Richard M Lovering

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo
    Joseph A Roche
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neuroreport 19:1579-84. 2008
  2. doi request reprint Architecture of healthy and dystrophic muscles detected by optical coherence tomography
    Richard M Lovering
    University of Maryland School of Medicine, Department of Orthopaedics, 100 Penn Street, Baltimore, Maryland, USA
    Muscle Nerve 47:588-90. 2013
  3. pmc Location of myofiber damage in skeletal muscle after lengthening contractions
    Richard M Lovering
    Department of Physiology, School of Medicine, University of Maryland, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Muscle Nerve 40:589-94. 2009
  4. pmc Architecture and fiber type of the pyramidalis muscle
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Anat Sci Int 83:294-7. 2008
  5. pmc Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments
    Richard M Lovering
    Department of Physiology, University of Maryland, Baltimore, 21201, USA
    Am J Physiol Cell Physiol 300:C803-13. 2011
  6. pmc Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling
    Richard M Lovering
    Univ of Maryland School of Medicine, Dept of Physiology, 685 W Baltimore St, HSF 1, RM, 580, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 297:C571-80. 2009
  7. ncbi request reprint Identification of skeletal muscle mutations in tail snips from neonatal mice using immunohistochemistry
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biotechniques 42:702, 704. 2007
  8. ncbi request reprint Recovery of function in skeletal muscle following 2 different contraction-induced injuries
    Richard M Lovering
    Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Arch Phys Med Rehabil 88:617-25. 2007
  9. ncbi request reprint Leptomeningeal plaques, a "common" finding
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Clin Anat 19:696-7. 2006
  10. ncbi request reprint The muscular dystrophies: from genes to therapies
    Richard M Lovering
    Department of Physiology, University of Maryland, School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    Phys Ther 85:1372-88. 2005

