I S Lossos

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Higher-grade transformation of follicular lymphoma -- a continuous enigma
    I S Lossos
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Leukemia 19:1331-3. 2005
  2. pmc Biased use of the IGHV4 family and evidence for antigen selection in Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas
    Daxing Zhu
    Division of Hematology Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
    PLoS ONE 6:e29114. 2011
  3. pmc Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation
    Isabel Romero-Camarero
    Experimental Therapeutics and Translational Oncology Program, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    Nat Commun 4:1338. 2013
  4. doi request reprint Association between non-Hodgkin lymphoma and renal cell carcinoma
    Chen Lossos
    Department of Medicine, Division of Hematology Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Leuk Lymphoma 52:2254-61. 2011
  5. ncbi request reprint Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions
    Izidore S Lossos
    Department of Hematology and Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue D8 4, Miami, FL 33136, USA
    Semin Cancer Biol 13:191-202. 2003
  6. ncbi request reprint IL-4 in lymphoma: does the target matter?
    Izidore S Lossos
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Leuk Lymphoma 48:1261-3. 2007
  7. ncbi request reprint Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms
    Yasodha Natkunam
    Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Haematologica 92:176-83. 2007
  8. ncbi request reprint Prognostic biomarkers in diffuse large B-cell lymphoma
    Izidore S Lossos
    Department of Medicine, Division of Hematology Oncology, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    J Clin Oncol 24:995-1007. 2006
  9. ncbi request reprint Molecular pathogenesis of diffuse large B-cell lymphoma
    Izidore S Lossos
    University of Miami, Sylvester Comprehensive Cancer Center, Department of Hematology and Oncology, 1475 NW 12th Ave D8 4, Miami, FL 33136, USA
    J Clin Oncol 23:6351-7. 2005
  10. ncbi request reprint The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression
    Izidore S Lossos
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Cancer Cell 12:189-91. 2007

Research Grants

  1. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
  2. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
  3. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2005
  4. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2009
  5. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2009
  6. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2007
  7. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2007
  8. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2006
  9. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010

Detail Information

Publications79

  1. ncbi request reprint Higher-grade transformation of follicular lymphoma -- a continuous enigma
    I S Lossos
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Leukemia 19:1331-3. 2005
  2. pmc Biased use of the IGHV4 family and evidence for antigen selection in Chlamydophila psittaci-negative ocular adnexal extranodal marginal zone lymphomas
    Daxing Zhu
    Division of Hematology Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
    PLoS ONE 6:e29114. 2011
    ....
  3. pmc Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation
    Isabel Romero-Camarero
    Experimental Therapeutics and Translational Oncology Program, Instituto de Biologia Molecular y Celular del Cancer, CSIC Universidad de Salamanca, 37007 Salamanca, Spain
    Nat Commun 4:1338. 2013
    ....
  4. doi request reprint Association between non-Hodgkin lymphoma and renal cell carcinoma
    Chen Lossos
    Department of Medicine, Division of Hematology Oncology, University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Leuk Lymphoma 52:2254-61. 2011
    ..Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that patients with NHL are at increased risk for RCC...
  5. ncbi request reprint Higher grade transformation of follicular lymphoma: phenotypic tumor progression associated with diverse genetic lesions
    Izidore S Lossos
    Department of Hematology and Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475 NW 12th Avenue D8 4, Miami, FL 33136, USA
    Semin Cancer Biol 13:191-202. 2003
    ..These lesions affect different aspects of normal cell physiology (apoptosis, cell cycle control, and proliferation) and are potential targets for gene-specific therapies...
  6. ncbi request reprint IL-4 in lymphoma: does the target matter?
    Izidore S Lossos
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Leuk Lymphoma 48:1261-3. 2007
  7. ncbi request reprint Expression of the RNA-binding protein VICKZ in normal hematopoietic tissues and neoplasms
    Yasodha Natkunam
    Pathology, Stanford University School of Medicine, Stanford, CA, USA
    Haematologica 92:176-83. 2007
    ..The presence of VICKZ in normal germinal centers (GC) prompted us to characterize the expression pattern of this protein in lymphoid and hematopoietic tissues...
