Christopher Lu

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI
    Pamela D Winterberg
    Department of Pediatrics, Nephrology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Renal Physiol 305:F164-72. 2013
  2. pmc Acute kidney injury: a conspiracy of Toll-like receptor 4 on endothelia, leukocytes, and tubules
    Christopher Y Lu
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Pediatr Nephrol 27:1847-54. 2012
  3. pmc Successful renal re-transplantation in the presence of pre-existing anti-DQ5 antibodies when there was zero mismatch at class I human leukocyte antigen A, B, & C: a case report
    John Hartono
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
    J Med Case Reports 3:41. 2009
  4. ncbi request reprint The inflammatory response to ischemic acute kidney injury: a result of the 'right stuff' in the 'wrong place'?
    Christopher Y Lu
    Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, Texas 63110, USA
    Curr Opin Nephrol Hypertens 16:83-9. 2007
  5. ncbi request reprint Acute bile duct ligation ameliorates ischemic renal failure
    D Rohan Jeyarajah
    Department of Surgery, Southwestern Medical School, Dallas, Tex 75390 9156, USA
    Nephron Physiol 95:p28-35. 2003
  6. pmc IRF-1 promotes inflammation early after ischemic acute kidney injury
    Yanxia Wang
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 20:1544-55. 2009
  7. ncbi request reprint Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase
    Mariusz L Kielar
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Soc Nephrol 14:389-96. 2003
  8. doi request reprint Renal transplantation in the elderly
    Ramesh Saxena
    Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Int Urol Nephrol 41:195-210. 2009
  9. pmc Infection by gram-negative organisms via the biliary route results in greater mortality than portal venous infection
    D Rohan Jeyarajah
    Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390 9156, USA
    Clin Diagn Lab Immunol 10:664-9. 2003
  10. ncbi request reprint Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10
    D Rohan Jeyarajah
    Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA
    Am J Physiol Gastrointest Liver Physiol 291:G91-4. 2006

Research Grants

  1. TLR4 and murine ischemic acute renal failure
    Christopher Y Lu; Fiscal Year: 2010
  2. TLR4 and murine ischemic acute renal failure
    Christopher Lu; Fiscal Year: 2009
  3. TLR4 and murine ischemic acute renal failure
    Christopher Lu; Fiscal Year: 2007
  4. RAE 1 and renal injury
    Christopher Lu; Fiscal Year: 2004
  5. RENAL PROTECTION BY DOCOSAHEXAENOIC ACID
    Christopher Lu; Fiscal Year: 2002
  6. TLR4 and murine ischemic acute renal failure
    Christopher Y Lu; Fiscal Year: 2010

