Hanzhang Lu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 60:357-63. 2008
  2. ncbi request reprint Noninvasive quantification of cerebral blood volume in humans during functional activation
    Hong Gu
    Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Building C, Room 383, Baltimore, MD 21042, USA
    Neuroimage 30:377-87. 2006
  3. pmc Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 26:932-48. 2013
  4. pmc A review of the development of Vascular-Space-Occupancy (VASO) fMRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 62:736-42. 2012
  5. pmc Alterations in cerebral metabolic rate and blood supply across the adult lifespan
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cereb Cortex 21:1426-34. 2011
  6. pmc Improving fMRI sensitivity by normalization of basal physiologic state
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Hum Brain Mapp 31:80-7. 2010
  7. pmc Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 67:42-9. 2012
  8. ncbi request reprint Predicting grade of cerebral glioma using vascular-space occupancy MR imaging
    H Lu
    Department of Radiology, New York University School of Medicine, New York, NY, USA
    AJNR Am J Neuroradiol 29:373-8. 2008
  9. ncbi request reprint Detrimental effects of BOLD signal in arterial spin labeling fMRI at high field strength
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 56:546-52. 2006
  10. ncbi request reprint Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI
    Hanzhang Lu
    Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
    NMR Biomed 21:226-32. 2008

Collaborators

Detail Information

Publications68

  1. pmc Quantitative evaluation of oxygenation in venous vessels using T2-Relaxation-Under-Spin-Tagging MRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 60:357-63. 2008
    ..0 +/- 1.8%. Contrast agent infusion (Gd-DTPA, 0.1 mmol/kg) reduced venous blood T2 by 11.2 ms. The results of this study show that TRUST MRI is a useful technique for quantitative assessment of blood oxygenation in the brain...
  2. ncbi request reprint Noninvasive quantification of cerebral blood volume in humans during functional activation
    Hong Gu
    Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Building C, Room 383, Baltimore, MD 21042, USA
    Neuroimage 30:377-87. 2006
    ..This technique, with its ability to measure quantitative CBV values noninvasively, provides a valuable tool for quantifying hemodynamic signals associated with brain activation...
  3. pmc Noninvasive functional imaging of cerebral blood volume with vascular-space-occupancy (VASO) MRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 26:932-48. 2013
    ..The sensitivity of the VASO technique is the primary disadvantage when compared with BOLD, but this technique is increasingly demonstrating its utility in neuroscientific and clinical applications...
  4. pmc A review of the development of Vascular-Space-Occupancy (VASO) fMRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 62:736-42. 2012
    ..With recent development of more sensitive VASO acquisitions, the availability of arterial-based VASO sequences, and improvement in spatial coverage, this technique is finding its place in neuroscience and clinical studies...
  5. pmc Alterations in cerebral metabolic rate and blood supply across the adult lifespan
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cereb Cortex 21:1426-34. 2011
    ....
  6. pmc Improving fMRI sensitivity by normalization of basal physiologic state
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Hum Brain Mapp 31:80-7. 2010
    ..Time-to-peak of the BOLD responses was also studied and it was found that subjects with higher basal venous oxygenation tend to slower BOLD responses...
  7. pmc Calibration and validation of TRUST MRI for the estimation of cerebral blood oxygenation
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Magn Reson Med 67:42-9. 2012
    ..840 ± 0.036 based on Pulse-Oximetry. These data suggest that the availability of this calibration plot should enhance the applicability of T(2) -Relaxation-Under-Spin-Tagging MRI for noninvasive assessment of cerebral blood oxygenation...
  8. ncbi request reprint Predicting grade of cerebral glioma using vascular-space occupancy MR imaging
    H Lu
    Department of Radiology, New York University School of Medicine, New York, NY, USA
    AJNR Am J Neuroradiol 29:373-8. 2008
    ..We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a recently developed imaging technique, is of diagnostic value for predicting tumor grade...
