Oscar Lopez

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
  2. doi request reprint Mild cognitive impairment
    Oscar L Lopez
    Continuum (Minneap Minn) 19:411-24. 2013
  3. doi request reprint Patterns of compensation and vulnerability in normal subjects at risk of Alzheimer's disease
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15215, USA
    J Alzheimers Dis 33:S427-38. 2013
  4. pmc Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 79:1599-606. 2012
  5. pmc Collaborative research between academia and industry using a large clinical trial database: a case study in Alzheimer's disease
    Roy Jones
    Research Institute for the Care of Older People, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
    Trials 12:233. 2011
  6. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
  7. ncbi request reprint Diagnosis, risk factors, and treatment of vascular dementia
    Oscar L Lopez
    Department of Neurology, 3501 Forbes Avenue, Suite 830, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 4:358-67. 2004
  8. ncbi request reprint Non-cognitive symptoms in mild cognitive impairment subjects
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurocase 11:65-71. 2005
  9. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
  10. pmc Neuropsychological characteristics of mild cognitive impairment subgroups
    O L Lopez
    Department of Neurology, University of Pittsburgh, School of Medicine, PA 15213, USA
    J Neurol Neurosurg Psychiatry 77:159-65. 2006

Detail Information

Publications86

  1. pmc Genetic association between APOE*4 and neuropsychiatric symptoms in patients with probable Alzheimer's disease is dependent on the psychosis phenotype
    Drew Christie
    VISN 20 Mental Illness, Seattle, WA, USA
    Behav Brain Funct 8:62. 2012
    ..The E4 allele of the apolipoprotein E (APOE) gene is a well-documented risk factor for the development of AD. However, genetic association studies of the APOE 4 allele and BPS in AD have produced conflicting findings...
  2. doi request reprint Mild cognitive impairment
    Oscar L Lopez
    Continuum (Minneap Minn) 19:411-24. 2013
    ....
  3. doi request reprint Patterns of compensation and vulnerability in normal subjects at risk of Alzheimer's disease
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15215, USA
    J Alzheimers Dis 33:S427-38. 2013
    ..The understanding of the dynamic of these factors at different age periods will be essential for the implementation of primary prevention treatments for AD...
  4. pmc Incidence of mild cognitive impairment in the Pittsburgh Cardiovascular Health Study-Cognition Study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neurology 79:1599-606. 2012
    ..9 years) in the Cardiovascular Health Study-Cognition Study from 1998-1999 to 2010-2011...
  5. pmc Collaborative research between academia and industry using a large clinical trial database: a case study in Alzheimer's disease
    Roy Jones
    Research Institute for the Care of Older People, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
    Trials 12:233. 2011
    ..We present here a successful example of this type of collaboration in the field of dementia...
  6. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  7. ncbi request reprint Diagnosis, risk factors, and treatment of vascular dementia
    Oscar L Lopez
    Department of Neurology, 3501 Forbes Avenue, Suite 830, Pittsburgh, PA 15213, USA
    Curr Neurol Neurosci Rep 4:358-67. 2004
    ..Therefore, there is a need for a better definition of VaD. This is extremely important to better understand its risk factors, as well as to create homogenous cohorts suitable for drug trials...
  8. ncbi request reprint Non-cognitive symptoms in mild cognitive impairment subjects
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurocase 11:65-71. 2005
    ....
  9. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  10. pmc Neuropsychological characteristics of mild cognitive impairment subgroups
    O L Lopez
    Department of Neurology, University of Pittsburgh, School of Medicine, PA 15213, USA
    J Neurol Neurosurg Psychiatry 77:159-65. 2006
    ..To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study...
  11. doi request reprint Predicting cognitive decline in Alzheimer's disease: an integrated analysis
    Oscar L Lopez
    Department of Neurology, Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA
    Alzheimers Dement 6:431-9. 2010
    ..Numerous patient- and disease-related factors increase the risk of rapid cognitive decline in patients with Alzheimer's disease (AD). The ability of pharmacological treatment to attenuate this risk remains undefined...