Collaborators

Detail Information

Publications35

  1. pmc Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo
    Joseph A Roche
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Neuroreport 19:1579-84. 2008
    ..Our data indicate that recovery of control muscles from injury primarily involves sarcolemmal repair whereas recovery of dysferlin-null muscles primarily involves myogenesis without repair and long-term survival of myofibers...
  2. doi request reprint Architecture of healthy and dystrophic muscles detected by optical coherence tomography
    Richard M Lovering
    University of Maryland School of Medicine, Department of Orthopaedics, 100 Penn Street, Baltimore, Maryland, USA
    Muscle Nerve 47:588-90. 2013
    ..Optical coherence tomography (OCT) is an emerging technology that can generate high resolution 1-10 μm cross-sectional imaging of tissue in vivo and in real time...
  3. pmc Location of myofiber damage in skeletal muscle after lengthening contractions
    Richard M Lovering
    Department of Physiology, School of Medicine, University of Maryland, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Muscle Nerve 40:589-94. 2009
    ..Results suggest that myofiber injury occurs primarily in the middle portion of the muscle, with interstitial edema in the middle and distal portions...
  4. pmc Architecture and fiber type of the pyramidalis muscle
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Anat Sci Int 83:294-7. 2008
    ..The results show that this is a muscle of mixed fiber type composition, similar to the rectus abdominus, and that the estimated forces generated by this muscle are relatively small...
  5. pmc Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments
    Richard M Lovering
    Department of Physiology, University of Maryland, Baltimore, 21201, USA
    Am J Physiol Cell Physiol 300:C803-13. 2011
    ..Our results suggest that keratin filaments containing K19- and desmin-based intermediate filaments can play independent, complementary, or antagonistic roles in the physiology and morphology of fast-twitch skeletal muscle...
  6. pmc Malformed mdx myofibers have normal cytoskeletal architecture yet altered EC coupling and stress-induced Ca2+ signaling
    Richard M Lovering
    Univ of Maryland School of Medicine, Dept of Physiology, 685 W Baltimore St, HSF 1, RM, 580, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 297:C571-80. 2009
    ..These malformations are not associated with gross disruptions in cytoskeletal or t-tubule structure; however, alterations in myofiber Ca(2+) signaling are evident...
  7. ncbi request reprint Identification of skeletal muscle mutations in tail snips from neonatal mice using immunohistochemistry
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biotechniques 42:702, 704. 2007
  8. ncbi request reprint Recovery of function in skeletal muscle following 2 different contraction-induced injuries
    Richard M Lovering
    Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Arch Phys Med Rehabil 88:617-25. 2007
    ..To determine if the proliferation of myogenic cells is equally important to recovery of contractile function after 2 different types of contraction-induced muscle injuries...
  9. ncbi request reprint Leptomeningeal plaques, a "common" finding
    Richard M Lovering
    Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
    Clin Anat 19:696-7. 2006
  10. ncbi request reprint The muscular dystrophies: from genes to therapies
    Richard M Lovering
    Department of Physiology, University of Maryland, School of Medicine, 685 W Baltimore St, Baltimore, MD 21201, USA
    Phys Ther 85:1372-88. 2005
    ..This perspective covers some of the basic molecular biological advances together with the clinical manifestations of the muscular dystrophies and the latest approaches to their management...
  11. pmc Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from contraction-induced injuries
    Joseph A Roche
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 298:C298-312. 2010
    ..Myogenesis to replace lost fibers does not appear to be significantly compromised in dysferlin-null mice...
  12. pmc Structural and functional evaluation of branched myofibers lacking intermediate filaments
    Mariah H Goodall
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, 21201, USA
    Am J Physiol Cell Physiol 303:C224-32. 2012
    ..Thus, there are complex roles for desmin-based and K19-based IFs in skeletal muscle, with the null and DKO mutations having different effects on Ca(2+) reuptake and myofiber branching...
  13. pmc Influences of desmin and keratin 19 on passive biomechanical properties of mouse skeletal muscle
    Sameer B Shah
    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA
    J Biomed Biotechnol 2012:704061. 2012
    ..This work provides additional insight into the influences of IFs on structure-function relationships in skeletal muscle. It may also have implications for understanding the progression of desminopathies and other IF-related myopathies...
  14. pmc Unmasking potential intracellular roles for dysferlin through improved immunolabeling methods
    Joseph A Roche
    Department of Physiology, University of Maryland School of Medicine, Baltimore, USA
    J Histochem Cytochem 59:964-75. 2011
    ..They suggest that dysferlin has an important function in the internal membrane systems of skeletal muscle, involved in calcium homeostasis and excitation-contraction coupling...
  15. ncbi request reprint Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization
    Michele R Stone
    Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Cell Sci 120:3999-4008. 2007
    ..This is the first demonstration of a mammalian phenotype associated with a genetic perturbation of keratin 19...
  16. pmc Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles
    Stephen J P Pratt
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Physiol 591:559-70. 2013
    ....
  17. pmc Use of autologous platelet-rich plasma to treat muscle strain injuries
    Jason W Hammond
    Union Memorial Hospital, Department of Orthopedic Surgery, Baltimore, Maryland, USA
    Am J Sports Med 37:1135-42. 2009
    ..Standard nonoperative therapy for acute muscle strains usually involves short-term rest, ice, and nonsteroidal anti-inflammatory medications, but there is no clear consensus on how to accelerate recovery...
  18. pmc S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle
    Benjamin L Prosser
    Center for Biomedical Engineering and Technology, University of Maryland, Baltimore, Maryland, USA
    Am J Physiol Cell Physiol 299:C891-902. 2010
    ..We conclude that the absence of S100A1 suppresses physiological AP-induced Ca(2+) release flux, resulting in impaired contractile activation and force production in skeletal muscle...
  19. ncbi request reprint Dexamethasone and recovery of contractile tension after a muscle injury
    Marc Hakim
    Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA
    Clin Orthop Relat Res 439:235-42. 2005
    ..The data indicate that one dose of dexamethasone administered soon after muscle strain may facilitate recovery of contractile tension without causing major adverse consequences in this experimental model...
  20. pmc Gait analysis of locomotory impairment in rats before and after neuromuscular injury
    Wenlong Tang
    Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    J Neurosci Methods 181:249-56. 2009