  9. ncbi request reprint Detrimental effects of BOLD signal in arterial spin labeling fMRI at high field strength
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 56:546-52. 2006
    ..Correction methods are proposed to reduce the artifact, giving increased number of activated voxels (18+/-5%, P=0.006) and more accurate estimation of CBF temporal characteristics...
  10. ncbi request reprint Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI
    Hanzhang Lu
    Department of Radiology, New York University School of Medicine, New York, NY 10016, USA
    NMR Biomed 21:226-32. 2008
    ..5 T and 3 T gave mean +/- SD scBV values of 4.3 +/- 0.7 ml/100 mL tissue (n = 6) and 4.4 +/- 0.7 ml/100 mL tissue (n = 4), respectively, consistent with the expectation that the scBV values would not be field-dependent...
  11. pmc Baseline blood oxygenation modulates response amplitude: Physiologic basis for intersubject variations in functional MRI signals
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 60:364-72. 2008
    ..4% and -30.0%, respectively, when using visual stimulation. TRUST MRI is a useful measurement for fMRI studies to control for the modulatory effects of baseline oxygenation that are unique to each subject...
  12. doi request reprint Cerebrovascular reactivity in the brain white matter: magnitude, temporal characteristics, and age effects
    Binu P Thomas
    1 Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA 2 Biomedical Engineering Graduate Program, UT Southwestern Medical Center, Dallas, Texas, USA 3 Department of Bioengineering, UT Arlington, Arlington, Texas, USA
    J Cereb Blood Flow Metab 34:242-7. 2014
    ..These data suggest that characteristics of WM CVR are different from that of GM and caution should be used when interpreting pathologic WM CVR results. ..
  13. pmc On the sensitivity of ASL MRI in detecting regional differences in cerebral blood flow
    Sina Aslan
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Magn Reson Imaging 28:928-35. 2010
    ..In summary, rCBF is a more sensitive index to detect small differences in CBF, rather than the much-sought-after aCBF, since it reduces data noise caused by inter-subject variations in global CBF...
  14. pmc Estimation of labeling efficiency in pseudocontinuous arterial spin labeling
    Sina Aslan
    Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 63:765-71. 2010
    ..We propose that the labeling efficiency should be estimated using phase-contrast velocity MRI on a subject-specific basis...
  15. pmc Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease
    Uma S Yezhuvath
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neurobiol Aging 33:75-82. 2012
    ..004). Our data suggest that early AD subjects have evidence of significant forebrain vascular contractility deficits. The localization, while differing from CBF findings, appears to be spatially similar to PIB amyloid imaging findings...
  16. pmc A comparison of physiologic modulators of fMRI signals
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Hum Brain Mapp 34:2078-88. 2013
    ..Hum Brain Mapp 34:2078-2088, 2013. © 2011 Wiley Periodicals, Inc. ..
  17. pmc Determination of spin compartment in arterial spin labeling MRI
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 65:120-7. 2011
    ..The arterial blood volume was calculated to be 1.18 ± 0.21 mL/100 g. A postlabeling delay time of 2 s is sufficient to allow the spins to completely enter the tissue space for gray matter but not for white matter...
  18. ncbi request reprint Magnetic field correlation imaging
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, NY 10016, USA
    Magn Reson Med 55:1350-61. 2006
    ..5 and 3 T, and human brain images obtained at 3 T are shown to demonstrate the method's feasibility. The preliminary results suggest that MFC imaging may be useful for the quantitative assessment of iron within the brain...
  19. ncbi request reprint Functional magnetic resonance imaging based on changes in vascular space occupancy
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 50:263-74. 2003
    ..Arguments supporting a better gray matter localization for the VASO-fMRI approach compared to BOLD are provided...
  20. pmc Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 78:415-25. 2013
    ..We additionally used a model-based approach to examine the fMRI data in the context of CVR, which again suggested an age-related change in the two frontal regions, but not in the visual and MTL regions...
