Susan Lowey

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface
    Niels Volkmann
    Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 2:e1123. 2007
  2. pmc Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 288:14780-7. 2013
  3. pmc Common structural motifs for the regulation of divergent class II myosins
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 285:16403-7. 2010
  4. pmc Crystal structures of monomeric actin bound to cytochalasin D
    Usha B Nair
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Biol 384:848-64. 2008
  5. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
  6. pmc Myosin isoforms show unique conformations in the actin-bound state
    Niels Volkmann
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:3227-32. 2003
  7. ncbi The structural basis of myosin V processive movement as revealed by electron cryomicroscopy
    Niels Volkmann
    The Program of Cell Adhesion, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell 19:595-605. 2005
  8. pmc Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Biol 371:902-13. 2007
  9. ncbi Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states
    Mark A Rould
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 281:31909-19. 2006
  10. pmc A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin
    Jennifer J Sherwood
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 101:10973-8. 2004

Collaborators

Detail Information

Publications14

  1. pmc The R403Q myosin mutation implicated in familial hypertrophic cardiomyopathy causes disorder at the actomyosin interface
    Niels Volkmann
    Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 2:e1123. 2007
    ..It has been proposed that these molecular changes must trigger events that ultimately lead to the clinical phenotype...
  2. pmc Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 288:14780-7. 2013
    ..These transient kinetic studies on mouse cardiac myosins provide strong evidence that the functional impact of an FHC mutation on myosin depends on the isoform backbone...
  3. pmc Common structural motifs for the regulation of divergent class II myosins
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 285:16403-7. 2010
    ..Several of these interactions have now been visualized in a wide variety of native myosin filaments, testifying to the generality of these structural motifs across the phylogenetic tree...
  4. pmc Crystal structures of monomeric actin bound to cytochalasin D
    Usha B Nair
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Biol 384:848-64. 2008
    ..We speculate that these changes represent a potential conformation that the actin monomer can adopt on the pathway to polymerization or in the filament...
  5. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
    ..Thus, the functional consequences of the mutation are fundamentally changed depending upon the context of the cardiac MHC isoform...
  6. pmc Myosin isoforms show unique conformations in the actin-bound state
    Niels Volkmann
    The Burnham Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 100:3227-32. 2003
    ....
  7. ncbi The structural basis of myosin V processive movement as revealed by electron cryomicroscopy
    Niels Volkmann
    The Program of Cell Adhesion, The Burnham Institute, La Jolla, California 92037, USA
    Mol Cell 19:595-605. 2005
    ..Our findings reveal how the structural elements of myosin V work together to allow myosin V to step along actin for multiple ATPase cycles without dissociating...
  8. pmc Evidence for an interaction between the SH3 domain and the N-terminal extension of the essential light chain in class II myosins
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Mol Biol 371:902-13. 2007
    ..Given that SH3 domains are known to bind proline-rich ligands, we suggest that the N-terminal extension of ELC interacts with actin and modulates myosin kinetics by binding to the SH3 domain during the ATPase cycle...
  9. ncbi Crystal structures of expressed non-polymerizable monomeric actin in the ADP and ATP states
    Mark A Rould
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 281:31909-19. 2006
    ....
  10. pmc A point mutation in the regulatory light chain reduces the step size of skeletal muscle myosin
    Jennifer J Sherwood
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, 05405, USA
    Proc Natl Acad Sci U S A 101:10973-8. 2004
    ....
  11. ncbi Cardiac myosin isoforms from different species have unique enzymatic and mechanical properties
    Ulf P Malmqvist
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405 0068, USA
    Biochemistry 43:15058-65. 2004
    ..Thus, nature has adapted the function of cardiac myosin isoforms to optimize power output for hearts of a given species...
  12. ncbi So near and yet so far from understanding molecular motors: recollections in honor of John T. Edsall
    Susan Lowey
    University of Vermont, College of Medicine, Department of Molecular Physiology and Biophysics, Health Science Research Facility, 149 Beaumont Ave, Burlington, VT 05405 0075, USA
    Biophys Chem 100:171-5. 2003
  13. ncbi Functional consequences of mutations in the myosin heavy chain at sites implicated in familial hypertrophic cardiomyopathy
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405 0075, USA
    Trends Cardiovasc Med 12:348-54. 2002
    ..This review discusses the problems encountered in reaching a definitive answer on the effect of MHC mutations...
  14. pmc The carboxyl-terminal isoforms of smooth muscle myosin heavy chain determine thick filament assembly properties
    Arthur S Rovner
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Cell Biol 156:113-23. 2002
    ....

Research Grants4