Michael T Lotze

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011
  2. ncbi Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
  3. ncbi Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
    Therese Ostberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, 171 176 Stockholm, Sweden
    Arthritis Res Ther 10:R1. 2008
  4. ncbi Identifying biomarkers and surrogates of tumors (cancer biometrics): correlation with immunotherapies and immune cells
    Michael T Lotze
    Translational Research, University of Pittsburgh Molecular Medicine Institute, 300 Technology Drive, Rm 411, Pittsburgh, PA 15219, USA
    Cancer Immunol Immunother 53:256-61. 2004
  5. ncbi High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
    Michael T Lotze
    University of Pittsburgh School of Medicine, Room 411, 300 Technology Drive, Pittsburgh, Pennsylvania 15219, USA
    Nat Rev Immunol 5:331-42. 2005
  6. ncbi The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity
    Michael T Lotze
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Immunol Rev 220:60-81. 2007
  7. ncbi High-mobility group box 1, oxidative stress, and disease
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Antioxid Redox Signal 14:1315-35. 2011
  8. ncbi A primer on cancer immunology and immunotherapy
    Michael T Lotze
    Molecular Medicine Institute, 300 Technology Drive, PA 15219, Pittsburgh, USA
    Cancer Immunol Immunother 53:135-8. 2004
  9. ncbi Ethyl pyruvate administration inhibits hepatic tumor growth
    Xiaoyan Liang
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Leukoc Biol 86:599-607. 2009
  10. ncbi In vivo expansion of two distinct dendritic cells in mouse livers and its impact on liver immune regulation
    Yalan Wang
    Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Liver Transpl 12:1850-61. 2006

Detail Information

Publications96

  1. ncbi Defining the critical hurdles in cancer immunotherapy
    Bernard A Fox
    Earle A, Chiles Research Institute, Robert W, Franz Research Center, Providence Cancer Center, Providence Portland Medical Center, Portland, OR, USA
    J Transl Med 9:214. 2011
    ..Each of these hurdles can significantly delay clinical translation of promising advances in immunotherapy yet if overcome, have the potential to improve outcomes of patients with cancer...
  2. ncbi Emerging concepts in biomarker discovery; the US-Japan Workshop on Immunological Molecular Markers in Oncology
    Hideaki Tahara
    Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    J Transl Med 7:45. 2009
    ..The institution of an interactive consortium for high throughput molecular monitoring of clinical trials with voluntary participation might provide cost-effective solutions...
  3. ncbi Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis
    Therese Ostberg
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, 171 176 Stockholm, Sweden
    Arthritis Res Ther 10:R1. 2008
    ..In the present study we asked whether nuclear sequestration of HMGB1 preventing HMGB1 release would be beneficial for synovitis treatment...
  4. ncbi Identifying biomarkers and surrogates of tumors (cancer biometrics): correlation with immunotherapies and immune cells
    Michael T Lotze
    Translational Research, University of Pittsburgh Molecular Medicine Institute, 300 Technology Drive, Rm 411, Pittsburgh, PA 15219, USA
    Cancer Immunol Immunother 53:256-61. 2004
    ..The ability to integrate these rapidly evolving strategies will consume much of our coordinate effort in cancer and cancer therapeutics for the near future...
  5. ncbi High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
    Michael T Lotze
    University of Pittsburgh School of Medicine, Room 411, 300 Technology Drive, Pittsburgh, Pennsylvania 15219, USA
    Nat Rev Immunol 5:331-42. 2005
    ..Here, we discuss these features of HMGB1 and summarize recent advances that have led to the preclinical development of therapeutics that modulate HMGB1 release and activity...
  6. ncbi The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity
    Michael T Lotze
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Immunol Rev 220:60-81. 2007
    ....
  7. ncbi High-mobility group box 1, oxidative stress, and disease
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    Antioxid Redox Signal 14:1315-35. 2011
    ....
  8. ncbi A primer on cancer immunology and immunotherapy
    Michael T Lotze
    Molecular Medicine Institute, 300 Technology Drive, PA 15219, Pittsburgh, USA
    Cancer Immunol Immunother 53:135-8. 2004
    ....
