Francis E Lotrich

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Serotonin transporter promoter polymorphism in African Americans : allele frequencies and implications for treatment
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pharmacogenomics 3:145-7. 2003
  2. pmc Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Electronic address
    J Psychosom Res 75:475-83. 2013
  3. pmc Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-α treatment
    Francis E Lotrich
    Western Psychiatric Institute and Clinics, Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 38:985-95. 2013
  4. pmc Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 31:48-53. 2013
  5. ncbi request reprint Inflammatory cytokines, growth factors, and depression
    Francis Lotrich
    Western Psychiatric Institute and Clinics, Pittsburgh, PA 15213, USA
    Curr Pharm Des 18:5920-35. 2012
  6. pmc Major depression during interferon-alpha treatment: vulnerability and prevention
    Francis E Lotrich
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Dialogues Clin Neurosci 11:417-25. 2009
  7. pmc Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients
    Francis E Lotrich
    NIMH Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Foundation Center of Excellence in Geriatric Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Psychiatry Neurosci 33:123-30. 2008
  8. pmc Depression following pegylated interferon-alpha: characteristics and vulnerability
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychosom Res 63:131-5. 2007
  9. pmc Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Neuropharmacol 33:191-7. 2010
  10. pmc Gene-environment interactions in geriatric depression
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, 3811 Ohara Street, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 34:357-76, viii. 2011

