J C Lotz

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Mechanobiology of the intervertebral disc
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California, San Francisco 94143 0514, USA
    Biochem Soc Trans 30:853-8. 2002
  2. ncbi Animal models of intervertebral disc degeneration: lessons learned
    Jeffrey C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94143 0514, USA
    Spine (Phila Pa 1976) 29:2742-50. 2004
  3. ncbi Disc regeneration: why, when, and how
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California, San Francisco, CA 94143 0514, USA
    Neurosurg Clin N Am 16:657-63, vii. 2005
  4. ncbi Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: review of animal model data
    Jeffrey C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, Box 0514, 533 Parnassus Avenue, University Hall U 454, San Francisco, CA 94110, USA
    J Bone Joint Surg Am 88:76-82. 2006
  5. ncbi Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading
    J C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Spine (Phila Pa 1976) 25:1477-83. 2000
  6. ncbi Tibial plateau fracture as a measure of early estrogen-dependent bone fragility in rats
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California at San Francisco, 94143 0514, USA
    J Orthop Res 18:326-32. 2000
  7. ncbi Analytic model to predict the strength of tendon repairs
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    J Orthop Res 16:399-405. 1998
  8. ncbi Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
    Spine (Phila Pa 1976) 23:2493-506. 1998
  9. ncbi Use of ultrasound in spinal arthrodesis. A rabbit model
    P A Glazer
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 23:1142-8. 1998
  10. ncbi Partial lacerations of human digital flexor tendons: a biomechanical analysis
    J S Hariharan
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0728, USA
    J Hand Surg Am 22:1011-5. 1997

Collaborators

Detail Information

Publications59

  1. ncbi Mechanobiology of the intervertebral disc
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California, San Francisco 94143 0514, USA
    Biochem Soc Trans 30:853-8. 2002
    ..Results from this model demonstrate how deviations in spinal stress induce a cycle of altered cell function and morphology as the disc remodels to a new homoeostatic configuration...
  2. ncbi Animal models of intervertebral disc degeneration: lessons learned
    Jeffrey C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94143 0514, USA
    Spine (Phila Pa 1976) 29:2742-50. 2004
    ..A literature review of intervertebral disc degeneration animal models...
  3. ncbi Disc regeneration: why, when, and how
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California, San Francisco, CA 94143 0514, USA
    Neurosurg Clin N Am 16:657-63, vii. 2005
    ..This article describes approaches to cell therapy, reviews relevant studies, and discusses ways to maximize clinical efficacy. Tissue engineering approaches for disc regeneration and healing have significant clinical potential...
  4. ncbi Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: review of animal model data
    Jeffrey C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, Box 0514, 533 Parnassus Avenue, University Hall U 454, San Francisco, CA 94110, USA
    J Bone Joint Surg Am 88:76-82. 2006
    ..Consequently, while nuclear insufficiency is likely the root of degenerative change, the end plate and peripheral part of the anulus are more likely the source of patient discomfort...
  5. ncbi Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading
    J C Lotz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Spine (Phila Pa 1976) 25:1477-83. 2000
    ..An in vivo study of the toxic consequences of static compressive stress on the intervertebral disc...
  6. ncbi Tibial plateau fracture as a measure of early estrogen-dependent bone fragility in rats
    J C Lotz
    Orthopaedic Bioengineering Laboratory, University of California at San Francisco, 94143 0514, USA
    J Orthop Res 18:326-32. 2000
    ....
  7. ncbi Analytic model to predict the strength of tendon repairs
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    J Orthop Res 16:399-405. 1998
    ..To this end, we expect that our analytic model will serve as a basis for the design of more efficient, and consequently stronger, suture techniques...
  8. ncbi Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco, California, USA
    Spine (Phila Pa 1976) 23:2493-506. 1998
    ....
  9. ncbi Use of ultrasound in spinal arthrodesis. A rabbit model
    P A Glazer
    Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts, USA
    Spine (Phila Pa 1976) 23:1142-8. 1998
    ..These results provide a basis for continued evaluation of biologic improvement of spinal arthrodesis with the use of ultrasound...
  10. ncbi Partial lacerations of human digital flexor tendons: a biomechanical analysis
    J S Hariharan
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0728, USA
    J Hand Surg Am 22:1011-5. 1997
    ....
  11. ncbi Biomechanical analysis of multilevel fixation methods in the lumbar spine
    P A Glazer
    Department of Orthopaedic Surgery, University of California, San Francisco, USA
    Spine (Phila Pa 1976) 22:171-82. 1997
    ..Rigidity of fixation in the lumbar spine may aid in the maintenance of lordosis...