  21. pmc Test-retest reproducibility of a rapid method to measure brain oxygen metabolism
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 69:675-81. 2013
    ..002) and subjects (P = 0.01), and their coefficients of variation were greater than that of CMRO(2). The simplicity and reliability features may afford this global CMRO(2) technique great potential for immediate clinical applications...
  22. pmc Regional changes of cortical mean diffusivities with aging after correction of partial volume effects
    Tina Jeon
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8542, USA
    Neuroimage 62:1705-16. 2012
    ..The established comprehensive unbiased cortical MD profiles of young, elderly healthy subjects and AD patients at the lobe, gyral and voxel level may serve as clinical references for cortical microstructure...
  23. pmc On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRI
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 61:659-67. 2009
    ..Specific recommendations for VASO MRI acquisition and processing strategies are provided...
  24. ncbi request reprint Microvessel density estimation in the human brain by means of dynamic contrast-enhanced echo-planar imaging
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016 3240, USA
    Magn Reson Med 56:1145-50. 2006
    ..Lower- and upper-bound estimates for the microvessel density were derived from the Q-values, and were found to be in reasonable accord with previously cited values determined by histology...
  25. ncbi request reprint Novel approach to the measurement of absolute cerebral blood volume using vascular-space-occupancy magnetic resonance imaging
    Hanzhang Lu
    Center of Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 54:1403-11. 2005
    ..In comparison with previous pre/postcontrast difference approaches, VASO MRI provides maximal signal difference between pre- and postcontrast situation and does not require the use of whole blood for signal normalization...
  26. pmc White matter cerebral blood flow is inversely correlated with structural and functional connectivity in the human brain
    Sina Aslan
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 56:1145-53. 2011
    ..These findings suggest a clear association between white matter perfusion and gray matter activity, but the nature of this relationship requires further investigations given that they are negatively, rather than positively, correlated...
  27. pmc The influence of carbon dioxide on brain activity and metabolism in conscious humans
    Feng Xu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cereb Blood Flow Metab 31:58-67. 2011
    ....
  28. pmc On the assessment of cerebrovascular reactivity using hypercapnia BOLD MRI
    Uma S Yezhuvath
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    NMR Biomed 22:779-86. 2009
    ..With these technological optimizations, CVR mapping may become a useful method for studies of neurological and psychiatric diseases...
  29. pmc On improving the speed and reliability of T2-relaxation-under-spin-tagging (TRUST) MRI
    Feng Xu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 68:198-204. 2012
    ..6 ms, which allows the determination of global venous oxygenation with scan duration of 1 min 12 s and an estimation precision of ± 1% (in units of oxygen saturation percentage)...
  30. ncbi request reprint Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging
    Hanzhang Lu
    Department of Radiology, Center of Biomedical Imaging, New York University School of Medicine, New York, NY 10016, USA
    NMR Biomed 19:236-47. 2006
    ..Diffusion kurtosis imaging is a useful method to study non-Gaussian diffusion behavior and can provide complementary information to that of DTI...
  31. ncbi request reprint Sustained poststimulus elevation in cerebral oxygen utilization after vascular recovery
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cereb Blood Flow Metab 24:764-70. 2004
    ....
  32. ncbi request reprint Multiple acquisitions with global inversion cycling (MAGIC): a multislice technique for vascular-space-occupancy dependent fMRI
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Magn Reson Med 51:9-15. 2004
    ..Multislice VASO-fMRI images of visual stimulation show effective blood nulling in all slices and appropriate functional activations in all volunteers (n=4)...
  33. pmc Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016, USA
    Magn Reson Med 61:481-5. 2009
    ....
  34. ncbi request reprint Diffusional kurtosis imaging: the quantification of non-gaussian water diffusion by means of magnetic resonance imaging
    Jens H Jensen
    Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016 3240, USA
    Magn Reson Med 53:1432-40. 2005
    ..It may be useful for assessing tissue structure abnormalities associated with a variety of neuropathologies...