  12. pmc Effectiveness and safety of donepezil in Hispanic patients with Alzheimer's disease: a 12-week open-label study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    J Natl Med Assoc 100:1350-8. 2008
    ..This study evaluated the efficacy and safety of donepezil hydrochloride (donepezil) in Hispanics with mild-to-moderate AD...
  13. ncbi request reprint Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh School of Medicine, 3501 Forbes Ave, Suite 830, Oxford Bldg, Pittsburgh, PA 15213 3323, USA
    Arch Neurol 64:416-20. 2007
    ..To examine the incidence of dementia in subjects with mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study...
  14. ncbi request reprint The growing burden of Alzheimer's disease
    Oscar L Lopez
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Manag Care 17:S339-45. 2011
    ..The clinical presentation of AD is heterogeneous and insidious, and the psychological and financial effects of AD on caregivers and family members are significant...
  15. pmc Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study
    O L Lopez
    Department of Psychiatry and Neurology, University of Pittsburgh, PA, USA
    Neurology 70:1664-71. 2008
    ....
  16. ncbi request reprint Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease
    O L Lopez
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 67:660-5. 2006
    ..To determine the relationship between major depression and the presence of Lewy bodies (LBs) in patients with Alzheimer disease (AD)...
  17. ncbi request reprint Alteration of a clinically meaningful outcome in the natural history of Alzheimer's disease by cholinesterase inhibition
    Oscar L Lopez
    Alzheimer s Disease Research Center and Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Am Geriatr Soc 53:83-7. 2005
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD) using clinically meaningful outcomes...
  18. ncbi request reprint Geographic variations in stroke incidence and mortality among older populations in four US communities
    Aiman El-Saed
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Rm 405, Pittsburgh, PA 15213, USA
    Stroke 37:1975-9. 2006
    ..The purpose of this study was to compare stroke incidence and mortality rates in 4 US communities...
  19. pmc Pathways linking late-life depression to persistent cognitive impairment and dementia
    Meryl A Butters
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 10:345-57. 2008
    ....
  20. pmc Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy
    Charles F Reynolds
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 68:51-60. 2011
    ..Cognitive impairment in late-life depression is a core feature of the illness...
  21. pmc The relationship of excess cognitive impairment in MCI and early Alzheimer's disease to the subsequent emergence of psychosis
    Elise A Weamer
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Int Psychogeriatr 21:78-85. 2009
    ..This study seeks to determine whether the degree of cognitive impairment and cognitive decline in early AD predicts subsequent AD + P onset...
  22. ncbi request reprint Alzheimer disease subjects with psychosis have increased schizotypal symptoms before dementia onset
    Elise A Eror
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 58:325-30. 2005
    ..One prediction of this model would be that AD+P subjects would have evidence of increased degrees of subsyndromal psychosis before AD onset...
  23. pmc Patterns of mild cognitive impairment after treatment of depression in the elderly
    Rishi K Bhalla
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 17:308-16. 2009
    ....
  24. ncbi request reprint Prevalence of cognitive disorders differs as a function of age in HIV virus infection
    James T Becker
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    AIDS 18:S11-8. 2004
    ..The purpose of this report is to describe the prevalence and incidence of cognitive impairment in HIV-infected individuals enrolled in a community-based study...
  25. ncbi request reprint Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health study
    Constantine G Lyketsos
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
    JAMA 288:1475-83. 2002
    ..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI...
  26. ncbi request reprint Factors associated with geographic variations in stroke incidence among older populations in four US communities
    Aiman El-Saed
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Rm 405, Pittsburgh, PA 15213, USA
    Stroke 37:1980-5. 2006
    ..The purpose of this study was to study possible reasons for the lower stroke incidence in Allegheny County...
  27. ncbi request reprint Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohort
    Anne B Newman
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 53:1101-7. 2005
    ..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)...
  28. ncbi request reprint Alzheimer disease with psychosis: excess cognitive impairment is restricted to the misidentification subtype
    Gina Perez-Madriñan
    Dept of Psychiatry, Univ of Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 12:449-56. 2004
    ..We hypothesized that these two groups differed in their patterns of cognitive impairment, compared with AD subjects without psychosis...