  8. ncbi request reprint Prognostic biomarkers in diffuse large B-cell lymphoma
    Izidore S Lossos
    Department of Medicine, Division of Hematology Oncology, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    J Clin Oncol 24:995-1007. 2006
    ..This review summarizes the recent advances in our understanding of prognostic biomarkers in DLBCL and discusses whether this is the right time for biomarkers-guided risk-adjusted therapy...
  9. ncbi request reprint Molecular pathogenesis of diffuse large B-cell lymphoma
    Izidore S Lossos
    University of Miami, Sylvester Comprehensive Cancer Center, Department of Hematology and Oncology, 1475 NW 12th Ave D8 4, Miami, FL 33136, USA
    J Clin Oncol 23:6351-7. 2005
    ..This review summarizes the progress in understanding of DLBCL biology and presents a state-of-the-art overview of DLBCL molecular pathogenesis...
  10. ncbi request reprint The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression
    Izidore S Lossos
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA
    Cancer Cell 12:189-91. 2007
    ..These finding suggest that IRF4 may function as a key regulator of germinal center reaction and a guardian of lymphomagenesis...
  11. pmc Diffuse large B cell lymphoma: from gene expression profiling to prediction of outcome
    Izidore S Lossos
    Division of Hematology Oncology, Department of Medicine, University of Miami Sylvester Cancer Center, 1475 NW 12th Avenue, D8 4, Miami, Florida, USA
    Biol Blood Marrow Transplant 14:108-11. 2008
    ..Herein, we summarize the progress made in better prediction of prognosis of DLBCL patients as a result of gene expression profiling...
  12. ncbi request reprint AID is expressed in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas and is not correlated with intraclonal heterogeneity
    I S Lossos
    Department of Medicine, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    Leukemia 18:1775-9. 2004
    ..This dissociation suggests that AID expression and SHM may occur at the time prior to the clinical detection of transformed lymphoma...
  13. pmc Transformation of follicular lymphoma
    Izidore S Lossos
    Department of Medicine and Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, 1475NW 12th Ave, D8 4, Miami, FL 33136, USA
    Best Pract Res Clin Haematol 24:147-63. 2011
    ..Furthermore, we specifically emphasize gaps in our knowledge that should be addressed in future studies...
  14. doi request reprint High rate and prolonged duration of complete remissions induced by rituximab, methotrexate, doxorubicin, cyclophosphamide, vincristine, ifosfamide, etoposide, cytarabine, and thalidomide (R-MACLO-IVAM-T), a modification of the National Cancer Institute 89
    Izidore S Lossos
    Department of Medicine, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Leuk Lymphoma 51:406-14. 2010
    ..The progression-free survival at 3 years was 78% (95% CI: 51-91%). These results compare favorably with previously reported outcomes suggesting that durable remissions can be achieved without myeloablative therapy...
  15. ncbi request reprint Expression of a single gene, BCL-6, strongly predicts survival in patients with diffuse large B-cell lymphoma
    I S Lossos
    Department of Medicine, Division of Oncology, Stanford University Medical Center, CA 94305-5151, USA
    Blood 98:945-51. 2001
    ..High BCL-6 mRNA expression should be considered a new favorable prognostic factor in DLBCL and should be used in the stratification and the design of risk-adjusted therapies for patients with DLBCL. (Blood. 2001;98:945-951)..
  16. ncbi request reprint The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene
    I S Lossos
    Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305 5151, USA
    Leukemia 17:1390-7. 2003
    ..Neither the nature of the substituted promoters nor the presence of activating mutations in the BCL6 regulatory sequences correlated with the allelic expression of the BCL6 gene in these tumors...