  9. ncbi Ethyl pyruvate administration inhibits hepatic tumor growth
    Xiaoyan Liang
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Leukoc Biol 86:599-607. 2009
    ..EP administration may have a therapeutic role in the treatment of cancer in conjunction with other therapeutic agents...
  10. ncbi In vivo expansion of two distinct dendritic cells in mouse livers and its impact on liver immune regulation
    Yalan Wang
    Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Liver Transpl 12:1850-61. 2006
    ..TLR 9 ligation stimulated very high IL-12 in CD11c(+) DC, but high IL-10 and no IL-12 in B220(+) DC. In conclusion, through these mechanisms, liver DC may be actively involved in immune regulation in the liver...
  11. ncbi Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury
    Allan Tsung
    Department of Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Presbyterian Hospital F1200, Pittsburgh, PA 15213, USA
    J Leukoc Biol 81:119-28. 2007
    ..It thus appears that functional TLR4 on DC is required for I/R-induced injury. Furthermore, HMGB1 may direct the inflammatory responses mediated by DC, at least in part, by enhancing TLR4 expression and reactivity to it and other DAMPs...
  12. ncbi Cutting edge: high-mobility group box 1 preconditioning protects against liver ischemia-reperfusion injury
    Kunihiko Izuishi
    Department of Surgery, University of Pittsburgh, PA 15213, USA
    J Immunol 176:7154-8. 2006
    ..Our studies demonstrate that in contrast to the role of HMGB1 as an early mediator of inflammation and organ damage in hepatic I/R, HMGB1 preconditioning can be protective...
  13. ncbi High mobility group box I (HMGB1) release from tumor cells after treatment: implications for development of targeted chemoimmunotherapy
    Xiang Da Eric Dong
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh, PA 15232, USA
    J Immunother 30:596-606. 2007
    ....
  14. ncbi Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis
    SHAIVAL H DAVE
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Leukoc Biol 86:633-43. 2009
    ..Ethyl pyruvate and other strategies to inhibit HMGB1 release and function represent promising interventions in chronic inflammatory diseases...
  15. ncbi miR-17-92 expression in differentiated T cells - implications for cancer immunotherapy
    Kotaro Sasaki
    Department of Immunology, University of Pittsburgh School of Medicine, PA 15213, USA
    J Transl Med 8:17. 2010
    ..We identified miRs differentially regulated between type-1 and type-2 T cells, and determined how the expression of such miRs is regulated...
  16. ncbi Endogenous HMGB1 regulates autophagy
    Daolin Tang
    Damage Associated Molecular Pattern Molecule Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Cell Biol 190:881-92. 2010
    ..Thus, endogenous HMGB1 is a critical pro-autophagic protein that enhances cell survival and limits programmed apoptotic cell death...
  17. ncbi Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice
    Yuji Satoh
    Biologic Therapeutics Program, University of Pittsburgh Cancer Institute, 5725 CHP-MT, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Exp Ther Oncol 2:337-49. 2002
    ..Simultaneous local gene therapy with IL-12 will further improve clinical efficacy without placing the patient at risk for systemic toxicity...
  18. ncbi High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists
    Petar J Popovic
    Division of Surgical Oncology, Department of Surgery and Molecular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15232, USA
    J Immunol 177:8701-7. 2006
    ..Our observations suggest that HMGB1 may play a critical role in regulating the immune response during chronic inflammation and tissue damage through modulation of PDC function...
  19. ncbi The expression of the receptor for advanced glycation endproducts (RAGE) is permissive for early pancreatic neoplasia
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 109:7031-6. 2012
    ..Our results suggest a critical role for RAGE expression in the earliest stages of pancreatic carcinogenesis, potentially acting as the "autophagic switch," regulating mitochondrial STAT3 signaling...
  20. ncbi Metabolic regulation by HMGB1-mediated autophagy and mitophagy
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:1256-8. 2011
    ..These findings reveal a novel pathway coupling autophagy and cellular energy metabolism...