  29. ncbi request reprint Prediction of psychosis onset in Alzheimer disease: The role of cognitive impairment, depressive symptoms, and further evidence for psychosis subtypes
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Geriatr Psychiatry 14:352-60. 2006
    ..Most prior studies of the clinical correlates of AD+P have been limited, however, by the inclusion of prevalent cases...
  30. pmc Ginkgo biloba for prevention of dementia: a randomized controlled trial
    Steven T DeKosky
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 300:2253-62. 2008
    ..Ginkgo biloba is widely used for its potential effects on memory and cognition. To date, adequately powered clinical trials testing the effect of G. biloba on dementia incidence are lacking...
  31. ncbi request reprint Apolipoprotein E and alpha-1-antichymotrypsin genotypes do not predict time to psychosis in Alzheimer's disease
    Robert A Sweet
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA
    J Geriatr Psychiatry Neurol 15:24-30. 2002
    ..The findings support the hypothesis that these two genetic determinants of AD risk do not contribute to the risk of development of psychotic symptoms in AD...
  32. ncbi request reprint Focal atrophy and cerebrovascular disease increase dementia risk among cognitively normal older adults
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pennysylvania, USA
    J Neuroimaging 17:148-55. 2007
    ....
  33. pmc Mapping cerebellar degeneration in HIV/AIDS
    Andrea D Klunder
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 7332, USA
    Neuroreport 19:1655-9. 2008
    ..Profound cerebellar deficits in HIV/AIDS (P=0.007, corrected) were associated with depression, suggesting a surrogate disease marker for antiretroviral trials...
  34. pmc Tracking Alzheimer's disease
    Paul M Thompson
    Department of Neurology, Laboratory of Neuro Imaging, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Ann N Y Acad Sci 1097:183-214. 2007
    ..Strengths and weaknesses of these different imaging measures for basic neuroscience and drug trials are discussed...
  35. pmc Prediction of psychosis onset in Alzheimer disease: the role of depression symptom severity and the HTR2A T102C polymorphism
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1054-62. 2007
    ..This did not result from an interaction of HTR2A genotype with antidepressant use. Psychosis onset in AD is strongly associated with severity of depressive symptoms, an association that may be modified by HTR2A genotype...
  36. ncbi request reprint Evaluation of dementia in the cardiovascular health cognition study
    Oscar L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, PA 15261, USA
    Neuroepidemiology 22:1-12. 2003
    ..To describe a methodology to evaluate dementia and frequency of different types of dementia and prevalence of the Cardiovascular Health Study (CHS)...
  37. pmc Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 302:2663-70. 2009
    ..The herbal product Ginkgo biloba is taken frequently with the intention of improving cognitive health in aging. However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning...
  38. pmc Imaging cerebral blood flow in the cognitively normal aging brain with arterial spin labeling: implications for imaging of neurodegenerative disease
    Charles Lee
    Department of Radiology, Neuroradiology Division, University of Pittsburgh Medical Center, Pittsburgh, PA 15213 2582, USA
    J Neuroimaging 19:344-52. 2009
    ..The purpose of this article is to present ASL imaging features of 38 elderly cognitively normals (CN) with their rCBF values and an averaged profile of targeted anatomic regions rCBF values...
  39. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  40. pmc Trajectories of cognitive decline in Alzheimer's disease
    Patricia A Wilkosz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Int Psychogeriatr 22:281-90. 2010
    ..We therefore used latent class modeling to characterize trajectories of cognitive and behavioral decline in a cohort of AD subjects...
  41. pmc Depressed mood is not a risk factor for incident dementia in a community-based cohort
    James T Becker
    Department of Psychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:653-63. 2009
    ..To determine the relationship between depressed mood and the development of Alzheimer disease in cognitively normal individuals...
  42. pmc Identifying mild cognitive impairment at baseline in the Ginkgo Evaluation of Memory (GEM) study
    Beth E Snitz
    Department of Neurology, University of Pittsburgh
    Aging Ment Health 13:171-82. 2009
    ..To identify, characterize and compare the frequency of mild cognitive impairment (MCI) subtypes at baseline in a large, late-life cohort (n = 3063) recruited into a dementia prevention trial...
