Philip T LoVerde

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Presidential address. Sex and schistosomes: an interesting biological interplay with control implications
    Philip T LoVerde
    Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214, USA
    J Parasitol 88:3-13. 2002
  2. ncbi request reprint Molecular helminthology: an integrated approach
    Philip T LoVerde
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Am J Trop Med Hyg 66:346-7. 2002
  3. ncbi request reprint Schistosoma mansoni genome project: an update
    Philip T LoVerde
    Department of Microbiology and Immunology, State University of New York, Buffalo, NY 14214, USA
    Parasitol Int 53:183-92. 2004
  4. ncbi request reprint Vaccination with antioxidant enzymes confers protective immunity against challenge infection with Schistosoma mansoni
    Philip T LoVerde
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Mem Inst Oswaldo Cruz 99:37-43. 2004
  5. ncbi request reprint Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni
    Joelle M Carlo
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    FEBS J 274:4075-93. 2007
  6. ncbi request reprint DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:174-85. 2006
  7. ncbi request reprint SmTR2/4, a Schistosoma mansoni homologue of TR2/TR4 orphan nuclear receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Int J Parasitol 36:1113-22. 2006
  8. ncbi request reprint Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 148:31-43. 2006
  9. ncbi request reprint Identification and characterization of a novel fushi tarazu factor 1 (FTZ-F1) nuclear receptor in Schistosoma mansoni
    Changxue Lu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Research, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:25-36. 2006
  10. pmc Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:27. 2007

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Presidential address. Sex and schistosomes: an interesting biological interplay with control implications
    Philip T LoVerde
    Department of Microbiology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo 14214, USA
    J Parasitol 88:3-13. 2002
  2. ncbi request reprint Molecular helminthology: an integrated approach
    Philip T LoVerde
    School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 14214, USA
    Am J Trop Med Hyg 66:346-7. 2002
  3. ncbi request reprint Schistosoma mansoni genome project: an update
    Philip T LoVerde
    Department of Microbiology and Immunology, State University of New York, Buffalo, NY 14214, USA
    Parasitol Int 53:183-92. 2004
    ..Functional genomics is expected to accelerate the development of control and treatment strategies for schistosomiasis...
  4. ncbi request reprint Vaccination with antioxidant enzymes confers protective immunity against challenge infection with Schistosoma mansoni
    Philip T LoVerde
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14214, USA
    Mem Inst Oswaldo Cruz 99:37-43. 2004
    ..Our results serve as a basis for developing a subunit vaccine against schistosomiasis...
  5. ncbi request reprint Identification and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni
    Joelle M Carlo
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    FEBS J 274:4075-93. 2007
    ..In all, these data suggest the involvement of SmSmad1B in critical biological processes such as schistosome reproductive development...
  6. ncbi request reprint DNA binding and transactivation properties of the Schistosoma mansoni constitutive androstane receptor homologue
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:174-85. 2006
    ..We also demonstrate that a transcription activation function-1 (AF-1) is located in the SmCAR A/B domain...
  7. ncbi request reprint SmTR2/4, a Schistosoma mansoni homologue of TR2/TR4 orphan nuclear receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Int J Parasitol 36:1113-22. 2006
    ..A yeast-based transactivation assay demonstrated that the A/B domain, F domain and N-terminal part of the hinge region in SmTR2/4, when tethered to a GAL4 DNA binding domain, exhibited an autonomous transcription activation function...
  8. ncbi request reprint Isolation and characterization of Schistosoma mansoni constitutive androstane receptor
    Rong Hu
    Department of Microbiology and Immunology, School of Medicine, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 148:31-43. 2006
    ..The AGTGCA half site is essential for binding of SmCAR to the p14 gene upstream region. Therefore, AGTGCA probably serves as a high affinity binding half site for ESCKA containing nuclear receptors...
  9. ncbi request reprint Identification and characterization of a novel fushi tarazu factor 1 (FTZ-F1) nuclear receptor in Schistosoma mansoni
    Changxue Lu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Research, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:25-36. 2006
    ..Our results suggest that SmFTZ-F1alpha plays a role in regulating schistosome development and sexual differentiation similar to other FTZ-F1 family members...
  10. pmc Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:27. 2007
    ..NRs typically have a single DBD with a LBD...