  35. ncbi request reprint Intervoxel heterogeneity of event-related functional magnetic resonance imaging responses as a function of T(1) weighting
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuroimage 17:943-55. 2002
    ....
  36. pmc Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism
    Feng Xu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cereb Blood Flow Metab 32:1909-18. 2012
    ..5% (P<0.001) and 16.9±2.7% (P<0.001) for FiO(2) of 50% and 98%, respectively. The CBF showed minimal changes with hyperoxia. Our results suggest that modulation of inspired O(2) alters brain metabolism in a dose-dependent manner...
  37. pmc Comparison of relative cerebral blood flow maps using pseudo-continuous arterial spin labeling and single photon emission computed tomography
    Peiying Liu
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 25:779-86. 2012
    ..47 ± 0.39 and 2.44 ± 0.18 for PCASL and SPECT, respectively. On a single-voxel level, the variance between the modalities was still considerable, with an average rCBF difference of 0.27...
  38. pmc Noninvasive quantification of whole-brain cerebral metabolic rate of oxygen (CMRO2) by MRI
    Feng Xu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 62:141-8. 2009
    ..Owing to the noninvasive nature of this method, it may be a convenient and useful approach for assessment of brain metabolism in brain disorders as well as under various physiologic conditions...
  39. pmc In vivo vascular hallmarks of diffuse leukoaraiosis
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Magn Reson Imaging 32:184-90. 2010
    ..To characterize multiple patterns of vascular changes in leukoaraiosis using in vivo magnetic resonance imaging (MRI) techniques...
  40. pmc Validation of VASO cerebral blood volume measurement with positron emission tomography
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 65:744-9. 2011
    ..00±0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions...
  41. pmc Alterations in resting functional connectivity due to recent motor task
    Kuang Chi Tung
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuroimage 78:316-24. 2013
    ....
  42. pmc Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults
    Benjamin Y Tseng
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas, USA Department of Internal Medicine Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Magn Reson Imaging 38:1169-76. 2013
    ..To investigate differences in the age-related decline in brain tissue concentration between Masters athletes and sedentary older adults...
  43. pmc Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI
    Yulin Ge
    Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016, USA
    J Cereb Blood Flow Metab 32:403-12. 2012
    ..Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease...
  44. pmc Evaluation of MRI models in the measurement of CMRO2 and its relationship with CBF
    Ai Ling Lin
    Research Imaging Center, University of Texas Health Science Center, San Antonio, Texas, USA
    Magn Reson Med 60:380-9. 2008
    ..Our results indicate that if appropriate parameters are used, the SCM and MCM models are equivalent for quantifying the values of CMRO(2) and determining the flow-metabolism relationship...
  45. doi request reprint Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment
    Jie Liu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX, USA Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi an, China
    Alzheimers Dement 10:162-70. 2014
    ..To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI)...
  46. ncbi request reprint Determining the longitudinal relaxation time (T1) of blood at 3.0 Tesla
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 52:679-82. 2004
    ..3 +/- 0.6 ms/ degrees C and 19.8 +/- 0.8 ms/ degrees C for Hct values of 0.42 and 0.38, respectively. When a head coil transmit/receive setup was used, radiation damping caused a slight reduction (19 ms) of the measured T1 values...
  47. pmc Physiologic underpinnings of negative BOLD cerebrovascular reactivity in brain ventricles
    Binu P Thomas
    Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX 75390, USA Biomedical Engineering Graduate Program, UT Southwestern Medical Center, Dallas, TX 75390, USA Department of Bioengineering, UT Arlington, Arlington, TX 76019, USA
    Neuroimage 83:505-12. 2013
    ..The findings from this study suggest that CO2 inhalation results in the dilation of ventricular vessels accompanied by shrinkage in CSF space, which is responsible for the apparently negative CVR in brain ventricles...