  43. ncbi request reprint Alterations in the hemodynamic response function in cognitively impaired HIV/AIDS subjects
    Shannon B Juengst
    Department of Psychiatry, University of Pittsburgh School of Medicine, United States
    J Neurosci Methods 163:208-12. 2007
    ..The HRF of MNCD/HAD subjects did not return to baseline after 16s, suggesting subtle alterations in neuronal function, which may affect event-related fMRI studies...
  44. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  45. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  46. ncbi request reprint Three-dimensional patterns of hippocampal atrophy in mild cognitive impairment
    James T Becker
    Alzheimer s Disease Research Center, University of Pittsburgh, PA 15213, USA
    Arch Neurol 63:97-101. 2006
    ....
  47. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  48. ncbi request reprint Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment
    Steven T DeKosky
    Department of Neurology and the Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Ann Neurol 53:81-90. 2003
    ....
  49. ncbi request reprint Psychosis in Alzheimer disease: postmortem magnetic resonance spectroscopy evidence of excess neuronal and membrane phospholipid pathology
    Robert A Sweet
    Department of Psychiatry, Division of Geriatrics, Neuropsychiatry, University of Pittsburgh School of Medicine, PA, USA
    Neurobiol Aging 23:547-53. 2002
    ..Although AD+P has been inconsistently associated with more severe neuropathology, no prior studies have examined measures of neuronal and synaptic integrity...
  50. ncbi request reprint Research evaluation and prospective diagnosis of dementia with Lewy bodies
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Arch Neurol 59:43-6. 2002
    ..To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia...
  51. ncbi request reprint The Ginkgo Evaluation of Memory (GEM) study: design and baseline data of a randomized trial of Ginkgo biloba extract in prevention of dementia
    Steven T DeKosky
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    Contemp Clin Trials 27:238-53. 2006
    ..Studies such as these are necessary for this and a variety of other potential protective agents to evaluate their effectiveness in preventing or slowing the emergence of dementia in the elderly population...
  52. ncbi request reprint Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  53. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  54. ncbi request reprint Neuropathologic correlates of late-onset major depression
    Robert A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2242-50. 2004
    ..These preliminary findings suggest that AD is the predominant neuropathologic condition in LLMD subjects with dementia. Further assessment of the role of comorbid cerebrovascular disease and comorbid DLB is needed...
  55. pmc Effects of image normalization on the statistical analysis of perfusion MRI in elderly brains
    Weiying Dai
    Department of Computer Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Magn Reson Imaging 28:1351-60. 2008
    ..To fully understand the effects of an image processing methodology on the comparisons of regional patterns of brain perfusion over time and between subject groups...
  56. ncbi request reprint Differential cortical atrophy in subgroups of mild cognitive impairment
    Sandra Bell-McGinty
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Arch Neurol 62:1393-7. 2005
    ..To compare gray matter brain volumes in patients diagnosed with subtypes of mild cognitive impairment (MCI) (those with a focal amnestic disorder and those with more diffuse cognitive dysfunction) with those of elderly controls...
  57. pmc Event-related functional magnetic resonance imaging investigation of executive control in very old individuals with mild cognitive impairment
    Caterina Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 57:761-7. 2005
    ....
  58. pmc Abnormal regional cerebral blood flow in cognitively normal elderly subjects with hypertension
    Weiying Dai
    Department of Computer Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Stroke 39:349-54. 2008
    ..This is a noninvasive technique that does not require either injections or ionizing radiation and can measure absolute rCBF rates over the entire brain...
  59. pmc Three-dimensional surface mapping of the caudate nucleus in late-life depression
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 17:4-12. 2009
    ....
  60. pmc Localized measures of callosal atrophy are associated with late-life hypertension: AGES-Reykjavik Study
    Peter Harris
    Department of Neurology, University of California, Davis, CA, USA
    Neuroimage 43:489-96. 2008
    ..The posterior CC may be differentially vulnerable to hypertension-associated atrophy, possibly due to its relatively tenuous vascularization...