  11. pmc Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    BMC Evol Biol 7:150. 2007
    ..Thyroid hormone receptors (TRs) function as molecular switches in response to thyroid hormone to regulate gene transcription. TRs were previously believed to be present only in chordates...
  12. pmc Cross-reactivity of Schistosoma mansoni cytosolic superoxide dismutase, a protective vaccine candidate, with host superoxide dismutase and identification of parasite-specific B epitopes
    Claudia Carvalho-Queiroz
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    Infect Immun 72:2635-47. 2004
    ..All together, these findings serve as a basis for developing a subunit vaccine against schistosomiasis...
  13. ncbi request reprint Identification and characterization of a nuclear receptor subfamily I member in the Platyhelminth Schistosoma mansoni (SmNR1)
    Wenjie Wu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY, USA
    FEBS J 274:390-405. 2007
    ..Transient transfection in mammalian COS-7 cells showed that SmNR1/SmRXR1 could enhance the transcriptional activation of a DR2-dependent reporter gene. Our results demonstrate that SmNR1 is a partner of SmRXR1...
  14. pmc Schistosoma mansoni TGF-beta receptor II: role in host ligand-induced regulation of a schistosome target gene
    Ahmed Osman
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA
    PLoS Pathog 2:e54. 2006
    ..The results also provide additional evidence for a role for the TGF-beta signaling pathway in male-induced female reproductive development...
  15. pmc Nucleic acid vaccination with Schistosoma mansoni antioxidant enzyme cytosolic superoxide dismutase and the structural protein filamin confers protection against the adult worm stage
    Rosemary M Cook
    Department of Microbiology and Immunology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, New York 14214, USA
    Infect Immun 72:6112-24. 2004
    ..Our results demonstrate that adult worms can be targeted for immune elimination through vaccination. This represents an advance in schistosome vaccinology and allows for the development of a therapeutic as well as a prophylactic vaccine...
  16. ncbi request reprint Characterization of the DNA-binding properties and the transactivation activity of Schistosoma mansoni nuclear receptor fushi tarazu-factor 1alpha (SmFTZ-F1alpha)
    Changxue Lu
    Department of Microbiology and Immunology, School of Medicine and Biomedical Research, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 150:72-82. 2006
    ..Taken together, our results suggest that SmFTZ-F1alpha possesses the characteristic DNA binding specificity of FTZ-F1 subfamily members and the capacity to transactivate a reporter gene...
  17. ncbi request reprint Protection against Schistosoma mansoni utilizing DNA vaccination with genes encoding Cu/Zn cytosolic superoxide dismutase, signal peptide-containing superoxide dismutase and glutathione peroxidase enzymes
    Kamal A Shalaby
    Department of Microbiology, and Immunology, School of Medicine and Biomedical Sciences, State University of New York, 138 Farber Hall, Buffalo, NY 14214, USA
    Vaccine 22:130-6. 2003
    ..GPX(bb) showed levels of protection (23-55%) higher than GPX(m) (25-34%). The prime-boost strategy gave the same results as naked DNA or recombinant vaccinia virus alone except in the case of GPX, where the protection was 85%...
  18. ncbi request reprint Schistosoma mansoni (Platyhelminthes, Trematoda) nuclear receptors: sixteen new members and a novel subfamily
    Wenjie Wu
    Department of Microbiology and Immunology, and Center for Microbial Pathogenesis, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Gene 366:303-15. 2006
    ..mansoni nuclear receptors evolved from a second gene duplication. As the second gene duplication of NRs was thought to be specific to vertebrates, our data challenge the current theory of NR evolution...
  19. ncbi request reprint Expression of functional Schistosoma mansoni Smad4: role in Erk-mediated transforming growth factor beta (TGF-beta) down-regulation
    Ahmed Osman
    Department of Microbiology and Immunology and Witebsky Center for Microbial Pathogenesis and Immunology, School of Medicine, State University of New York, Buffalo, New York 14214, USA
    J Biol Chem 279:6474-86. 2004
    ..SmSmad4 was shown to complement a human Smad4 deficiency through the restoration of TGF-beta-responsiveness in MDA-MB-468 breast cancer cells...