  17. ncbi request reprint Optimization of quantitative real-time RT-PCR parameters for the study of lymphoid malignancies
    I S Lossos
    Department of Medicine, Stanford University Medical Center, CA, USA
    Leukemia 17:789-95. 2003
    ..The expression of the gene of interest in different samples should be normalized by concomitant measurement of the PRKG1 and/or the TBP gene products...
  18. ncbi request reprint BCL-6 mRNA expression in higher grade transformation of follicle center lymphoma: correlation with somatic mutations in the 5' regulatory region of the BCL-6 gene
    I S Lossos
    Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305 5306, USA
    Leukemia 16:1857-62. 2002
    ....
  19. pmc High incidence of false-positive PET scans in patients with aggressive non-Hodgkin's lymphoma treated with rituximab-containing regimens
    H S Han
    Division of Hematology and Oncology, The Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Ann Oncol 20:309-18. 2009
    ..Little is known about the predictive power of PET in rituximab-treated patients...
  20. ncbi request reprint LMO2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with anthracycline-based chemotherapy with and without rituximab
    Yasodha Natkunam
    Department of Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, CA, USA
    J Clin Oncol 26:447-54. 2008
    ..Here, we tested the prognostic impact of LMO2 protein expression in DLBCL patients treated with anthracycline-based chemotherapy with or without rituximab...
  21. pmc Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP
    Raquel Malumbres
    Department of Medicine, Division of Hematology Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 111:5509-14. 2008
    ..008). These findings demonstrate that the prognostic value of the 6-gene model remains significant in the era of R-CHOP treatment and that the model can be applied to routine FFPE tissue from initial diagnostic biopsies...
  22. pmc Expression of the human germinal center-associated lymphoma (HGAL) protein, a new marker of germinal center B-cell derivation
    Yasodha Natkunam
    Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr, Stanford, CA 94305, USA
    Blood 105:3979-86. 2005
    ..The restricted expression and GC specificity of HGAL protein suggest that it may have an important role in the diagnosis of specific lymphomas, and, potentially in the identification of subtypes associated with different prognoses...
  23. pmc Expression of the human germinal center-associated lymphoma (HGAL) protein identifies a subset of classic Hodgkin lymphoma of germinal center derivation and improved survival
    Yasodha Natkunam
    Department of Pathology, Stanford University School of Medicine, CA, USA
    Blood 109:298-305. 2007
    ..The association with improved OS in univariate but not multivariate analysis suggests that HGAL expression is related to known clinical parameters of improved survival...
  24. pmc Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas
    I S Lossos
    Departments of Medicine, Biochemistry, and Genetics, Division of Oncology and Howard Hughes Medical Institute, Stanford University Medical Center, Stanford, CA 94305 5306, USA
    Proc Natl Acad Sci U S A 97:10209-13. 2000
    ..Our findings validate the concept that lymphoid malignancies are derived from cells at discrete stages of normal lymphocyte maturation and that the malignant cells retain the genetic program of those normal cells...
  25. pmc The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas
    Yasodha Natkunam
    Department of Pathology, Stanford University School of Medicine, CA, USA, and Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK
    Blood 109:1636-42. 2007
    ..Our results warrant inclusion of LMO2 in multivariate analyses to construct a clinically applicable immunohistologic algorithm for predicting survival in patients with DLBCL...
  26. pmc Lymphoma cell VEGFR2 expression detected by immunohistochemistry predicts poor overall survival in diffuse large B cell lymphoma treated with immunochemotherapy (R-CHOP)
    Dita Gratzinger
    Department of Pathology, Stanford University School of Medicine, CA 94305 5324, USA
    Br J Haematol 148:235-44. 2010
    ..In contrast to our prior results with chemotherapy alone, microvessel density was not prognostic of PFS or OS with R-CHOP-like therapy...
  27. pmc Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components
    Sheren F Younes
    Department of Pathology, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Surg Pathol 34:1266-76. 2010
    ....