  61. pmc 3D pattern of brain atrophy in HIV/AIDS visualized using tensor-based morphometry
    Ming Chang Chiang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 34:44-60. 2007
    ..To perform TBM, we developed a new MRI-based analysis technique that uses fluid image warping, and a new alpha-entropy-based information-theoretic measure of image correspondence, called the Jensen-Rényi divergence (JRD)...
  62. pmc Multivariate tensor-based morphometry on surfaces: application to mapping ventricular abnormalities in HIV/AIDS
    Yalin Wang
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7332, USA
    Neuroimage 49:2141-57. 2010
    ..The resulting analysis pipeline may improve the power of surface-based morphometry studies of the brain...
  63. pmc Basal forebrain atrophy is a presymptomatic marker for Alzheimer's disease
    Andrew M Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Alzheimers Dement 4:271-9. 2008
    ....
  64. pmc Does Ginkgo biloba reduce the risk of cardiovascular events?
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
    Circ Cardiovasc Qual Outcomes 3:41-7. 2010
    ..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia...
  65. pmc Genome-wide association studies of MRI-defined brain infarcts: meta-analysis from the CHARGE Consortium
    Stephanie Debette
    Department of Neurology, Boston University School of Medicine, Boston, Mass, USA
    Stroke 41:210-7. 2010
    ..We performed meta-analysis of genome-wide association studies of white participants in 6 studies comprising the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium...
  66. ncbi request reprint Multivariate statistics of the Jacobian matrices in tensor based morphometry and their application to HIV/AIDS
    Natasha Lepore
    Laboratory of Neuro Imaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Med Image Comput Comput Assist Interv 9:191-8. 2006
    ..We apply a manifold version of Hotelling's T2 test to the strain matrices. Our results complement those found from the determinants of the Jacobians alone and provide greater power in detecting group differences in brain structure...
  67. pmc Genome-wide analysis of genetic loci associated with Alzheimer disease
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
    JAMA 303:1832-40. 2010
    ..Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD)...
  68. pmc Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline
    Paul M Thompson
    Laboratory of Neuro Imaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095 1769, USA
    Proc Natl Acad Sci U S A 102:15647-52. 2005
    ..They provide an approach to gauge the impact of AIDS on the living brain and show that the brain is still vulnerable to infection even when patients are receiving antiretroviral therapy...
  69. ncbi request reprint Psychotic symptoms in Alzheimer disease: evidence for subtypes
    Sarah E Cook
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 11:406-13. 2003
    ..Psychotic symptoms in Alzheimer disease (AD) identify a phenotype with distinct neurobiology and genetic architecture. The authors investigated whether AD with psychosis is homogeneous or is a composite of subtypes...
  70. doi request reprint Dementia: is it time for a change in focus?
    Lewis H Kuller
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Alzheimers Dement 4:S77-84. 2008
    ....
  71. pmc A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly
    April J Ho
    Laboratory of Neuroimaging, Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:8404-9. 2010
    ..These brain maps reveal that a commonly carried susceptibility allele for obesity is associated with structural brain atrophy, with implications for the health of the elderly...
  72. ncbi request reprint Gene-environment interactions with cognition in late life and compression of morbidity
    James T Becker
    Am J Psychiatry 164:849-52. 2007
  73. ncbi request reprint Risk factors for dementia in the cardiovascular health cognition study
    Lewis H Kuller
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA 15261, USA
    Neuroepidemiology 22:13-22. 2003
    ..The Cardiovascular Health Cognition Study has evaluated the determinants of dementia among 3,608 participants that had a magnetic resonance imaging (MRI) of the brain in 1991 and were followed to 1998-1999...
  74. pmc Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia
    Owen T Carmichael
    Neurology and Computer Science Departments, Center for Neuroscience, University of California Davis, 1544 Newton Court, Davis, CA 95616, USA
    Alzheimer Dis Assoc Disord 21:14-24. 2007
    ..Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes...
  75. pmc Ventricular volume and dementia progression in the Cardiovascular Health Study
    Owen T Carmichael
    Neurology Department, University of California, Davis, CA 95616, USA
    Neurobiol Aging 28:389-97. 2007
    ..Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology...
