Research Topics
Genomes and Genes | Richard M LoveringSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivoJoseph A Roche
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Neuroreport 19:1579-84. 2008..Our data indicate that recovery of control muscles from injury primarily involves sarcolemmal repair whereas recovery of dysferlin-null muscles primarily involves myogenesis without repair and long-term survival of myofibers...
Architecture of healthy and dystrophic muscles detected by optical coherence tomographyRichard M Lovering
University of Maryland School of Medicine, Department of Orthopaedics, 100 Penn Street, Baltimore, Maryland, USA
Muscle Nerve 47:588-90. 2013..Optical coherence tomography (OCT) is an emerging technology that can generate high resolution 1-10 μm cross-sectional imaging of tissue in vivo and in real time...- Location of myofiber damage in skeletal muscle after lengthening contractionsRichard M Lovering
Department of Physiology, School of Medicine, University of Maryland, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
Muscle Nerve 40:589-94. 2009..Results suggest that myofiber injury occurs primarily in the middle portion of the muscle, with interstitial edema in the middle and distal portions... - Architecture and fiber type of the pyramidalis muscleRichard M Lovering
Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Anat Sci Int 83:294-7. 2008..The results show that this is a muscle of mixed fiber type composition, similar to the rectus abdominus, and that the estimated forces generated by this muscle are relatively small... - Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filamentsRichard M Lovering
Department of Physiology, University of Maryland, Baltimore, 21201, USA
Am J Physiol Cell Physiol 300:C803-13. 2011..Our results suggest that keratin filaments containing K19- and desmin-based intermediate filaments can play independent, complementary, or antagonistic roles in the physiology and morphology of fast-twitch skeletal muscle... 
Identification of skeletal muscle mutations in tail snips from neonatal mice using immunohistochemistryRichard M Lovering
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Biotechniques 42:702, 704. 2007- Recovery of function in skeletal muscle following 2 different contraction-induced injuriesRichard M Lovering
Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Arch Phys Med Rehabil 88:617-25. 2007..To determine if the proliferation of myogenic cells is equally important to recovery of contractile function after 2 different types of contraction-induced muscle injuries... - Leptomeningeal plaques, a "common" findingRichard M Lovering
Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
Clin Anat 19:696-7. 2006 - The muscular dystrophies: from genes to therapiesRichard M Lovering
Department of Physiology, University of Maryland, School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
Phys Ther 85:1372-88. 2005..This perspective covers some of the basic molecular biological advances together with the clinical manifestations of the muscular dystrophies and the latest approaches to their management... - Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signalingRichard M Lovering
Univ of Maryland School of Medicine, Dept of Physiology, 685 W Baltimore St, HSF 1, RM, 580, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 297:C571-80. 2009..These malformations are not associated with gross disruptions in cytoskeletal or t-tubule structure; however, alterations in myofiber Ca(2+) signaling are evident... - Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from contraction-induced injuriesJoseph A Roche
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 298:C298-312. 2010..Myogenesis to replace lost fibers does not appear to be significantly compromised in dysferlin-null mice... - Structural and functional evaluation of branched myofibers lacking intermediate filamentsMariah H Goodall
Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, 21201, USA
Am J Physiol Cell Physiol 303:C224-32. 2012..Thus, there are complex roles for desmin-based and K19-based IFs in skeletal muscle, with the null and DKO mutations having different effects on Ca(2+) reuptake and myofiber branching... - Influences of desmin and keratin 19 on passive biomechanical properties of mouse skeletal muscleSameer B Shah
Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
J Biomed Biotechnol 2012:704061. 2012..This work provides additional insight into the influences of IFs on structure-function relationships in skeletal muscle. It may also have implications for understanding the progression of desminopathies and other IF-related myopathies... - Unmasking potential intracellular roles for dysferlin through improved immunolabeling methodsJoseph A Roche
Department of Physiology, University of Maryland School of Medicine, Baltimore, USA
J Histochem Cytochem 59:964-75. 2011..They suggest that dysferlin has an important function in the internal membrane systems of skeletal muscle, involved in calcium homeostasis and excitation-contraction coupling... - Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganizationMichele R Stone
Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Cell Sci 120:3999-4008. 2007..This is the first demonstration of a mammalian phenotype associated with a genetic perturbation of keratin 19... - S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscleBenjamin L Prosser
Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, USA
Am J Physiol Cell Physiol 299:C891-902. 2010..We conclude that the absence of S100A1 suppresses physiological AP-induced Ca(2+) release flux, resulting in impaired contractile activation and force production in skeletal muscle... - Use of autologous platelet-rich plasma to treat muscle strain injuriesJason W Hammond
Union Memorial Hospital, Department of Orthopedic Surgery, Baltimore, Maryland, USA
Am J Sports Med 37:1135-42. 2009..Standard nonoperative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery... - Dexamethasone and recovery of contractile tension after a muscle injuryMarc Hakim
Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA
Clin Orthop Relat Res 439:235-42. 2005..The data indicate that one dose of dexamethasone administered soon after muscle strain may facilitate recovery of contractile tension without causing major adverse consequences in this experimental model... - Gait analysis of locomotory impairment in rats before and after neuromuscular injuryWenlong Tang
Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