  28. ncbi request reprint Distinct IL-4-induced gene expression, proliferation, and intracellular signaling in germinal center B-cell-like and activated B-cell-like diffuse large-cell lymphomas
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, 1475 NW 12th Ave D8 4, Miami, FL 33136, USA
    Blood 105:2924-32. 2005
    ..These differences in tyrosine phosphatase expression might underlie distinct expression profiles of some of the IL-4 target genes and could contribute to a different clinical outcome of patients with GCB-like and ABC-like DLBCLs...
  29. ncbi request reprint BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma
    Takashi Akasaka
    Division of Oncology, Department of Medicine, Stanford University Medical Center, CA, USA
    Blood 102:1443-8. 2003
    ..Our study demonstrated that BCL6 translocation is not necessary for transformation but that BCL6 translocation in FL may constitute a subgroup with a higher risk to transform into aggressive lymphoma...
  30. ncbi request reprint T cell activation following infection of primary follicle center lymphoma B cells with adenovirus encoding CD154
    M J Cantwell
    Immunogenex, Inc, La Jolla, CA, USA
    Leukemia 15:1451-7. 2001
    ..As such, Ad-CD154-transduced lymphoma B cells may have potential for the active immune therapy of patients with follicle center lymphoma...
  31. ncbi request reprint A polymorphism in the BCL-6 gene is associated with follicle center lymphoma
    I S Lossos
    Department of Medicine, Stanford University Medical Center, CA 94305 5151, USA
    Leuk Lymphoma 42:1343-50. 2001
    ....
  32. ncbi request reprint Pharmacotherapy of large B-cell lymphoma
    Maricer P Escalon
    University of Miami Sylvester Cancer Center, 1475 NW 12 Ave Suite 3400 D8 4, Miami, FL 33136, USA
    Expert Opin Pharmacother 9:2247-58. 2008
    ..DLBCL was considered incurable until combination chemotherapy became available...
  33. pmc T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6
    XiaoQing Lu
    Department of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Mol Cell Biol 27:2166-79. 2007
    ....
  34. ncbi request reprint Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes
    Izidore S Lossos
    Division of Oncology, Department of Medicine, Stanford University Medical Center, Stanford, Calif, USA
    N Engl J Med 350:1828-37. 2004
    ..Several gene-expression signatures can be used to predict the prognosis in diffuse large-B-cell lymphoma, but the lack of practical tests for a genome-scale analysis has restricted the use of this method...
  35. ncbi request reprint Apoptosis-stimulating protein of p53-2 (ASPP2/53BP2L) is an E2F target gene
    D Chen
    Department of Medicine, Division of Hematology and Medical Oncology, L586B, Oregon Health and Science University, Portland, OR 97239, USA
    Cell Death Differ 12:358-68. 2005
    ..Typical for an E2F target, ASPP2/53BP2L expression was maximal in early S-phase. Thus, ASPP2/53BP2L is downstream of E2F, suggesting that it functions as a common link between the p53/p73 and Rb/E2F apoptotic pathways...
  36. ncbi request reprint Gene expression profiling in diffuse large B-cell lymphoma
    Daniel Morgensztern
    Division of Hematology Oncology, Department of Medicine, Washington University in St Louis, St Louis, MO, USA
    Leuk Lymphoma 48:669-82. 2007
    ..These insights may lead to the discovery of new targeted therapies. This review describes the progress that has been made in our understanding of DLBCL as a result of gene expression profiling...
  37. ncbi request reprint Optimization of RNA extraction from formalin-fixed, paraffin-embedded lymphoid tissues
    Jun Chen
    Department of Medicine, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA corrected
    Diagn Mol Pathol 16:61-72. 2007
    ....
  38. pmc Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
    Raquel Malumbres
    Department of Medicine, Division of Hematology Oncology and Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 113:3754-64. 2009
    ..A 9-miRNA signature was identified that could precisely differentiate the 2 major subtypes of DLBCL. Finally, expression of some of the miRNAs in this signature is correlated with clinical outcome of uniformly treated DLBCL patients...
  39. pmc Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy
    Kristopher A Sarosiek
    Department of Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    Br J Haematol 147:308-18. 2009
    ....
