Xuelin Lou


Affiliation: University of Wisconsin
Country: USA


  1. Ji C, Zhang Y, Xu P, Xu T, Lou X. Nanoscale Landscape of Phosphoinositides Revealed by Specific Pleckstrin Homology (PH) Domains Using Single-molecule Superresolution Imaging in the Plasma Membrane. J Biol Chem. 2015;290:26978-93 pubmed publisher
    ..These data reveal the nanoscale landscape of key inositol phospholipids in the native PM and imply a framework for local cellular signaling and lipid-protein interactions at a nanometer scale. ..
  2. Ji C, Lou X. Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes. J Vis Exp. 2016;: pubmed publisher
  3. Lou X, Fan F, Messa M, Raimondi A, Wu Y, Looger L, et al. Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses. Proc Natl Acad Sci U S A. 2012;109:E515-23 pubmed publisher
  4. Mahapatra S, Fan F, Lou X. Tissue-specific dynamin-1 deletion at the calyx of Held decreases short-term depression through a mechanism distinct from vesicle resupply. Proc Natl Acad Sci U S A. 2016;113:E3150-8 pubmed publisher
    ..This role comes into play primarily during brief high-frequency stimulation. ..
  5. Ji C, Fan F, Lou X. Vesicle Docking Is a Key Target of Local PI(4,5)P2 Metabolism in the Secretory Pathway of INS-1 Cells. Cell Rep. 2017;20:1409-1421 pubmed publisher
    ..Thus, different spatiotemporal PI(4,5)P2 signaling regulates distinct steps of vesicle trafficking, and vesicle docking may be a key target of local PI(4,5)P2 signaling in vivo. ..
  6. Fan F, Funk L, Lou X. Dynamin 1- and 3-Mediated Endocytosis Is Essential for the Development of a Large Central Synapse In Vivo. J Neurosci. 2016;36:6097-115 pubmed publisher
    ..This study highlights the important role of dynamin-mediated endocytosis in the development of central synapses in the mammalian brain. ..