    ..Use of this technology should be valuable for monitoring the progression of a neuromuscular disease and the effects of therapeutic interventions...
  21. pmc An in vivo rodent model of contraction-induced injury in the quadriceps muscle
    Stephen J P Pratt
    University of Maryland School of Medicine, Department of Orthopaedics, Baltimore, MD, United States
    Injury 43:788-93. 2012
    ..A controlled muscle injury in the quadriceps also allows one to study a muscle, with mixed fibre types, which is extremely relevant to gait in humans and quadruped models...
  22. pmc Diffusion tensor MRI to assess damage in healthy and dystrophic skeletal muscle after lengthening contractions
    Alan B McMillan
    Department of Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Biomed Biotechnol 2011:970726. 2011
    ..The data suggest that DTI is an accurate indicator of muscle injury, even at early time points where the MR signal changes are dominated by local edema...
  23. ncbi request reprint Contractile function, sarcolemma integrity, and the loss of dystrophin after skeletal muscle eccentric contraction-induced injury
    Richard M Lovering
    Department of Physical Therapy and Rehabilitation Sciences, School of Medicine, University of Maryland, Baltimore 21201, USA
    Am J Physiol Cell Physiol 286:C230-8. 2004
    ..These data indicate the selective vulnerability of dystrophin after a single eccentric contraction-induced injury and suggest a critical role of dystrophin in force transduction...
  24. doi request reprint Changes in contraction-induced phosphorylation of AMP-activated protein kinase and mitogen-activated protein kinases in skeletal muscle after ovariectomy
    Lindsay M Wohlers
    Department of Kinesiology, School of Public Health, University of Maryland, College Park, Maryland 21045, USA
    J Cell Biochem 107:171-8. 2009
    ....
  25. ncbi request reprint The contribution of contractile pre-activation to loss of function after a single lengthening contraction
    Richard M Lovering
    Department of Physical Therapy and Rehabilitation Science, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    J Biomech 38:1501-7. 2005
    ..Our goal was to evaluate the contributions of angular velocity, arc of motion, and timing of contractile activation relative to the onset of joint motion in an animal model of muscle injury using a single lengthening contraction...
  26. pmc Use of BODIPY (493/503) to visualize intramuscular lipid droplets in skeletal muscle
    Espen E Spangenburg
    Department of Kinesiology, University of Maryland, School of Public Health, College Park, MD 20742, USA
    J Biomed Biotechnol 2011:598358. 2011
    ..We believe that the use of the BODIPY (493/503) dye is an acceptable alternative and, under certain conditions, a simpler method for visualizing LDs stored within skeletal muscle...
  27. pmc Genetic deletion of trkB.T1 increases neuromuscular function
    Susan G Dorsey
    University of Maryland Baltimore School of Nursing, Baltimore, Maryland 21201, USA
    Am J Physiol Cell Physiol 302:C141-53. 2012
    ..On the basis of these findings, we conclude that the trkB signaling pathway might represent a novel target for intervention across diseases characterized by deficits in neuromuscular function...
  28. pmc Determinants of the repeated-bout effect after lengthening contractions
    Dana M DiPasquale
    Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
    Am J Phys Med Rehabil 90:816-24. 2011
    ..We hypothesized that the RBE would occur soon after the initial injury and persist for several weeks and that the RBE would occur even if the second injury was performed under different biomechanical conditions than the first...
  29. pmc Early metabolic changes measured by 1H MRS in healthy and dystrophic muscle after injury
    Su Xu
    Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Appl Physiol 113:808-16. 2012
    ..These results show that it is possible to obtain meaningful in vivo (1)H MRS regarding skeletal muscle injury...
  30. ncbi request reprint Effect of testosterone on the female anterior cruciate ligament
    Richard M Lovering
    University of Maryland School of Medicine, Department of Physiology, 100 Penn St, Baltimore, MD 21201, USA
    Am J Physiol Regul Integr Comp Physiol 289:R15-22. 2005
    ..Instead, the relationship between T, FAI, and ACL stiffness was likely influenced by another hormone or sex hormone binding globulin...
  31. pmc Bex1 knock out mice show altered skeletal muscle regeneration
    Jae Hyung Koo
    Department of Anatomy and Neurobiology, School of Medicine, University of Maryland Baltimore, Baltimore, MD 21201, USA
    Biochem Biophys Res Commun 363:405-10. 2007
    ..Thus, our results provide the first evidence that Bex1-KO mice show altered muscle regeneration, and allow us to propose that the interaction of Bex1 with Ca(2+)/CaM may be involved in skeletal muscle regeneration...
  32. pmc Fiber type composition of cadaveric human rotator cuff muscles
    Richard M Lovering
    Department of Physiology, University of Maryalnd School of Medicine, Baltimore, MD 21201, USA
    J Orthop Sports Phys Ther 38:674-80. 2008
    ..Descriptive cadaveric laboratory study...
  33. pmc Evaluation and imaging of an untreated grade III hamstring tear: a case report
    Brett B Clark
    Department of Orthopaedics, University of Maryland School of Medicine, 100 Penn St, AHB, Rm 540, Baltimore, MD 21201, USA
    Clin Orthop Relat Res 469:3248-52. 2011
    ..The hamstring muscles are particularly susceptible as they cross two joints and regularly perform lengthening contractions during running. We describe a patient with return to full function after a large hamstring tear...
  34. ncbi request reprint Fiber length variability within the flexor carpi ulnaris and flexor carpi radialis muscles: implications for surgical tendon transfer
    Jan Friden
    Department of Hand Surgery, Sahlgrenska University Hospital, Goteborg, Sweden
    J Hand Surg Am 29:909-14. 2004
    ..The purpose of this study was to understand the detailed architectural properties of the human flexor carpi radialis (FCR) and flexor carpi ulnaris (FCU) muscles and their implications for tendon transfer surgery...
  35. ncbi request reprint Intermediate filament-like protein syncoilin in normal and myopathic striated muscle
    Karl J A McCullagh
    MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuromuscul Disord 17:970-9. 2007
    ..The data show that absence of alpha-dystrobrevin or desmin leads to dynamic changes in syncoilin that may compensate for, or participate in, different muscle myopathies...

Research Grants4

  1. The Role of Cytokeratins in Skeletal Muscle Injury
    RICHARD LOVERING; Fiscal Year: 2006
    ..The proposed research is designed to elucidate some of the shared cellular and molecular mechanisms. ..
  2. The Role of Intermediate Filaments in Skeletal Muscle Injury and Disease
    RICHARD LOVERING; Fiscal Year: 2007
    ..They should also elucidate some of the shared cellular and molecular mechanisms of muscle disease and of muscle injury, treatment, and recovery. ..
  3. Mechanisms of Force Loss in Injured and Dystrophic Skeletal Muscle
    Richard M Lovering; Fiscal Year: 2010
    ..There is keen interest in identifying specific pathological processes in order to develop rationale therapies, but also to use biological markers and outcome measures that can monitor the response to therapies. ..