  40. pmc Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas
    Kristopher A Sarosiek
    Department of Molecular and Cellular Pharmacology, University of Miami, FL, USA
    Blood 115:570-80. 2010
    ..Moreover, based on IL-21's potency in vitro and in animal models, our findings indicate that this cytokine should be examined in clinical studies of DLBCL...
  41. ncbi request reprint HGAL is a novel interleukin-4-inducible gene that strongly predicts survival in diffuse large B-cell lymphoma
    Izidore S Lossos
    Division of Oncology, Department of Medicine and the Department of Health Research and Policy, Stanford University School of Medicine, CA, USA
    Blood 101:433-40. 2003
    ..This association was independent of the clinical international prognostic index. High HGAL mRNA expression should be used as a prognostic factor in DLBCL...
  42. pmc Characterization of D-cyclin proteins in hematolymphoid neoplasms: lack of specificity of cyclin-D2 and D3 expression in lymphoma subtypes
    Ryan A Metcalf
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Mod Pathol 23:420-33. 2010
    ..For diagnostic purposes, however, the expression of D-cyclin proteins should be interpreted with caution in the subclassification of lymphoma types...
  43. pmc Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
    Kristopher A Sarosiek
    Department of Molecular and Cellular Pharmacology, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 107:13069-74. 2010
    ..Our findings show that this direct xenograft model can be used for testing novel PEL therapeutic strategies and also can provide a rational basis for evaluation of bortezomib in clinical trials...
  44. doi request reprint Expression profiles of adult T-cell leukemia-lymphoma and associations with clinical responses to zidovudine and interferon alpha
    Ash A Alizadeh
    Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Leuk Lymphoma 51:1200-16. 2010
    ..Demonstration of specific gene expression signatures associated with response to AZT-IFNalpha therapy may provide novel insights into the mechanisms of action in ATLL...
  45. doi request reprint Double trouble in follicular lymphoma: A rare and unusual synergy of oncogenes in the germinal center
    Ash A Alizadeh
    Division of Hematology and Oncology, Department of Medicine, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
    Leuk Lymphoma 49:377-80. 2008
  46. ncbi request reprint Diffuse large B-cell lymphoma: insights gained from gene expression profiling
    Izidore S Lossos
    Department of Hematology and Oncology, University of Miami, Sylvester Comprehensive Cancer Center, Miami, Florida 33136, USA
    Int J Hematol 77:321-9. 2003
    ..However, we now realize that the disease is extremely heterogeneous. This review summarizes the progress in understanding DLBCL that has been made as a result of the application of gene expression profiling...
  47. ncbi request reprint Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome
    Izidore S Lossos
    Division of Medical Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Leuk Lymphoma 43:2309-17. 2002
    ..Larger studies as well as analysis of different tumor types are warranted...
  48. ncbi request reprint Molecular prognostic factors in diffuse large B-cell lymphoma
    Daniel Morgensztern
    Division of Hematology Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, 1475 NW 12th Ave, D8 4, Miami, Florida 33136, USA
    Curr Treat Options Oncol 6:269-77. 2005
    ..Such materials should be gathered as an integral part of any planned study...
  49. pmc Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes
    Izidore S Lossos
    Division of Oncology, Department of Medicine, Stanford Genome Technology Center, and Howard Hughes Medical Institute, Stanford, CA 94305 5306, USA
    Proc Natl Acad Sci U S A 99:8886-91. 2002
    ....
  50. doi request reprint The transcription factor LMO2 is a robust marker of vascular endothelium and vascular neoplasms and selected other entities
    Dita Gratzinger
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Am J Clin Pathol 131:264-78. 2009
    ..The restricted expression pattern, nuclear localization, and crisp staining of LMO2 in paraffin blocks make it an attractive candidate for the diagnostic immunohistochemistry laboratory...