  21. ncbi Cytolytic cells induce HMGB1 release from melanoma cell lines
    Norimasa Ito
    Department of Surgery, University of Pittsburgh School of Medicine, Hillman Cancer Center, 5117 Centre Avenue, Room G 21, Pittsburgh, PA 15213, USA
    J Leukoc Biol 81:75-83. 2007
    ..Specifically, HMGB1 may promote healing or immune reactivity, depending on the nature of the local inflammatory response and the presence (or absence) of immune effectors...
  22. ncbi The Receptor for Advanced Glycation End-products (RAGE) protects pancreatic tumor cells against oxidative injury
    Rui Kang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2175-84. 2011
    ..Taken together, these results suggest that RAGE is an important regulator of oxidative injury...
  23. ncbi Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18
    Wataru Hashimoto
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Int J Cancer 103:508-13. 2003
    ..These results are consistent with the notion that NK cells, but not NKT cells, are the major effectors in IL-18-induced innate immunity...
  24. ncbi Imaging analysis of STAT1 and NF-kappaB translocation in dendritic cells at the single cell level
    Jukka Vakkila
    Molecular Medicine Institute, University of Pittsburgh, 300 Technology Drive, Pittsburgh, PA 15219, USA
    J Immunol Methods 294:123-34. 2004
    ..Imaging analysis is a method that could be valuable for quality control of cell therapy preparations...
  25. ncbi High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases
    Wei Yan
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Hepatology 55:1863-75. 2012
    ....
  26. ncbi Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression
    Xiaoyan Liang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    Cancer Res 72:2791-801. 2012
    ..Taken together, our findings provide a novel clinical strategy to enhance the efficacy of HDIL-2 immunotherapy for patients with cancer...
  27. ncbi High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress
    Daolin Tang
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Antioxid Redox Signal 15:2185-95. 2011
    ..Autophagy, the process by which cells break down spent biochemical and damaged components, plays an important role in cell survival following stress. High mobility group box 1 (HMGB1) regulates autophagy in response to oxidative stress...
  28. ncbi High-mobility group box 1 is essential for mitochondrial quality control
    Daolin Tang
    Department of Surgery, G 27A Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15219, USA
    Cell Metab 13:701-11. 2011
    ..Our findings reveal an essential role for HMGB1 in autophagic surveillance with important effects on mitochondrial quality control...
  29. ncbi Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity
    Wentao Gao
    Department of Molecular Genetics, University of Pittsburgh, PA 15219, USA
    J Immunol 170:107-13. 2003
    ..These results suggest that IL-1H4 could play an important role in the link between innate and adaptive immunity and may be useful for tumor immunotherapy...
  30. ncbi Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 175:7661-8. 2005
    ..Together, these results demonstrate that TLR4 engagement on actively phagocytic nonparenchymal cells such as Kupffer cells is required for warm I/R-induced injury and inflammation in the liver...
  31. ncbi Biological activities of cytokine-neutralizing hyaluronic acid-antibody conjugates
    Liang Tso Sun
    Department of Biomedical Engineering, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Wound Repair Regen 18:302-10. 2010
    ..Covalent attachment of cytokine-neutralizing antibodies to matrix-forming polymers could lead to the development of materials capable of locally regulating wound healing and inflammatory responses in the setting of tissue regeneration...
  32. ncbi Natural killer-dendritic cell cross-talk in cancer immunotherapy
    Pawel Kalinski
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Expert Opin Biol Ther 5:1303-15. 2005
    ..Stage I/II clinical trials that are being implemented at present should allow evaluation of the immunological and clinical efficacy of combined NK-DC therapy of melanoma and other cancers...
  33. ncbi Systemic inflammation and remote organ injury following trauma require HMGB1
    Ryan M Levy
    Dept of Surgery, F 1200 PUH, Univ of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1538-44. 2007
    ..Collectively, these data demonstrate a critical role for a TLR4-HMGB1 pathway in the initiation of systemic inflammation and end-organ injury following isolated peripheral tissue injury...
