I T Lott
Affiliation: University of California
- Cognitive deficits and associated neurological complications in individuals with Down's syndromeIra T Lott
Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA 92868, USA
Lancet Neurol 9:623-33. 2010..Dementia that resembles Alzheimer's disease is common in adults with Down's syndrome. Early-onset dementia in adults with Down's syndrome does not seem to be associated with atherosclerotic complications...
- Antioxidants in Down syndromeIra T Lott
Department of Pediatrics and Neurology, School of Medicine, University of California Irvine UCI, Orange, CA 92868, USA
Biochim Biophys Acta 1822:657-63. 2012..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
- Neurological phenotypes for Down syndrome across the life spanIra T Lott
Department of Pediatrics and Neurology, School of Medicine, University of California Irvine UCI, Orange, CA, USA
Prog Brain Res 197:101-21. 2012..Mouse models for DS are providing a platform for the formulation of clinical trials with intervention targeted to synaptic plasticity, brain biochemistry, and morphological brain alterations...
- Down syndrome and dementia: seizures and cognitive declineIra T Lott
Department of Pediatrics, School of Medicine, University of California, Irvine UCI, Orange, CA92868, USA
J Alzheimers Dis 29:177-85. 2012..We conclude that there is a strong association of seizures with cognitive decline in demented individuals with DS. Prospective studies exploring this relationship in DS are indicated...
- Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementationIra T Lott
Department of Pediatrics, School of Medicine, University of California, Irvine UCI, Orange, California, USA
Am J Med Genet A 155:1939-48. 2011..Our findings are similar to studies of antioxidant supplementation in Alzheimer disease in the general population. The feasibility of carrying out a clinical trial for dementia in Down syndrome is demonstrated...
- Beta-amyloid, oxidative stress and down syndromeIra T Lott
Department of Pediatrics and Neurology, Alzheimer Disease Research Center, University of California, Irvine, School of Medicine, Irvine, California 92868, USA
Curr Alzheimer Res 3:521-8. 2006..Since the pathological processes leading to AD are seen across the lifespan in DS, an opportunity is afforded for early pharmacological intervention in the disorder...
- Alzheimer disease and Down syndrome: factors in pathogenesisIra T Lott
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697, USA
Neurobiol Aging 26:383-9. 2005..The study of individuals with DS may help to identify common pathogenic links as well as a disassociation between vascular disease and AD...
- Longitudinal prescribing patterns for psychoactive medications in community-based individuals with developmental disabilities: utilization of pharmacy recordsI T Lott
Department of Pediatrics, College of Medicine, University of California Irvine, 101 The City Drive South, ZC 4482, Orange, CA 92868, USA
J Intellect Disabil Res 48:563-71. 2004..Little is known about longitudinal prescribing practices for psychoactive medications for individuals with intellectual disabilities and developmental disabilities (IDDD) who are living in community settings...
- Down syndrome and Alzheimer disease: response to donepezilIra T Lott
Department of Pediatrics, University of California, Irvine Medical Center, 101 The City Dr S, Bldg 2, Third Floor, Orange, CA 92868 4482, USA
Arch Neurol 59:1133-6. 2002..Individuals with Down syndrome who develop Alzheimer disease may show an improvement in cognitive functioning after treatment with acetylcholinesterase inhibitors...
- Down syndrome and Alzheimer's disease: a link between development and agingI T Lott
Department of Pediatrics, University of California, Irvine, Orange, CA 92868, USA
Ment Retard Dev Disabil Res Rev 7:172-8. 2001..Study of the process by which AD evolves in DS affords an opportunity to understand an important link between development and aging. This review will focus on advances in the molecular and clinical basis of this association...
- Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down SyndromeE Head
Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4540, USA
Neurobiol Dis 8:252-65. 2001..C1q-positive neurons were associated with activated microglia. These results provide evidence for Abeta-mediated inflammatory factors contributing to the rapid accumulation of neuropathology in DS brain...
- Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological interventionE Head
Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
J Alzheimers Dis 11:61-76. 2007..In combination, adults with DS may be a unique group of individuals well-suited for studies involving the manipulation or upregulation of compensatory responses as an approach to promote successful brain aging in the general population...
- Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory eventsR J Haier
Department of Pediatrics, University of California, Irvine 92697 4475, USA
Neuroimage 39:1324-32. 2008..We report functional and structural brain indicators that may precede the onset of dementia in individuals with Down's syndrome (DS)...
- Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndromeE Head
Institute for Brain Aging and Dementia, University of California, Irvine, California, 92697-4540, USA
Neurobiol Dis 8:792-806. 2001..Oxidatively modified Abeta may reflect the efforts of microglial cells to take up and degrade Abeta. Oxidative modification of Abeta may be an early event in Abeta pathogenesis and may be important for plaque biogenesis...
- Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementiaR J Haier
Department of Pediatrics, University of California, Irvine 92697 5000, USA
Neurology 61:1673-9. 2003....
- Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brainM Nistor
Institute for Brain Aging and Dementia, CA, United States
Neurobiol Aging 28:1493-506. 2007..Treatments to slow or prevent AD in the general population targeting secretase activity may be more efficacious in adults with DS if combined with approaches that enhance Abeta degradation and clearance...
- Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndromeE Head
Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
J Neuropathol Exp Neurol 62:917-26. 2003..Thus, compensatory growth responses may occur in DS prior to extensive AD pathology and may be one mechanism underlying observations in PET studies of hypermetabolism in the entorhinal cortex of individuals with DS...
- Neurological changes and emotional functioning in adults with Down SyndromeL D Nelson
University of California, Irvine, Medical Center, Neurology Department, 101 City Drive, Route 81, Building 53, Room 225, Orange, California 92868, USA
J Intellect Disabil Res 45:450-6. 2001..These results, along with abnormalities in brain imaging and the presence of pathological reflexes, suggested that frontal lobe dysfunction is likely to be an early manifestation of Alzheimer's Disease in Down Syndrome...
- Down syndrome and beta-amyloid depositionElizabeth Head
Institute for Brain Aging and Dementia, Department of Neurology, University of California, Irvine, California, USA
Curr Opin Neurol 17:95-100. 2004..The purpose of the current review is therefore to summarize developments and advances in our understanding of beta-amyloid pathogenesis in Down syndrome over the past year...
- Rapid assessment of severe cognitive impairment in individuals with developmental disabilitiesD M Walsh
Department of Psychiatry and Human Behavior, College of Medicine, Gillespie Neuroscience Research Facility, University of California, Irvine, CA 92697 1675, USA
J Intellect Disabil Res 51:91-100. 2007..Furthermore, most standardized intelligence tests are of limited usefulness for individuals with severe cognitive deficits because of floor effects...
- Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndromeElizabeth Head
Institute for Brain Aging and Dementia, University of California at Irvine, Irvine, CA 92697 4540, USA
Neurosci Lett 330:99-103. 2002..Abeta within or around neurons in addition to contributing to NFT formation may also trigger apoptotic pathways. Caspase activation may lead to the cleavage of critical cellular proteins and neuronal cell death associated with DS...
- Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementiaPinar E Coskun
Mitochondrial and Molecular Medicine and Genetics, University of California Irvine, Irvine, CA, USA
J Alzheimers Dis 20:S293-310. 2010..Therefore, mtDNA alterations may be responsible for both age-related dementia and the associated neuropathological changes observed in AD and DSAD...
- Down syndrome: from understanding the neurobiology to therapyKatheleen Gardiner
Department of Pediatrics, Intellectual and Developmental Disabilities Research Center, University of Colorado Denver, Aurora, Colorado 80045, USA
J Neurosci 30:14943-5. 2010....
- Toward a research agenda for Down syndromeIra T Lott
Department of Pediatrics, Neurology and Neurobiology, University of California, Irvine, University of California Medical Center, Orange, California, USA
Ment Retard Dev Disabil Res Rev 13:288-9. 2007
- Alzheimer's disease in Down syndrome: neurobiology and riskWarren B Zigman
Department of Psychology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
Ment Retard Dev Disabil Res Rev 13:237-46. 2007....