  48. pmc Perfusion deficit to cholinergic challenge in veterans with Gulf War Illness
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neurotoxicology 32:242-6. 2011
    ....
  49. pmc Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity
    Jinsoo Uh
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States
    Neurobiol Aging 31:2038-46. 2010
    ..These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity...
  50. ncbi request reprint Experimental measurement of extravascular parenchymal BOLD effects and tissue oxygen extraction fractions using multi-echo VASO fMRI at 1.5 and 3.0 T
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Magn Reson Med 53:808-16. 2005
    ..During visual stimulation, OEF values measured at 1.5 and 3.0 T were in good agreement, giving 0.23 +/- 0.01 and 0.21 +/- 0.01, respectively...
  51. doi request reprint Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2 ) in neonates using MRI
    Peiying Liu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 27:332-40. 2014
    ..Copyright © 2014 John Wiley & Sons, Ltd. ..
  52. pmc Life-long aerobic exercise preserved baseline cerebral blood flow but reduced vascular reactivity to CO2
    Binu P Thomas
    Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas, USA Biomedical Engineering Graduate Program, UT Southwestern Medical Center, Dallas, Texas UT Arlington, Arlington, Texas, USA
    J Magn Reson Imaging 38:1177-83. 2013
    ..To examine the potential benefits of life-long aerobic exercise on brain health, in particular cerebrovascular function...
  53. doi request reprint Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study
    John Hart
    Berman Laboratory for Learning and Memory, Center for Brain Health, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 2200 W Mockingbird Ln, Dallas, TX 75235, USA
    JAMA Neurol 70:326-35. 2013
    ..CONCLUSIONS Cognitive deficits and depression appear to be more common in aging former NFL players compared with healthy controls. These deficits are correlated with white matter abnormalities and changes in regional cerebral blood flow...
  54. pmc A randomized, placebo-controlled proof-of-concept, crossover trial of phenytoin for hydrocortisone-induced declarative memory changes
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8849, USA
    J Affect Disord 150:551-8. 2013
    ..We examined whether phenytoin attenuated the effects of hydrocortisone on declarative memory. Functional magnetic resonance imaging (fMRI) assessed task-related hippocampal activation...
  55. pmc Measurement of N-acetylaspartylglutamate in the human frontal brain by 1H-MRS at 7 T
    Changho Choi
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Magn Reson Med 64:1247-51. 2010
    ..13 and 0.28 by difference editing (95% confidence intervals 0.07-0.19 and 0.22-0.34), respectively, assuming identical relaxation effects between the metabolites...
  56. ncbi request reprint Routine clinical brain MRI sequences for use at 3.0 Tesla
    Hanzhang Lu
    Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Magn Reson Imaging 22:13-22. 2005
    ..0 T with the goal of maintaining, as much as possible, the well-characterized 1.5-T image contrast characteristics for daily clinical diagnosis, while benefiting from the increased signal to noise at higher field...
  57. pmc A BOLD Perspective on Age-Related Neurometabolic-Flow Coupling and Neural Efficiency Changes in Human Visual Cortex
    Joanna Lynn Hutchison
    School of Behavioral and Brain Sciences, University of Texas at Dallas Richardson, TX, USA Department of Psychiatry, University of Texas Southwestern Medical Center Dallas, TX, USA
    Front Psychol 4:244. 2013
    ..Age-related declines in neurometabolic-flow coupling might lead to neural efficiency reductions that can adversely affect visual task performance...
  58. pmc The Relationship Between M in "Calibrated fMRI" and the Physiologic Modulators of fMRI
    Hanzhang Lu
    Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Open Neuroimag J 5:112-9. 2011
    ..Potential biases in hypercapnia-based M estimation were also discussed in the context of possible reduction of CMRO(2) during hypercapnia...