  34. ncbi Helper activity of natural killer cells during the dendritic cell-mediated induction of melanoma-specific cytotoxic T cells
    Jeffrey L Wong
    Department of Surgery, University of Pittsburgh, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 1863, USA
    J Immunother 34:270-8. 2011
    ..These results indicate that the helper function of NK cells can be used in clinical settings to improve the effectiveness of DC-based cancer vaccines...
  35. ncbi Direct molecular interactions between HMGB1 and TP53 in colorectal cancer
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
    Autophagy 8:846-8. 2012
    ..Thus, HMGB1 and TP53 are critical in the cross-regulation of apoptosis and autophagy and central to colon cancer biology...
  36. ncbi The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
    ..Together, these results demonstrate that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process...
  37. ncbi Combined treatment with interleukin-18 and low-dose interleukin-2 induced regression of a murine sarcoma and memory response
    Young Ik Son
    Department of Surgery and Division of Biologic Therapeutics, University of Pittsburgh Cancer Institute, Pennsylvania, USA
    J Immunother 26:234-40. 2003
    ....
  38. ncbi Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1
    Richard A DeMarco
    Department of Surgery, Molecular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Mol Immunol 42:433-44. 2005
    ..The implications for tumorigenesis and tumor progression are quite important as they may be for other states of chronic inflammation...
  39. ncbi Masquerader: high mobility group box-1 and cancer
    Jessica E Ellerman
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 13:2836-48. 2007
    ..This review focuses on current knowledge and speculation on the role of HMGB1 in the development of cancer, metastasis, and potential targets for therapy...
  40. ncbi Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models
    Toru Kitagawa
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Gene Med 5:958-65. 2003
    ..CONCLUSIONS: Particle-mediated transfection is a useful non-viral transfection method in a system which does not require high-level gene expression for a prolonged time of period...
  41. ncbi p53/HMGB1 complexes regulate autophagy and apoptosis
    Kristen M Livesey
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 72:1996-2005. 2012
    ..These insights provide a novel link between HMGB1 and p53 in the cross-regulation of apoptosis and autophagy in the setting of cell stress, providing insights into their reciprocal roles in carcinogenesis...
  42. ncbi RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation
    Louis J Sparvero
    Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, Pittsburgh, USA
    J Transl Med 7:17. 2009
    ..Understanding the molecular structure and function of it and its ligands in the setting of inflammation is critically important in understanding the role of this receptor in tumor biology...
  43. ncbi Dicer-regulated microRNAs 222 and 339 promote resistance of cancer cells to cytotoxic T-lymphocytes by down-regulation of ICAM-1
    Ryo Ueda
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 106:10746-51. 2009
    ..This study suggests development of novel miR-targeted therapy to promote cytolysis of tumor cells...
  44. ncbi Low-dose cisplatin administration in murine cecal ligation and puncture prevents the systemic release of HMGB1 and attenuates lethality
    Pinhua Pan
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Leukoc Biol 86:625-32. 2009
    ..Platinating agents in general and Cis specifically may be a novel approach to the treatment of sepsis...
  45. ncbi Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health
    Michael T Lotze
    Translational Research, University of Pittsburgh Molecular Medicine Institute, Pittsburgh, Pennsylvania, USA
    J Immunother (1997) 28:79-119. 2005
    ..Concrete recommendations for current application and enabling further development in cancer biometrics are summarized. This will allow a more informed, rapid, and accurate assessment of novel cancer therapies...
  46. ncbi RAGE regulates autophagy and apoptosis following oxidative injury
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 7:442-4. 2011
    ..These findings provide insight into how crosstalk between apoptosis and autophagy is mediated via ROS signaling with a process involving RAGE...
  47. ncbi Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells
    Masatoshi Eto
    Department of Surgery/Division of Surgical Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    Int J Urol 13:148-56. 2006
    ..Our results also show that the increase in intracellular ceramide strongly correlates with apoptosis induced by serum deprivation even in androgen-independent prostate cancer cell lines...