  12. ncbi Carbonated apatite cement augmentation of pedicle screw fixation in the lumbar spine
    J C Lotz
    Department of Orthopaedic Surgery, University of California, San Francisco
    Spine (Phila Pa 1976) 22:2716-23. 1997
    ..In response to cyclic loading, all measures of bio-mechanical performance improved 30-63%. CONCLUSIONS: The data suggest that augmentation with this carbonated apatite cancellous bone cement can enhance immediate screw fixation...
  13. ncbi Comparative mechanical analysis of dorsal versus palmar placement of core suture for flexor tendon repairs
    O Soejima
    Hand and Microvascular Surgery Service, University of California, San Francisco 94143 0728, USA
    J Hand Surg Am 20:801-7. 1995
    ..This suggests that there are biomechanical advantages to dorsal as opposed to palmar placement of the core suture in clinical tendon repair...
  14. ncbi Acute biomechanical and histological effects of intradiscal electrothermal therapy on human lumbar discs
    F S Kleinstueck
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143 0514, USA
    Spine (Phila Pa 1976) 26:2198-207. 2001
    ..CONCLUSION: The data from this study suggest that the temperatures developed during intradiscal electrothermal therapy are insufficient to alter collagen architecture or stiffen the treated motion segment acutely...
  15. ncbi Use of electromagnetic fields in a spinal fusion. A rabbit model
    P A Glazer
    Department of Orthopaedic Surgery, University of California, San Francisco, USA
    Spine (Phila Pa 1976) 22:2351-6. 1997
    ..This investigation provides a basis for continued evaluation of biologic enhancement of spinal arthrodesis with the use of a pulsed electromagnetic field...
  16. ncbi Magnetic resonance imaging measurement of relaxation and water diffusion in the human lumbar intervertebral disc under compression in vitro
    E J Chiu
    Department of Radiology, University of California, Berkeley San Francisco, California, USA
    Spine (Phila Pa 1976) 26:E437-44. 2001
    ..CONCLUSIONS: This study demonstrated that magnetic resonance imaging can be used to measure significant changes in T1, T2, or diffusion in intervertebral disc specimens by region, loading condition, or Thompson grade...
  17. ncbi Parametric finite element analysis of vertebral bodies affected by tumors
    C M Whyne
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, U-470 Box 0514, 533 Parnassus Avenue, San Francisco, CA 94143-0514, USA
    J Biomech 34:1317-24. 2001
    ..The results of this parametric study suggest that vertebral tumor size and bone density contribute significantly to a patients risk for vertebral fracture and should be incorporated in clinical assessment paradigms...
  18. ncbi Instrumentation of the cervicothoracic junction after destabilization
    H U Bueff
    Department of Orthopaedic Surgery, University of California, San Francisco, USA
    Spine (Phila Pa 1976) 20:1789-92. 1995
    ..Posterior constructs showed increased stiffness over anterior plates...
  19. ncbi Biomechanical analysis of lumbosacral fixation
    P A Glazer
    Department of Orthopaedic Surgery, University of California, San Francisco, USA
    Spine (Phila Pa 1976) 21:1211-22. 1996
    ..Rigidity of fixation at the lumbosacral junction may be enhanced by use of appropriate anterior interbody fusion techniques...
  20. ncbi Effect of frozen storage on the creep behavior of human intervertebral discs
    N Dhillon
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, California 94143 0514, USA
    Spine (Phila Pa 1976) 26:883-8. 2001
    ..These results may not apply to tissue kept frozen for long durations and with poor packaging...
  21. ncbi Biaxial testing of human annulus fibrosus and its implications for a constitutive formulation
    E C Bass
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, CA 94143 0514, USA
    Ann Biomed Eng 32:1231-42. 2004
    ..Since the annulus is in a state of multaxial stress in vivo, we conclude that uniaxial tests alone are insufficient to prescribe a physiologically relevant W for this tissue...
  22. pmc Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy
    M E Cooke
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143 0514, USA
    Osteoarthritis Cartilage 19:1210-8. 2011
    ..We hypothesized that a structured three-dimensional co-culture using hMSC and chondrocytes would provide chondroinductive cues to hMSC without inducing hypertrophy...
  23. ncbi Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94107, USA
    Spine (Phila Pa 1976) 30:2683-8. 2005
    ..A quantitative high-resolution magic angle spinning (HR-MAS) NMR study of human lumbar discs was conducted to determine biomarkers of disc degeneration...