  76. ncbi request reprint Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
    Hanae Nakashima-Yasuda
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, HUP Maloney 3rd Floor, Philadelphia, PA 19104 4283, USA
    Acta Neuropathol 114:221-9. 2007
    ..This study expands the concept of TDP-43 proteinopathies by implicating TDP-43 lesions in mechanisms of neurodegeneration in LB disorders...
  77. doi request reprint Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study
    Fumiko Irie
    Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA
    Arch Neurol 65:89-93. 2008
    ..Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes...
  78. ncbi request reprint Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study
    Deborah E Barnes
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Arch Gen Psychiatry 63:273-9. 2006
    ..It has been hypothesized that depressive symptoms and dementia may be attributable to underlying vascular disease in some older persons...
  79. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  80. ncbi request reprint 3D mapping of ventricular and corpus callosum abnormalities in HIV/AIDS
    Paul M Thompson
    Laboratory of Neuro Imaging, Dept of Neurology, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:12-23. 2006
    ..We (1) identified regions with greatest differences between AIDS patients and healthy controls and (2) correlated specific 3D patterns of structural differences with measures of immune system deterioration and cognitive decline...
  81. ncbi request reprint Statin use and the risk of incident dementia: the Cardiovascular Health Study
    Thomas D Rea
    Department of Medicine, University of Washington, Seattle 98101, USA
    Arch Neurol 62:1047-51. 2005
    ..Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce cardiovascular risk through mechanisms that might affect the development of dementia...
  82. ncbi request reprint Physical activity, APOE genotype, and dementia risk: findings from the Cardiovascular Health Cognition Study
    Laura Jean Podewils
    Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Am J Epidemiol 161:639-51. 2005
    ..A similar pattern was observed for Alzheimer's disease and vascular dementia. Mechanisms to explain the observed relations deserve further study...
  83. ncbi request reprint Survival following dementia onset: Alzheimer's disease and vascular dementia
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
    J Neurol Sci 229:43-9. 2005
    ..4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive...
  84. ncbi request reprint Incidence and prevalence of dementia in the Cardiovascular Health Study
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
    J Am Geriatr Soc 52:195-204. 2004
    ..To estimate the incidence and prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in the Cardiovascular Health Study (CHS) cohort...
  85. ncbi request reprint Mean template for tensor-based morphometry using deformation tensors
    Natasha Lepore
    Laboratory of Neuro Imaging, UCLA, Los Angeles, CA 90095, USA
    Med Image Comput Comput Assist Interv 10:826-33. 2007
    ..These results are compared to the ones found using the 'best' control, B. Statistics on both shapes are evaluated using cumulative distribution functions of the p-values in maps of inter-group differences...
  86. ncbi request reprint Dementia with Lewy bodies
    Ian McKeith
    Institute for Ageing and Health, University of Newcastle, Newcastle upon Tyne, UK
    Lancet Neurol 3:19-28. 2004
    ..Clear guidance on the management of DLB is urgently needed. Virtually unrecognised 20 years ago, DLB could within this decade be one of the most treatable neurodegenerative disorders of late life...

Research Grants9

  1. Alzheimers Disease in Mild Cognitive Impairment
    Oscar Lopez; Fiscal Year: 2006
    ..2) the MCI multiple cognitive deficit-type, which represents a temporal elongation of the normal transition from aged to AD. Consequently, these participants will have a reduced risk to develop AD (5 percent per year). ..
  2. Predictors of Alzheimers Disease in Mild Cognitive Impairment
    Oscar Lopez; Fiscal Year: 2007
    ..g., structural and perfusion MRI, plasma beta-amyloid) and the factors that modify the risk to express the clinical syndrome takes on an added importance. ..
  3. Predictors of Alheimers Disease in Mild Cognitive Impairment
    Oscar Lopez; Fiscal Year: 2009
    ..This analysis will be conducted in a context of a large cohort using detailed medical information, and it constitutes an integrative approach to truly understand the development of AD and MCI in the general population. ..
  4. Predictors of Alheimers Disease in Mild Cognitive Impairment
    Oscar L Lopez; Fiscal Year: 2010
    ..This analysis will be conducted in a context of a large cohort using detailed medical information, and it constitutes an integrative approach to truly understand the development of AD and MCI in the general population. ..