  48. ncbi Successful simultaneous measurement of cell membrane and cytokine induced phosphorylation pathways [CIPP] in human peripheral blood mononuclear cells
    David T Montag
    Department of Bioengineering, University of Pittsburgh, PA 15219, USA
    J Immunol Methods 313:48-60. 2006
    ..This method enables the rapid functional analysis of subsets within complex cell mixtures and provides an opportunity for assessing abnormalities arising in the setting of acute or chronic inflammatory states...
  49. ncbi High-mobility group box 1 and cancer
    Daolin Tang
    The DAMP Laboratory, Department of Surgery, G 27 Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Ave, Pittsburgh, PA 15213, USA
    Biochim Biophys Acta 1799:131-40. 2010
    ..Here, we focus on the role of HMGB1 in cancer, the mechanisms by which it contributes to carcinogenesis, and therapeutic strategies based on targeting HMGB1...
  50. ncbi AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway
    Rui Kang
    The DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Autophagy 8:989-91. 2012
    ..Thus, AGER is an important inflammatory mediator that modulates crosstalk between prosurvival pathways, IL6-pSTAT3 and autophagy, in PDA tumor cells, and contributes to early PanIN formation...
  51. ncbi Focus on FOCIS: interleukin 2 treatment associated autoimmunity
    Stergios J Moschos
    University of Pittsburgh Federation of Clinical Immunologic Societies Center of Excellence, Pittsburgh, Pennsylvania 15213 1683, USA
    Clin Immunol 127:123-9. 2008
    ..We present studies investigating the mechanisms for the therapeutic benefit of HDIL2 in melanoma...
  52. ncbi Addicted to death: invasive cancer and the immune response to unscheduled cell death
    Herbert J Zeh
    University of Pittsburgh School of Medicine Institute, Room 411, 300 Technology Drive, Pittsburgh, PA 15219, USA
    J Immunother (1997) 28:1-9. 2005
    ..quot; This new understanding could inform and drive the development of more effective biologic therapies for patients with cancer...
  53. ncbi Evidence of the capability of the CMV enhancer to activate in trans gene expression in mammalian cells
    Leonardo D'Aiuto
    Department of Surgery, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15219, USA
    DNA Cell Biol 25:171-80. 2006
    ..These findings may have implications in understanding the processes that underlie gene therapy because of the potential alteration of endogenous gene expression...
  54. ncbi HMGB1 as an autophagy sensor in oxidative stress
    Rui Kang
    DAMP Laboratory, Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Autophagy 7:904-6. 2011
    ..These findings provide insight into how HMGB1, a damage associated molecular pattern (DAMP), triggers autophagy as defense mechanism under conditions of cellular stress...
  55. ncbi Cell-mediated autophagy promotes cancer cell survival
    William J Buchser
    Department of Surgery, Graduate School of Public Health, University of Pittsburgh and Biostatistics Facility, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15232, USA
    Cancer Res 72:2970-9. 2012
    ..Our findings therefore show that the lymphocyte-induced cell-mediated autophagy promotes cancer cell survival and may represent an important target for development of novel therapies...
  56. ncbi Synergistic interleukin-18 and low-dose interleukin-2 promote regression of established murine neuroblastoma in vivo
    Richard E Redlinger
    Department of Surgery, University of Pittsburgh School of Medicine, Division of Pediatric Surgery, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213-2583, USA
    J Pediatr Surg 38:301-7; discussion 301-7. 2003
    ..However, dendritic cell vaccination combined with IL-2 plus IL-18 cytokine treatment did allow for the establishment of a complete and durable antitumor response...
  57. ncbi MicroRNAs in immune regulation--opportunities for cancer immunotherapy
    Hideho Okada
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Int J Biochem Cell Biol 42:1256-61. 2010
    ..We have also demonstrated that the ability of tumors to serve as targets for cytolytic effectors is regulated by miR-222 and miR-339...
  58. ncbi Pharmacologic administration of interleukin-2
    Antonio Romo de Vivar Chavez
    University of Pittsburgh Cancer Institute, Pennsylvania, USA
    Ann N Y Acad Sci 1182:14-27. 2009
    ..The possible role of autophagy inhibitors to enhance efficacy and limit toxicity as well as possible problems with this approach are considered...