Detail Information

Publications28

  1. ncbi request reprint Serotonin transporter promoter polymorphism in African Americans : allele frequencies and implications for treatment
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pharmacogenomics 3:145-7. 2003
    ....
  2. pmc Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States Electronic address
    J Psychosom Res 75:475-83. 2013
    ..Elevated anger has also been associated with lower long-chain omega-3 (LCn-3) fatty acid levels. We examined whether fatty acids could influence vulnerability to anger during IFN-α exposure...
  3. pmc Brain-derived neurotrophic factor serum levels and genotype: association with depression during interferon-α treatment
    Francis E Lotrich
    Western Psychiatric Institute and Clinics, Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 38:985-95. 2013
    ..Nonetheless, the results support the hypothesis that BDNF levels influence resiliency against developing inflammatory cytokine-associated depression, and specifically to a subset of symptoms distinct from those influenced by 5-HTTLPR...
  4. pmc Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 31:48-53. 2013
    ..These prospective data support the role of fatty acid status in depression vulnerability and indicate a potential role for omega-3 fatty acids in the prevention of inflammation-induced depression...
  5. ncbi request reprint Inflammatory cytokines, growth factors, and depression
    Francis Lotrich
    Western Psychiatric Institute and Clinics, Pittsburgh, PA 15213, USA
    Curr Pharm Des 18:5920-35. 2012
    ....
  6. pmc Major depression during interferon-alpha treatment: vulnerability and prevention
    Francis E Lotrich
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Dialogues Clin Neurosci 11:417-25. 2009
    ..The interplay of these factors strongly predicts who is at risk for IFN-MDD, and indicates several potentially modifiable targets for the personalized prevention of IFN-MDD...
  7. pmc Serotonin transporter genotype interacts with paroxetine plasma levels to influence depression treatment response in geriatric patients
    Francis E Lotrich
    NIMH Advanced Center in Interventions and Services Research for Late Life Mood Disorders and the John A Hartford Foundation Center of Excellence in Geriatric Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Psychiatry Neurosci 33:123-30. 2008
    ..To investigate whether variable antidepressant response may be influenced by an interaction between the serotonin transporter promoter polymorphism (5-HTTLPR) and antidepressant concentration...
  8. pmc Depression following pegylated interferon-alpha: characteristics and vulnerability
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychosom Res 63:131-5. 2007
    ..The first objective was to further characterize this depression and, secondly, to examine whether pre-treatment temperament was correlated with subsequent vulnerability to IFN-alpha...
  9. pmc Labile anger during interferon alfa treatment is associated with a polymorphism in tumor necrosis factor alpha
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Clin Neuropharmacol 33:191-7. 2010
    ..We therefore hypothesized that this TNF-alpha polymorphism would influence susceptibility to psychiatric symptoms during interferon alfa therapy...
  10. pmc Gene-environment interactions in geriatric depression
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, 3811 Ohara Street, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 34:357-76, viii. 2011
    ..Each of these may interact with either predisposing traumas in early childhood or precipitating events later in life...
  11. doi request reprint The role of inflammation in the pathophysiology of depression: different treatments and their effects
    Francis E Lotrich
    University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15123, USA
    J Rheumatol Suppl 88:48-54. 2011
    ..These findings suggest that targeting proinflammatory cytokines and their signaling pathways may represent a unique therapeutic opportunity to treat depression and related conditions, such as labile anger, irritability, and fatigue...
  12. ncbi request reprint Aging and clinical pharmacology: implications for antidepressants
    Francis E Lotrich
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Pharmacol 45:1106-22. 2005
    ..The authors review these age-associated differences and discuss their implications for antidepressant use in older adults...
  13. ncbi request reprint Dextromethorphan-induced delirium and possible methadone interaction
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Geriatr Pharmacother 3:17-20. 2005
    ..It is metabolized primarily by the cytochrome P450 (CYP) 2D6 isozyme. Methadone has been found to inhibit CYP2D6, indicating a potential for interaction with dextromethorphan...
  14. pmc Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism
    Francis E Lotrich
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Biol Psychiatry 65:344-8. 2009
    ..Genetic differences in the serotonin reuptake transporter promoter (5-HTTLPR) may interact with the inflammatory system and influence depression risk...
  15. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  16. pmc Cytokine-induced depression during IFN-alpha treatment: the role of IL-6 and sleep quality
    Aric A Prather
    Behavioral Immunology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 23:1109-16. 2009
    ....
  17. pmc Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms
    Alexandre Y Dombrovski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Advanced Center for Interventions and Services Research in Late Life Mood Disorders, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Int Clin Psychopharmacol 25:37-45. 2010
    ..Our findings of intolerance of a second-generation antipsychotics and persistence of psychosis in patients with low-expression alleles needs to be replicated...
  18. ncbi request reprint Neuroendocrine response to intravenous citalopram in healthy control subjects: pharmacokinetic influences
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Psychopharmacology (Berl) 178:268-75. 2005
    ..The neuroendocrine response to intravenous citalopram may provide an acute, functional, in vivo measure of the neural serotonin (5-HT) system...
  19. ncbi request reprint Meta-analysis of serotonin transporter polymorphisms and affective disorders
    Francis E Lotrich
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Psychiatr Genet 14:121-9. 2004
    ..These factors should Influence the interpretation of the association found in this analysis...
  20. pmc Poor sleep quality predicts onset of either major depression or subsyndromal depression with irritability during interferon-alpha treatment
    Peter L Franzen
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychiatry Res 177:240-5. 2010
    ..These findings may have important implications for understanding, predicting, and possibly preventing depression, particularly in individuals treated with IFN-alpha...
  21. pmc Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Expert Rev Neurother 12:1143-61. 2012
    ....
  22. ncbi request reprint Utility of sparse concentration sampling for citalopram in elderly clinical trial subjects
    Robert R Bies
    Department of Psychiatry and Pharmaceutical Sciences, University of Pittsburgh, 805 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15213, USA
    J Clin Pharmacol 44:1352-9. 2004
    ..This is particularly valuable for populations such as the elderly, who are not typically available for pharmacokinetic studies...
  23. ncbi request reprint Relevance of assessing drug concentration exposure in pharmacogenetic and imaging studies
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Psychopharmacol 20:33-40. 2006
    ..For the design and interpretation of neuroimaging, pharmacogenetic, and behavioural studies, the assessment of drug concentration exposure is therefore feasible and has potentially important ramifications...
  24. pmc Preventing depression in later life: state of the art and science circa 2011
    Fawzi Hindi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 34:67-78. 2011
    ..In this article, the published literature is reviewed to summarize what is known about depression prevention in older adults, and, ultimately, to inform future research...
  25. doi request reprint Escitalopram reduces attentional performance in anxious older adults with high-expression genetic variants at serotonin 2A and 1B receptors
    Eric J Lenze
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Int J Neuropsychopharmacol 16:279-88. 2013
    ..These results, if confirmed, could lead to the personalization of SSRI use to reduce adverse neurocognitive effects...
  26. ncbi request reprint Sex steroid hormone gene polymorphisms and depressive symptoms in women at midlife
    Howard M Kravitz
    Department of Psychiatry, Rush University Medical Center, Chicago, Illinois 60612, USA
    Am J Med 119:S87-93. 2006
    ..13 to 51.82). These data provide evidence that selected genes involved in estrogen synthesis and metabolism increase the odds of more depressive symptoms in women who are premenopausal or perimenopausal...
  27. pmc Age, model for end-stage liver disease score, and organ functioning predict posttransplant tacrolimus neurotoxicity
    Andrea DiMartini
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 14:815-22. 2008
    ..We discuss the implications of these findings and the relevance for future clinical care in these high-risk patients...
  28. ncbi request reprint Translational research in late-life mood disorders: implications for future intervention and prevention research
    Gwenn S Smith
    PET Centre, Centre for Addiction and Mental Health, Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Neuropsychopharmacology 32:1857-75. 2007
    ..Geriatric depression could serve as a model for translational research integrating basic and clinical neuroscience approaches that would have implications for the study of other neuropsychiatric disorders...

Research Grants3

  1. Vulnerability to major depression: The role of delta sleep in patients receiving
    Francis E Lotrich; Fiscal Year: 2010
    ..This may be a common pathway for genes, stress, and inflammation to influence risk for depression. ..
  2. Pharmacogenomics of Interferon-Induced Depression
    Francis Lotrich; Fiscal Year: 2007
    ..This developmental program will initiate the candidate's long-term interdisciplinary and integrative strategy for delineating genetic vulnerability to depression. ..