Research Topics
| Hanzhang LuSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRIHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 60:357-63. 2008..0 +/- 1.8%. Contrast agent infusion (Gd-DTPA, 0.1 mmol/kg) reduced venous blood T2 by 11.2 ms. The results of this study show that TRUST MRI is a useful technique for quantitative assessment of blood oxygenation in the brain...
Noninvasive quantification of cerebral blood volume in humans during functional activationHong Gu
Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Building C, Room 383, Baltimore, MD 21042, USA
Neuroimage 30:377-87. 2006..This technique, with its ability to measure quantitative CBV values noninvasively, provides a valuable tool for quantifying hemodynamic signals associated with brain activation...- A review of the development of Vascular-Space-Occupancy (VASO) fMRIHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuroimage 62:736-42. 2012..With recent development of more sensitive VASO acquisitions, the availability of arterial-based VASO sequences, and improvement in spatial coverage, this technique is finding its place in neuroscience and clinical studies... - Alterations in cerebral metabolic rate and blood supply across the adult lifespanHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cereb Cortex 21:1426-34. 2011.... - Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenationHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Magn Reson Med 67:42-9. 2012..840 ± 0.036 based on Pulse-Oximetry. These data suggest that the availability of this calibration plot should enhance the applicability of T(2) -Relaxation-Under-Spin-Tagging MRI for noninvasive assessment of cerebral blood oxygenation... - Detrimental effects of BOLD signal in arterial spin labeling fMRI at high field strengthHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 56:546-52. 2006..Correction methods are proposed to reduce the artifact, giving increased number of activated voxels (18+/-5%, P=0.006) and more accurate estimation of CBF temporal characteristics... - Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signalsHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 60:364-72. 2008..4% and -30.0%, respectively, when using visual stimulation. TRUST MRI is a useful measurement for fMRI studies to control for the modulatory effects of baseline oxygenation that are unique to each subject... - Improving fMRI sensitivity by normalization of basal physiologic stateHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Hum Brain Mapp 31:80-7. 2010..Time-to-peak of the BOLD responses was also studied and it was found that subjects with higher basal venous oxygenation tend to slower BOLD responses... - Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRIHanzhang Lu
Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
NMR Biomed 21:226-32. 2008..5 T and 3 T gave mean +/- SD scBV values of 4.3 +/- 0.7 ml/100 mL tissue (n = 6) and 4.4 +/- 0.7 ml/100 mL tissue (n = 4), respectively, consistent with the expectation that the scBV values would not be field-dependent... - Predicting grade of cerebral glioma using vascular-space occupancy MR imagingH Lu
Department of Radiology, New York University School of Medicine, New York, NY, USA
AJNR Am J Neuroradiol 29:373-8. 2008..We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a recently developed imaging technique, is of diagnostic value for predicting tumor grade... - On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flowSina Aslan
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Magn Reson Imaging 28:928-35. 2010..In summary, rCBF is a more sensitive index to detect small differences in CBF, rather than the much-sought-after aCBF, since it reduces data noise caused by inter-subject variations in global CBF... - Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's diseaseUma S Yezhuvath
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neurobiol Aging 33:75-82. 2012..004). Our data suggest that early AD subjects have evidence of significant forebrain vascular contractility deficits. The localization, while differing from CBF findings, appears to be spatially similar to PIB amyloid imaging findings... - Magnetic field correlation imagingJens H Jensen
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, NY 10016, USA
Magn Reson Med 55:1350-61. 2006..5 and 3 T, and human brain images obtained at 3 T are shown to demonstrate the method's feasibility. The preliminary results suggest that MFC imaging may be useful for the quantitative assessment of iron within the brain... - Determination of spin compartment in arterial spin labeling MRIPeiying Liu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 65:120-7. 2011..The arterial blood volume was calculated to be 1.18 ± 0.21 mL/100 g. A postlabeling delay time of 2 s is sufficient to allow the spins to completely enter the tissue space for gray matter but not for white matter... - Estimation of labeling efficiency in pseudocontinuous arterial spin labelingSina Aslan
Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 63:765-71. 2010..We propose that the labeling efficiency should be estimated using phase-contrast velocity MRI on a subject-specific basis... - Regional changes of cortical mean diffusivities with aging after correction of partial volume effectsTina Jeon
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8542, USA
Neuroimage 62:1705-16. 2012..The established comprehensive unbiased cortical MD profiles of young, elderly healthy subjects and AD patients at the lobe, gyral and voxel level may serve as clinical references for cortical microstructure... - On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRIJinsoo Uh
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 61:659-67. 2009..Specific recommendations for VASO MRI acquisition and processing strategies are provided... - On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRIUma S Yezhuvath
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA
NMR Biomed 22:779-86. 2009..With these technological optimizations, CVR mapping may become a useful method for studies of neurological and psychiatric diseases... - The influence of carbon dioxide on brain activity and metabolism in conscious humansFeng Xu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Cereb Blood Flow Metab 31:58-67. 2011.... - Microvessel density estimation in the human brain by means of dynamic contrast-enhanced echo-planar imagingJens H Jensen
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016 3240, USA
Magn Reson Med 56:1145-50. 2006..Lower- and upper-bound estimates for the microvessel density were derived from the Q-values, and were found to be in reasonable accord with previously cited values determined by histology... - White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brainSina Aslan