  59. ncbi Rapid flow cytometric measurement of cytokine-induced phosphorylation pathways [CIPP] in human peripheral blood leukocytes
    David T Montag
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15232, USA
    Clin Immunol 121:215-26. 2006
    ....
  60. ncbi Mechanistic insights into achievement of cardiac allograft long-term survival by treatment with immature dendritic cells and sub-dose sirolimus
    Ran Tao
    Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Heart Lung Transplant 25:310-9. 2006
    ..CONCLUSIONS: Sirolimus enhances immature DC tolerogenicity by induction of T-cell apoptosis, and promotes immature DC-induced inhibition of Stat1, ERK and ATF-2 activation...
  61. ncbi Damage associated molecular pattern molecule-induced microRNAs (DAMPmiRs) in human peripheral blood mononuclear cells
    Sebnem Unlu
    Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e38899. 2012
    ..Our findings demonstrate that a specific microRNA expression signature is associated with the inflammatory response to damaged/injured cells and carries implications for many acute and chronic inflammatory disorders...
  62. ncbi Pediatric cancers are infiltrated predominantly by macrophages and contain a paucity of dendritic cells: a major nosologic difference with adult tumors
    Jukka Vakkila
    Molecular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Cancer Res 12:2049-54. 2006
    ..We hypothesized that the difference could be reflected in the inflammatory cell infiltrates of pediatric and adult cancer...
  63. ncbi Autophagy inhibition in combination cancer treatment
    Kristen M Livesey
    University of Pittsburgh, G 27A Hillman Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Curr Opin Investig Drugs 10:1269-79. 2009
    ..Screening for new agents is ongoing, which, coupled with conventional chemotherapeutic compounds, may usher in a new generation of autophagy-inhibiting agents...
  64. ncbi The biology of interleukin-2 efficacy in the treatment of patients with renal cell carcinoma
    Antonio Romo de Vivar Chavez
    Department of Surgery, University of Pittsburgh, G 27A Hillman Cancer Center 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Med Oncol 26:3-12. 2009
    ..At best, we can only speculate that the disturbed homeostatic host/tumor interaction is reset in a small subset of patients allowing an antitumor response to recover or ensue...
  65. ncbi The enhanced tumor selectivity of an oncolytic vaccinia lacking the host range and antiapoptosis genes SPI-1 and SPI-2
    Z Sheng Guo
    Division of Surgical Oncology, University of Pittsburgh Cancer Institute, PA 15232, USA
    Cancer Res 65:9991-8. 2005
    ..Given its enhanced tumor selectivity, improved safety profile, and substantial oncolytic effects following systemic delivery in murine models, it should also serve as a useful vector for tumor-directed gene therapy...
  66. ncbi Murine dendritic cell-induced tumor apoptosis is partially mediated by nitric oxide
    Hiromune Shimamura
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, U.S.A
    J Immunother (1997) 25:226-34. 2002
    ..Therefore, the authors' data demonstrate a novel mechanism for DC-induced tumor-cell apoptosis that does not require DC-tumor cell contact and is partially mediated by nitric oxide...
  67. ncbi C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells
    Masatoshi Eto
    Department of Surgery/Division of Biological Therapeutics, University of Pittsburgh School of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15219, USA
    Prostate 57:66-79. 2003
    ..Neither apoptosis nor an increase in C16 ceramide was observed in androgen-independent cell lines following androgen ablation...
  68. ncbi Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness
    Siamak Agha-Mohammadi
    Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA
    J Gene Med 6:817-28. 2004
    ..In its current form, however, the system is less than ideal for in vivo or gene therapy uses due to difficulties in set-up procedures, high basal leakiness, and unpredictable delivery and efficiency...
  69. ncbi Viruses as gene delivery vectors: application to gene function, target validation, and assay development
    Michael T Lotze
    Molecular Genetics and Biochemistry, University of Pittsburgh Cancer Institute, UPMC Health System, Pennsylvania 15261, USA
    Cancer Gene Ther 9:692-9. 2002
    ..The individual scientists presenting at the meeting illustrated many of the unique and useful characteristics of such vector systems including retrovirus, adenovirus, herpes virus, simbis virus, and baculovirus...
