R D Lopez

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer
    Zhiyong Liu
    Division of Hematology and Oncology, Department of Pathology, The Univeresity of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 180:6044-53. 2008
  2. ncbi request reprint CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy str
    R D Lopez
    Division of Bone Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
    Blood 96:3827-37. 2000
  3. ncbi request reprint CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells
    R D Lopez
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, 35294, USA
    Cancer Immunol Immunother 49:629-40. 2001
  4. ncbi request reprint Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases
    Richard D Lopez
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, 35294 3300, USA
    Immunol Res 26:207-21. 2002
  5. ncbi request reprint Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12
    Ben L Guo
    Bone Marrow Transplantation Program, THT 541, University of Alabama at Birmingham, 1900 University Blvd, Birmingham, AL 35294, USA
    Cancer Immunol Immunother 50:625-37. 2002
  6. ncbi request reprint gammadelta T cells: a new frontier for immunotherapy?
    Lawrence S Lamb
    Department of Medicine, Division of Hematology and Oncology, Bone Marrow Transplantation Program, University of Alabama at Birmingham School of Medicine, 32594 0006, USA
    Biol Blood Marrow Transplant 11:161-8. 2005
  7. ncbi request reprint Ex vivo expanded human Vgamma9Vdelta2+ gammadelta-T cells mediate innate antitumor activity against human prostate cancer cells in vitro
    Zhiyong Liu
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Urol 173:1552-6. 2005
  8. ncbi request reprint Innate anti-breast cancer immunity of apoptosis-resistant human gammadelta-T cells
    Ben L Guo
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Breast Cancer Res Treat 93:169-75. 2005

Research Grants

  1. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2004

Collaborators

  • EDMUND WALLER
  • Lawrence S Lamb
  • Zhiyong Liu
  • Ben L Guo
  • Isam Eldin A Eltoum
  • Benjamin H Beck
  • Ben Guo
  • Gretchen A Cloud
  • Wayne A Aldrich
  • Li Nan
  • Bradley C Gehrs
  • Klaus A Hollmig

Detail Information

Publications8

  1. ncbi request reprint Protective immunosurveillance and therapeutic antitumor activity of gammadelta T cells demonstrated in a mouse model of prostate cancer
    Zhiyong Liu
    Division of Hematology and Oncology, Department of Pathology, The Univeresity of Alabama at Birmingham, 1900 University Boulevard, Birmingham, AL 35294, USA
    J Immunol 180:6044-53. 2008
    ..These findings provide a biological rationale for clinical trials designed to adoptively transfer ex vivo expanded autologous gammadelta T cells for the treatment of prostate cancer...
  2. ncbi request reprint CD2-mediated IL-12-dependent signals render human gamma delta-T cells resistant to mitogen-induced apoptosis, permitting the large-scale ex vivo expansion of functionally distinct lymphocytes: implications for the development of adoptive immunotherapy str
    R D Lopez
    Division of Bone Marrow Transplantation, Stanford University School of Medicine, Stanford, CA, USA
    Blood 96:3827-37. 2000
    ..Blood. 2000;96:3827-3837)..
  3. ncbi request reprint CD58/LFA-3 and IL-12 provided by activated monocytes are critical in the in vitro expansion of CD56+ T cells
    R D Lopez
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, 35294, USA
    Cancer Immunol Immunother 49:629-40. 2001
    ..The biological and therapeutic implications of these findings are discussed...
  4. ncbi request reprint Human gammadelta-T cells in adoptive immunotherapy of malignant and infectious diseases
    Richard D Lopez
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, 35294 3300, USA
    Immunol Res 26:207-21. 2002
    ..Both the biologic and practical implications of these findings are considered and discussed particularly as they relate to the development of future adoptive immunotherapy strategies...
  5. ncbi request reprint Down-regulation of IL-2 receptor alpha (CD25) characterizes human gammadelta-T cells rendered resistant to apoptosis after CD2 engagement in the presence of IL-12
    Ben L Guo
    Bone Marrow Transplantation Program, THT 541, University of Alabama at Birmingham, 1900 University Blvd, Birmingham, AL 35294, USA
    Cancer Immunol Immunother 50:625-37. 2002
    ..The biological and clinical implications of these findings are discussed...
  6. ncbi request reprint gammadelta T cells: a new frontier for immunotherapy?
    Lawrence S Lamb
    Department of Medicine, Division of Hematology and Oncology, Bone Marrow Transplantation Program, University of Alabama at Birmingham School of Medicine, 32594 0006, USA
    Biol Blood Marrow Transplant 11:161-8. 2005
    ....
  7. ncbi request reprint Ex vivo expanded human Vgamma9Vdelta2+ gammadelta-T cells mediate innate antitumor activity against human prostate cancer cells in vitro
    Zhiyong Liu
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Urol 173:1552-6. 2005
    ..Herein we report the innate antitumor activity of expanded human Vgamma9Vdelta2+ gammadelta-T cells against human prostate cancer cells...
  8. ncbi request reprint Innate anti-breast cancer immunity of apoptosis-resistant human gammadelta-T cells
    Ben L Guo
    Bone Marrow Transplantation Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Breast Cancer Res Treat 93:169-75. 2005
    ....

Research Grants4

  1. Gamma Delta T Cells--Immunotherapy for Melanoma
    Richard Lopez; Fiscal Year: 2004
    ..These findings may provide the basis for the rational design of future immunotherapy trials for the treatment of melanoma or other malignancies. ..