Research Topics
| William E LowrySummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?William E Lowry
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA, United States
Curr Opin Genet Dev 22:429-34. 2012..In this review, I will attempt to summarize the data that serve to distinguish these types of pluripotent stem cells and speculate on the ramifications of any differences...
Generation of human induced pluripotent stem cells from dermal fibroblastsW E Lowry
Department of Molecular Cell and Developmental Biology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, 615 Charles E Young Drive South, University of California, Los Angeles, CA 90095, USA
Proc Natl Acad Sci U S A 105:2883-8. 2008..In the future, the use of defined factors to change cell fate may be the key to routine nuclear reprogramming of human somatic cells...- Roadblocks en route to the clinical application of induced pluripotent stem cellsWilliam E Lowry
Department of Molecular, Cell and Developmental Biology, 621 Charles Young Drive South, University of California Los Angeles, Los Angeles, CA 90095, USA
J Cell Sci 123:643-51. 2010..In this Essay, we discuss what we believe are important issues that should be considered when attempting to bring hiPSC-based technology to the clinic... - Dynamic distribution of linker histone H1.5 in cellular differentiationJing Yu Li
Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
PLoS Genet 8:e1002879. 2012..Our data reveal for the first time a specific and novel function for linker histone subtype H1.5 in maintenance of condensed chromatin at defined gene families in differentiated human cells... - Defining the nature of human pluripotent stem cell progenyMichaela Patterson
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Cell Res 22:178-93. 2012..These findings provide support for the idea that hPSCs can serve as useful in vitro models of early human development, but also raise important issues for disease modeling and the clinical application of hPSC derivatives... - Female human iPSCs retain an inactive X chromosomeJason Tchieu
Department of Biological Chemistry, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, David Geffen School of Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90024, USA
Cell Stem Cell 7:329-42. 2010.... - Directed differentiation of human-induced pluripotent stem cells generates active motor neuronsSaravanan Karumbayaram
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Stem Cells 27:806-11. 2009..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases... - Nipah Virus Envelope-Pseudotyped Lentiviruses Efficiently Target ephrinB2-Positive Stem Cell Populations In Vitro and Bypass the Liver Sink When Administered In VivoKarina Palomares
Department of Microbiology, Immunology and Molecular Genetics
J Virol 87:2094-108. 2013..Bypassing the liver sink is a critical barrier for targeted gene therapy. The extraordinary specificity of NiV-G for ephrinB2 holds promise for targeting specific ephrinB2(+) populations in vivo or in vitro... - Progress in understanding reprogramming to the induced pluripotent stateKathrin Plath
David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, California, USA
Nat Rev Genet 12:253-65. 2011..To inform the next phase in understanding reprogramming, we review the latest findings, highlight ongoing debates and outline future challenges... 
Signaling in adult stem cellsWilliam E Lowry
Department of Molecular, Cell and Developmental Biology, UCLA, Los Angeles, CA 90095, USA
Front Biosci 12:3911-27. 2007....- Molecular analyses of human induced pluripotent stem cells and embryonic stem cellsMark H Chin
Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Cell Stem Cell 7:263-9. 2010.... - Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cellsTae Sub Park
Department of Molecular Cell and Developmental Biology, University of California, Los Angeles, CA, USA
Stem Cells 27:783-95. 2009.... - PTK7 marks the first human developmental EMT in vitroDavid N Chan
Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 7:e50432. 2012..We also find that cells that undergo this developmental EMT retain developmental plasticity as sorting, dissociation and re-plating reestablishes an epithelial phenotype... - Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signaturesMark H Chin
Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Cell Stem Cell 5:111-23. 2009..Together, these data suggest that iPSCs should be considered a unique subtype of pluripotent cell...
Research Grants
- Identification and characterization of cancer cells of origin in the epidermisWilliam E Lowry; Fiscal Year: 2010..Recent data suggests that stem cells play a prominent role in many aspects of cancer biology. This application aims to understand whether stem cells or their progeny are involved in the initiation of cancers. ..