  70. ncbi TRAIL, FasL and a blocking anti-DR5 antibody augment paclitaxel-induced apoptosis in human non-small-cell lung cancer
    Christine Odoux
    Biological Therapeutics Laboratory, Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Int J Cancer 97:458-65. 2002
    ..These data suggest that the use of new combination treatment with PA and ligands targeting Fas or TRAIL receptors would be particularly efficacious...
  71. ncbi PAMPs and DAMPs: signal 0s that spur autophagy and immunity
    Daolin Tang
    Department of Surgery, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    Immunol Rev 249:158-75. 2012
    ..Here, we review recent advances in our understanding of autophagic molecular mechanisms and functions in emergent immunity...
  72. ncbi Zinc in innate and adaptive tumor immunity
    Erica John
    Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    J Transl Med 8:118. 2010
    ..Based on this novel synthesis, approaches which locally regulate zinc levels to promote survival of immune cells and/or induce tumor apoptosis are in order...
  73. ncbi Eosinophilic granulocytes and damage-associated molecular pattern molecules (DAMPs): role in the inflammatory response within tumors
    Ramin Lotfi
    University of Pittsburgh, Hillmann Cancer Center, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    J Immunother 30:16-28. 2007
    ..This overview on eosinophil biology in the context of cancer and necrosis, introduces intriguing and novel strategies targeting eosinophils to enable more effective biologic therapy for cancer patients...
  74. ncbi Interleukin-17 promotes angiogenesis and tumor growth
    Muneo Numasaki
    Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Blood 101:2620-7. 2003
    ..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
  75. ncbi Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production
    Sanjay Kumar
    Musculoskeletal Diseases, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, PA, 19406, USA
    Cytokine 18:61-71. 2002
    ..Finally, we have localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7b may be involved in immune response, inflammatory diseases and/or cancer...
  76. ncbi Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: helper role of CD8+ T cells in the development of T helper type 1 responses
    Robbie B Mailliard
    Department of Surgery, Cancer Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA
    J Exp Med 195:473-83. 2002
    ....
  77. ncbi Paucity of dendritic cells in pancreatic cancer
    Ramsey M Dallal
    Department of Surgery and Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Surgery 131:135-8. 2002
    ..The median survival was 18.9 months. No other indices measured correlated with survival. CONCLUSIONS: In patients with pancreatic adenocarcinoma, there is a paucity of immune cells within the tumor...
  78. ncbi Design principles for cytokine-neutralizing gels: Cross-linking effects
    Liang Tso Sun
    Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 6:4708-15. 2010
    ..These results suggest an important design principle for preparing cytokine-regulating materials based on consideration of transport phenomena...
  79. ncbi Interleukin-18 as a novel, distinct, and distant member of the interleukin-1 family promoting development of the adaptive immune response: the interleukin-18 issue of the Journal of Immunotherapy
    Michael T Lotze
    University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA
    J Immunother 25:S1-3. 2002
  80. ncbi Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
    Anna Rubartelli
    Cell Biology Unit, National Cancer Research Institute, Largo Rosanna Benzi 10, 16132 Genova, Italy
    Trends Immunol 28:429-36. 2007
    ..We propose that chronic inflammation associated with autoimmunity, chronic viral infection and cancer is probably mediated by persistent release and function of DAMPs, promoting and promoted by a disordered redox environment...
  81. ncbi Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells: a critical role for nitric oxide
    Yasuhiko Nishioka
    Third Department of Internal Medicine, University of Tokushima School of Medicine, Japan
    J Leukoc Biol 73:621-9. 2003
    ..These results suggest that NO produced by DCs might play an important role in IL-12-mediated immune suppression in mice but not in humans...