  24. ncbi Introduction: disc degeneration: summary
    Howard S An
    Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Spine (Phila Pa 1976) 29:2677-8. 2004
  25. doi Structural factors that mediate scleral stiffness
    David S Schultz
    Department of Mechanical Engineering, University of California, Berkeley, Berkeley, California 94143 0730, USA
    Invest Ophthalmol Vis Sci 49:4232-6. 2008
    ..The intent of this study was to correlate measures of structurally relevant biochemical constituents with tensile mechanical behavior in porcine and human posterior sclera...
  26. ncbi The effect on anterior column loading due to different vertebral augmentation techniques
    Dheera Ananthakrishnan
    Orthopaedic Biomechanics Laboratory, San Francisco General Hospital, University of California, 1001 Potrero Ave, 3A36, San Francisco, CA 94110, USA
    Clin Biomech (Bristol, Avon) 20:25-31. 2005
    ..The two most popular operative treatments of compression wedge fractures are vertebroplasty and kyphoplasty, however, which method leads to restoration of normal spinal loading is unknown...
  27. ncbi Intervertebral disc replacement maintains cervical spine kinetics
    Christian M Puttlitz
    Orthopaedic Biomechanics Laboratory, San Francisco General Hospital, and the Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94110, USA
    Spine (Phila Pa 1976) 29:2809-14. 2004
    ..An in vitro biomechanical study of C4-C5 intervertebral disc replacement using a cadaveric model...
  28. ncbi Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome
    Edward Diao
    Department of Orthopaedic Surgery, University of California, San Francisco, 500 Parnassus MU 320W, San Francisco, CA 94143 0728, USA
    J Orthop Res 23:218-23. 2005
    ..We hypothesized that such pressure would cause electrophysiologic changes in the median nerve in a dose-related manner, with NCS/EMG changes consistent with CTS in humans...
  29. ncbi Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy
    Kayvan R Keshari
    Department of Radiology, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    Magn Reson Med 53:519-27. 2005
    ..The results of this study support the feasibility of using in vivo spectroscopy for detecting chemical changes associated with disc degeneration...
  30. ncbi Glycation increases human annulus fibrosus stiffness in both experimental measurements and theoretical predictions
    Diane R Wagner
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco, CA, USA
    J Biomech 39:1021-9. 2006
    ..In the future, this structurally guided constitutive relationship may provide further insight into the structure-function relationships of the annulus fibrosus...
  31. doi Biomechanical comparison of three fixation techniques for unstable thoracolumbar burst fractures. Laboratory investigation
    Frank L Acosta
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosurg Spine 8:341-6. 2008
    ....
  32. ncbi Intradiscal thermal therapy does not stimulate biologic remodeling in an in vivo sheep model
    Elisa C Bass
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, 94143 0514, USA
    Spine (Phila Pa 1976) 31:139-45. 2006
    ..Thermal energy was delivered in vivo to ovine cervical discs and the postheating response was monitored over time...
  33. ncbi Dependence of mechanical behavior of the murine tail disc on regional material properties: a parametric finite element study
    Adam H Hsieh
    Orthopaedic Mechanobiology Laboratory, Department of Mechanical Engineering, Graduate Program in Bioengineering, University of Maryland, College Park, USA
    J Biomech Eng 127:1158-67. 2005
    ..Sensitivity analyses suggest that further characterization of nucleus pulposus material properties should be pursued, due to its significance in steady-state and transient disc mechanical response...
  34. doi Lactic acid and proteoglycans as metabolic markers for discogenic back pain
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94158 2330, USA
    Spine (Phila Pa 1976) 33:312-7. 2008
    ..These samples were then analyzed using ex vivo proton high resolution magic angle spinning (HR-MAS) NMR spectroscopy to produce metabolic profiles for comparison between the 2 patient groups...
  35. ncbi ISSLS prize winner: repeated disc injury causes persistent inflammation
    Jill A Ulrich
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, San Francisco, CA 94143 0514, USA
    Spine (Phila Pa 1976) 32:2812-9. 2007
    ..An in vivo rat model of disc degeneration with emphasis on characterizing acute and chronic cytokine production...
  36. ncbi Temperature and thermal dose distributions during intradiscal electrothermal therapy in the cadaveric lumbar spine
    Frank S Kleinstueck
    Department of Orthopaedic Surgery, University of California at San Francisco, California, USA
    Spine (Phila Pa 1976) 28:1700-8; discussion 1709. 2003
    ..Human cadaveric lumbar spines were used to assess the temperature and thermal dose distribution during intradiscal electrothermal therapy in vitro...
