O L Lopez

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint [Neuropathology of Alzheimer's disease and mild cognitive impairment]
    O L Lopez
    Departamento de Neurologia, Facultad de Medicina, Universidad de Pittsburgh, Pittsburgh, PA 15213, USA
    Rev Neurol 37:155-63. 2003
  2. ncbi request reprint [Classification of mild cognitive impairment in a population study]
    O L Lopez
    Alzeheimer s disease Research Center, Departamento de Neurología y Psiquiatría, University of Pittsburgh, Facultad de Medicina, Pittsburgh, PA 15261, USA
    Rev Neurol 37:140-4. 2003
  3. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
  4. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
  5. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
  6. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
  7. ncbi request reprint Risk modifiers for peripheral sensory neuropathy in HIV infection/AIDS
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, PA, USA
    Eur J Neurol 11:97-102. 2004
  8. ncbi request reprint Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
    O L Lopez
    Departments of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 64:1539-47. 2005
  9. ncbi request reprint [Factors that modify the natural course of Alzheimer's disease]
    O L Lopez
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Rev Neurol 37:149-55. 2003
  10. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012

Detail Information

Publications34

  1. ncbi request reprint [Neuropathology of Alzheimer's disease and mild cognitive impairment]
    O L Lopez
    Departamento de Neurologia, Facultad de Medicina, Universidad de Pittsburgh, Pittsburgh, PA 15213, USA
    Rev Neurol 37:155-63. 2003
    ..However, the mechanisms of specific vulnerability of the cholinergic system to AD, as well as the initial process that leads to the complex neuropathological lesions are unknown...
  2. ncbi request reprint [Classification of mild cognitive impairment in a population study]
    O L Lopez
    Alzeheimer s disease Research Center, Departamento de Neurología y Psiquiatría, University of Pittsburgh, Facultad de Medicina, Pittsburgh, PA 15261, USA
    Rev Neurol 37:140-4. 2003
    ..The purpose of this study was to describe the methodology for the diagnosis of mild cognitive impairment (MCI) in the Cardiovascular Health Study Cognition Study (CHS CS)...
  3. ncbi request reprint Psychiatric symptoms vary with the severity of dementia in probable Alzheimer's disease
    Oscar L Lopez
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:346-53. 2003
    ..Education and race were independently associated with psychosis. However, while education was associated with psychosis in mild/moderate stages, race was associated with psychosis in moderate/severe stages...
  4. ncbi request reprint Patterns of change in the treatment of psychiatric symptoms in patients with probable Alzheimer's disease from 1983 to 2000
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 15:67-73. 2003
    ..g., aggression, agitation) and sleep disorders in AD. Although the use of SHA has a proven deleterious effect on patients with AD, their use has increased over the past two decades...
  5. ncbi request reprint Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 1
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1385-9. 2003
    ..To examine the prevalence of mild cognitive impairment (MCI) and its diagnostic classification in the Cardiovascular Health Study (CHS) Cognition Study...
  6. ncbi request reprint Risk factors for mild cognitive impairment in the Cardiovascular Health Study Cognition Study: part 2
    Oscar L Lopez
    Departments of Neurology and Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 60:1394-9. 2003
    ..To examine the risk factors for mild cognitive impairment (MCI) in a longitudinal population study-the Cardiovascular Health Study Cognition Study...
  7. ncbi request reprint Risk modifiers for peripheral sensory neuropathy in HIV infection/AIDS
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, PA, USA
    Eur J Neurol 11:97-102. 2004
    ..The peripheral neurotoxic effect of anti-retroviral medication should be taken into account in the design of long-term therapies...
  8. ncbi request reprint Classification of vascular dementia in the Cardiovascular Health Study Cognition Study
    O L Lopez
    Departments of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 64:1539-47. 2005
    ..To describe the diagnostic classification of subjects with incident vascular dementia (VaD) participating in the Cardiovascular Health Study (CHS) Cognition Study...
  9. ncbi request reprint [Factors that modify the natural course of Alzheimer's disease]
    O L Lopez
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Rev Neurol 37:149-55. 2003
    ..Current palliative treatments for AD may alter the natural history of the disease by extending the time that affected patients may live at home...