  82. ncbi Cancer genomics: the unknown unknowns
    Michael T Lotze
    Curr Opin Investig Drugs 7:497-500. 2006
  83. ncbi Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate
    Cecilia K Zetterström
    Department of Woman and Child Health, Pediatric Rheumatology Research Unit, Karolinska Institutet Karolinska University Hospital, Stockholm, Sweden
    J Leukoc Biol 83:31-8. 2008
    ..Together, these results suggest a new mechanism for the anti-rheumatic effects of gold salts in RA and the potential of drugs, which interfere with intracellular HMGB1 transport mechanisms, as novel agents to treat RA...
  84. ncbi Dealing with death: HMGB1 as a novel target for cancer therapy
    Michael T Lotze
    Curr Opin Investig Drugs 4:1405-9. 2003
    ..This, coupled with its ability to accelerate tumor growth in immunodeficient murine models, suggests that it is a possible therapeutic target in patients with cancer...
  85. ncbi Interleukin-12: biological properties and clinical application
    Michele Del Vecchio
    Medical Oncology Unit 2, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Italy
    Clin Cancer Res 13:4677-85. 2007
    ..More effective application of this cytokine, and of newly identified IL-12 family members (IL-23 and IL-27), should be evaluated as therapeutic agents with considerable potential in cancer patients...
  86. ncbi Inflammation and necrosis promote tumour growth
    Jukka Vakkila
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Nat Rev Immunol 4:641-8. 2004
  87. ncbi Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells
    Shin ichiro Fujii
    Research Unit for Cellular Immunotherapy, Research Center for Allergy and Immunology RCAI, RIKEN, Yokohama, Kanagawa 230 0045, Japan
    Cancer Sci 96:897-902. 2005
    ....
  88. ncbi Report on the ISBTC mini-symposium on biologic effects of targeted therapeutics
    Michael B Atkins
    Beth Israel Deaconess Medical Center, Boston, MA, USA
    J Immunother 30:577-90. 2007
    ....
  89. ncbi Damage associated molecular pattern molecules
    Michael T Lotze
    Clin Immunol 124:1-4. 2007
  90. ncbi IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Immunol 175:6177-89. 2005
    ....
  91. ncbi Detecting DNA: getting and begetting cancer
    Adam M Farkas
    Curr Opin Investig Drugs 8:981-6. 2007
  92. ncbi A basis for distinguishing cultured dendritic cells and macrophages in cytospins and fixed sections
    Jukka Vakkila
    Hospital for Children and Adolescents, University of Helsinki, Biomedicum, 4th Floor, Suite B431b, P.O. Box 700, FIN-00029, HUS, Finland
    Pediatr Dev Pathol 8:43-51. 2005
    ....
  93. ncbi High-dose recombinant interleukin-18 induces an effective Th1 immune response to murine MOPC-315 plasmacytoma
    Zdenka L Jonak
    GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406, USA
    J Immunother 25:S20-7. 2002
    ..Therefore, this provides a convenient pharmacodynamic reference to the biologic response to IL-18 that may serve to guide the conduct of clinical trials...
  94. ncbi Induction of peripheral tolerance by local delivery of dendritic cell progenitors to cardiac allografts in a murine heterotopic heart transplantation model
    Hiroharu Hikawa
    Department of Cardiovascular Surgery, Yokohama City University, 3 6 Fukuura, Kanazawa Ku, Yokohama, Kanagawa 236 0004, Japan
    Gen Thorac Cardiovasc Surg 55:307-14. 2007
    ..Our purpose was to identify whether tolerance limited to the cardiac allograft is inducible by direct delivery of DCs to the myocardium, thus diminishing the potential for systemic side effects...
  95. ncbi Interleukin-17 augments tumor necrosis factor-alpha-induced elaboration of proangiogenic factors from fibroblasts
    Muneo Numasaki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Immunol Lett 93:39-43. 2004
    ..Our findings also demonstrate that IL-17 might be a potential contributor to the inflammatory angiogenesis via induction of proangiogenic factors by stromal fibroblasts...
  96. ncbi The critical need for cancer biometrics: quantitative, reproducible measures of cancer to define response to therapy
    Michael T Lotze
    Curr Opin Investig Drugs 4:649-51. 2003