  20. ncbi request reprint Cloning of Schistosoma mansoni Seven in Absentia (SmSINA)(+) homologue cDNA, a gene involved in ubiquitination of SmRXR1 and SmRXR2
    Marcelo R Fantappie
    Department of Microbiology and Immunology, Witebsky Center for Microbial Pathogenesis and Immunology, School of Medicine and Biomedical Sciences, 138 Farber Hall, State University of New York, Buffalo, NY 14214, USA
    Mol Biochem Parasitol 131:45-54. 2003
    ..Our findings suggest that SmSINA regulates ubiquitination and ubiquitin-induced degradation of schistosome nuclear receptors (RXR1 and RXR2) via the ubiquitin-proteasome pathway...
  21. ncbi request reprint The Schistosoma mansoni gene index: gene discovery and biology by reconstruction and analysis of expressed gene sequences
    Joseph M Merrick
    Department of Microbiology, State University of New York, Buffalo, New York 14214, USA
    J Parasitol 89:261-9. 2003
    ..The utility of EST analysis is demonstrated by identifying new protease genes, which may be involved in hemoglobin degradation...
  22. pmc Nuclear hormone receptors in parasitic helminths
    Wenjie Wu
    Department of Biochemistry, School of Medicine and Biomedical Science, State University of New York, Buffalo, NY 14214, USA
    Mol Cell Endocrinol 334:56-66. 2011
    ..NRs in parasitic Nematoda follow the nematode evolutionary lineage with a feature of multiple duplication of SupNRs and gene loss...
  23. pmc Schistosoma mansoni: TGF-beta signaling pathways
    Philip T LoVerde
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Exp Parasitol 117:304-17. 2007
    ..Studies on signaling in schistosomes opens a new era for investigation of host-parasite and male-female interactions...
  24. ncbi request reprint Schistosoma mansoni genome: closing in on a final gene set
    Brian J Haas
    The J C Venter Institute, Rockville, MD 20850, USA
    Exp Parasitol 117:225-8. 2007
    ..mansoni and Schistosoma japonicum to define a comprehensive list of protein-coding genes...
  25. ncbi request reprint High levels of IgG4 to Schistosoma mansoni egg antigens in individuals with periportal fibrosis
    Alda M S Silveira
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal Minas Gerais, Belo Horizonte, Brazil
    Am J Trop Med Hyg 66:542-9. 2002
    ..This report demonstrates a specific humoral response in patients presenting with initial fibrosis, a form of schistosomiasis transient between intestinal and severe hepatosplenic...
  26. doi request reprint Schistosoma mansoni: SmE78, a nuclear receptor orthologue of Drosophila ecdysone-induced protein 78
    Wenjie Wu
    Southwest Foundation for Biomedical Research, P O Box 760549, San Antonio, TX 78245 0594, USA
    Exp Parasitol 119:313-8. 2008
    ..The result is consistent with the previous studies that Ecdysterone was effective in stimulating host location activities in miracidia. The data suggest that SmE78 may be involved in transduction of an ecdysone signal in S. mansoni...
  27. ncbi request reprint Schistosoma mansoni: Heterologous complementation of a yeast null mutant by SmRbx, a protein similar to a RING box protein involved in ubiquitination
    Débora N Santos
    Departamento de Bioquimica e Imunologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, Pampulha, Belo Horizonte, MG 31270 901, Brazil
    Exp Parasitol 116:440-9. 2007
    ..These results suggest that SmRbx protein is involved in the SCF complex formation...
  28. pmc Schistosoma mansoni: identification of SmNR4A, a member of nuclear receptor subfamily 4
    Wenjie Wu
    Departments of Biochemistry and Pathology, University of Texas Health Sciences Center, San Antonio, TX 78229 3800, USA
    Exp Parasitol 120:208-13. 2008
    ..The results demonstrated that SmNR4A expression was regulated throughout development. It was highly expressed in daughter sporocysts and 35-day worms, but barely expressed in cercariae and 1-h and 3-day schistosomules...
  29. ncbi request reprint Characterisation of a Rho homologue of Schistosoma mansoni
    Jon J Vermeire
    Department of Biological Sciences, Illinois State University, Normal, IL 61790 4120, USA
    Int J Parasitol 33:721-31. 2003
    ..mansoni including orthologues of Rho, Cdc42, and Rac. These data suggest that S. mansoni Rho1 plays a role in signalling in adult worms, especially females...