  10. pmc Genome-wide association analysis of age-at-onset in Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Mol Psychiatry 17:1340-6. 2012
    ..These findings need to be confirmed in additional well-powered samples...
  11. pmc Determinants of vascular dementia in the Cardiovascular Health Cognition Study
    L H Kuller
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurology 64:1548-52. 2005
    ..The authors evaluated 3,375 participants without dementia at the time of MRI in 1991 to 1994 over 5.7 years for incident dementia and type of dementia...
  12. pmc Plasma amyloid levels and the risk of AD in normal subjects in the Cardiovascular Health Study
    O L Lopez
    Department of Psychiatry and Neurology, University of Pittsburgh, PA, USA
    Neurology 70:1664-71. 2008
    ....
  13. pmc Physical activity predicts gray matter volume in late adulthood: the Cardiovascular Health Study
    K I Erickson
    Department of Psychology, University of Pittsburgh, PA, USA
    Neurology 75:1415-22. 2010
    ....
  14. ncbi request reprint Psychiatric symptoms associated with cortical-subcortical dysfunction in Alzheimer's disease
    O L Lopez
    Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 13:56-60. 2001
    ..Frontal-subcortical dysfunction may also be associated with emotional lability and apathy in AD, although these may be related to a greater involvement of frontal-basal ganglia circuits...
  15. pmc Long-term effects of the concomitant use of memantine with cholinesterase inhibition in Alzheimer disease
    O L Lopez
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 80:600-7. 2009
    ..There are no long-term studies of the effects of memantine in combination with ChEIs use in Alzheimer disease (AD). This study was conducted to examine the effects of ChEIs and memantine on time to death and time to NH admission...
  16. ncbi request reprint Preclinical Alzheimer disease: neuropsychological test performance 1.5 to 8 years prior to onset
    J Saxton
    University of Pittsburgh, Oxford Building, Room 738, Pittsburgh, PA 15213, USA
    Neurology 63:2341-7. 2004
    ..To determine if individuals ultimately diagnosed with Alzheimer disease (AD) exhibited evidence of cognitive impairment on neuropsychological tests administered between 1.5 years and 8.1 years before dementia onset...
  17. pmc Neuropsychological characteristics of mild cognitive impairment subgroups
    O L Lopez
    Department of Neurology, University of Pittsburgh, School of Medicine, PA 15213, USA
    J Neurol Neurosurg Psychiatry 77:159-65. 2006
    ..To describe the neuropsychological characteristics of mild cognitive impairment (MCI) subgroups identified in the Cardiovascular Health Study (CHS) cognition study...
  18. pmc Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia
    J Saxton
    Department of Neurology, University of Pittsburgh, 3471 Fifth Avenue, Suite 811, Pittsburgh, PA 15213, USA
    J Neurol Neurosurg Psychiatry 80:737-43. 2009
    ..To compare rates of mild cognitive impairment (MCI) and rates of progression to dementia using different MCI diagnostic systems...
  19. ncbi request reprint Psychotic symptoms in Alzheimer's disease are not associated with more severe neuropathologic features
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Int Psychogeriatr 12:547-58. 2000
    ..The association of AD+P with a more rapidly progressive course of AD appears to be mediated by a neuropathologic process other than increased severity of plaque and tangle formation...
  20. pmc Age, Alzheimer disease, and brain structure
    C A Raji
    Departments of Pathology, School of Medicine and Graduate School of Public Health, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2582, USA
    Neurology 73:1899-905. 2009
    ..Lack of clear understanding remains on the overlapping atrophy patterns of aging and early Alzheimer disease (AD) pathology in gray matter (GM) of the brain in vivo...
  21. ncbi request reprint Dopamine receptor genetic variation, psychosis, and aggression in Alzheimer disease
    R A Sweet
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Arch Neurol 55:1335-40. 1998
    ..To examine if selected polymorphisms in the dopamine receptor genes DRD1, DRD2, DRD3, and DRD4 are associated with the presence of psychosis or aggressive behavior in patients with Alzheimer disease (AD)...
  22. pmc Predicting risk of dementia in older adults: The late-life dementia risk index
    D E Barnes
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Neurology 73:173-9. 2009
    ..To develop a late-life dementia risk index that can accurately stratify older adults into those with a low, moderate, or high risk of developing dementia within 6 years...