  51. doi request reprint [18F]-fluorodeoxyglucose positron emission tomography combined with computed tomography detection of asymptomatic late pulmonary toxicity in patients with non-Hodgkin lymphoma treated with rituximab-containing chemotherapy
    Dimitrios Kalkanis
    Department of Radiology, Division of Nuclear Medicine, Jackson Memorial Hospital and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Leuk Lymphoma 50:904-11. 2009
    ..84. Rituximab-containing chemotherapy for NHL may be associated with asymptomatic late pulmonary toxicity characterised by a distinct FDG uptake pattern. Awareness of this finding is important and should not be confused with lymphoma...
  52. pmc IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma
    Juan Carlos Ramos
    Division of Hematology Oncology, Department of Medicine, University of Miami Miller School of Medicine, FL 33136, USA
    Blood 109:3060-8. 2007
    ..These molecular features may help guide treatment. AZT and IFN-alpha is a suppressive rather than a curative regimen, and patients in clinical remission should remain on maintenance therapy indefinitely...
  53. doi request reprint Primary bone lymphoma--the University of Miami experience
    Alvaro Alencar
    Division of Hematology Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Leuk Lymphoma 51:39-49. 2010
    ..Although the current data support the use of combined modality treatment for localized PBL, randomized controlled trials are needed especially now, when rituximab is routinely added to chemotherapy regimens...
  54. ncbi request reprint Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipients
    Susanne Auffermann-Gretzinger
    Division of Oncology and Bone Marrow Transplantation, Department of Medicine, The Blood Center, Stanford University Medical Center, CA 94305, USA
    Blood 99:1442-8. 2002
    ..This information has potential implications for manipulation of immune responses after allogeneic HCT...
  55. pmc Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: a study of 51 cases
    Mohamed E Salama
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Am J Clin Pathol 132:39-49. 2009
    ..Our results highlight the histologic and immunoarchitectural spectrum of NMZL and the usefulness of immunohistochemical analysis for CD43, CD23, CD21, BCL6, HGAL, and LMO2 in the diagnosis of NMZL...
  56. ncbi request reprint Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature
    Sakher Abdullah
    Department of Medicine, Division of Hematology and Oncology, University of Miami Sylvester Cancer Center, Miami, FL 331396, USA
    Leuk Lymphoma 46:1651-7. 2005
    ..This is the first report of precursor B-cell lymphoblastic lymphoma of dura mater. A review of the literature on primary lymphomas of cranial dura mater is presented...
  57. pmc PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling
    XiaoQing Lu
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, Monash University, Victoria, Australia
    Blood 112:4098-108. 2008
    ..These observations identify a novel regulatory loop for the regulation of IL-4-induced STAT6 signaling that may have important implications in both neoplastic and inflammatory processes...
  58. ncbi request reprint Non-Hodgkin's lymphoma in the microarray era
    Izidore S Lossos
    Division of Hematology Oncology, Department of Medicine, University of Miami, FL
    Clin Lymphoma 5:128-9. 2004
  59. pmc HGAL, a lymphoma prognostic biomarker, interacts with the cytoskeleton and mediates the effects of IL-6 on cell migration
    XiaoQing Lu
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, FL 33136, USA
    Blood 110:4268-77. 2007
    ..Inhibition of lymphocyte migration might contribute to the less aggressive clinical behavior of HGAL-expressing lymphomas...
  60. doi request reprint Pulmonary marginal zone lymphoma: a single centre experience and review of the SEER database
    Alexandra Stefanovic
    Department of Medicine, Division of Hematology Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    Leuk Lymphoma 49:1311-20. 2008
    ..Our single institution experience and review of the SEER database, confirm the indolent features and favourable outcome of this rare disease...
  61. ncbi request reprint Mutation of the ATM gene is not involved in the pathogenesis of either follicle center lymphoma or its transformation to higher-grade lymphoma
    Izidore S Lossos
    Department of Medicine, Stanford University Medical Center, CA 94305 5151, USA
    Leuk Lymphoma 43:1079-85. 2002
    ..No new ATM gene mutations were associated with transformation from FCL to DLBCL. Thus, ATM gene mutations do not play a pivotal role either in the pathogenesis of FCL or in its transformation to DLBCL...