Collaborators

Detail Information

Publications16

  1. pmc Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI
    Pamela D Winterberg
    Department of Pediatrics, Nephrology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Renal Physiol 305:F164-72. 2013
    ..Altogether our data support the following autocrine pathway in renal tubular cells: ROS > IRF1 > IFNα > IFNARI > CXCL2...
  2. pmc Acute kidney injury: a conspiracy of Toll-like receptor 4 on endothelia, leukocytes, and tubules
    Christopher Y Lu
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Pediatr Nephrol 27:1847-54. 2012
    ..The temporal-spatial roles and potential therapeutics targeting this particular receptor-ligand interaction are also explored...
  3. pmc Successful renal re-transplantation in the presence of pre-existing anti-DQ5 antibodies when there was zero mismatch at class I human leukocyte antigen A, B, & C: a case report
    John Hartono
    Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA
    J Med Case Reports 3:41. 2009
    ..We now report successful renal transplantation of a patient who had pre-existing antibodies against his donor's human leukocyte antigen-DQ5...
  4. ncbi request reprint The inflammatory response to ischemic acute kidney injury: a result of the 'right stuff' in the 'wrong place'?
    Christopher Y Lu
    Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, Texas 63110, USA
    Curr Opin Nephrol Hypertens 16:83-9. 2007
    ..How injury elicits inflammation remains a major question in understanding acute kidney injury. The present review examines the hypothesis that molecules released by injured cells elicit inflammation...
  5. ncbi request reprint Acute bile duct ligation ameliorates ischemic renal failure
    D Rohan Jeyarajah
    Department of Surgery, Southwestern Medical School, Dallas, Tex 75390 9156, USA
    Nephron Physiol 95:p28-35. 2003
    ..Using a murine model, we now test the hypothesis that these hepatic cytokines help determine the outcome of ischemic acute renal failure...
  6. pmc IRF-1 promotes inflammation early after ischemic acute kidney injury
    Yanxia Wang
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 20:1544-55. 2009
    ..Taken together, these data suggest that IRF-1 gene activation by reactive oxygen species is an early signal that promotes inflammation after ischemic renal injury...
  7. ncbi request reprint Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase
    Mariusz L Kielar
    Department of Internal Medicine, Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Soc Nephrol 14:389-96. 2003
    ..In addition, the data may have therapeutic implications, because the DHA improves ARF even when administered at 4 h after reperfusion...
  8. doi request reprint Renal transplantation in the elderly
    Ramesh Saxena
    Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Int Urol Nephrol 41:195-210. 2009
    ..Appropriate immunosuppressive agents and dosages should be selected to minimize adverse events while reducing the risk of acute rejections and maximizing patient and renal allograft survival...
  9. pmc Infection by gram-negative organisms via the biliary route results in greater mortality than portal venous infection
    D Rohan Jeyarajah
    Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas 75390 9156, USA
    Clin Diagn Lab Immunol 10:664-9. 2003
    ....
  10. ncbi request reprint Impact of bile duct obstruction on hepatic E. coli infection: role of IL-10
    D Rohan Jeyarajah
    Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX, USA
    Am J Physiol Gastrointest Liver Physiol 291:G91-4. 2006
    ..coli infection. This impaired clearance is associated with increased IL-10 production. However, transgenic knockout of IL-10 increased mortality after hepatic infection...
  11. doi request reprint Role of immunoglobulin (Ig)-G and IgM antibodies against donor human leukocyte antigens in organ transplant recipients
    Peter Stastny
    Departments of Internal Medicine, Cardiothoracic Surgery, and Surgical Transplantation, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Hum Immunol 70:600-4. 2009
    ..In addition, IgM antibodies against donor HLA appeared to be associated with decreased survival of kidney and heart allografts...
  12. ncbi request reprint Maladaptive role of IL-6 in ischemic acute renal failure
    Mariusz L Kielar
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Soc Nephrol 16:3315-25. 2005
    ..It is concluded that macrophages infiltrate the area of the vascular bundles of the outer medulla, these macrophages produce IL-6, and this IL-6 exacerbates ischemic murine acute renal failure...
  13. ncbi request reprint The regulation of ischemic acute renal failure by extrarenal organs
    Mariusz L Kielar
    Departments of Internal Medicine and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Curr Opin Nephrol Hypertens 11:451-7. 2002
    ..Recent work suggests that extrarenal organs, such as the liver, lung, spleen, brain, lymphoid tissues, and bone marrow, regulate acute renal failure. We now review several examples of such regulation...
  14. ncbi request reprint Pancreas after kidney transplantation
    Sundaram Hariharan
    Division of Nephrology, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 13:1109-18. 2002
  15. pmc Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1
    Qing Qing Wu
    Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 300:F1180-92. 2011
    ..Although Nrf2-dependent increases in HO-1 have been described, our data suggest that BARD's effects on tubular and leukocyte HO-1 during ischemic AKI may be Nrf2 independent. We also found that BARD ameliorated cisplatin nephrotoxicity...
  16. ncbi request reprint Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro
    Ying Zhang
    Div of Nephrology Internal Medicine Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 286:F1193-201. 2004
    ..The production of G-CSF by the kidney after ischemia-reperfusion provides a means of communication from the injured kidney to the bone marrow. This supports the known inflammatory response to ischemia...

Research Grants11

  1. TLR4 and murine ischemic acute renal failure
    Christopher Y Lu; Fiscal Year: 2010
    ..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
  2. TLR4 and murine ischemic acute renal failure
    Christopher Lu; Fiscal Year: 2009
    ..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
  3. TLR4 and murine ischemic acute renal failure
    Christopher Lu; Fiscal Year: 2007
    ..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..
  4. RAE 1 and renal injury
    Christopher Lu; Fiscal Year: 2004
    ..The "RAE 1 - NKG2D vicious cycle" proposed here would be a novel insight into progressive renal injury. New therapy might be directed at interdicting this vicious cycle. ..
  5. RENAL PROTECTION BY DOCOSAHEXAENOIC ACID
    Christopher Lu; Fiscal Year: 2002
    ..abstract_text> ..
  6. TLR4 and murine ischemic acute renal failure
    Christopher Y Lu; Fiscal Year: 2010
    ..Altogether, this is a novel approach to ischemic ARF and may yield new insights and therapies of a disease that continues, despite modern therapy, to have a high mortality. ..