  23. ncbi request reprint Lewy bodies in the amygdala increase risk for major depression in subjects with Alzheimer disease
    O L Lopez
    Alzheimer s Disease Research Center, Department of Neurology, University of Pittsburgh School of Medicine, PA, USA
    Neurology 67:660-5. 2006
    ..To determine the relationship between major depression and the presence of Lewy bodies (LBs) in patients with Alzheimer disease (AD)...
  24. ncbi request reprint The psychotic phenomenon in probable Alzheimer's disease: a positron emission tomography study
    O L Lopez
    Alzheimer's Disease Research Center and Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 13:50-5. 2001
    ..In these patients, a left prefrontal-temporal cortex dysfunction appears to be a common denominator for the development of the psychotic phenomenon in AD...
  25. ncbi request reprint Increased familial risk of the psychotic phenotype of Alzheimer disease
    R A Sweet
    Division of Geriatrics and Neuropsychiatry, School of Medicine, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 58:907-11. 2002
    ..Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors...
  26. pmc Genome-wide association study of Alzheimer's disease
    M I Kamboh
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Transl Psychiatry 2:e117. 2012
    ..43. This is a potential candidate gene for AD as this is expressed in the brain and is involved in lipid metabolism. These findings need to be confirmed in additional samples...
  27. pmc Right prosubiculum amyloid plaque density correlates with anosognosia in Alzheimer's disease
    G A Marshall
    Department of Neurology, University of Pittsburgh, Pennsylvania, USA
    J Neurol Neurosurg Psychiatry 75:1396-400. 2004
    ..There is an association between impaired awareness and frontal-executive cognitive deficits. Anosognosia is also correlated with decreased metabolism in the right hemisphere, particularly in frontal lobe regions...
  28. pmc Cholinesterase inhibitor treatment alters the natural history of Alzheimer's disease
    O L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Neurol Neurosurg Psychiatry 72:310-4. 2002
    ..To describe the effect of cholinesterase inhibitors (CEIs) on the natural course of Alzheimer's disease (AD)...
  29. pmc Replication study of genome-wide associated SNPs with late-onset Alzheimer's disease
    L C Burns
    Department of Human Genetics, University of Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 156:507-12. 2011
    ..0002). Although we have been unable to replicate the reported GWAS association with AD risk in our sample, we have identified two new associations with AAO and disease duration that need to be confirmed in additional studies...
  30. ncbi request reprint Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory
    D I Kaufer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neuropsychiatry Clin Neurosci 12:233-9. 2000
    ..The NPI-Q provides a brief, reliable, informant-based assessment of neuropsychiatric symptoms and associated caregiver distress that may be suitable for use in general clinical practice...
  31. pmc Initial experience in using continuous arterial spin-labeled MR imaging for early detection of Alzheimer disease
    C A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    AJNR Am J Neuroradiol 31:847-55. 2010
    ..We investigated the diagnostic utility of perfusion MR imaging for early detection of AD compared with structural imaging...
  32. ncbi request reprint Functional neuroimaging indicators of successful executive control in the oldest old
    C Rosano
    School of Public Health, Department of Epidemiology, University of Pittsburgh, PA 15260, USA
    Neuroimage 28:881-9. 2005
    ..Older adults who are able to perform executive control tasks as well as young adults, also seem to implement speed-accuracy trade-off strategies which may rely on increased parietal activation...
  33. ncbi request reprint [Difficulties in differential diagnosis of long-term Creutzfeldt- Jakob disease]
    O L Lopez
    Departamento de Neurologia, University of Pittsburgh Medical Center, Pennsylvania
    Neurologia 10:37-40. 1995
    ..Only two of them had shown signs of CJD in the terminal stages. In this study we examine the clinical characteristics of these patients, and discuss of differentiating CJD from other entities, especially from AD...
  34. pmc Generalized tensor-based morphometry of HIV/AIDS using multivariate statistics on deformation tensors
    N Lepore
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    IEEE Trans Med Imaging 27:129-41. 2008
    ..This increased detection sensitivity may empower drug trials and large-scale studies of disease that use tensor-based morphometry...