J Neurosci Methods 181:249-56. 2009..Use of this technology should be valuable for monitoring the progression of a neuromuscular disease and the effects of therapeutic interventions... - An in vivo rodent model of contraction-induced injury in the quadriceps muscleStephen J P Pratt
University of Maryland School of Medicine, Department of Orthopaedics, Baltimore, MD, United States
Injury 43:788-93. 2012..A controlled muscle injury in the quadriceps also allows one to study a muscle, with mixed fibre types, which is extremely relevant to gait in humans and quadruped models... - Diffusion tensor MRI to assess damage in healthy and dystrophic skeletal muscle after lengthening contractionsAlan B McMillan
Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Biomed Biotechnol 2011:970726. 2011..The data suggest that DTI is an accurate indicator of muscle injury, even at early time points where the MR signal changes are dominated by local edema... - The contribution of contractile pre-activation to loss of function after a single lengthening contractionRichard M Lovering
Department of Physical Therapy and Rehabilitation Science, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
J Biomech 38:1501-7. 2005..CONCLUSION: The data indicated that the duration of an isometric contraction prior to a single lengthening contraction determined the extent of muscle injury irrespective of two different angular velocities... - Contractile function, sarcolemma integrity, and the loss of dystrophin after skeletal muscle eccentric contraction-induced injuryRichard M Lovering
Department of Physical Therapy and Rehabilitation Sciences, School of Medicine, University of Maryland, Baltimore 21201, USA
Am J Physiol Cell Physiol 286:C230-8. 2004..These data indicate the selective vulnerability of dystrophin after a single eccentric contraction-induced injury and suggest a critical role of dystrophin in force transduction... - Changes in contraction-induced phosphorylation of AMP-activated protein kinase and mitogen-activated protein kinases in skeletal muscle after ovariectomyLindsay M Wohlers
Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland 21045, USA
J Cell Biochem 107:171-8. 2009.... - Use of BODIPY (493/503) to visualize intramuscular lipid droplets in skeletal muscleEspen E Spangenburg
Department of Kinesiology, University of Maryland, School of Public Health, College Park, MD 20742, USA
J Biomed Biotechnol 2011:598358. 2011..We believe that the use of the BODIPY (493/503) dye is an acceptable alternative and, under certain conditions, a simpler method for visualizing LDs stored within skeletal muscle... - Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic musclesStephen J P Pratt
Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Physiol 591:559-70. 2013.... - Genetic deletion of trkB.T1 increases neuromuscular functionSusan G Dorsey
University of Maryland Baltimore School of Nursing, Baltimore, Maryland 21201, USA
Am J Physiol Cell Physiol 302:C141-53. 2012..On the basis of these findings, we conclude that the trkB signaling pathway might represent a novel target for intervention across diseases characterized by deficits in neuromuscular function... - Determinants of the repeated-bout effect after lengthening contractionsDana M DiPasquale
Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Am J Phys Med Rehabil 90:816-24. 2011..We hypothesized that the RBE would occur soon after the initial injury and persist for several weeks and that the RBE would occur even if the second injury was performed under different biomechanical conditions than the first... - Early metabolic changes measured by 1H MRS in healthy and dystrophic muscle after injurySu Xu
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
J Appl Physiol 113:808-16. 2012..These results show that it is possible to obtain meaningful in vivo (1)H MRS regarding skeletal muscle injury... - Effect of testosterone on the female anterior cruciate ligamentRichard M Lovering
University of Maryland School of Medicine, Department of Physiology, 100 Penn St, Baltimore, MD 21201, USA
Am J Physiol Regul Integr Comp Physiol 289:R15-22. 2005..Instead, the relationship between T, FAI, and ACL stiffness was likely influenced by another hormone or sex hormone binding globulin... - Bex1 knock out mice show altered skeletal muscle regenerationJae Hyung Koo
Department of Anatomy and Neurobiology, School of Medicine, University of Maryland Baltimore, Baltimore, MD 21201, USA
Biochem Biophys Res Commun 363:405-10. 2007..Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca(2+)/CaM may be involved in skeletal muscle regeneration... - Fiber type composition of cadaveric human rotator cuff musclesRichard M Lovering
Department of Physiology, University of Maryalnd School of Medicine, Baltimore, MD 21201, USA
J Orthop Sports Phys Ther 38:674-80. 2008..Descriptive cadaveric laboratory study... - Evaluation and imaging of an untreated grade III hamstring tear: a case reportBrett B Clark
Department of Orthopaedics, University of Maryland School of Medicine, 100 Penn St, AHB, Rm 540, Baltimore, MD 21201, USA
Clin Orthop Relat Res 469:3248-52. 2011..This case suggests a benign natural history for this injury and the appropriateness of noninvasive treatment... - Fiber length variability within the flexor carpi ulnaris and flexor carpi radialis muscles: implications for surgical tendon transferJan Friden
Department of Hand Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
J Hand Surg Am 29:909-14. 2004..The purpose of this study was to understand the detailed architectural properties of the human flexor carpi radialis (FCR) and flexor carpi ulnaris (FCU) muscles and their implications for tendon transfer surgery... - Intermediate filament-like protein syncoilin in normal and myopathic striated muscleKarl J A McCullagh
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Neuromuscul Disord 17:970-9. 2007..The data show that absence of alpha-dystrobrevin or desmin leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies...
Research Grants
- The Role of Cytokeratins in Skeletal Muscle InjuryRICHARD LOVERING; Fiscal Year: 2006..The proposed research is designed to elucidate some of the shared cellular and molecular mechanisms. ..
- The Role of Intermediate Filaments in Skeletal Muscle Injury and DiseaseRICHARD LOVERING; Fiscal Year: 2007..They should also elucidate some of the shared cellular and molecular mechanisms of muscle disease and of muscle injury, treatment, and recovery. ..
- Mechanisms of Force Loss in Injured and Dystrophic Skeletal MuscleRichard M Lovering; Fiscal Year: 2010..There is keen interest in identifying specific pathological processes in order to develop rationale therapies, but also to use biological markers and outcome measures that can monitor the response to therapies. ..