc Pto mutants differentially activate Prf-dependent, avrPto-independent resistance and gene-for-gene resistance
    Fangming Xiao
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Plant Physiol 131:1239-49. 2003
    ..Furthermore, 35S::Pto(G50S) plants exhibited normal induction of defense genes in recognition of avrPto. Thus, the AvrPto-independent defense activation and gene-for-gene resistance mediated by Pto are functionally separable...
  18. ncbi request reprint [The influence of heat-induced epitope retrieval on endogenous avidin-binding activity (EABA) and blocking of EABA in immunohistochemistry]
    Xiaoge Zhou
    Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, Beijing 100050, China
    Zhonghua Bing Li Xue Za Zhi 31:491-6. 2002
    ..To study the influence of heat-induced epitope retrieval (HIER) on endogenous avidin-binding activity (EABA) and to establish an effective way to block EABA in immunohistochemistry...
  19. ncbi request reprint Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei
    Yan Dong Wang
    P O Box 6888, Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People s Republic of China
    Biotechnol Appl Biochem 37:39-43. 2003
    ..Furthermore, in combination with the results of previous studies, it is very probable that different IPP biosynthesis pathways exist during different growth phases in Taxus cells...
  20. pmc Unique epitope of bovine immunodeficiency virus gag protein spans the cleavage site between p16(MA) and p2L
    Ming Lu
    Department of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, Kansas 66506, USA
    Clin Diagn Lab Immunol 9:1277-81. 2002
    ..These experiments revealed that the epitope spans the cleavage site between p16(MA) and p2L and presumably will be valuable in distinguishing the two viruses...
  21. doi request reprint Two distinct disulfide bonds formed in human heat shock transcription factor 1 act in opposition to regulate its DNA binding activity
    Ming Lu
    Department of Chemistry and Center for Innovative BioPhysio Sensor Technology, Pusan National University, 609 735 Busan, South Korea
    Biochemistry 47:6007-15. 2008
    ..We propose that these interesting effects further explain cellular HSF1 trimerization, DNA binding, and transcription when cells are under stress...