  37. ncbi Theoretical model and experimental results for the nonlinear elastic behavior of human annulus fibrosus
    Diane R Wagner
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California at San Francisco, Box 0514, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
    J Orthop Res 22:901-9. 2004
    ..We anticipate that this constitutive formulation will be useful for computational simulations of the disc's biomechanical response and for elucidating structure-function relationships of the annulus fibrosus...
  38. ncbi Biomechanical testing of posterior atlantoaxial fixation techniques
    Robert P Melcher
    Department of Orthopaedics, Traumatology, Spine Center, Klinikum Karlsbad Langensteinbach, Germany
    Spine (Phila Pa 1976) 27:2435-40. 2002
    ..An in vitro biomechanical study of C1-C2 posterior fusion techniques was conducted using a cadaveric model...
  39. ncbi Micro-computed tomography evaluation of trabecular bone structure on loaded mice tail vertebrae
    Ahi Sema Issever
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Spine (Phila Pa 1976) 28:123-8. 2003
    ..A micro-computed tomography (CT) study of the trabecular bone structure on loaded mice tail vertebral bodies was conducted...
  40. ncbi Scaphoid kinematic behavior after division of the transverse carpal ligament
    Toshiyuki Ishiko
    Hand and Microvascular Surgery Laboratory, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Hand Surg Am 28:267-71. 2003
    ..Accordingly the purpose of this study was to determine the flexion/extension behavior of the scaphoid during global wrist radial/ulnar deviation before and after division of the transverse carpal ligament (TCL)...
  41. ncbi Effect of cementless bowed stem distal surface contour and coronal slot on femoral bone strains and torsional stability
    Michael D Ries
    Department of Orthopaedic Surgery, University of California, San Francisco, California 94143 0728, USA
    J Arthroplasty 18:494-8. 2003
    ..Our data demonstrate that a long bowed cementless stem with a distal coronal slot and flutes is associated with decreased bone strains and fracture risk during stem insertion compared to a fully porous-coated stem...
  42. ncbi Prolonged spinal loading induces matrix metalloproteinase-2 activation in intervertebral discs
    Adam H Hsieh
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Spine (Phila Pa 1976) 28:1781-8. 2003
    ..An established in vivo mouse model of compression-induced disc degeneration was used to investigate the effects of load on matrix catabolism...
  43. ncbi Dorsal and palmar material properties of the adult human flexor profundus tendon in Zone II
    Osamu Soejima
    Hand Surgery Service, Department of Orthopaedic Surgery, Fukuoka University School of Medicine, Fukuoka, Japan
    Hand Surg 8:53-8. 2003
    ..These differences suggest that there may be biomechanical advantages in placing core sutures dorsally when repairing flexor tendons, a technique that we have previously described...
  44. ncbi The compressive creep properties of normal and degenerated murine intervertebral discs
    Erika I Palmer
    Orthopaedic Bioengineering Lab, Department of Orthopaedic Surgery, University of California, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
    J Orthop Res 22:164-9. 2004
    ..Overall, our data demonstrate that architectural remodeling stimulated by excessive loading diminishes the disc's ability to resist compression. These results are similar to degeneration-dependent changes reported for human discs...
  45. ncbi Heat-induced changes in porcine annulus fibrosus biomechanics
    Elisa C Bass
    DePuy Acromed, 32 Paramount Drive, Raynham, MA 02767, USA
    J Biomech 37:233-40. 2004
    ..These findings should aid the interpretation of clinical outcomes and provide a basis for the future design of optimum dosing regimens...
  46. ncbi In vivo growth factor treatment of degenerated intervertebral discs
    Andrew J L Walsh
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Spine (Phila Pa 1976) 29:156-63. 2004
    ..An in vivo model was used to investigate the response of degenerated discs to various exogenous growth factors...
  47. pmc Biomechanics of cervical laminoplasty: kinetic studies comparing different surgical techniques, temporal effects and the degree of level involvement
    Christian M Puttlitz
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco 94110, USA
    Eur Spine J 13:213-21. 2004
    ..Therefore, early physical therapy should be considered to preserve a more physiologic pattern of cervical range of motion...
  48. ncbi Stability analysis of craniovertebral junction fixation techniques
    Christian M Puttlitz
    Department of Orthopaedic Surgery, University of California at San Francisco, 1001 Potrero Avenue, Room 3A36, San Francisco, CA 94110, USA
    J Bone Joint Surg Am 86:561-8. 2004
    ..The purpose of this study was to determine the primary stability afforded by this novel construct and compare its stability with the current standard of bilateral longitudinal plates combined with C1-C2 transarticular screws...