  59. ncbi request reprint Quantitative assessment of iron accumulation in the deep gray matter of multiple sclerosis by magnetic field correlation imaging
    Y Ge
    Center for Biomedical Imaging, Department of Radiology, New York University Medical Center, New York, NY 10016, USA
    AJNR Am J Neuroradiol 28:1639-44. 2007
    ..We propose that there is an excess accumulation of iron in the deep gray matter in patients with MS that can be measured with a newly developed quantitative MR technique--magnetic field correlation (MFC) imaging...
  60. ncbi request reprint Measurements of cerebral perfusion and arterial hemodynamics during visual stimulation using TURBO-TILT
    Jeroen Hendrikse
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    Magn Reson Med 50:429-33. 2003
    ....
  61. ncbi request reprint An account of the discrepancy between MRI and PET cerebral blood flow measures. A high-field MRI investigation
    Manus J Donahue
    The Russell H Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University, Baltimore, MD, USA
    NMR Biomed 19:1043-54. 2006
    ..The recent availability of MRI field strengths of 3.0 T and higher will facilitate the use of MRI-based CBF measurements in the clinic...
  62. ncbi request reprint Theoretical and experimental investigation of the VASO contrast mechanism
    Manus J Donahue
    Russell H Morgan Department of Radiology and Radiological Sciences, Division of MR Research, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Magn Reson Med 56:1261-73. 2006
    ..Thus, many competing effects contribute to VASO contrast and care should be taken during interpretation...
  63. pmc Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA)
    John J Strouse
    Division of Pediatric Hematology, Department of Pediatrics, the Neurocirculatory Physiology Laboratory, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Blood 108:379-81. 2006
    ..005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD...
  64. ncbi request reprint In vivo flow territory mapping of major brain feeding arteries
    Peter Jan van Laar
    Department of Radiology Hp E01 332, University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Neuroimage 29:136-44. 2006
    ..To relate focal brain lesions to underlying flow territories in individual cases, knowledge of the anatomy of the circle of Willis is essential...
  65. doi request reprint Effects of traumatic brain injury on working memory-related brain activation in adolescents
    Mary R Newsome
    Cognitive Neuroscience Laboratory, Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, TX 77030, USA
    Neuropsychology 22:419-25. 2008
    ..The overrecruitment of frontal and extrafrontal regions during encoding and retrieval following TBI may represent a compensatory process...
  66. ncbi request reprint Retinotopic mapping in the human visual cortex using vascular space occupancy-dependent functional magnetic resonance imaging
    Hanzhang Lu
    The Russel H Morgan Department of Radiology, Baltimore, Maryland, USA
    Neuroreport 16:1635-40. 2005
    ..Disadvantages of vascular space occupancy functional magnetic resonance imaging include lower contrast-to-noise ratio (about 1/3 of that of blood oxygenation level-dependent method) and limited volume coverage (nine slices for TR=3 s)...
  67. ncbi request reprint Flow territory mapping of the cerebral arteries with regional perfusion MRI
    Jeroen Hendrikse
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 35:882-7. 2004
    ....
  68. ncbi request reprint Automated optimal detection and classification of neural action potentials in extra-cellular recordings
    Pramodsingh H Thakur
    Zanvyl Krieger Mind Brain Institute, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    J Neurosci Methods 162:364-76. 2007
    ..This algorithm provides an accurate estimate of the signal to noise ratio and provides an accurate estimate of spike times and spike shapes...

Research Grants6

  1. Modulation of brain activity by control of the inspired air
    Hanzhang Lu; Fiscal Year: 2010
    ..This approach is non-invasive, convenient and cost effective, thus may provide a new means for interventions such as seizure termination in epilepsy patients. ..
  2. Measurement of Absolute Cerebral Blood Volume using Magnetic Resonance Imaging
    Hanzhang Lu; Fiscal Year: 2007
    ..In this project, a new technique will be developed to measure CBV in human brain using MRI. ..
  3. Normalized functional MRI in human brain disorders
    Hanzhang Lu; Fiscal Year: 2010
    ....