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuroimage 56:1145-53. 2011..These findings suggest a clear association between white matter perfusion and gray matter activity, but the nature of this relationship requires further investigations given that they are negatively, rather than positively, correlated... - Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imagingHanzhang Lu
Center of Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
Magn Reson Med 54:1403-11. 2005..In comparison with previous pre/postcontrast difference approaches, VASO MRI provides maximal signal difference between pre- and postcontrast situation and does not require the use of whole blood for signal normalization... - On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRIFeng Xu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 68:198-204. 2012..6 ms, which allows the determination of global venous oxygenation with scan duration of 1 min 12 s and an estimation precision of ± 1% (in units of oxygen saturation percentage)... - Sustained poststimulus elevation in cerebral oxygen utilization after vascular recoveryHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Cereb Blood Flow Metab 24:764-70. 2004.... - Multiple acquisitions with global inversion cycling (MAGIC): a multislice technique for vascular-space-occupancy dependent fMRIHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Magn Reson Med 51:9-15. 2004..Multislice VASO-fMRI images of visual stimulation show effective blood nulling in all slices and appropriate functional activations in all volunteers (n=4)... - Functional magnetic resonance imaging based on changes in vascular space occupancyHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 50:263-74. 2003..Arguments supporting a better gray matter localization for the VASO-fMRI approach compared to BOLD are provided... - Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brainJens H Jensen
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
Magn Reson Med 61:481-5. 2009.... - Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imagingHanzhang Lu
Department of Radiology, Center of Biomedical Imaging, New York University School of Medicine, New York, NY 10016, USA
NMR Biomed 19:236-47. 2006..Diffusion kurtosis imaging is a useful method to study non-Gaussian diffusion behavior and can provide complementary information to that of DTI... - Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolismFeng Xu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
J Cereb Blood Flow Metab 32:1909-18. 2012..5% (P<0.001) and 16.9±2.7% (P<0.001) for FiO(2) of 50% and 98%, respectively. The CBF showed minimal changes with hyperoxia. Our results suggest that modulation of inspired O(2) alters brain metabolism in a dose-dependent manner... - Comparison of relative cerebral blood flow maps using pseudo-continuous arterial spin labeling and single photon emission computed tomographyPeiying Liu
University of Texas Southwestern Medical Center, Dallas, TX, USA
NMR Biomed 25:779-86. 2012..47 ± 0.39 and 2.44 ± 0.18 for PCASL and SPECT, respectively. On a single-voxel level, the variance between the modalities was still considerable, with an average rCBF difference of 0.27... - Validation of VASO cerebral blood volume measurement with positron emission tomographyJinsoo Uh
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 65:744-9. 2011..00±0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions... - In vivo vascular hallmarks of diffuse leukoaraiosisJinsoo Uh
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Magn Reson Imaging 32:184-90. 2010..To characterize multiple patterns of vascular changes in leukoaraiosis using in vivo magnetic resonance imaging (MRI) techniques... - Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRIFeng Xu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 62:141-8. 2009..Owing to the noninvasive nature of this method, it may be a convenient and useful approach for assessment of brain metabolism in brain disorders as well as under various physiologic conditions... - Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRIYulin Ge
Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016, USA
J Cereb Blood Flow Metab 32:403-12. 2012..Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease... - Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBFAi Ling Lin
Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA
Magn Reson Med 60:380-9. 2008..Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO(2) and determining the flow-metabolism relationship... - Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imagingJens H Jensen
Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016 3240, USA
Magn Reson Med 53:1432-40. 2005..It may be useful for assessing tissue structure abnormalities associated with a variety of neuropathologies... - Intervoxel heterogeneity of event-related functional magnetic resonance imaging responses as a function of T(1) weightingHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Neuroimage 17:943-55. 2002.... - Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrityJinsoo Uh
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
Neurobiol Aging 31:2038-46. 2010..These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity... - Experimental measurement of extravascular parenchymal BOLD effects and tissue oxygen extraction fractions using multi-echo VASO fMRI at 1.5 and 3.0 THanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Magn Reson Med 53:808-16. 2005..During visual stimulation, OEF values measured at 1.5 and 3.0 T were in good agreement, giving 0.23 +/- 0.01 and 0.21 +/- 0.01, respectively... - Perfusion deficit to cholinergic challenge in veterans with Gulf War IllnessPeiying Liu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neurotoxicology 32:242-6. 2011.... - Determining the longitudinal relaxation time (T1) of blood at 3.0 TeslaHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Magn Reson Med 52:679-82. 2004..3 +/- 0.6 ms/ degrees C and 19.8 +/- 0.8 ms/ degrees C for Hct values of 0.42 and 0.38, respectively. When a head coil transmit/receive setup was used, radiation damping caused a slight reduction (19 ms) of the measured T1 values... - Test-retest reproducibility of a rapid method to measure brain oxygen metabolismPeiying Liu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 69:675-81. 2013..002) and subjects (P = 0.01), and their coefficients of variation were greater than that of CMRO(2). The simplicity and reliability features may afford this global CMRO(2) technique great potential for immediate clinical applications... - Routine clinical brain MRI sequences for use at 3.0 TeslaHanzhang Lu
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Magn Reson Imaging 22:13-22. 2005..CONCLUSION: When parameters are adjusted for changes in relaxation rates, routine clinical scans at 3.0 T can provide similar image appearance as 1.5 T, but with superior image quality and/or increased speed... - Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 TChangho Choi
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Magn Reson Med 64:1247-51. 2010..13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites... 
Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional studyJohn Hart
Berman Laboratory for Learning and Memory, Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 2200 W Mockingbird Ln, Dallas, TX 75235, USA
JAMA Neurol 70:326-35. 2013..CONCLUSIONS Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls. These deficits are correlated with white matter abnormalities and changes in regional cerebral blood flow...- The Relationship Between M in "Calibrated fMRI" and the Physiologic Modulators of fMRIHanzhang Lu
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Open Neuroimag J 5:112-9. 2011..Potential biases in hypercapnia-based M estimation were also discussed in the context of possible reduction of CMRO(2) during hypercapnia... - Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imagingY Ge
Center for Biomedical Imaging, Department of Radiology, New York University Medical Center, New York, NY 10016, USA
AJNR Am J Neuroradiol 28:1639-44. 2007..We propose that there is an excess accumulation of iron in the deep gray matter in patients with MS that can be measured with a newly developed quantitative MR technique--magnetic field correlation (MFC) imaging... - Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILTJeroen Hendrikse
Department of Radiology, University Medical Center, Utrecht, The Netherlands
Magn Reson Med 50:429-33. 2003.... - Effects of traumatic brain injury on working memory-related brain activation in adolescentsMary R Newsome
Cognitive Neuroscience Laboratory, Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, TX 77030, USA
Neuropsychology 22:419-25. 2008..The overrecruitment of frontal and extrafrontal regions during encoding and retrieval following TBI may represent a compensatory process... - Theoretical and experimental investigation of the VASO contrast mechanismManus J Donahue
Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University, Baltimore, Maryland 21205, USA
Magn Reson Med 56:1261-73. 2006..Thus, many competing effects contribute to VASO contrast and care should be taken during interpretation... - An account of the discrepancy between MRI and PET cerebral blood flow measures. A high-field MRI investigationManus J Donahue
The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University, Baltimore, MD, USA
NMR Biomed 19:1043-54. 2006..The recent availability of MRI field strengths of 3.0 T and higher will facilitate the use of MRI-based CBF measurements in the clinic... - Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)John J Strouse
Division of Pediatric Hematology, Department of Pediatrics, the Neurocirculatory Physiology Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Blood 108:379-81. 2006..005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD... - In vivo flow territory mapping of major brain feeding arteriesPeter Jan van Laar
Department of Radiology Hp E01 332, University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands
Neuroimage 29:136-44. 2006..To relate focal brain lesions to underlying flow territories in individual cases, knowledge of the anatomy of the circle of Willis is essential... - Retinotopic mapping in the human visual cortex using vascular space occupancy-dependent functional magnetic resonance imagingHanzhang Lu
The Russel H Morgan Department of Radiology, Baltimore, Maryland, USA
Neuroreport 16:1635-40. 2005..Disadvantages of vascular space occupancy functional magnetic resonance imaging include lower contrast-to-noise ratio (about 1/3 of that of blood oxygenation level-dependent method) and limited volume coverage (nine slices for TR=3 s)... - Automated optimal detection and classification of neural action potentials in extra-cellular recordingsPramodsingh H Thakur
Zanvyl Krieger Mind Brain Institute, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
J Neurosci Methods 162:364-76. 2007..This algorithm provides an accurate estimate of the signal to noise ratio and provides an accurate estimate of spike times and spike shapes... - Flow territory mapping of the cerebral arteries with regional perfusion MRIJeroen Hendrikse
Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
Stroke 35:882-7. 2004....
Research Grants
- Modulation of brain activity by control of the inspired airHanzhang Lu; Fiscal Year: 2010..This approach is non-invasive, convenient and cost effective, thus may provide a new means for interventions such as seizure termination in epilepsy patients. ..
- Measurement of Absolute Cerebral Blood Volume using Magnetic Resonance ImagingHanzhang Lu; Fiscal Year: 2007..In this project, a new technique will be developed to measure CBV in human brain using MRI. ..
- Normalized functional MRI in human brain disordersHanzhang Lu; Fiscal Year: 2010....