  62. doi request reprint Central nervous system manifestations of marginal zone B-cell lymphoma
    Soley Bayraktar
    Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center, FL 33136, USA
    Ann Hematol 89:1003-9. 2010
    ..Primary or secondary CNS involvement by MZBCL display indolent clinical behavior and have a generally favorable prognosis, underlining the importance of their differentiation from aggressive lymphomas that more commonly involve the CNS...
  63. ncbi request reprint Ocular involvement as the initial manifestation of T-cell chronic lymphocytic leukemia
    Carmen J Calfa
    Department of Medicine, Hematology Oncology, University of Miami Miller School of Medicine and Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA
    Am J Ophthalmol 144:326-9. 2007
    ..To present a case of T-cell chronic lymphocytic leukemia (T-CLL) manifesting as an intraocular lymphoma...
  64. doi request reprint C-C chemokine receptor 1 expression in human hematolymphoid neoplasia
    Matthew W Anderson
    Dept of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA
    Am J Clin Pathol 133:473-83. 2010
    ..These data suggest that CCR1 may be useful for lymphoma classification and support a role for chemokine signaling in the pathogenesis of hematolymphoid neoplasia...
  65. pmc Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci
    Manuel F Rosado
    Sylvester Comprehensive Cancer Center, Division of Hematology Oncology, Department of Medicine, University of Miami, FL 33136, USA
    Blood 107:467-72. 2006
    ..In South Florida, OALs are not associated with C psittaci infections...
  66. ncbi request reprint Prognostic significance of VEGF, VEGF receptors, and microvessel density in diffuse large B cell lymphoma treated with anthracycline-based chemotherapy
    Dita Gratzinger
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Lab Invest 88:38-47. 2008
    ..Dependence on autocrine vascular endothelial growth factor receptor-1-mediated signaling may render a subset of diffuse large B-cell lymphomas susceptible to anthracycline-based therapy...
  67. ncbi request reprint Primary diffuse large cell lymphoma of the mandible
    Manuel F Rosado
    Division of Hematology Oncology, Department of Medicine, University of Miami, Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital, Miami, Florida, USA
    Leuk Lymphoma 45:1049-53. 2004
    ..Multi-center prospective clinical trials are needed to determine the optimal therapeutic approach to this rare diffuse large cell lymphoma presentation...
  68. ncbi request reprint Somatostatin receptor scintigraphy in MALT lymphoma of the lacrimal gland treated with rituximab
    Daniel Morgensztern
    Hematology Oncology Division, University of Miami Sylvester Cancer Center Miami, FL 33136, USA
    Leuk Lymphoma 45:1275-8. 2004
    ..We present a case of lacrimal gland MALT lymphoma demonstrating the usefulness of somatostatin receptor scintigraphy for initial staging and evaluation of response to treatment...
  69. doi request reprint Expression of HGAL in primary cutaneous large B-cell lymphomas: evidence for germinal center derivation of primary cutaneous follicular lymphoma
    Xiuyan Xie
    Department of Clinical Pathology, Cleveland Clinic, Cleveland, OH 44195, USA
    Mod Pathol 21:653-9. 2008
    ..Characterizing PCLBCLs with markers of B-cell maturation stage is a useful framework for studying, classifying, and clinically stratifying these lymphomas...
  70. ncbi request reprint Analysis of FAS (CD95) gene mutations in higher-grade transformation of follicle center lymphoma
    Bao Do
    Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA
    Leuk Lymphoma 44:1317-23. 2003
    ..Nine of the polymorphisms occurred in non-translated regions, while one silent mutation was located in exon 7. Neither loss of heterozygosity nor occurrence of new mutations was observed upon higher-grade transformation of FCL to DLBCL...
  71. ncbi request reprint The t(14;18) defines a unique subset of diffuse large B-cell lymphoma with a germinal center B-cell gene expression profile
    James Z Huang
    Department of Pathology, The Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Blood 99:2285-90. 2002
    ..CD10 protein expression is useful in identifying cases of DLBCL with a germinal center B-cell gene expression profile and is often expressed in cases with the t(14;18)...
