Research Topics
| Christopher LuSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Acute kidney injury: a conspiracy of Toll-like receptor 4 on endothelia, leukocytes, and tubulesChristopher Y Lu
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
Pediatr Nephrol 27:1847-54. 2012..The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored...- Successful renal re-transplantation in the presence of pre-existing anti-DQ5 antibodies when there was zero mismatch at class I human leukocyte antigen A, B, & C: a case reportJohn Hartono
Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
J Med Case Reports 3:41. 2009..We now report successful renal transplantation of a patient who had pre-existing antibodies against his donor's human leukocyte antigen-DQ5... 
The inflammatory response to ischemic acute kidney injury: a result of the 'right stuff' in the 'wrong place'?Christopher Y Lu
Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, Texas 63110, USA
Curr Opin Nephrol Hypertens 16:83-9. 2007..How injury elicits inflammation remains a major question in understanding acute kidney injury. The present review examines the hypothesis that molecules released by injured cells elicit inflammation...- IRF-1 promotes inflammation early after ischemic acute kidney injuryYanxia Wang
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
J Am Soc Nephrol 20:1544-55. 2009..Taken together, these data suggest that IRF-1 gene activation by reactive oxygen species is an early signal that promotes inflammation after ischemic renal injury... - Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthaseMariusz L Kielar
Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Soc Nephrol 14:389-96. 2003..In addition, the data may have therapeutic implications, because the DHA improves ARF even when administered at 4 h after reperfusion... - Infection by gram-negative organisms via the biliary route results in greater mortality than portal venous infectionD Rohan Jeyarajah
Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390 9156, USA
Clin Diagn Lab Immunol 10:664-9. 2003.... - Acute bile duct ligation ameliorates ischemic renal failureD Rohan Jeyarajah
Department of Surgery, Southwestern Medical School, Dallas, Tex 75390 9156, USA
Nephron Physiol 95:p28-35. 2003..Using a murine model, we now test the hypothesis that these hepatic cytokines help determine the outcome of ischemic acute renal failure... 
Renal transplantation in the elderlyRamesh Saxena
Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
Int Urol Nephrol 41:195-210. 2009..Appropriate immunosuppressive agents and dosages should be selected to minimize adverse events while reducing the risk of acute rejections and maximizing patient and renal allograft survival...- Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10D Rohan Jeyarajah
Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA
Am J Physiol Gastrointest Liver Physiol 291:G91-4. 2006..coli infection. This impaired clearance is associated with increased IL-10 production. However, transgenic knockout of IL-10 increased mortality after hepatic infection... - Role of immunoglobulin (Ig)-G and IgM antibodies against donor human leukocyte antigens in organ transplant recipientsPeter Stastny
Departments of Internal Medicine, Cardiothoracic Surgery, and Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, USA
Hum Immunol 70:600-4. 2009..In addition, IgM antibodies against donor HLA appeared to be associated with decreased survival of kidney and heart allografts... - Maladaptive role of IL-6 in ischemic acute renal failureMariusz L Kielar
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Soc Nephrol 16:3315-25. 2005..It is concluded that macrophages infiltrate the area of the vascular bundles of the outer medulla, these macrophages produce IL-6, and this IL-6 exacerbates ischemic murine acute renal failure... - The regulation of ischemic acute renal failure by extrarenal organsMariusz L Kielar
Departments of Internal Medicine and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
Curr Opin Nephrol Hypertens 11:451-7. 2002..Recent work suggests that extrarenal organs, such as the liver, lung, spleen, brain, lymphoid tissues, and bone marrow, regulate acute renal failure. We now review several examples of such regulation... - Pancreas after kidney transplantationSundaram Hariharan
Division of Nephrology, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA
J Am Soc Nephrol 13:1109-18. 2002 - Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARĪ³, and HO-1Qing Qing Wu
Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 300:F1180-92. 2011..Although Nrf2-dependent increases in HO-1 have been described, our data suggest that BARD's effects on tubular and leukocyte HO-1 during ischemic AKI may be Nrf2 independent. We also found that BARD ameliorated cisplatin nephrotoxicity... - Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitroYing Zhang
Div. of Nephrology (Internal Medicine Univ. of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA
Am J Physiol Renal Physiol 286:F1193-201. 2004..The production of G-CSF by the kidney after ischemia-reperfusion provides a means of communication from the injured kidney to the bone marrow. This supports the known inflammatory response to ischemia...
Research Grants
- TLR4 and murine ischemic acute renal failureChristopher Y Lu; Fiscal Year: 2010..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
- TLR4 and murine ischemic acute renal failureChristopher Lu; Fiscal Year: 2009..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
- TLR4 and murine ischemic acute renal failureChristopher Lu; Fiscal Year: 2007..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
- RAE 1 and renal injuryChristopher Lu; Fiscal Year: 2004..The "RAE 1 - NKG2D vicious cycle" proposed here would be a novel insight into progressive renal injury. New therapy might be directed at interdicting this vicious cycle. ..
- RENAL PROTECTION BY DOCOSAHEXAENOIC ACIDChristopher Lu; Fiscal Year: 2002..abstract_text> ..
- TLR4 and murine ischemic acute renal failureChristopher Y Lu; Fiscal Year: 2010..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..