Brian J Lopresti

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Ann Neurol 55:306-19. 2004
  2. ncbi Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic dege
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 172:1603-16. 2008
  3. ncbi Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
  4. ncbi Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
  5. ncbi Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
  6. ncbi Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm. B-938, PA 15213, USA
    Neuroimage 33:94-102. 2006
  7. ncbi The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
  8. ncbi Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  9. ncbi Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
  10. ncbi Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008

Detail Information

Publications29

  1. ncbi Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
    Ann Neurol 55:306-19. 2004
    ..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
  2. ncbi Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic dege
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 172:1603-16. 2008
    ..A combination of PET imaging and the assessment of these peripheral immune parameters may facilitate longitudinal assessment of lentiviral encephalitis in living patients as well as evaluation of therapeutic efficacies...
  3. ncbi Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  4. ncbi Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  5. ncbi Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  6. ncbi Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm. B-938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  7. ncbi The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
    ....
  8. ncbi Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  9. ncbi Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  10. ncbi Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  11. ncbi PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurobiol Aging 30:1217-26. 2009
    ....
  12. ncbi Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  13. ncbi A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  14. ncbi Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  15. ncbi Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET
    Charles M Laymon
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:814-7. 2009
    ..We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses...
  16. ncbi Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:1344-9. 2011
    ....
  17. ncbi Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ)
    Charles M Laymon
    Department of Radiology, UPMC Presbyterian Hospital, University of Pittsburgh, Room B 938, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Mol Imaging Biol 14:115-22. 2012
    ..We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses...
  18. ncbi In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, USA
    Am J Psychiatry 169:55-63. 2012
    ....
  19. ncbi A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007
    ....
  20. ncbi Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  21. ncbi Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  22. ncbi Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA...
  23. ncbi Impact of amyloid imaging on drug development in Alzheimer's disease
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nucl Med Biol 34:809-22. 2007
    ....
  24. ncbi Influence of pediatric vaccines on amygdala growth and opioid ligand binding in rhesus macaque infants: A pilot study
    Laura Hewitson
    Department of Obstetrics and Gynecology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Acta Neurobiol Exp (Wars) 70:147-64. 2010
    ..The macaque infant is a relevant animal model in which to investigate specific environmental exposures and structural/functional neuroimaging during neurodevelopment...
  25. ncbi Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  26. ncbi Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    William E Klunk
    University of Pittsburgh Medical School Pittsburgh, MA, USA
    Brain 129:2805-7. 2006
  27. ncbi Development of positron emission tomography β-amyloid plaque imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Semin Nucl Med 42:423-32. 2012
    ..It is likely that the full clinical impact of these imaging agents will be realized by identifying presymptomatic subjects who would benefit from early drug treatments with future disease-modifying AD therapeutics...
  28. ncbi The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Prog Neurobiol 80:308-22. 2006
    ..Current evidence suggests these findings might be applied to the development of clinical assessments of microglial activation in neurological disorders...
  29. ncbi PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS
    Sriram Venneti
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Invest 113:981-9. 2004
    ....