  30. ncbi request reprint Mapping of the complement C9 binding domain in paramyosin of the blood fluke Schistosoma mansoni
    Jiusheng Deng
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Int J Parasitol 37:67-75. 2007
    ..Taken together, this study has mapped the complement regulatory domain in Pmy, capable of binding to C8 and C9 and preventing polyC9 formation, to its C-terminal region...
  31. ncbi request reprint Advances in schistosome genomics
    Najib M A El-Sayed
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Trends Parasitol 20:154-7. 2004
  32. ncbi request reprint Human schistosomiasis mansoni: intensity of infection differentially affects the production of interleukin-10, interferon-gamma and interleukin-13 by soluble egg antigen or adult worm antigen stimulated cultures
    Alda M S Silveira
    Laboratorio de Imunologia, Faculdade de Ciências da Saúde Universidade Vale do Rio Doce, Governador Valadares, Brazil
    Trans R Soc Trop Med Hyg 98:514-9. 2004
    ..mansoni infection, shifting the immune response from Th0 in egg-negative individuals from an endemic area to a Th2 polarization in chronic infected individuals...
  33. ncbi request reprint The spatial distribution of Schistosoma mansoni infection before and after chemotherapy in the Jequitinhonha Valley in Brazil
    Andrea Gazzinelli
    Escola de Enfermagem, Universidade Federal de Minas Gerais, 30130 100 Belo Horizonte, MG, Brazil
    Mem Inst Oswaldo Cruz 101:63-71. 2006
    ..These results are consistent with the production and antiparasitic effect of high levels of IgE in Schistosoma mansoni infection...
  34. doi request reprint A unique nuclear receptor direct repeat 17 (DR17) is present within the upstream region of Schistosoma mansoni female-specific p14 gene
    Marcelo Rosado Fantappié
    Instituto de Bioquimica Medica, Programa de Biotecnologia e Biologia Molecular, Universidade Federal do Rio de Janeiro, CCS, Ilha do Fundao, Rio de Janeiro 21941 590, Brazil
    Biochem Biophys Res Commun 371:689-93. 2008
    ..This finding supports our hypothesis that the expression of Schistosoma mansonip14 gene is regulated through the nuclear receptor signaling pathway...
  35. ncbi request reprint Exposure to Schistosoma mansoni infection in a rural area in Brazil. Part III: household aggregation of water-contact behaviour
    Jeffrey Bethony
    Department of Microbiology and Tropical Medicine, The George Washington University Medical Center, Washington, DC 20037, USA
    Trop Med Int Health 9:381-9. 2004
    ..Our results also support a focus on the household in the implementation of schistosomiasis prevention and control efforts...
  36. ncbi request reprint Cytological and biochemical evidence for a gonad-preferential interplay of SmFKBP12 and SmTbetaR-I in Schistosoma mansoni
    Jürgen Knobloch
    Institut fur Genetik, Genetische Parasitologie und Biologisch Medizinisches Forschungszentrum, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Mol Biochem Parasitol 138:227-36. 2004
    ..From these data we conclude an SmFKBP12/SmTbetaR-I, but not an SmCN/SmFKBP12 interplay in the female gonads...
  37. ncbi request reprint Production of calcium-mobilizing metabolites by a novel member of the ADP-ribosyl cyclase family expressed in Schistosoma mansoni
    Stephen P Goodrich
    Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, New York 12983, USA
    Biochemistry 44:11082-97. 2005
    ..Alternatively, the function of NACE may be to catabolize extracellular NAD(+) to prevent its use by host enzymes that utilize this source of NAD(+) to facilitate immune responses...
  38. pmc Inhibition of the complement membrane attack complex by Schistosoma mansoni paramyosin
    Jiusheng Deng
    Departments of Human Microbiology Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Infect Immun 71:6402-10. 2003
    ..Taken together, these findings suggest that an exogenous form of S. mansoni paramyosin inhibits activation of the terminal pathway of complement and thus has an important immunomodulatory role in schistosomiasis...
  39. pmc Socioeconomic determinants of schistosomiasis in a poor rural area in Brazil
    Andrea Gazzinelli
    Nursing School, Escola de Enfermagem, Universidade Federal de Minas Gerais, Av Alfredo Balena 190, Belo Horizonte 30 130 100, MG, Brazil
    Acta Trop 99:260-71. 2006
    ..The potential role of socioeconomic development in conjunction with schistosomiasis control is described and areas for further studies are identified...