  49. ncbi Intervertebral disc cell therapy for regeneration: mesenchymal stem cell implantation in rat intervertebral discs
    Gwen Crevensten
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143 0514, USA
    Ann Biomed Eng 32:430-4. 2004
    ..A trend of increased disc height compared to blank gel suggests an increase in matrix synthesis. The results indicate that MSCs can maintain viability and proliferate within the rat intervertebral disc...
  50. pmc Intervertebral disc degeneration: the role of the mitochondrial pathway in annulus fibrosus cell apoptosis induced by overload
    Francois Rannou
    Division of Biomedical Sciences, University of California, Riverside, California 92521 0121, USA
    Am J Pathol 164:915-24. 2004
    ..Our results from human samples, mouse models, and annulus fibrosus culture experiments demonstrate that the mechanical overload-induced IVD degeneration is mediated through the mitochondrial apoptotic pathway in IVD cells...
  51. ncbi Biological response of the intervertebral disc to dynamic loading
    Andrew J L Walsh
    Department of Orthopaedic Surgery, Orthopaedic Bioengineering Laboratory, University of California, U 470 Box 0514 533, Parnassus Avenue, San Francisco, CA 94143 0514, USA
    J Biomech 37:329-37. 2004
    ..The results have implications in the prevention of intervertebral disc degeneration, suggesting that loading conditions may be optimized to promote maintenance of normal structure and function...
  52. ncbi Percutaneous plasma decompression alters cytokine expression in injured porcine intervertebral discs
    Conor W O'Neill
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Spine J 4:88-98. 2004
    ..Clinical data suggest discectomy may also help patients with contained discs and no clear neural compromise. However, the mechanisms of clinical efficacy are uncertain, and consequently bases for treatment optimization are limited...
  53. ncbi Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition
    Jau Ren Mao
    Department of Pediatrics, University of California, Laurel Heights Campus, 3333 California Street, Box 1245, San Francisco, California 94118, USA
    Nat Genet 30:421-5. 2002
    ..This study confirms a causative role for TNXB in human Ehlers-Danlos syndrome and suggests that tenascin-X is an essential regulator of collagen deposition by dermal fibroblasts...
  54. doi Chondrogenic differentiation of human mesenchymal stem cells in three-dimensional alginate gels
    Jinping Xu
    Department of Orthodontics and Pediatric Dentistry, The University of Michigan School of Dentistry, Ann Arbor, Michigan, USA
    Tissue Eng Part A 14:667-80. 2008
    ..The derivation of this staging scheme may aid in defining maximally responsive time points for mechanobiological modulation of constructs to produce optimally engineered tissues...
  55. ncbi Ventral approach to the lumbar spine of the Sprague-Dawley rat
    Marc Antoine Rousseau
    Orthopaedic Bioengineering Lab, University of California San Francisco, San Francisco, CA, USA
    Lab Anim (NY) 33:43-5. 2004
    ....
  56. ncbi Glucosamine HCl alters production of inflammatory mediators by rat intervertebral disc cells in vitro
    Andrew J L Walsh
    Department of Orthopaedic Surgery, Orthopaedic Bioengineering Laboratory, University of California, San Francisco, 533 Parnassus Ave, Box 0514, San Francisco, CA 94143 0514, USA
    Spine J 7:601-8. 2007
    ..Intradiscal injection of glucosamine has been proposed as a treatment for chronic discogenic low back pain. However, there have been no studies of the direct effects of glucosamine on disc cells...
  57. ncbi The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture
    Kee Won Rhyu
    Department of Orthopaedic Surgery, University of California at San Francisco, 2100 Webster Street, Suite 110, San Francisco, CA 94115, USA
    Spine J 7:451-8. 2007
    ..Percutaneous discectomy can be performed by a variety of methods. One method, electrosurgical ablation, has been shown in a chronic animal model to alter the expression of inflammatory cytokines in degenerated discs...
  58. ncbi Stab incision for inducing intervertebral disc degeneration in the rat
    Marc Antoine A Rousseau
    Orthopaedic Bioengineering Laboratory, Department of Orthopaedic Surgery, University of California, San Francisco, San Francisco, CA 94143 0514, USA
    Spine (Phila Pa 1976) 32:17-24. 2007
    ..The degenerative response of rat tail and lumbar intervertebral discs to a stab incision was evaluated...
  59. pmc Biological and mechanical consequences of transient intervertebral disc bending
    Charles Court
    Orthopaedic Surgery, University of California, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
    Eur Spine J 16:1899-906. 2007
    ..Taken together, this suggests that cellular damage accumulation may be an important injury mechanism that is distinct from acute mechanical failure...