MARK ANTHONY LOVELL

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Protection against amyloid beta peptide toxicity by zinc
    M A Lovell
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    Brain Res 823:88-95. 1999
  2. ncbi request reprint Decreased base excision repair and increased helicase activity in Alzheimer's disease brain
    M A Lovell
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 101 Sanders Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Brain Res 855:116-23. 2000
  3. ncbi request reprint Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain
    M A Lovell
    Sanders Brown Center on Aging, Departments of Chemistry, Neurology, and Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Free Radic Biol Med 28:418-27. 2000
  4. ncbi request reprint Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid
    M A Lovell
    University of Kentucky, Department of Chemistry, Sanders Brown Center on Aging, 101 Sanders Brown Bldg, 800 S Limestone St, Lexington, KY 40536 0230, USA
    Arch Neurol 58:392-6. 2001
  5. ncbi request reprint Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease
    Mark A Lovell
    From the Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 101 Sanders Brown Bldg, University of Kentucky, Lexington 40536 0230, USA
    Neurobiol Aging 23:179-86. 2002
  6. ncbi request reprint Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid
    Mark A Lovell
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 5:229-39. 2003
  7. ncbi request reprint Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease
    Mark A Lovell
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 983:84-96. 2003
  8. ncbi request reprint Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain
    Mark A Lovell
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 800 S Limestone St, 101 Sanders Brown Bldg, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurobiol Aging 27:909-17. 2006

Research Grants

Detail Information

Publications8

  1. ncbi request reprint Protection against amyloid beta peptide toxicity by zinc
    M A Lovell
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    Brain Res 823:88-95. 1999
    ..Together, these data suggest that Zn functions as a double-edged sword, affording protection against Abeta at low concentrations and enhancing toxicity at high concentrations...
  2. ncbi request reprint Decreased base excision repair and increased helicase activity in Alzheimer's disease brain
    M A Lovell
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 101 Sanders Brown Building, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536 0230, USA
    Brain Res 855:116-23. 2000
    ..The modest increase in DNA helicase activity in some brain regions in AD may interfere with base excision repair mechanisms. Overall, the decreased repair of DNA damage could be involved in the pathogenesis of neurodegeneration in AD...
  3. ncbi request reprint Decreased thioredoxin and increased thioredoxin reductase levels in Alzheimer's disease brain
    M A Lovell
    Sanders Brown Center on Aging, Departments of Chemistry, Neurology, and Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Free Radic Biol Med 28:418-27. 2000
    ..This decrease in the antioxidant Trx-TR system may contribute to the increased oxidative stress and subsequent neurodegeneration observed in the brain in AD...
  4. ncbi request reprint Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid
    M A Lovell
    University of Kentucky, Department of Chemistry, Sanders Brown Center on Aging, 101 Sanders Brown Bldg, 800 S Limestone St, Lexington, KY 40536 0230, USA
    Arch Neurol 58:392-6. 2001
    ....
  5. ncbi request reprint Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease
    Mark A Lovell
    From the Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 101 Sanders Brown Bldg, University of Kentucky, Lexington 40536 0230, USA
    Neurobiol Aging 23:179-86. 2002
    ..In addition, the data show that these structures, once formed, have a much slower carbon turnover rate than normal brain and are not in a formation/enzymatic degradation equilibrium...
  6. ncbi request reprint Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid
    Mark A Lovell
    Sanders Brown Center on Aging, University of Kentucky, 800 S Limestone St, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 5:229-39. 2003
    ....
  7. ncbi request reprint Wilms' tumor suppressor (WT1) is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer's disease
    Mark A Lovell
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 983:84-96. 2003
    ..Together, these data suggest a role for WT1 in the neurodegeneration observed in AD brain...
  8. ncbi request reprint Isolation of neural precursor cells from Alzheimer's disease and aged control postmortem brain
    Mark A Lovell
    Sanders Brown Center on Aging and Alzheimer s Disease Research Center, 800 S Limestone St, 101 Sanders Brown Bldg, University of Kentucky, Lexington, KY 40536 0230, USA
    Neurobiol Aging 27:909-17. 2006
    ..These results raise the possibility of stimulation of inherent precursor cells of aged individuals or AD patients to replace neurons lost in aging and/or neurodegeneration...

Research Grants2

  1. Development of a Diagnostic Test for Alzheimer's Disease
    Mark Lovell; Fiscal Year: 2007
    ..This protein-protein complex is a sensitive and specific biomarker of AD including early stages of AD (mild cognitive impairment) when therapeutic interventions are most likely to have beneficial effects. ..