  72. ncbi request reprint Central nervous system relapse of systemic non-Hodgkin's lymphoma: results of treatment based on high-dose methotrexate combination chemotherapy
    Felix Bokstein
    Neuro Oncology Center Hadassah Hebrew University Hospital, Jerusalem, Israel
    Leuk Lymphoma 43:587-93. 2002
    ..Durable responses are rare. Since both CNS and systemic relapses appear in tandem, future trials should evaluate alternative modalities in order to enhance drug delivery into the CNS...
  73. ncbi request reprint Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations
    Jose A Martinez-Climent
    Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Spain
    Blood 101:3109-17. 2003
    ..This process is associated with the acquisition of a variable spectrum of genomic imbalances affecting recurrent chromosomal areas that harbor overexpressed or underexpressed genes targeted upon transformation...
  74. ncbi request reprint Somatically mutated immunoglobulin IGHV@ genes without intraclonal heterogeneity indicate a postgerminal centre origin of primary intraocular diffuse large B-cell lymphomas
    Raquel Malumbres
    Division of Hematology Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    Br J Haematol 138:749-55. 2007
    ..The sequences showed no evidence of antigen selection and revealed absence of intraclonal heterogeneity in four of five cases, suggesting that PIOL and PCNSL may differ in their ontogeny...
  75. doi request reprint Expression of the human germinal-centre-associated lymphoma protein in diffuse large B-cell lymphomas in patients with rheumatoid arthritis
    Eva Baecklund
    Department of Rheumatology, University Hospital, Uppsala, Sweden
    Br J Haematol 141:69-72. 2008
    ..This supports that a majority of RA-DLBCL are of non-GC origin, indicating a specific role for activated peripheral B cells in the pathogenesis of RA-DLBCL...
  76. ncbi request reprint Chronic lymphocytic leukemia-associated nephrotic syndrome caused by focal segmental glomerulosclerosis
    Manuel F Rosado
    Am J Hematol 77:205-6. 2004
  77. doi request reprint Lenalidomide monotherapy in relapsed or refractory aggressive non-Hodgkin's lymphoma
    Peter H Wiernik
    Our Lady of Mercy Cancer Center, New York Medical College, Bronx, NY, USA
    J Clin Oncol 26:4952-7. 2008
    ..We report the results of a phase II, single-arm, multicenter trial evaluating the safety and efficacy of lenalidomide oral monotherapy in patients with relapsed or refractory aggressive NHL...
  78. doi request reprint Successful use of semi-nested PCR for the diagnosis of primary intraocular lymphoma
    Michael R Feilmeier
    Leuk Lymphoma 49:1612-5. 2008
  79. ncbi request reprint Rituximab for treatment of chemoimmunotherapy naive marginal zone lymphoma
    Izidore S Lossos
    Leuk Lymphoma 48:1630-2. 2007

Research Grants10

  1. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  2. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..
  3. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2005
    ..These mechanistic studies may provide approaches for new therapeutic strategies. ..
  4. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2009
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..
  5. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2009
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  6. Prognostic Models in Diffuse Large B-Cell Lymphoma
    Izidore Lossos; Fiscal Year: 2007
    ..Further, establishment of a paraffin-based RNA prognostic model using the new methodology of RNA extraction could serve as a paradigm for other lymphomas and tumors. ..
  7. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2007
    ..These mechanistic studies may provide approaches for new therapeutic strategies. ..
  8. Significance and Function of HGAL in Lymphoma
    Izidore Lossos; Fiscal Year: 2006
    ..These mechanistic studies may provide approaches for new therapeutic strategies. ..
  9. Significance and Function of HGAL in Lymphoma
    Izidore S Lossos; Fiscal Year: 2010
    ..These findings will not only elucidate the mechanisms of tumor dissemination but also will identify a new potential molecular target for novel therapeutic intervention. ..